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Article ; Online: MOLECULAR PHYLOGENETIC ANALYSIS OF GYRINICOLA BATRACHIENSIS (NEMATODA: OXYUROIDEA) LENDS SUPPORT TO THE MONOPHYLY OF THE GENUS AND THE RESURRECTION OF GYRINICOLINAE.

Walker, Matthew A / Bolek, Matthew G / Zieman, Elliott A / Langford, Gabriel J / Reyda, Florian B / Jiménez, F Agustín

2023 Volume 109, Issue 6, Page(s) 622–632

Abstract: Gyrinicola Yamaguti, 1938, includes 6 species of oxyurid found within the intestinal tract of numerous, larval, anuran species in Europe, Asia, South America, and North America. The systematic placement and hierarchical treatment of the genus has shifted ...

Abstract	Gyrinicola Yamaguti, 1938, includes 6 species of oxyurid found within the intestinal tract of numerous, larval, anuran species in Europe, Asia, South America, and North America. The systematic placement and hierarchical treatment of the genus has shifted at least 5 times since its discovery; the group was first considered as its own family (Gyrinicolidae), then treated as a subfamily (Gyrinicolinae) of Cosmocercidae, then as a member of the Pharyngodonidae, followed by movement back to the Cosmocercidae, and finally a recent proposal suggested the resurrection of the Gyrinicolidae. Species in the genus vary widely in the morphology of the uterine tract, a characteristic often used to indicate membership in the genus, as it is tied to the reproductive mode. However, until recently very few genetic data were available to aid in the placement of this unique group of worms, and before this study to the best of our knowledge none existed for the North American species. To examine the monophyly and placement of the Gyrinicola we sampled populations of Gyrinicola batrachiensis across North America and screened them for genetic diversity using nuclear markers 18S and 28S. Phylogenies suggest at least 3 clades exist among the nematodes from North America and that these clades, alongside Gyrinicola japonica, form a well-supported group within Oxyuroidea. Further representation of Pharyngodonidae from other vertebrate classes may help clarify the relationship of this historical grouping to other members of the Oxyuroidea.
MeSH term(s)	Animals ; Oxyuroidea/anatomy & histology ; Phylogeny ; Nematoda/genetics ; Anura ; Reproduction
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	300870-8
ISSN	1937-2345 ; 0022-3395
ISSN (online)	1937-2345
ISSN	0022-3395
DOI	10.1645/22-108
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Article ; Online: Erratum to "halo naevus or malignant melanoma: A case report" [JPRAS open volume 16, June 2018, pages 98-99].

Langford, Matthew A / Al-Ghazal, Sharif K

JPRAS open

2019 Volume 26, Page(s) 109

Abstract: This corrects the article DOI: 10.1016/j.jpra.2018.03.003.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.jpra.2018.03.003.].
Language	English
Publishing date	2019-11-21
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2834721-3
ISSN	2352-5878 ; 2352-5878
ISSN (online)	2352-5878
ISSN	2352-5878
DOI	10.1016/j.jpra.2019.11.005
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Article: Effectiveness of Flat-Panel Fluoroscopy in Direct Anterior Total Hip Arthroplasty: A Comparison to Image Intensifier Fluoroscopy With Radiopaque Grid.

Gapinski, Zachary A / Kerr, Matthew S / Langford, Joshua R / Avilucea, Frank R

Arthroplasty today

2023 Volume 24, Page(s) 101253

Abstract: Introduction: The use of traditional, image intensifier fluoroscopy with a radiopaque grid during direct anterior total hip arthroplasty (DA THA) has demonstrated reduced variability in component positioning and operative time compared to fluoroscopy ... ...

Abstract	Introduction: The use of traditional, image intensifier fluoroscopy with a radiopaque grid during direct anterior total hip arthroplasty (DA THA) has demonstrated reduced variability in component positioning and operative time compared to fluoroscopy without a grid. A disadvantage of image intensifier fluoroscopy is spatial distortion, particularly compared to flat-panel fluoroscopy systems. The purpose of this study is to determine whether flat-panel fluoroscopy decreases variability in component positioning during DA THA compared to the use of traditional grid fluoroscopy. Methods: We retrospectively reviewed 70 consecutive DA THAs between February 2020 and February 2021: 36 using flat-panel fluoroscopy, and 34 using traditional fluoroscopy with a grid. Radiographs were independently reviewed by 2 authors to identify components exceeding goal parameters: cup abduction of 40 ± 10 degrees, as well as offset and limb lengths within 10 mm of the contralateral side. Binary values for goal parameter achievement were assigned for each THA. Results: No significant difference was observed in the number of hips that met goals for cup abduction (100% vs 97%, Conclusions: We demonstrated no significant difference in component positioning in DA THAs utilizing flat-panel fluoroscopy as compared to using traditional fluoroscopy with a grid.
Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article
ISSN	2352-3441
ISSN	2352-3441
DOI	10.1016/j.artd.2023.101253
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Article ; Online: Pyogenic flexor tenosynovitis due to

Garry, Conor / Ernst, Andrew / Langford, Matthew / Adams, Daniel J

BMJ case reports

2023 Volume 16, Issue 7

Abstract: Pyogenic flexor tenosynovitis is relatively common but is seldom reported in young children. ...

Abstract	Pyogenic flexor tenosynovitis is relatively common but is seldom reported in young children.
MeSH term(s)	Child ; Humans ; Infant ; Child, Preschool ; Kingella kingae ; Tenosynovitis/diagnosis ; Tenosynovitis/drug therapy ; Affect ; Antibiotic Prophylaxis ; Physical Examination
Language	English
Publishing date	2023-07-11
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-254357
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Article ; Online: The Radial Synergy Test: An Aid to Diagnose de Quervain's Tenosynovitis.

Lee, Chihua / Langford, Phillip N / Sullivan, Graham E / Langford, Matthew A / Hogan, Christopher J / Ruland, Robert T

Hand (New York, N.Y.)

2021 Volume 18, Issue 2_suppl, Page(s) 32S–37S

Abstract: Background: Diagnosis of de Quervain's tenosynovitis is made clinically. Finkelstein's and Eichoff's tests are commonly utilized examination maneuvers. Their specificity has been questioned due to a propensity to provoke pain in asymptomatic patients. ... ...

Abstract	Background: Diagnosis of de Quervain's tenosynovitis is made clinically. Finkelstein's and Eichoff's tests are commonly utilized examination maneuvers. Their specificity has been questioned due to a propensity to provoke pain in asymptomatic patients. Using the principle of synergism, the novel radial synergy test takes advantage of isometric contraction of the first dorsal compartment with resisted abduction of the small finger. Methods: Electromyography was performed on 3 authors and the first dorsal compartment sampled during the maneuver. Sensitivity evaluation was performed via retrospective chart review for patients diagnosed with de Quervain's from 2013 to 2018. Inclusion criteria were documented radial synergy test, Eichoff's test, and ≥90% pain relief after lidocaine/corticosteroid injection. We enrolled 222 patients with 254 affected extremities. Specificity evaluation was performed via a prospective cohort of volunteers undergoing radial synergy and Eichoff's tests. Inclusion criterion was lack of preexisting wrist pain. Score > 0 on Visual Analog Scale was considered positive. We enrolled 48 volunteers with 93 tested extremities. Results: Electromyography revealed positive recruitment of the first dorsal compartment. Sensitivity of the radial synergy test was inferior to Eichoff's test (97% vs 91%, relative risk [RR] = 0.93 [95% confidence interval [CI] = 0.89-0.97], Conclusions: We describe and evaluate the radial synergy test, a novel examination maneuver to aid the diagnosis of de Quervain's. This serves as an adjunct for future diagnostic evaluations with its high specificity. Level of evidence: Level II, diagnostic study.
MeSH term(s)	Humans ; Tenosynovitis/diagnosis ; De Quervain Disease/diagnosis ; Prospective Studies ; Retrospective Studies ; Pain/diagnosis ; Lidocaine
Chemical Substances	Lidocaine (98PI200987)
Language	English
Publishing date	2021-12-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2277325-3
ISSN	1558-9455 ; 1558-9447
ISSN (online)	1558-9455
ISSN	1558-9447
DOI	10.1177/15589447211057297
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Article ; Online: Halo naevus or malignant melanoma: A case report.

Langford, Matthew A / Al-Ghazal, Sharif K

JPRAS open

2018 Volume 16, Page(s) 98–99

Abstract: This is a report describing the case of a 66-year-old male with development of halo naevi. A biopsy of one of these naevi revealed a malignant melanoma with extensive regression. The purpose of this report is to identify that development of halo naevi ... ...

Abstract	This is a report describing the case of a 66-year-old male with development of halo naevi. A biopsy of one of these naevi revealed a malignant melanoma with extensive regression. The purpose of this report is to identify that development of halo naevi outside of childhood or adolescence should raise suspicion and may require biopsy.
Language	English
Publishing date	2018-04-06
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2834721-3
ISSN	2352-5878 ; 2352-5878
ISSN (online)	2352-5878
ISSN	2352-5878
DOI	10.1016/j.jpra.2018.03.003
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Article ; Online: Examining the role of different weakness categories for mobility and future falls in older Americans.

McGrath, Ryan / Jurivich, Donald A / Christensen, Bryan K / Choi, Bong-Jin / Langford, Matthew / Rhee, Yeong / Tomkinson, Grant R / Hackney, Kyle J

Aging clinical and experimental research

2023 Volume 35, Issue 11, Page(s) 2491–2498

Abstract: Background: Recently developed absolute and body size normalized handgrip strength (HGS) cut-points could be used individually and collectively to predict mobility problems and falls.: Aims: We examined the associations of (1) each absolute and ... ...

Abstract	Background: Recently developed absolute and body size normalized handgrip strength (HGS) cut-points could be used individually and collectively to predict mobility problems and falls. Aims: We examined the associations of (1) each absolute and normalized weakness cut-point, (2) collective weakness categories, and (3) changes in weakness status on future falls in older Americans. Methods: The analytic sample included 11,675 participants from the 2006-2018 waves of the Health and Retirement Study. Falls were self-reported. Men were classified as weak if their HGS was < 35.5-kg (absolute), < 0.45 kg/kg (body mass normalized), or < 1.05 kg/kg/m Results: Older Americans below each absolute and normalized cut-point had greater odds for future falls: 1.23 (95% confidence interval (CI): 1.15-1.32) for absolute weakness, 1.20 (CI 1.11-1.29) for body mass index normalized weakness, and 1.26 (CI 1.17-1.34) for body mass normalized weakness. Persons below 1, 2, or all 3 weakness cut-points had 1.17 (CI 1.07-1.27), 1.29 (CI 1.18-1.40), and 1.36 (CI 1.24-1.48) greater odds for future falls, respectively. Those in some changing weakness categories had greater odds for future falls: 1.26 (CI 1.08-1.48) for persistent and 1.31 (CI 1.11-1.55) for progressive. Discussion: Collectively using these weakness cut-points may improve their predictive value. Conclusion: We recommend HGS be evaluated in mobility and fall risk assessments.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Hand Strength ; Accidental Falls ; Retirement ; Self Report ; Body Mass Index
Language	English
Publishing date	2023-08-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-023-02516-6
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Zs.A 3343: Show issues

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Article ; Online: Actinobacillus pleuropneumoniae encodes multiple phase-variable DNA methyltransferases that control distinct phasevarions.

Nahar, Nusrat / Tram, Greg / Jen, Freda E-C / Phillips, Zachary N / Weinert, Lucy A / Bossé, Janine T / Jabbari, Jafar S / Gouil, Quentin / Du, Mei R M / Ritchie, Matthew E / Bowden, Rory / Langford, Paul R / Tucker, Alexander W / Jennings, Michael P / Turni, Conny / Blackall, Patrick J / Atack, John M

Nucleic acids research

2023 Volume 51, Issue 7, Page(s) 3240–3260

Abstract: Actinobacillus pleuropneumoniae is the cause of porcine pleuropneumonia, a severe respiratory tract infection that is responsible for major economic losses to the swine industry. Many host-adapted bacterial pathogens encode systems known as phasevarions ( ...

Abstract	Actinobacillus pleuropneumoniae is the cause of porcine pleuropneumonia, a severe respiratory tract infection that is responsible for major economic losses to the swine industry. Many host-adapted bacterial pathogens encode systems known as phasevarions (phase-variable regulons). Phasevarions result from variable expression of cytoplasmic DNA methyltransferases. Variable expression results in genome-wide methylation differences within a bacterial population, leading to altered expression of multiple genes via epigenetic mechanisms. Our examination of a diverse population of A. pleuropneumoniae strains determined that Type I and Type III DNA methyltransferases with the hallmarks of phase variation were present in this species. We demonstrate that phase variation is occurring in these methyltransferases, and show associations between particular Type III methyltransferase alleles and serovar. Using Pacific BioSciences Single-Molecule, Real-Time (SMRT) sequencing and Oxford Nanopore sequencing, we demonstrate the presence of the first ever characterised phase-variable, cytosine-specific Type III DNA methyltransferase. Phase variation of distinct Type III DNA methyltransferase in A. pleuropneumoniae results in the regulation of distinct phasevarions, and in multiple phenotypic differences relevant to pathobiology. Our characterisation of these newly described phasevarions in A. pleuropneumoniae will aid in the selection of stably expressed antigens, and direct and inform development of a rationally designed subunit vaccine against this major veterinary pathogen.
MeSH term(s)	Animals ; Swine ; Phase Variation ; Actinobacillus pleuropneumoniae/genetics ; Actinobacillus pleuropneumoniae/metabolism ; DNA Modification Methylases/genetics ; DNA Modification Methylases/metabolism ; DNA Methylation ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Bacteria/genetics ; DNA/metabolism
Chemical Substances	DNA Modification Methylases (EC 2.1.1.-) ; Methyltransferases (EC 2.1.1.-) ; DNA (9007-49-2)
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad091
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Article ; Online: The management of complications of small joint arthrodesis and arthroplasty.

Satteson, Ellen S / Langford, Matthew A / Li, Zhongyu

Hand clinics

2015 Volume 31, Issue 2, Page(s) 243–266

Abstract: Arthrodesis and arthroplasty are surgical options used for the management of pain, stiffness, deformity, and instability related to arthritis and traumatic injury of the small joints of the hand. Arthrodesis and arthroplasty come with a risk of ... ...

Abstract	Arthrodesis and arthroplasty are surgical options used for the management of pain, stiffness, deformity, and instability related to arthritis and traumatic injury of the small joints of the hand. Arthrodesis and arthroplasty come with a risk of postoperative infection. Superficial soft tissue infections can often be managed with oral antibiotics alone. Deep infections and osteomyelitis frequently require removal of hardware in addition to antibiotics and may require surgical revision once the infection is cleared. Selection of the most appropriate revision technique depends on the underlying cause of the initial failure, patients' functional and outcome needs, and surgeon preference.
MeSH term(s)	Arthrodesis/adverse effects ; Arthroplasty/adverse effects ; Hand Injuries/complications ; Hand Injuries/surgery ; Hand Joints/injuries ; Hand Joints/surgery ; Humans ; Reoperation
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1315374-2
ISSN	1558-1969 ; 0749-0712
ISSN (online)	1558-1969
ISSN	0749-0712
DOI	10.1016/j.hcl.2015.01.002
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Article ; Online: The identification of effective welfare indicators for laboratory-housed macaques using a Delphi consultation process.

Truelove, Melissa A / Martin, Jessica E / Langford, Fritha M / Leach, Matthew C

Scientific reports

2020 Volume 10, Issue 1, Page(s) 20402

Abstract: Despite the importance for both animal welfare and scientific integrity of effective welfare assessment in non-human primates, there has been little or no consensus as what should be assessed. A Delphi consultation process was undertaken to identify the ... ...

Abstract	Despite the importance for both animal welfare and scientific integrity of effective welfare assessment in non-human primates, there has been little or no consensus as what should be assessed. A Delphi consultation process was undertaken to identify the animal- and environment-based measures of welfare for laboratory-housed macaques and to determine their relative importance in on-site welfare assessments. One-hundred fifteen potential indictors were identified through a comprehensive literature search, followed by a two-round iterative electronic survey process to collect expert opinion. Stable group response and consensus about the validity, reliability, and feasibility of the proposed indicators (67.5% agreement) was achieved by the completion of Round Two. A substantially higher proportion of environment-based measures (72%: n = 44/61) were considered as valid, reliable, and feasible compared to the animal-based measures (22%: n = 12/54). The indicators that ranked most highly for assessing welfare were the presence of self-harm behaviours and the provision of social enrichment. This study provides an empirical basis upon which these indicators can be validated and then integrated into assessment tools developed for macaques and emphasises the need to include both animal- and environment-based indicators for accurate welfare monitoring.
MeSH term(s)	Animal Husbandry/ethics ; Animal Husbandry/instrumentation ; Animal Husbandry/organization & administration ; Animal Welfare/ethics ; Animal Welfare/organization & administration ; Animals ; Consensus ; Delphi Technique ; Expert Testimony ; Female ; Humans ; Macaca/physiology ; Macaca/psychology ; Male ; Self-Injurious Behavior/prevention & control ; Self-Injurious Behavior/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2020-11-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-77437-9
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