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Article: Dietary Macronutrient Composition Differentially Modulates the Remodeling of Mitochondrial Oxidative Metabolism during NAFLD.

Kattapuram, Nathan / Zhang, Christine / Muyyarikkandy, Muhammed S / Surugihalli, Chaitra / Muralidaran, Vaishna / Gregory, Tabitha / Sunny, Nishanth E

Metabolites

2021 Volume 11, Issue 5

Abstract: Diets rich in fats and carbohydrates aggravate non-alcoholic fatty liver disease (NAFLD), of which mitochondrial dysfunction is a central feature. It is not clear whether a high-carbohydrate driven 'lipogenic' diet differentially affects mitochondrial ... ...

Abstract	Diets rich in fats and carbohydrates aggravate non-alcoholic fatty liver disease (NAFLD), of which mitochondrial dysfunction is a central feature. It is not clear whether a high-carbohydrate driven 'lipogenic' diet differentially affects mitochondrial oxidative remodeling compared to a high-fat driven 'oxidative' environment. We hypothesized that the high-fat driven 'oxidative' environment will chronically sustain mitochondrial oxidative function, hastening metabolic dysfunction during NAFLD. Mice (C57BL/6NJ) were reared on a low-fat (LF; 10% fat calories), high-fat (HF; 60% fat calories), or high-fructose/high-fat (HFr/HF; 25% fat and 34.9% fructose calories) diet for 10 weeks. De novo lipogenesis was determined by measuring the incorporation of deuterium from D
Language	English
Publishing date	2021-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11050272
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Article ; Online: Limited magnetic resonance imaging of the lumbar spine has high sensitivity for detection of acute fractures, infection, and malignancy.

Wang, Benjamin / Fintelmann, Florian J / Kamath, Ravi S / Kattapuram, Susan V / Rosenthal, Daniel I

Skeletal radiology

2016 Volume 45, Issue 12, Page(s) 1687–1693

Abstract: Objective: The objective of this study is to determine how a limited protocol MR examination compares to a full conventional MR examination for the detection of non-degenerative pathology such as acute fracture, infection, and malignancy.: Materials ... ...

Abstract	Objective: The objective of this study is to determine how a limited protocol MR examination compares to a full conventional MR examination for the detection of non-degenerative pathology such as acute fracture, infection, and malignancy. Materials and methods: A sample of 349 non-contrast MR exams was selected retrospectively containing a 3:1:1:1 distribution of negative/degenerative change only, acute fracture, infection, and malignancy. This resulted in an even distribution of pathology and non-pathology. A limited protocol MR exam was simulated by extracting T1-weighted sagittal and T2-weighted fat-saturated (or STIR) sagittal sequences from each exam and submitting them for blinded review by two experienced musculoskeletal radiologists. The exams were evaluated for the presence or absence of non-degenerative pathology. Interpretation of the limited exam was compared to the original report of the full examination. If either reader disagreed with the original report, the case was submitted for an unblinded adjudication process with the participation of a third musculoskeletal radiologist to establish a consensus diagnosis. Results: There were five false negatives for a sensitivity of 96.9 % for the limited protocol MR exam. Infection in the psoas, paraspinal muscles, and sacroiliac joint, as well as acute fractures in transverse processes and sacrum were missed by one or more readers. No cases of malignancy were missed. Overall diagnostic accuracy was 96.0 % (335/349). Conclusions: MR imaging of the lumbar spine limited to sagittal T1-weighted and sagittal T2 fat-saturated (or STIR) sequences has high sensitivity for the detection of acute fracture, infection, or malignancy compared to a conventional MR examination.
Language	English
Publishing date	2016-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-016-2493-5
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Article ; Online: Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD.

Muyyarikkandy, Muhammed S / McLeod, Marc / Maguire, Meghan / Mahar, Rohit / Kattapuram, Nathan / Zhang, Christine / Surugihalli, Chaitra / Muralidaran, Vaishna / Vavilikolanu, Kruthi / Mathews, Clayton E / Merritt, Matthew E / Sunny, Nishanth E

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2020 Volume 34, Issue 11, Page(s) 14832–14849

Abstract: Mitochondrial adaptation during non-alcoholic fatty liver disease (NAFLD) include remodeling of ketogenic flux and sustained tricarboxylic acid (TCA) cycle activity, which are concurrent to onset of oxidative stress. Over 70% of obese humans have NAFLD ... ...

Abstract	Mitochondrial adaptation during non-alcoholic fatty liver disease (NAFLD) include remodeling of ketogenic flux and sustained tricarboxylic acid (TCA) cycle activity, which are concurrent to onset of oxidative stress. Over 70% of obese humans have NAFLD and ketogenic diets are common weight loss strategies. However, the effectiveness of ketogenic diets toward alleviating NAFLD remains unclear. We hypothesized that chronic ketogenesis will worsen metabolic dysfunction and oxidative stress during NAFLD. Mice (C57BL/6) were kept (for 16-wks) on either a low-fat, high-fat, or high-fat diet supplemented with 1.5X branched chain amino acids (BCAAs) by replacing carbohydrate calories (ketogenic). The ketogenic diet induced hepatic lipid oxidation and ketogenesis, and produced multifaceted changes in flux through the individual steps of the TCA cycle. Higher rates of hepatic oxidative fluxes fueled by the ketogenic diet paralleled lower rates of de novo lipogenesis. Interestingly, this metabolic remodeling did not improve insulin resistance, but induced fibrogenic genes and inflammation in the liver. Under a chronic "ketogenic environment," the hepatocyte diverted more acetyl-CoA away from lipogenesis toward ketogenesis and TCA cycle, a milieu which can hasten oxidative stress and inflammation. In summary, chronic exposure to ketogenic environment during obesity and NAFLD has the potential to aggravate hepatic mitochondrial dysfunction.
MeSH term(s)	Amino Acids, Branched-Chain/metabolism ; Animals ; Carbohydrate Metabolism ; Citric Acid Cycle ; Diet, Ketogenic/adverse effects ; Lipogenesis ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria, Liver/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Oxidative Stress
Chemical Substances	Amino Acids, Branched-Chain
Language	English
Publishing date	2020-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202001495R
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Magnetic resonance imaging of bone and soft tissue infections.

Kattapuram, T M / Treat, M E / Kattapuram, S V

Current clinical topics in infectious diseases

2001 Volume 21, Page(s) 190–226

MeSH term(s)	Abscess/diagnostic imaging ; Acute Disease ; Adult ; Aged ; Arthritis/diagnostic imaging ; Cellulitis/diagnostic imaging ; Chronic Disease ; Communicable Diseases/diagnostic imaging ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Osteomyelitis/diagnostic imaging ; Osteomyelitis/etiology ; Radiography
Language	English
Publishing date	2001
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605626-x
ISSN	0195-3842
ISSN	0195-3842
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Article: Idiopathic and diabetic skeletal muscle necrosis: evaluation by magnetic resonance imaging.

Kattapuram, Taj M / Suri, Rajeev / Rosol, Michael S / Rosenberg, Andrew E / Kattapuram, Susan V

Skeletal radiology

2005 Volume 34, Issue 4, Page(s) 203–209

Abstract: Objective: Idiopathic and diabetic-associated muscle necrosis are similar, uncommon clinical entities requiring conservative management and minimal intervention to avoid complications and prolonged hospitalization. An early noninvasive diagnosis is ... ...

Abstract	Objective: Idiopathic and diabetic-associated muscle necrosis are similar, uncommon clinical entities requiring conservative management and minimal intervention to avoid complications and prolonged hospitalization. An early noninvasive diagnosis is therefore essential. We evaluated the magnetic resonance imaging (MRI) characteristics of muscle necrosis in 14 patients, in eight of whom the diagnoses were confirmed histologically. Design and patients: Two experienced musculoskeletal radiologists performed retrospective evaluations of the MRI studies of 14 patients with the diagnoses of skeletal muscle infarction. In 10 cases gadolinium-enhanced (T1-weighted fat-suppressed) sequences were available along with T1-weighted, T2-weighted images and STIR sequences, while in four cases contrast-enhanced images were not available. Results: Eight patients had underlying diabetes and in six patients the cause of the myonecrosis was considered idiopathic. T1-weighted images demonstrated isointense swelling of the involved muscle, with mildly displaced fascial planes. There was effacement of the fat signal intensity within the muscle. Fat-suppressed T2-weighted images showed diffuse heterogeneous high signal intensity in the muscles suggestive of edema. Perifascial fluid collection was seen in eight cases. Subcutaneous edema was present in seven patients. Following intravenous gadolinium administration, MRI demonstrated a focal area of heterogeneously enhancing mass with peripheral enhancement. Within this focal lesion, linear dark areas were seen with serpentine enhancing streaks separating them in eight cases. In two cases, a central relatively nonenhancing mass with irregular margins and peripheral enhancement was noted. The peripheral enhancement involved a significant part of the muscle. No focal fluid collection was noted. Conclusions: We believe that the constellation of imaging findings on T1- and T2-weighted images and post-gadolinium sequences is highly suggestive of muscle necrosis. We consider certain specific findings on gadolinium-enhanced images to be characteristic. The findings reported here should provide radiologists with useful information in making the diagnosis of skeletal muscle necrosis without resorting to invasive procedures.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biopsy ; Contrast Media/administration & dosage ; Diabetes Mellitus, Type 1/complications ; Diagnosis, Differential ; Edema/diagnosis ; Fascia/pathology ; Female ; Gadolinium DTPA ; Humans ; Image Enhancement/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Muscle, Skeletal/pathology ; Muscular Diseases/complications ; Muscular Diseases/diagnosis ; Necrosis ; Observer Variation ; Retrospective Studies
Chemical Substances	Contrast Media ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2005-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-004-0881-8
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Article: Case report 181: calcified popliteal cyst (Baker cyst).

Kattapuram, S V

Skeletal radiology

1982 Volume 7, Issue 4, Page(s) 279–281

MeSH term(s)	Aneurysm/diagnostic imaging ; Calcinosis/diagnostic imaging ; Diabetes Complications ; Diagnosis, Differential ; Female ; Humans ; Knee Joint/diagnostic imaging ; Middle Aged ; Popliteal Artery ; Radiography ; Synovial Cyst/diagnostic imaging
Language	English
Publishing date	1982-01
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/bf00361987
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Article: Osteoarthritis: with emphasis on primary osteoarthritis of the shoulder.

Phillips, W C / Kattapuram, S V

Delaware medical journal

1991 Volume 63, Issue 10, Page(s) 609–613

Abstract: Fifty-three shoulders in 35 patients were found to have osteoarthritis (OA) of the shoulder using radiographic criteria to establish the diagnosis. Thirty of these shoulders did not exhibit any predetermined signs of secondary OA and were labeled primary ...

Abstract	Fifty-three shoulders in 35 patients were found to have osteoarthritis (OA) of the shoulder using radiographic criteria to establish the diagnosis. Thirty of these shoulders did not exhibit any predetermined signs of secondary OA and were labeled primary OA. The average age of the patients was 79 years. This article discusses OA, with special emphasis on primary OA of the shoulder. Primary OA of the shoulder appears to occur in older individuals and may not be as rare as many observers have stated.
MeSH term(s)	Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/epidemiology ; Prevalence ; Radiography ; Shoulder Joint/diagnostic imaging
Language	English
Publishing date	1991-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	428380-6
ISSN	0011-7781
ISSN	0011-7781
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Zs.B 103: Show issues

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Article: Percutaneous biopsy of skeletal lesions.

Kattapuram, S V / Rosenthal, D I

AJR. American journal of roentgenology

1991 Volume 157, Issue 5, Page(s) 935–942

Abstract: Percutaneous needle biopsy of lesions affecting the musculoskeletal system should be considered a routine radiologic procedure. Although relatively safe, the procedure requires expertise. An experienced radiologist and the cooperation of a skilled ... ...

Abstract	Percutaneous needle biopsy of lesions affecting the musculoskeletal system should be considered a routine radiologic procedure. Although relatively safe, the procedure requires expertise. An experienced radiologist and the cooperation of a skilled pathologist are essential. Consultation with the orthopedic surgeon is also important, especially when resection of the lesion is contemplated. Recent advances in imaging techniques and the availability of various cutting and trephine needles have made it easier to perform biopsies safely and accurately, even in difficult locations. The procedure obviates surgery in many instances and facilitates appropriate surgical planning in others. This review offers a pragmatic approach to percutaneous needle biopsy of skeletal lesions. It is hoped that more radiologists will be encouraged to undertake these valuable procedures.
MeSH term(s)	Biopsy, Needle/methods ; Bone Diseases/pathology ; Bone and Bones/pathology ; Humans ; Needles ; Radiography, Interventional/methods
Language	English
Publishing date	1991-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/ajr.157.5.1927811
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Article: Hemophiliac pseudotumor of the sacrum.

Ehara, S / Kattapuram, S V

Radiation medicine

1989 Volume 7, Issue 5, Page(s) 214–216

Abstract: Although the pelvis is a common site for hemophiliac pseudotumors, involvement of the axial skeleton, such as the spine and sacrum, is rare. A rare case of hemophiliac pseudotumor arising from a healed fracture of the sacrum is reported. Findings of ... ...

Abstract	Although the pelvis is a common site for hemophiliac pseudotumors, involvement of the axial skeleton, such as the spine and sacrum, is rare. A rare case of hemophiliac pseudotumor arising from a healed fracture of the sacrum is reported. Findings of plain radiographs, CT, and radionuclide bone scan may simulate tumors of neural origin, but the heterogeneity of MRI is suggestive of hemophiliac pseudotumor.
MeSH term(s)	Adult ; Diagnosis, Differential ; Fractures, Bone/complications ; Hematoma/diagnosis ; Hematoma/diagnostic imaging ; Hematoma/etiology ; Hemophilia A/complications ; Humans ; Male ; Pelvic Bones/injuries ; Radiography ; Radionuclide Imaging ; Sacrum/diagnostic imaging ; Spinal Neoplasms/diagnosis ; Spinal Neoplasms/diagnostic imaging
Language	English
Publishing date	1989-09
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	639138-2
ISSN	1862-5274 ; 0288-2043
ISSN (online)	1862-5274
ISSN	0288-2043
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Zs.A 2249: Show issues

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Article: Tuberculosis of contralateral costo-transverse joints.

Levine, S M / Marianacci, E B / Kattapuram, S V

Skeletal radiology

1997 Volume 26, Issue 12, Page(s) 741–743

Abstract: We present a case of multifocal tuberculosis of contralateral costo-transverse joints. Even in countries where tuberculosis is common, extrapulmonary multifocal infection is uncommon. Furthermore, a bilateral, symmetric distribution is distinctly unusual. ...

Abstract	We present a case of multifocal tuberculosis of contralateral costo-transverse joints. Even in countries where tuberculosis is common, extrapulmonary multifocal infection is uncommon. Furthermore, a bilateral, symmetric distribution is distinctly unusual. The index of suspicion for tuberculosis should increase when the patient is from a country where tuberculosis is endemic or when a history of AIDS is present.
MeSH term(s)	Adult ; Biopsy, Needle ; Diagnosis, Differential ; Female ; Humans ; Joints/microbiology ; Joints/pathology ; Low Back Pain/diagnosis ; Low Back Pain/etiology ; Low Back Pain/microbiology ; Magnetic Resonance Imaging ; Mycobacterium tuberculosis/isolation & purification ; Ribs/diagnostic imaging ; Ribs/microbiology ; Ribs/pathology ; Thoracic Vertebrae/diagnostic imaging ; Thoracic Vertebrae/pathology ; Tomography, X-Ray Computed ; Tuberculosis, Osteoarticular/complications ; Tuberculosis, Osteoarticular/diagnosis ; Tuberculosis, Osteoarticular/microbiology
Language	English
Publishing date	1997-12
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s002560050323
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