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Article ; Online: S. K. Adesina, O. Idowu, A. O. Ogundaini, H. Oladimeji, T. A. Olugbade, G. O. Onawunmi and M. Pais, 'Antimicrobial constituents of the leaves of EAcalypha wilkesiana and acalypha hispida'. Phytotherapy research14(5) 2000, 371-374

Adesina / Idowu / Ogundaini / Oladimeji / Olugbade / Onawunmi / Pais

2000 Volume 14, Issue 8, Page(s) 661

Abstract: The original article to which this Erratum refers was published in Phytotherapy Research 14(5) 2000, 371-374. Following publication of this paper in the August 2000 issue of Phytotherapy Research (14(5):371-374), it has come to our attention that the ... ...

Abstract	The original article to which this Erratum refers was published in Phytotherapy Research 14(5) 2000, 371-374. Following publication of this paper in the August 2000 issue of Phytotherapy Research (14(5):371-374), it has come to our attention that the dates of receipt and acceptance were printed incorrectly. The corrected dates appear below. The publishers would like to apologise for any confusion caused. Received 28 August 1996 Accepted 15 June 1997
Language	English
Publishing date	2000-12
Publishing country	England
Document type	Journal Article
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/1099-1573(200012)14:8<661::aid-ptr817>3.0.co;2-r
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Article: Exploring the bioaccessibility and intestinal absorption of major classes of pure phenolic compounds using

Pais, Adriana C S / Coscueta, Ezequiel R / Pintado, Maria Manuela / Silvestre, Armando J D / Santos, Sónia A O

Heliyon

2024 Volume 10, Issue 7, Page(s) e28894

Abstract: The bioaccessibility and bioavailability of phenolic compounds (PC) influence directly their role in disease prevention/control. Studies have evaluated this ability through complex plant and food matrices, which may reflect more a synergistic effect of ... ...

Abstract	The bioaccessibility and bioavailability of phenolic compounds (PC) influence directly their role in disease prevention/control. Studies have evaluated this ability through complex plant and food matrices, which may reflect more a synergistic effect of the matrix than the ability of the PCs, hindering their individual exploitation in nutraceutical or pharmaceutical applications. In the present study ten pure PCs representing major classes were evaluated for their bioaccessibility and intestinal absorption in an
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28894
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Article: Obesity-related glomerulopathy in children: connecting pathophysiology to clinical care.

Mangat, Guneive / Nair, Nikhil / Barat, Oren / Abboud, Brian / Pais, Priya / Bagga, Sumedha / Raina, Rupesh

Clinical kidney journal

2022 Volume 16, Issue 4, Page(s) 611–618

Abstract: Obesity has continued to emerge as a worldwide pandemic and has been associated with a significant increase in associated comorbidities. These include well-known conditions such as hypertension and diabetes, as well as lesser-known conditions such as ... ...

Abstract	Obesity has continued to emerge as a worldwide pandemic and has been associated with a significant increase in associated comorbidities. These include well-known conditions such as hypertension and diabetes, as well as lesser-known conditions such as obesity-related glomerulopathy (ORG). The main etiology of ORG is podocyte damage, but contributing theories include dysfunctional renin-angiotensin-aldosterone system activation, hyperinsulinemia and lipid deposition. Recent advances have made strides in understanding the complex pathophysiology of ORG. The key to treating ORG is weight loss and proteinuria reduction. Lifestyle modification, pharmacological interventions and surgery are mainstays of management. A special focus on obese children is required, as childhood obesity tracks into adulthood and primary prevention is key. In this review we discuss the pathogenesis, clinical features and established and newer treatment modalities of ORG.
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfac233
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Article ; Online: Effects of a Polypill, Aspirin, and the Combination of Both on Cognitive and Functional Outcomes: A Randomized Clinical Trial.

Bosch, Jacqueline J / O'Donnell, Martin J / Gao, Peggy / Joseph, Philip / Pais, Prem / Xavier, Denis / Dans, Antonio / Lopez Jaramillo, Patricio / Yusuf, Salim

JAMA neurology

2024 Volume 80, Issue 3, Page(s) 251–259

Abstract: Importance: Vascular risk factors are associated with cognitive decline but studies addressing individual risk factors have not demonstrated an effect of risk factor management on the preservation of cognition. Few trials have examined the effect of ... ...

Abstract	Importance: Vascular risk factors are associated with cognitive decline but studies addressing individual risk factors have not demonstrated an effect of risk factor management on the preservation of cognition. Few trials have examined the effect of vascular risk factor management on function. Objective: To determine if a polypill could reduce cognitive and functional decline in people with risk factors but without manifest cardiovascular disease. Design, setting, and participants: The International Polycap Study 3 (TIPS-3) was a 2 × 2 × 2 factorial randomized clinical trial. Hospital and community-based centers in 8 countries recruited and followed up participants between July 30, 2012, and September 30, 2020. A total of 5713 individuals were randomly assigned to treatment groups, and 2098 people 65 years or older at intermediate risk of cardiovascular disease completed a cognitive assessment and were included in the analyses. Interventions: Polypill (antihypertensives and a statin), aspirin, or a combination of both treatments. Main outcomes and measures: Cognitive and functional assessments completed at baseline, 2 years, and study end. The primary outcome was the effect of a polypill compared with placebo and a polypill plus aspirin compared with double placebo on the composite outcome of the proportion of participants in each group who experienced a substantive decrease (>1.5 SD change) in cognitive or functional abilities. Results: Of the 2389 study participants older than 65 years, a total of 2098 (88%; mean [SD] age, 70.1 [4.5] years; 1266 female individuals [60%]) completed the baseline and follow-up assessment. A total of 1796 participants (86%) had hypertension, and 680 participants (32%) had impaired fasting plasma glucose levels. Mean (SD) baseline systolic blood pressure was 146.1 (17.7) mm Hg, and mean (SD) low-density lipoprotein cholesterol (LDL-C) level was 124.3 (40.7) mg/dL and decreased by 5.7 mm Hg and 24 mg/dL, respectively, among those assigned to the polypill group. During a 5-year follow-up, there were no significant differences between treatment groups in the number of participants who experienced substantive cognitive decline (356 assigned polypill, 328 assigned placebo) or dementia (2 assigned polypill, 4 assigned placebo). Functional decline was reduced during follow-up for those assigned to polypill compared with placebo (mean [SD] country-standardized adjusted follow-up Standard Assessment of Global Everyday Activities [SAGEA] scores, 0.06 [0.03] vs 0.15 [0.03]; P = .01) and polypill plus aspirin compared with double placebo (mean [SD] country-standardized adjusted follow-up SAGEA scores, 0.01 [0.04] vs 0.14 [0.04]; P = .01). Conclusions and relevance: In this randomized clinical trial of patients 65 years or older with vascular risk factors, a polypill, with or without aspirin, was not associated with reduced cognitive outcomes but was associated with reduced functional decline.
MeSH term(s)	Humans ; Female ; Aged ; Aspirin/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/etiology ; Hydrochlorothiazide/therapeutic use ; Drug Combinations ; Cognition
Chemical Substances	Aspirin (R16CO5Y76E) ; Hydrochlorothiazide (0J48LPH2TH) ; Drug Combinations
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702023-X
ISSN	2168-6157 ; 2168-6149
ISSN (online)	2168-6157
ISSN	2168-6149
DOI	10.1001/jamaneurol.2022.5088
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Article ; Online: Transition of an estuarine benthic meiofauna assemblage 1.7 and 2.8 years after a mining disaster.

Coppo, Gabriel / Pais, Fabiano S / Ferreira, Tiago O / Halanych, Ken M / Donnelly, Kyle / Mazzuco, Ana Carolina / Bernardino, Angelo F

PeerJ

2023 Volume 11, Page(s) e14992

Abstract: Background: Estuaries are transitional coastal ecosystems that are threatened by multiple sources of human pollution. In 2015, mining tailings from an upstream dam failure caused massive metal contamination that impacted benthic assemblages on the ... ...

Abstract	Background: Estuaries are transitional coastal ecosystems that are threatened by multiple sources of human pollution. In 2015, mining tailings from an upstream dam failure caused massive metal contamination that impacted benthic assemblages on the Brazilian Rio Doce estuary. Methods: In this study, we investigate and compare meiofaunal assemblages with eDNA metabarcoding 1.7 years (2017) and 2.8 years (2018) after the initial contamination by mine tailings in order to evaluate the continued impact of sediment mine tailing contaminants on the structure of benthic assemblages after the disaster. Results: The community was dominated by Arthropoda and Nematoda 1.7 yr after the impacts (42 and 29% of meiofaunal sequence reads, respectively) but after 2.8 years Arthropoda (64.8% of meiofaunal sequence reads) and Rotifera (11.8%) were the most common taxa. This continued impact on meiofaunal assemblage revealed a lower phylogenetic diversity (7.8-fold) in 2018, despite overall decrease in metal concentration (Al, Ba, Cr, As, Fe, Zn, Mn, Pb, Cd, Co) in sediments. Our data suggests that differences in benthic assemblages and loss of diversity may be influenced by contaminants in sediments of this estuary, and indicate that broad eDNA assessments are greatly useful to understand the full range of biodiversity changes in dynamic estuarine ecosystems.
MeSH term(s)	Animals ; Humans ; Ecosystem ; Phylogeny ; Geologic Sediments/chemistry ; Environmental Monitoring ; Metals ; Mining ; Disasters
Chemical Substances	Metals
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.14992
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Article ; Online: Percutaneous nephrolithotomy versus retrograde intrarenal surgery for treatment of renal stones in adults.

Soderberg, Leah / Ergun, Onuralp / Ding, Maylynn / Parker, Robin / Borofsky, Michael S / Pais, Vernon / Dahm, Philipp

The Cochrane database of systematic reviews

2023 Volume 11, Page(s) CD013445

Abstract: Background: Kidney stones (also called renal stones) can be a source of pain, obstruction, and infection. Depending on size, location, composition, and other patient factors, the treatment of kidney stones can involve observation, shock wave lithotripsy, ...

Abstract	Background: Kidney stones (also called renal stones) can be a source of pain, obstruction, and infection. Depending on size, location, composition, and other patient factors, the treatment of kidney stones can involve observation, shock wave lithotripsy, retrograde intrarenal surgery (RIRS; i.e. ureteroscopic approaches), percutaneous nephrolithotomy (PCNL), or a combination of these approaches. Objectives: To assess the effects of percutaneous nephrolithotomy (PCNL) versus retrograde intrarenal surgery (RIRS) for the treatment of renal stones in adults. Search methods: We performed a comprehensive search of the Cochrane Library, MEDLINE, Embase, Scopus, and two trials registries up to 23 March 2023. We applied no restrictions on publication language or status. Selection criteria: We included randomized controlled trials that evaluated PCNL (grouped by access size in French gauge [Fr] into three groups: ≥ 24 Fr [standard PCNL], 15-23 Fr [mini-PCNL and minimally invasive PCNL], and < 15 Fr [ultra-mini-, mini-micro-, super-mini-, and micro-PCNL]) versus RIRS. Data collection and analysis: Two review authors independently selected studies and extracted data from the included studies. Our primary outcomes were stone-free rate, major complications, and need for secondary interventions. Our main secondary outcomes were unplanned medical visits to emergency/urgent care or outpatient clinic, length of hospital stay, ureteral stricture or injury, and quality of life. We performed statistical analyses using a random-effects model. We rated the certainty of evidence using GRADE criteria. We adopted a minimally contextualized approach with predefined thresholds for minimal clinically important differences (MCIDs). Main results: We included 42 trials assessing the effects of PCNL versus RIRS in 4571 randomized participants. Twenty-two studies were published as full-text articles, and 20 were published as abstract proceedings. The average size of stones ranged from 10.1 mm to 39.1 mm. Most studies did not report sources of funding or conflicts of interest. The main results for the most important outcomes are summarized below. Stone-free rate PCNL compared with RIRS may improve stone-free rates (risk ratio [RR] 1.13, 95% confidence interval [CI] 1.08 to 1.18; I Authors' conclusions: Based on a large body of evidence from 42 trials, we found that PCNL compared with RIRS may improve stone-free rates and may reduce the need for secondary interventions, but probably has little or no effect on major complications. PCNL compared with RIRS may have little or no effect on ureteral stricture rates and may increase length of hospital stay. We found no evidence on unplanned medical visits or participant quality of life. Because of the considerable shortcomings of the included trials, the evidence for most outcomes was of low certainty. Access size for PCNL was less than 24 Fr in most studies that provided this information. We expect the findings of this review to be helpful for shared decision-making about management choices for individuals with renal stones.
MeSH term(s)	Adult ; Humans ; Nephrolithotomy, Percutaneous/adverse effects ; Constriction, Pathologic ; Quality of Life ; Kidney Calculi/surgery ; Lithotripsy ; Ureteral Obstruction
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	1469-493X
ISSN (online)	1469-493X
DOI	10.1002/14651858.CD013445.pub2
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Article ; Online: Peripartum Takotsubo Cardiomyopathy: A Review and Insights from a National Registry.

Vazirani, Ravi / Blanco-Ponce, Emilia / Almendro Delia, Manuel / Martín-Garcia, Agustín C / Fernández-Cordón, Clara / Uribarri, Aitor / Vedia, Oscar / Sionis, Alessandro / Salamanca, Jorge / Corbí-Pascual, Miguel / Pérez-Castellanos, Alberto / Martínez-Selles, Manuel / Manuel-Becerra, Víctor / Raposeiras-Roubín, Sergio / Aritza-Conty, David / Lopez-País, Javier / Guillén-Marzo, Marta / Lluch-Requerey, Carmen / Núñez-Gil, Iván J

Journal of cardiovascular development and disease

2024 Volume 11, Issue 2

Abstract: Takotsubo syndrome (TTS) during the peripartum period is a relevant cause of morbidity in this population; its clinical course and prognosis, compared to the general TTS population, is yet to be elucidated. Our aim was to analyze the clinical features ... ...

Abstract	Takotsubo syndrome (TTS) during the peripartum period is a relevant cause of morbidity in this population; its clinical course and prognosis, compared to the general TTS population, is yet to be elucidated. Our aim was to analyze the clinical features and prognosis of peripartum TTS in a nationwide prospective specifically oriented registry database and consider the published literature. Peripartum TTS patients from the prospective nationwide RETAKO registry-as well as peripartum TTS patients from the published literature-were included, and multiple comparisons between groups were performed in order to assess for statistically and clinically relevant prognostic differences between the groups. Patients with peripartum TTS exhibit a higher prevalence of secondary forms, dyspnea, atypical symptoms, and echocardiographic patterns, as well as less ST-segment elevation than the general TTS population. In the literature, patients with peripartum TTS had a higher Killip status on admission. TTS during the peripartum period has a higher prevalence of angina and dyspnea, as well as physical triggers, neither of which are related to a worse prognosis. Killip status on admission was higher in the literature for patients with TTS but with excellent mid- and long-term prognoses after the acute phase, despite mostly being secondary forms.
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2777082-5
ISSN	2308-3425 ; 2308-3425
ISSN (online)	2308-3425
ISSN	2308-3425
DOI	10.3390/jcdd11020037
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Article ; Online: Social Support and Cognitive Impairment: Results from a Portuguese 4-Year Prospective Study.

Pais, Ricardo / Ruano, Luís / Moreira, Carla / Fraga, Sílvia / P Carvalho, Ofélia / Barros, Henrique

International journal of environmental research and public health

2021 Volume 18, Issue 16

Abstract: 1) Background: In an ageing society, social relationships may benefit cognitive performance with an impact on the health of older people. This study aims to estimate the effect of different social support sources on the risk of cognitive impairment in a ...

Abstract	(1) Background: In an ageing society, social relationships may benefit cognitive performance with an impact on the health of older people. This study aims to estimate the effect of different social support sources on the risk of cognitive impairment in a sample of older Portuguese people. (2) Methods: From the Portuguese EpiPorto cohort study, we followed a sample of participants with 60 to 85 years (
MeSH term(s)	Aged ; Aged, 80 and over ; Cognitive Dysfunction/epidemiology ; Cohort Studies ; Humans ; Male ; Portugal/epidemiology ; Prospective Studies ; Social Support
Language	English
Publishing date	2021-08-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18168841
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Article ; Online: Current Research on the Bioprospection of Linear Diterpenes from

Pais, Adriana C S / Saraiva, Jorge A / Rocha, Sílvia M / Silvestre, Armando J D / Santos, Sónia A O

Marine drugs

2019 Volume 17, Issue 10

Abstract: Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown ... ...

Abstract	Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga
MeSH term(s)	Anti-Infective Agents/isolation & purification ; Antioxidants/isolation & purification ; Diterpenes/isolation & purification ; Diterpenes/pharmacology ; Green Chemistry Technology/methods ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Structure ; Phaeophyceae/chemistry ; Plant Extracts/isolation & purification ; Seaweed/chemistry
Chemical Substances	Anti-Infective Agents ; Antioxidants ; Diterpenes ; Plant Extracts
Language	English
Publishing date	2019-09-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md17100556
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Article ; Online: The Quest for Phenolic Compounds from Macroalgae: A Review of Extraction and Identification Methodologies.

Santos, Sónia A O / Félix, Rafael / Pais, Adriana C S / Rocha, Sílvia M / Silvestre, Armando J D

Biomolecules

2019 Volume 9, Issue 12

Abstract: The current interest of the scientific community for the exploitation of high-value compounds from macroalgae is related to the increasing knowledge of their biological activities and health benefits. Macroalgae phenolic compounds, particularly ... ...

Abstract	The current interest of the scientific community for the exploitation of high-value compounds from macroalgae is related to the increasing knowledge of their biological activities and health benefits. Macroalgae phenolic compounds, particularly phlorotannins, have gained particular attention due to their specific bioactivities, including antioxidant, antiproliferative, or antidiabetic. Notwithstanding, the characterization of macroalgae phenolic compounds is a multi-step task, with high challenges associated with their isolation and characterization, due to the highly complex and polysaccharide-rich matrix of macroalgae. Therefore, this fraction is far from being fully explored. In fact, a critical revision of the extraction and characterization methodologies already used in the analysis of phenolic compounds from macroalgae is lacking in the literature, and it is of uttermost importance to compile validated methodologies and discourage misleading practices. The aim of this review is to discuss the state-of-the-art of phenolic compounds already identified in green, red, and brown macroalgae, reviewing their structural classification, as well as critically discussing extraction methodologies, chromatographic separation techniques, and the analytical strategies for their characterization, including information about structural identification techniques and key spectroscopic profiles. For the first time, mass spectrometry data of phlorotannins, a chemical family quite exclusive of macroalgae, is compiled and discussed.
MeSH term(s)	Antioxidants/analysis ; Antioxidants/chemistry ; Chemical Fractionation/methods ; Chromatography, High Pressure Liquid/methods ; Hypoglycemic Agents/analysis ; Hypoglycemic Agents/chemistry ; Liquid-Liquid Extraction/methods ; Mass Spectrometry/methods ; Phenols/analysis ; Phenols/chemistry ; Phenols/isolation & purification ; Polysaccharides/analysis ; Polysaccharides/chemistry ; Seaweed/chemistry ; Solid Phase Extraction/methods ; Solvents ; Tannins/analysis ; Tannins/chemistry ; Tannins/isolation & purification
Chemical Substances	Antioxidants ; Hypoglycemic Agents ; Phenols ; Polysaccharides ; Solvents ; Tannins
Language	English
Publishing date	2019-12-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom9120847
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