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Article ; Online: Detection of α-papillomaviruses in extragenital cutaneous squamous cell carcinomas.

Weiss, Morgane / Ferré, Valentine M / Deschamps, Lydia / Evrard, Diane / Gonthier, Clémentine / Charpentier, Charlotte / Brunet-Possenti, Florence

The British journal of dermatology

2024 Volume 190, Issue 5, Page(s) 762–764

MeSH term(s)	Humans ; Carcinoma, Squamous Cell/pathology ; Skin Neoplasms/pathology ; Papillomaviridae/genetics ; Papillomavirus Infections ; DNA, Viral
Chemical Substances	DNA, Viral
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1093/bjd/ljae047
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Article: L’accompagnement de l’infirmière puéricultrice en Smur pédiatrique.

Caudéran, Charlotte / Charpentier, Marie-Françoise / Cartron, Emmanuelle

Soins. Pediatrie, puericulture

2021 Volume 42, Issue 321, Page(s) 40–43

Abstract: When a newborn baby is in need of rapid care outside the hospital where the mother has given birth, the nursery nurses work specifically to support the baby during the separation from its parents. They intervene before, during and after the separation of ...

Title translation	The support of the paediatric nurse in the paediatric emergency rapid response unit.
Abstract	When a newborn baby is in need of rapid care outside the hospital where the mother has given birth, the nursery nurses work specifically to support the baby during the separation from its parents. They intervene before, during and after the separation of mother and child, particularly during the transfer of the baby to the mobile paediatric emergency and resuscitation unit.
MeSH term(s)	Child ; Female ; Humans ; Infant, Newborn ; Mothers ; Nurses, Pediatric ; Parent-Child Relations ; Parents ; Pediatric Nursing
Language	French
Publishing date	2021-05-26
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1234484-9
ISSN	2214-9325 ; 1259-4792
ISSN (online)	2214-9325
ISSN	1259-4792
DOI	10.1016/j.spp.2021.05.010
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Zs.B 2788: Show issues

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Article ; Online: Future of Antiretroviral Drugs and Evolution of HIV-1 Drug Resistance.

Charpentier, Charlotte / Le Hingrat, Quentin / Ferré, Valentine Marie / Damond, Florence / Descamps, Diane

Viruses

2023 Volume 15, Issue 2

Abstract: Highly active antiretroviral (ARV) therapy has been used for many years, but the use in low- and middle-income countries of antiretroviral drugs with low genetic barrier to resistance, combined with limited availability of viral load testing, has led to ... ...

Abstract	Highly active antiretroviral (ARV) therapy has been used for many years, but the use in low- and middle-income countries of antiretroviral drugs with low genetic barrier to resistance, combined with limited availability of viral load testing, has led to higher rates of acquired drug resistance, sustaining the rate of transmitted drug resistance. Here, we describe the evolution of ARV drugs with the ongoing development of injectable long-acting forms and the requirements regarding all new ARV drugs (i.e., no transmitted drug resistance, no cross-resistance and high genetic barrier to resistance). Then, we report the evolution of both transmitted and acquired resistance regarding new ARV drugs. The WHO has set very ambitious but motivating goals for HIV testing, treatment and viral suppression, aiming to achieve rates of 95% for all three by 2025. Reaching these goals requires a wide implementation and use of close virological monitoring in LMICs.
MeSH term(s)	Humans ; HIV-1/genetics ; HIV Seropositivity ; Anti-Retroviral Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Developing Countries
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15020540
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Article ; Online: RSV-GenoScan: An automated pipeline for whole-genome human respiratory syncytial virus (RSV) sequence analysis.

Dosbaa, Alexandre / Guilbaud, Romane / Yusti, Anna-Maria Franco / Ferré, Valentine Marie / Charpentier, Charlotte / Descamps, Diane / Le Hingrat, Quentin / Coppée, Romain

Journal of virological methods

2024 Volume 327, Page(s) 114938

Abstract: Background: Advances in high-throughput sequencing (HTS) technologies and reductions in sequencing costs have revolutionised the study of genomics and molecular biology by making whole-genome sequencing (WGS) accessible to many laboratories. However, ... ...

Abstract	Background: Advances in high-throughput sequencing (HTS) technologies and reductions in sequencing costs have revolutionised the study of genomics and molecular biology by making whole-genome sequencing (WGS) accessible to many laboratories. However, the analysis of WGS data requires significant computational effort, which is the major drawback in implementing WGS as a routine laboratory technique. Objective: Automated pipelines have been developed to overcome this issue, but they do not exist for all organisms. This is the case for human respiratory syncytial virus (RSV), which is a leading cause of lower respiratory tract infections in infants, the elderly, and immunocompromised adults. Results: We present RSV-GenoScan, a fast and easy-to-use pipeline for WGS analysis of RSV generated by HTS on Illumina or Nanopore platforms. RSV-GenoScan automates the WGS analysis steps directly from the raw sequence data. The pipeline filters the sequence data, maps the reads to the RSV reference genomes, generates a consensus sequence, identifies the RSV subgroup, and lists amino acid mutations, insertions and deletions in the F and G viral genes. This enables the rapid identification of mutations in these coding genes that are known to confer resistance to monoclonal antibodies. Availability: RSV-GenoScan is freely available at https://github.com/AlexandreD-bio/RSV-GenoScan.
Language	English
Publishing date	2024-04-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2024.114938
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Article ; Online: Resistance to HIV Integrase Inhibitors: About R263K and E157Q Mutations.

Charpentier, Charlotte / Descamps, Diane

Viruses

2018 Volume 10, Issue 1

Abstract: The use of integrase inhibitors (INI) is increasing in antiretroviral therapies (ART) and INI are not all equal regarding genetic barrier to resistance. The aim of this manuscript was to review main in vivo and in vitro knowledge about two particular ... ...

Abstract	The use of integrase inhibitors (INI) is increasing in antiretroviral therapies (ART) and INI are not all equal regarding genetic barrier to resistance. The aim of this manuscript was to review main in vivo and in vitro knowledge about two particular integrase resistance-associated mutations: R263K and E157Q. The R263K mutation was the first mutation rarely found selected at time of virological failure in patients failing a first-line dolutegravir-based treatment. Further in vitro studies on R263K mutants showed a moderate increase in phenotypic resistance level and a drastic reduction in viral replicative capacity. No compensatory mutations were evidenced. The E157Q mutation is polymorphic, found between 1.7% and 5.6% of viral sequences issued from ART-naïve patients depending on the viral subtype; as well as acquired resistance emerging at failure of a raltegravir-based regimen in two case reports. We reported data on phenotypic resistance level of E157Q mutants and virological response of patients harboring a E157Q virus initiating an INI-based regimen, showing that dolutegravir might be the most recommended INI in such patients. These findings show that there is still a need for a better understanding of resistance mechanisms to INI and emphasized the importance of genotypic background in viral evolution under drug pressure.
MeSH term(s)	Alleles ; Amino Acid Substitution ; Codon ; Drug Resistance, Viral ; Genotype ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV Integrase/chemistry ; HIV Integrase/genetics ; HIV Integrase Inhibitors/chemistry ; HIV Integrase Inhibitors/pharmacology ; HIV-1/classification ; HIV-1/drug effects ; HIV-1/enzymology ; HIV-1/genetics ; Humans ; Mutation ; Structure-Activity Relationship
Chemical Substances	Codon ; HIV Integrase Inhibitors ; HIV Integrase (EC 2.7.7.-)
Language	English
Publishing date	2018-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v10010041
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Article ; Online: BA.2.86 variant emergence and spread dynamics through wastewater monitoring in Paris, France.

Wurtzer, Sébastien / Guilbaud, Romane / Levert, Morgane / Fagour, Nathalie / Le Hingrat, Quentin / Descamps, Diane / Tarantola, Arnaud / Grellet, Sophie / Londinsky, Nicolas / Moskovoy, Jean-Michel / Mouchel, Jean-Marie / Charpentier, Charlotte / Moulin, Laurent

The Science of the total environment

2024 Volume 917, Page(s) 170355

Abstract: Numerous SARS-CoV-2 variants are emerging as the epidemic continues, inducing new waves of contamination. In July 2023, a new variant named BA.2.86 was identified, raising concerns about its potential for viral escape, even in an immune population. The ... ...

Abstract	Numerous SARS-CoV-2 variants are emerging as the epidemic continues, inducing new waves of contamination. In July 2023, a new variant named BA.2.86 was identified, raising concerns about its potential for viral escape, even in an immune population. The reduction in patient-centered testing and the identification of variants by sequencing means that we are now blind to the spread of this new variant. The aim of this study was to track the signature of this variant in wastewater in Paris, France. This variant showed a very rapid spread, highly correlated with national flash studies involving sequencing of clinical samples, but with a moderate impact on virus circulation. This easy-to-implement approach enabled us to monitor the emergence and spread of this new variant in real time at low cost.
MeSH term(s)	Humans ; Paris ; Wastewater ; France ; Drug Contamination ; Epidemics
Chemical Substances	Wastewater
Language	English
Publishing date	2024-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.170355
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Zs.A 949: Show issues

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Article ; Online: Omicron SARS-CoV-2 variant: What we know and what we don't.

Ferré, Valentine Marie / Peiffer-Smadja, Nathan / Visseaux, Benoit / Descamps, Diane / Ghosn, Jade / Charpentier, Charlotte

Anaesthesia, critical care & pain medicine

2021 Volume 41, Issue 1, Page(s) 100998

MeSH term(s)	COVID-19 ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-12-10
Publishing country	France
Document type	Editorial
ISSN	2352-5568
ISSN (online)	2352-5568
DOI	10.1016/j.accpm.2021.100998
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Article ; Online: High SARS-CoV-2 seroprevalence among street adolescents in Lomé, Togo, 2021.

Sadio, Arnold Junior / Ferré, Valentine Marie / Konu, Rodion Yao / Dagnra, Anoumou Claver / Descamps, Diane / Ekouevi, Didier Koumavi / Charpentier, Charlotte

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 200

Abstract: Background: There is almost no data on the circulation of SARS-CoV-2 among street adolescents. We conducted a study to document the immunization status of street adolescents in Togo against different variants of SARS-CoV-2.: Methods: A cross- ... ...

Abstract	Background: There is almost no data on the circulation of SARS-CoV-2 among street adolescents. We conducted a study to document the immunization status of street adolescents in Togo against different variants of SARS-CoV-2. Methods: A cross-sectional study was carried out in 2021 in Lomé, the city with the highest number of COVID 19 cases in Togo (60%). Adolescents aged 13- and 19 years old living on the street were eligible for inclusion. A standardized questionnaire was administered face-to-face to adolescents. A sample of blood was taken and aliquots of plasma were transported to the virology laboratory of the Hôpital Bichat-Claude Bernard (Paris, France). SARS-CoV-2 anti-S and anti-N IgG were measured using chemiluminescent microparticle immunoassay. A quantitative miniaturized and parallel-arranged ELISA assay was used to detect IgG antibodies specifically directed against the different SARS-CoV-2 Variants of Concern (VOC). Results: A total of 299 street adolescents (5.2% female), median age 15 years, interquartile range (14-17 years), were included in this study. The prevalence of SARS-CoV-2 infection was 63.5% (95%CI: 57.8-69.0). Specific-IgG against the ancestral Wuhan strain was developed by 92.0% of subjects. The proportion of patients being immunized against each VOC was 86.8%, 51.1%, 56.3%, 60.0, and 30.5% for the Alpha, Beta, Gamma, Delta, and Omicron VOCs, respectively. Conclusion: This study showed a very high prevalence with approximately 2/3 of Togolese street adolescents having antibodies to SARS-CoV-2 due to a previous infection. These results confirm an under-reporting of COVID-19 cases in Togo, questioning the hypothesis of low virus circulation in Togo and even in Africa.
MeSH term(s)	Humans ; Adolescent ; Female ; Young Adult ; Adult ; Male ; SARS-CoV-2 ; Togo/epidemiology ; COVID-19/epidemiology ; Cross-Sectional Studies ; Seroepidemiologic Studies ; Immunoglobulin G ; Antibodies, Viral
Chemical Substances	Immunoglobulin G ; Antibodies, Viral
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08167-2
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Article ; Online: Anogenital symptoms and lesions in a series of 20 patients infected with monkeypox virus.

Rekik, Samia / Pluart, Diane Le / Ferré, Valentine / Charpentier, Charlotte / Laurain, Anne / Ghosn, Jade / Abramowitz, Laurent

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2023 Volume 25, Issue 5, Page(s) 1002–1005

Abstract: Aim: Monkeypox virus (MPXV) has been spreading in many European countries, the USA and Canada since May 2022. General symptoms, skin and anoperineal lesions have been reported. Anal pain is often reported, but anal canal lesions have yet to be described ...

Abstract	Aim: Monkeypox virus (MPXV) has been spreading in many European countries, the USA and Canada since May 2022. General symptoms, skin and anoperineal lesions have been reported. Anal pain is often reported, but anal canal lesions have yet to be described in these patients. The aim of this study was to describe anoperineal lesions in patients infected with MPXV undergoing systematic margin and anal canal examination at a tertiary care centre in France. Method: In this prospective descriptive study, systematic anal examination was performed in 20 patients diagnosed with MPXV infection at Bichat Hospital, Paris, France between 6 and 11 July 2022. Anal swabs were also obtained from all these patients for polymerase chain reaction testing for MPXV. Results: All the patients were men that have sex with men (MSM). Sixteen patients had anal symptoms: 13 reported anal pain, and the other anal symptoms described were anal bleeding (n = 12), pruritus (n = 11), dyschezia (n = 10), tenesmus (n = 13), burning (n = 3), swelling (n = 9) and discharge of mucus (n = 9). Proctological examination detected: (i) anal margin lesions in 14 patients (vesicles, n = 8; pustules, n = 6; ulceration, n = 6); (ii) anal canal lesions in 16 patients (ulceration, n = 13; ulcers, n = 4; pustules, n = 1), seven of whom presented anal hypertonia; and (iii) rectal lesions in 12 patients (congested rectum, n = 6; erythema, n = 10; ulcers, n = 2; not seen in one case). the presence of mucus was noted in 10 patients and the presence of blood in six patients. Conclusion: This is the first study to describe anal canal lesions in patients infected with MPXV. Most of the observed lesions were ulceration, accounting for the pain reported.
MeSH term(s)	Male ; Humans ; Female ; Monkeypox virus ; Homosexuality, Male ; Ulcer ; Sexual and Gender Minorities ; Anus Diseases/diagnosis ; Pain
Language	English
Publishing date	2023-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16513
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Zs.A 5799: Show issues

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Article ; Online: Mpox presenting as a chronic cutaneous ulcer in a patient with advanced HIV infection.

Lutz, William / Bertin, Chloe / Merlant, Marie / Mailhe, Morgane / Le Hingrat, Quentin / Descamps, Vincent / Guilhou, Thomas / Maisonobe, Lucas / Yazdanpanah, Yazdan / Deschamps, Lydia / Charpentier, Charlotte / Lariven, Sylvie

Clinical and experimental dermatology

2023 Volume 48, Issue 12, Page(s) 1364–1365

MeSH term(s)	Humans ; HIV Infections/complications ; Mpox (monkeypox) ; Ulcer ; Patients
Language	English
Publishing date	2023-08-18
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1093/ced/llad258
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