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Article: Performance of Radiologists in the Evaluation of the Chest Radiography with the Use of a "new software score" in Coronavirus Disease 2019 Pneumonia Suspected Patients.

Bagnera, Silvia / Bisanti, Francesca / Tibaldi, Claudia / Pasquino, Massimo / Berrino, Giulia / Ferraro, Roberta / Patania, Sebastiano

Journal of clinical imaging science

2020 Volume 10, Page(s) 40

Abstract: Objectives: The purpose of this study is to assess the performance of radiologists using a new software called "COVID-19 score" when performing chest radiography on patients potentially infected by coronavirus disease 2019 (COVID-19) pneumonia. Chest ... ...

Abstract	Objectives: The purpose of this study is to assess the performance of radiologists using a new software called "COVID-19 score" when performing chest radiography on patients potentially infected by coronavirus disease 2019 (COVID-19) pneumonia. Chest radiography (or chest X-ray, CXR) and CT are important for the imaging diagnosis of the coronavirus pneumonia (COVID-19). CXR mobile devices are efficient during epidemies, because allow to reduce the risk of contagion and are easy to sanitize. Material and methods: From February-April 2020, 14 radiologists retrospectively evaluated a pool of 312 chest X-ray exams to test a new software function for lung imaging analysis based on radiological features and graded on a three-point scale. This tool automatically generates a cumulative score (0-18). The intra- rater agreement (evaluated with Fleiss's method) and the average time for the compilation of the banner were calculated. Results: Fourteen radiologists evaluated 312 chest radiographs of COVID-19 pneumonia suspected patients (80 males and 38 females) with an average age of 64, 47 years. The inter-rater agreement showed a Fleiss' kappa value of 0.53 and the intra-group agreement varied from Fleiss' Kappa value between 0.49 and 0.59, indicating a moderate agreement (considering as "moderate" ranges 0.4-0.6). The years of work experience were irrelevant. The average time for obtaining the result with the automatic software was between 7 s (e.g., zero COVID-19 score) and 21 s (e.g., with COVID-19 score from 6 to 12). Conclusion: The use of automatic software for the generation of a CXR "COVID-19 score" has proven to be simple, fast, and replicable. Implementing this tool with scores weighed on the number of lung pathological areas, a useful parameter for clinical monitoring could be available.
Keywords	covid19
Language	English
Publishing date	2020-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2601233-9
ISSN	2156-5597 ; 2156-7514
ISSN (online)	2156-5597
ISSN	2156-7514
DOI	10.25259/JCIS_76_2020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hypofractionation and Concomitant Boost in Ductal Carcinoma In Situ (DCIS): Analysis of a Prospective Case Series with Long-Term Follow-Up.

Cante, Domenico / Paolini, Marina / Piva, Cristina / Petrucci, Edoardo / Radici, Lorenzo / Ferrario, Silvia / Mondini, Guido / Bagnera, Silvia / La Porta, Maria Rosa / Franco, Pierfrancesco

Life (Basel, Switzerland)

2022 Volume 12, Issue 6

Abstract: We previously reported on a cohort of breast cancer patients affected with ductal carcinoma in situ (DCIS) that were treated with breast conservative surgery and hypofractionated whole-breast radiotherapy with a concomitant boost to the lumpectomy cavity. ...

Abstract	We previously reported on a cohort of breast cancer patients affected with ductal carcinoma in situ (DCIS) that were treated with breast conservative surgery and hypofractionated whole-breast radiotherapy with a concomitant boost to the lumpectomy cavity. We now report on the long-term results of the oncological and toxicity outcomes, at a median follow-up of 11.2 years. We also include an analysis of the predictive factors for local recurrence (LR). Eighty-two patients with long-term observation were considered for this report. All received hypofractionated post-operative radiotherapy with a concomitant boost (45 Gy/20 fractions to the whole breast and 50 Gy/20 fractions to the lumpectomy cavity). We report on LC rates at 5 and 10 years, overall survival (OS), and breast-cancer-specific survival (BCSS), employing the Kaplan-Meier method. Cox proportional regression analysis was used to determine the role of selected clinical parameters on the risk of local recurrence, by the univariate and multivariate models. After a median follow-up of 11.2 years (range 5-15 years), 9 pts (11%) developed LR. The LR rates at 5 years and 10 years were 2.4% and 8.2%, respectively. The 5- and 10-year overall survival rates were 98.8% and 91.6%, respectively. The 5- and 10-year breast-cancer-specific survival rates were 100.0% and 99.0%. Late skin and subcutaneous toxicities were generally mild, and cosmetic results were good-excellent for most patients. For the univariate regression analysis, ER positive status (HR; 95% CI,
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12060889
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Article ; Online: Hypofractionation and Concomitant Boost in Ductal Carcinoma In Situ (DCIS)

Domenico Cante / Marina Paolini / Cristina Piva / Edoardo Petrucci / Lorenzo Radici / Silvia Ferrario / Guido Mondini / Silvia Bagnera / Maria Rosa La Porta / Pierfrancesco Franco

Life, Vol 12, Iss 889, p

Analysis of a Prospective Case Series with Long-Term Follow-Up

2022 Volume 889

Abstract	We previously reported on a cohort of breast cancer patients affected with ductal carcinoma in situ (DCIS) that were treated with breast conservative surgery and hypofractionated whole-breast radiotherapy with a concomitant boost to the lumpectomy cavity. We now report on the long-term results of the oncological and toxicity outcomes, at a median follow-up of 11.2 years. We also include an analysis of the predictive factors for local recurrence (LR). Eighty-two patients with long-term observation were considered for this report. All received hypofractionated post-operative radiotherapy with a concomitant boost (45 Gy/20 fractions to the whole breast and 50 Gy/20 fractions to the lumpectomy cavity). We report on LC rates at 5 and 10 years, overall survival (OS), and breast-cancer-specific survival (BCSS), employing the Kaplan–Meier method. Cox proportional regression analysis was used to determine the role of selected clinical parameters on the risk of local recurrence, by the univariate and multivariate models. After a median follow-up of 11.2 years (range 5–15 years), 9 pts (11%) developed LR. The LR rates at 5 years and 10 years were 2.4% and 8.2%, respectively. The 5- and 10-year overall survival rates were 98.8% and 91.6%, respectively. The 5- and 10-year breast-cancer-specific survival rates were 100.0% and 99.0%. Late skin and subcutaneous toxicities were generally mild, and cosmetic results were good–excellent for most patients. For the univariate regression analysis, ER positive status (HR; 95% CI, p = 0.021), PgR positive status (HR; 95% CI, p = 0.012), and the aggregate data of positive hormonal status (HR; 95% CI, p = 0.021) were inversely correlated to LR risk. Conversely, a high tumor grade (G3) was directly correlated with the risk of LR (HR; 95% CI, p = 0.048). For the multivariate regression analysis, a high tumor grade (G3) confirmed its negative impact on LR (HR 0.40; 95% CI 0.19–0.75, p = 0.047). Our long-term data demonstrate hypofractionated whole-breast radiotherapy with a concomitant boost ...
Keywords	ductal carcinoma in situ ; DCIS ; hypofractionated radiotherapy ; hypofractionation ; Science ; Q
Subject code	616
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Performance of Radiologists in the Evaluation of the Chest Radiography with the Use of a "new software score" in Coronavirus Disease 2019 Pneumonia Suspected Patients

Bagnera, Silvia / Bisanti, Francesca / Tibaldi, Claudia / Pasquino, Massimo / Berrino, Giulia / Ferraro, Roberta / Patania, Sebastiano

Journal of clinical imaging science

Abstract: OBJECTIVES: The purpose of this study is to assess the performance of radiologists using a new software called "COVID-19 score" when performing chest radiography on patients potentially infected by coronavirus disease 2019 (COVID-19) pneumonia Chest ... ...

Abstract	OBJECTIVES: The purpose of this study is to assess the performance of radiologists using a new software called "COVID-19 score" when performing chest radiography on patients potentially infected by coronavirus disease 2019 (COVID-19) pneumonia Chest radiography (or chest X-ray, CXR) and CT are important for the imaging diagnosis of the coronavirus pneumonia (COVID-19) CXR mobile devices are efficient during epidemies, because allow to reduce the risk of contagion and are easy to sanitize MATERIAL AND METHODS: From February-April 2020, 14 radiologists retrospectively evaluated a pool of 312 chest X-ray exams to test a new software function for lung imaging analysis based on radiological features and graded on a three-point scale This tool automatically generates a cumulative score (0-18) The intra- rater agreement (evaluated with Fleiss's method) and the average time for the compilation of the banner were calculated RESULTS: Fourteen radiologists evaluated 312 chest radiographs of COVID-19 pneumonia suspected patients (80 males and 38 females) with an average age of 64, 47 years The inter-rater agreement showed a Fleiss' kappa value of 0 53 and the intra-group agreement varied from Fleiss' Kappa value between 0 49 and 0 59, indicating a moderate agreement (considering as "moderate" ranges 0 4-0 6) The years of work experience were irrelevant The average time for obtaining the result with the automatic software was between 7 s (e g , zero COVID-19 score) and 21 s (e g , with COVID-19 score from 6 to 12) CONCLUSION: The use of automatic software for the generation of a CXR "COVID-19 score" has proven to be simple, fast, and replicable Implementing this tool with scores weighed on the number of lung pathological areas, a useful parameter for clinical monitoring could be available
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #695248
Database	COVID19

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Article ; Online: Correction to: Ten-year results of accelerated hypofractionated adjuvant whole-breast radiation with concomitant boost to the lumpectomy cavity after conserving surgery for early breast cancer.

Cante, Domenico / Petrucci, Edoardo / Sciacero, Piera / Piva, Cristina / Ferrario, Silvia / Bagnera, Silvia / Patania, Sebastiano / Mondini, Guido / Pasquino, Massimo / Casanova Borca, Valeria / Vellani, Giorgio / La Porta, Maria Rosa / Franco, Pierfrancesco

Medical oncology (Northwood, London, England)

2017 Volume 35, Issue 1, Page(s) 11

Abstract: An error inadvertently occurred in the discussion of the original publication when citing the local relapse rates of the EORTC 22881-10882 trial ('boost vs no boost trial'). ...

Abstract	An error inadvertently occurred in the discussion of the original publication when citing the local relapse rates of the EORTC 22881-10882 trial ('boost vs no boost trial').
Language	English
Publishing date	2017-12-12
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-017-1056-5
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Article ; Online: Ten-year results of accelerated hypofractionated adjuvant whole-breast radiation with concomitant boost to the lumpectomy cavity after conserving surgery for early breast cancer.

Medical oncology (Northwood, London, England)

2017 Volume 34, Issue 9, Page(s) 152

Abstract: Accelerated hypofractionated whole-breast radiotherapy (WBRT) is considered a standard therapeutic option for early breast cancer (EBC) in the postoperative setting after breast conservation (BCS). A boost to the lumpectomy cavity may further increase ... ...

Abstract	Accelerated hypofractionated whole-breast radiotherapy (WBRT) is considered a standard therapeutic option for early breast cancer (EBC) in the postoperative setting after breast conservation (BCS). A boost to the lumpectomy cavity may further increase local control. We herein report on the 10-year results of a series of EBC patients treated after BCS with hypofractionated WBRT with a concomitant photon boost to the surgical bed over 4 weeks. Between 2005 and 2007, 178 EBC patients were treated with a basic course of radiotherapy consisting of 45 Gy to the whole breast in 20 fractions (2.25 Gy daily) with an additional boost dose of 0.25 Gy delivered concomitantly to the lumpectomy cavity, for an additional dose of 5 Gy. Median follow-up period was 117 months. At 10-year, overall, cancer-specific, disease-free survival and local control were 92.2% (95% CI 88.7-93.4%), 99.2% (95% CI 96.7-99.7%), 95.5% (95% CI 91.2-97.2%) and 97.3% (95% CI 94.5-98.9%), respectively. Only eight patients recurred. Four in-breast recurrences, two axillary node relapses and two metastatic localizations were observed. Fourteen patients died during the observation period due to other causes while breast cancer-related deaths were eight. At last follow-up, ≥G2 fibrosis and telangiectasia were seen in 7% and 5% of patients. No major lung and heart toxicities were observed. Cosmetic results were excellent/good in 87.8% of patients and fair/poor in 12.2%. Hypofractionated WBRT with concomitant boost to the lumpectomy cavity after BCS in EBC led to consistent clinical results at 10 years. Hence, it can be considered a valid treatment option in this setting.
Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-017-1020-4
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Article ; Online: Breast calciphylaxis following coronary artery bypass grafting completely resolved with total parathyroidectomy.

Campanino, Pier Paolo / Tota, Donatella / Bagnera, Silvia / Regini, Elisa / Taverna, Giacomo / Luparia, Andrea / Durando, Manuela / Mariscotti, Giovanna / Gandini, Giovanni

The breast journal

2010 Volume 16, Issue 5, Page(s) 544–547

MeSH term(s)	Breast Diseases/etiology ; Breast Diseases/pathology ; Calciphylaxis/etiology ; Calciphylaxis/pathology ; Coronary Artery Bypass/adverse effects ; Female ; Humans ; Mammography ; Middle Aged ; Parathyroidectomy ; Ultrasonography, Mammary
Language	English
Publishing date	2010-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/j.1524-4741.2010.00966.x
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Article ; Online: Does accelerated hypofractionated adjuvant whole-breast radiotherapy increase mammographic density or change mammographic features?

Bagnera, Silvia / Milanesio, Luisella / Brachet Cota, Piero B / Berrino, Carla / Cataldi, Aldo / Gatti, Giovanni / Mondini, Guido / Paino, Ovidio / Comello, Erika G / Orlassino, Renzo / Pasquino, Massimo / Cante, Domenico / La Porta, Maria R / Patania, Sebastiano / La Valle, Giovanni

The British journal of radiology

2015 Volume 88, Issue 1055, Page(s) 20150312

Abstract: Objective: To compare mammographic features before and after accelerated hypofractionated adjuvant whole-breast radiotherapy (AWB-RT) and to evaluate possible appearance of modifications.: Methods: A retrospective review of 177 females before and ... ...

Abstract	Objective: To compare mammographic features before and after accelerated hypofractionated adjuvant whole-breast radiotherapy (AWB-RT) and to evaluate possible appearance of modifications. Methods: A retrospective review of 177 females before and after an AWB-RT treatment (follow-up ranging from 5 to 9 years) was performed by four radiologists focused in breast imaging who independently evaluated diffuse mammographic density patterns and reported on possible onset of focal alterations; modifications in density and fibrosis with parenchymal distortion were deemed as indicators of AWB-RT treatment impact in breast imaging. Results: Prevalent mammographic density (D) patterns in the 177 females evaluated were according to the American College of Radiology-Breast Imaging Reporting and Data System (ACR-BIRADS): D1, fibroadipose density (score percentage from 55.9% to 43.5%); and D2, scattered fibroglandular density (from 42.9% to 32.7%). No change in diffuse mammographic density and no significant difference in mammographic breast parenchymal structure were observed. "No change" was reported with score percentage from 87% to 79.6%. Appearance of fibrosis with parenchymal distortion was reported by all radiologists in only two cases (1.1%, p = 0.3); dystrophic calcification was identified with percentage score from 2.2% to 3.3% (small type) and from 9.6% to 12.9% (coarse type). Conclusion: No statistically significant changes in follow-up mammographies 5-9 years after AWB-RT were detected, justifying large-scale selection of AWB-RT treatment with no risk of altering radiological breast parameters of common use in tumour recurrence detection. Advances in knowledge: The hypofractionated radiotherapy (AWB-RT treatment) is a new proven, safe and effective modality in post-operative patients with early breast cancer with excellent local control and survival. In our study, the absence of changes in mammographic density patterns and in breast imaging before and after AWB-RT treatment (up to 5-9 years after radiotherapy) justifies large-scale use of AWB-RT treatment without hindrance in tumour recurrence diagnosis.
MeSH term(s)	Aged ; Aged, 80 and over ; Breast Density ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Dose Fractionation, Radiation ; Female ; Humans ; Mammary Glands, Human/abnormalities ; Middle Aged ; Radiography ; Radiotherapy, Adjuvant ; Retrospective Studies
Language	English
Publishing date	2015-09-22
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20150312
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