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  1. Article ; Online: The 2024 ASM Awards and Prize Program-recognizing excellence in the microbiological sciences.

    Nachamkin, Irving / Babady, N Esther

    Journal of clinical microbiology

    2024  Volume 62, Issue 3, Page(s) e0001224

    Abstract: The ASM Awards and Prize Program recognizes outstanding achievements in basic and applied research, clinical microbiology, education, leadership, and service. This editorial briefly describes how the program works and highlights several awards of ... ...

    Abstract The ASM Awards and Prize Program recognizes outstanding achievements in basic and applied research, clinical microbiology, education, leadership, and service. This editorial briefly describes how the program works and highlights several awards of interest to the clinical microbiology community.
    MeSH term(s) Humans ; Awards and Prizes ; Leadership
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.00012-24
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    Zs.A 1188: Show issues Location:
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  2. Article ; Online: Epidemiology and Outcomes of Non-albicans Candida Bloodstream Infections in Transplant Recipients and Cancer Patients.

    Otto, Caitlin / Babady, N Esther

    Mycopathologia

    2023  Volume 188, Issue 6, Page(s) 863–871

    Abstract: We performed a retrospective survey of non-Candida albicans candidemia in patients with cancer, including those with solid tumors and those with hematological malignancies as well as transplants patients both, solid-organ transplant recipients and ... ...

    Abstract We performed a retrospective survey of non-Candida albicans candidemia in patients with cancer, including those with solid tumors and those with hematological malignancies as well as transplants patients both, solid-organ transplant recipients and hematopoietic stem cell transplant recipients. The study was performed at two healthcare centers in New York City and covered the years 2018-2022. A total of 292 patients (318 isolates) were included in the study. In order of frequency, C. glabrata (38%) was the most common species recovered, followed by C. parapsilosis (19.2%), C. tropicalis (12.6%), C. krusei (10.7%), C. lusitaniae (5.7%), and C. guilliermondii (4.4%). Micafungin was the most common antifungal treatment and 18.5% of patients were on antifungal prophylaxis. The 30-day crude mortality was 40%. 4.5% of patients had more than one non-albicans species detected. In conclusion, this study represents one of the largest surveys of non-albicans species in cancer and transplant patients and provides data on the current epidemiology of these Candida species in this patient population.
    MeSH term(s) Humans ; Antifungal Agents/therapeutic use ; Transplant Recipients ; Retrospective Studies ; Microbial Sensitivity Tests ; Candida ; Candidemia/drug therapy ; Candidemia/epidemiology ; Candidemia/microbiology ; Candida glabrata ; Candida parapsilosis ; Candida tropicalis ; Neoplasms/complications ; Neoplasms/drug therapy
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2023-06-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391081-7
    ISSN 1573-0832 ; 0369-299X ; 0301-486X ; 0027-5530
    ISSN (online) 1573-0832
    ISSN 0369-299X ; 0301-486X ; 0027-5530
    DOI 10.1007/s11046-023-00765-7
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  3. Article ; Online: Clinical Metagenomics for Bloodstream Infections: Is the Juice Worth the Squeeze?

    Babady, N Esther

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 72, Issue 2, Page(s) 246–248

    MeSH term(s) Cell-Free Nucleic Acids ; Communicable Diseases ; High-Throughput Nucleotide Sequencing ; Humans ; Metagenomics ; Plasma ; Retrospective Studies ; Sepsis
    Chemical Substances Cell-Free Nucleic Acids
    Language English
    Publishing date 2020-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa041
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  4. Article ; Online: Nothing Basic About It: Guiding the Judicious Use of Diagnostic Tests.

    Babady, N Esther / Dien Bard, Jennifer

    Clinics in laboratory medicine

    2023  Volume 44, Issue 1, Page(s) xi–xiii

    MeSH term(s) Diagnostic Tests, Routine
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2023.12.001
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    Zs.A 1695: Show issues Location:
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  5. Article ; Online: An infant with nasal vestibulitis and paronychia.

    Algazaq, Jumanah / Kamboj, Mini / Babady, N Esther

    Pediatric dermatology

    2023  Volume 40, Issue 5, Page(s) 949–951

    MeSH term(s) Infant ; Humans ; Paronychia ; Candidiasis, Cutaneous
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15290
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    Zs.A 1882: Show issues Location:
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  6. Article: ADLM Guidance Document on Laboratory Diagnosis of Respiratory Viruses.

    Berry, Gregory J / Jhaveri, Tulip A / Larkin, Paige M K / Mostafa, Heba / Babady, N Esther

    The journal of applied laboratory medicine

    2024  

    Abstract: Respiratory viral infections are among the most frequent infections experienced worldwide. The COVID-19 pandemic has highlighted the need for testing and currently several tests are available for the detection of a wide range of viruses. These tests vary ...

    Abstract Respiratory viral infections are among the most frequent infections experienced worldwide. The COVID-19 pandemic has highlighted the need for testing and currently several tests are available for the detection of a wide range of viruses. These tests vary widely in terms of the number of viral pathogens included, viral markers targeted, regulatory status, and turnaround time to results, as well as their analytical and clinical performance. Given these many variables, selection and interpretation of testing requires thoughtful consideration. The current guidance document is the authors' expert opinion based on the preponderance of available evidence to address key questions related to best practices for laboratory diagnosis of respiratory viral infections including who to test, when to test, and what tests to use. An algorithm is proposed to help laboratories decide on the most appropriate tests to use for the diagnosis of respiratory viral infections.
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1093/jalm/jfae010
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  7. Article ; Online: Prevalence of astrovirus and sapovirus among adult oncology patients with acute gastroenteritis using a multiplexed gastrointestinal pathogen PCR panel.

    Cintron, Melvili / Jani, Krupa / Madhavappallil, Jerin / Kamboj, Mini / Babady, N Esther

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2024  Volume 43, Issue 3, Page(s) 525–531

    Abstract: Background: Multiplex syndromic gastrointestinal panels (GIPCR) have streamlined the diagnosis of infectious diarrhea. Additionally, they have expanded the number of pathogens that can be routinely evaluated, allowing further understanding of the ... ...

    Abstract Background: Multiplex syndromic gastrointestinal panels (GIPCR) have streamlined the diagnosis of infectious diarrhea. Additionally, they have expanded the number of pathogens that can be routinely evaluated, allowing further understanding of the prevalence of enteric pathogens in various patient populations. The goal of this study was to investigate the prevalence and clinical presentation of astrovirus and sapovirus gastroenteritis in adult oncology patients as detected by the FilmArray GIPCR.
    Methods: All GIPCR panel results from December 2017 to June 2021 were retrospectively reviewed to determine the prevalence of astrovirus and sapovirus in adult oncology patients. Medical records were also reviewed to obtain clinical information. Repeat GIPCR positivity and symptom duration were used to estimate prolonged viral shedding.
    Results: A total of 18,014 panels were performed on samples collected from 9303 adults. Overall, astrovirus and sapovirus were detected in 0.35% (33/9303) and 0.45% (42/9303) GIPCRs respectively. At least one viral target was detected in 424 (4.4%) patients. Astrovirus accounted for 7.8% (33/424) and sapovirus 9.9% (42/424) of patients. Diarrhea was the most common symptom documented. A subset of transplant patients had protracted viral detection with a median of ~27 days (range 23-43 days) for astrovirus and 97 days (range 11-495) for sapovirus. No clusters or outbreaks were identified during the study period.
    Conclusion: In oncology patients with viral gastroenteritis, astrovirus and sapovirus were the causative agents in 18% of the cases. Both viruses were associated with mild disease. Prolonged diarrhea and viral shedding were observed in a few transplant patients.
    MeSH term(s) Adult ; Humans ; Infant ; Sapovirus/genetics ; Prevalence ; Retrospective Studies ; Norovirus/genetics ; Gastroenteritis/diagnosis ; Diarrhea/epidemiology ; Neoplasms/complications ; Feces ; Polymerase Chain Reaction
    Language English
    Publishing date 2024-01-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-024-04748-4
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    Zs.A 1732: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Acetobacter tropicalis

    Raible, Kevin M / Algazaq, Jumanah N / Papanicolaou, Genovefa / Babady, N Esther

    Access microbiology

    2022  Volume 4, Issue 11, Page(s) acmi000374

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2022-11-24
    Publishing country England
    Document type Case Reports
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000374
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  9. Article ; Online: Effect of non-pharmaceutical interventions on the incidence of respiratory viruses at a tertiary cancer care center.

    Clark, Brenden / Cintron, Melvilí / Kamboj, Mini / Babady, N Esther

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2023  Volume 163, Page(s) 105442

    Abstract: Background: In March 2020, nonpharmaceutical interventions (NPIs) including face coverings and social distancing were adopted to curb the spread of SARS-CoV-2. Over the course of the pandemic, adherence to these NPIs has varied and eventually became ... ...

    Abstract Background: In March 2020, nonpharmaceutical interventions (NPIs) including face coverings and social distancing were adopted to curb the spread of SARS-CoV-2. Over the course of the pandemic, adherence to these NPIs has varied and eventually became optional in most non healthcare settings. We investigated the impact of relaxation of NPI on the incidence of respiratory viruses other than SARS-CoV-2 at a tertiary cancer care hospital.
    Methods: This was a retrospective cohort study of respiratory viral panel results performed at between 08/01/2014-07/31/2022. Only one viral target result per patient per year was included. Poisson regression models were used to compare 2019-2020, 2020-2021, and 2021-2022 incidence of respiratory viruses to those of 2014-2019. Interrupted time series analysis was performed using autoregressive integrated moving average models in order to compare expected and observed positivity rates.
    Results: A large reduction in the odds of testing positive for a respiratory virus was observed for most respiratory viruses when comparing results from 2019 to 2020 group to the corresponding period in 2014-2019. Subsequent seasons showed ongoing reductions in the odds of testing positive while slowly increasing over time back toward pre-pandemic levels. A time interrupted series analysis showed that the monthly positivity rate for all respiratory pathogens were reduced after 03/01/2020, when compared to the expected values forecast, except for adenovirus.
    Conclusions: This study provides valuable data that could be used to guide public health practices and support the efficacy of NPIs in curtailing the spread of novel and endemic respiratory viruses.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Incidence ; Retrospective Studies ; SARS-CoV-2 ; Neoplasms/epidemiology ; Neoplasms/prevention & control
    Language English
    Publishing date 2023-04-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2023.105442
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    Zs.A 3790: Show issues Location:
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  10. Article ; Online: The Successes and Challenges of SARS-CoV-2 Molecular Testing in the United States.

    Dien Bard, Jennifer / Babady, N Esther

    Clinics in laboratory medicine

    2022  Volume 42, Issue 2, Page(s) 147–160

    Abstract: SARS-CoV-2 was identified and diagnostic methods developed at an impressive speed due in great part to the wider use of molecular methods in 2019 compared with 2002 during the SARS pandemic. The development of rapid and novel molecular diagnostic assays, ...

    Abstract SARS-CoV-2 was identified and diagnostic methods developed at an impressive speed due in great part to the wider use of molecular methods in 2019 compared with 2002 during the SARS pandemic. The development of rapid and novel molecular diagnostic assays, leveraging of the high adaptability of molecular tests, and the integration of SARS-CoV-2 genotyping into public health, clinical, and research laboratories have been some of the successes in SARS-CoV-2 molecular testing. The main challenges are related to regulatory hurdles, supply chain constraints, and laboratory preparation.
    MeSH term(s) COVID-19/diagnosis ; Humans ; Molecular Diagnostic Techniques ; Pandemics ; Public Health ; SARS-CoV-2/genetics ; United States/epidemiology
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2022.02.007
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