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  1. Article ; Online: Neil J. Bulleid (1960-2023), a virtuoso of protein folding and redox biology.

    Braakman, Ineke / High, Stephen / Kadler, Karl / Sitia, Roberto / Tokatlidis, Kostas / Woodman, Philip

    The EMBO journal

    2023  Volume 42, Issue 17, Page(s) e115046

    MeSH term(s) Protein Folding ; Oxidation-Reduction ; Biology
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2023115046
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  2. Article ; Online: Beta-blockers for tenacious saliva: a case report.

    Woodman, Myles J / Howard, Paul

    BMJ supportive & palliative care

    2024  Volume 13, Issue e3, Page(s) e936–e938

    Abstract: This case report describes the care of a 75-year-old gentleman with metastatic head and neck cancer who was highly symptomatic with intractable tenacious oropharyngeal secretions. The patient reported subjective benefit from oral atenolol. A literature ... ...

    Abstract This case report describes the care of a 75-year-old gentleman with metastatic head and neck cancer who was highly symptomatic with intractable tenacious oropharyngeal secretions. The patient reported subjective benefit from oral atenolol. A literature review was undertaken and identified no previous studies on the use of β-blockers for secretions in malignant disease, although some anecdotal evidence for their use in motor neuron disease. The proposed underlying mechanism is that β1-blockade reduced the protein content of salivary secretions, hence reducing its viscosity. Further studies of both the role of β-adrenoreceptors in the control of secretion viscosity and the potential role of β-blockers in alleviating symptomatic tenacious secretions are warranted.
    MeSH term(s) Male ; Humans ; Aged ; Saliva/metabolism ; Adrenergic beta-Antagonists/therapeutic use ; Atenolol/metabolism
    Chemical Substances Adrenergic beta-Antagonists ; Atenolol (50VV3VW0TI)
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Review ; Case Reports ; Journal Article
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/bmjspcare-2022-003615
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  3. Article: Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments.

    Sleckman, B P / Bassing, C H / Hughes, M M / Okada, A / D'Auteuil, M / Wehrly, T D / Woodman, B B / Davidson, L / Chen, J / Alt, F W

    Proceedings of the National Academy of Sciences of the United States of America

    2000  Volume 97, Issue 14, Page(s) 7975–7980

    Abstract: ... on the V(D)J recombination mechanism, are infrequent within the endogenous TCRbeta locus. We have analyzed ... D, and J segments. ...

    Abstract T cell receptor (TCR) beta variable region genes are assembled in progenitor T cells from germ-line Vbeta, Dbeta, and Jbeta segments via an ordered two-step process in which Dbeta to Jbeta rearrangements occur on both alleles before appendage of a Vbeta to a preexisting DJbeta complex. Direct joining of Vbeta segments to nonrearranged Dbeta or Jbeta segments, while compatible with known restrictions on the V(D)J recombination mechanism, are infrequent within the endogenous TCRbeta locus. We have analyzed mechanisms that mediate ordered Vbeta, Dbeta, and Jbeta assembly via an approach in which TCRbeta minilocus recombination substrates were introduced into embryonic stem cells and then analyzed for rearrangement in normal thymocytes by recombinase-activating gene 2-deficient blastocyst complementation. These analyses demonstrated that Vbeta segments are preferentially targeted for rearrangement to Dbeta as opposed to Jbeta segments. In addition, we further demonstrated that Vbeta segments can be appended to nonrearranged endogenous Dbeta segments in which we have eliminated the ability of Dbeta segments to join to Jbeta segments. Our findings are discussed in the context of the mechanisms that regulate the ordered assembly and utilization of V, D, and J segments.
    MeSH term(s) Animals ; Cell Lineage ; Chimera ; DNA-Binding Proteins/genetics ; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor ; Genes, T-Cell Receptor beta ; Genetic Complementation Test ; Mice ; Models, Genetic ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Recombination, Genetic
    Chemical Substances DNA-Binding Proteins ; Rag2 protein, mouse ; Receptors, Antigen, T-Cell, alpha-beta ; V(D)J recombination activating protein 2
    Language English
    Publishing date 2000-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.130190597
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    Zs.A 1148: Show issues Location:
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  4. Article: Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

    Bassing, C H / Alt, F W / Hughes, M M / D'Auteuil, M / Wehrly, T D / Woodman, B B / Gärtner, F / White, J M / Davidson, L / Sleckman, B P

    Nature

    2000  Volume 405, Issue 6786, Page(s) 583–586

    Abstract: ... V), diversity (D) and joining (J) gene segments. V(D)J recombination is initiated by the recombinase ... activating gene (RAG)-1 and -2 proteins, which introduce DNA double-strand breaks between the V, D and J segments ... mediated at the level of RAG-1/2 recognition and cutting, specifies that V(D)J recombination occurs only ...

    Abstract The genes encoding the variable regions of lymphocyte antigen receptors are assembled from variable (V), diversity (D) and joining (J) gene segments. V(D)J recombination is initiated by the recombinase activating gene (RAG)-1 and -2 proteins, which introduce DNA double-strand breaks between the V, D and J segments and their flanking recombination signal sequences (RSSs). Generally expressed DNA repair proteins then carry out the joining reaction. The conserved heptamer and nonamer sequences of the RSSs are separated by non-conserved spacers of 12 or 23 base pairs (forming 12-RSSs and 23-RSSs). The 12/23 rule, which is mediated at the level of RAG-1/2 recognition and cutting, specifies that V(D)J recombination occurs only between a gene segment flanked by a 12-RSS and one flanked by a 23-RSS. Vbeta segments are appended to DJbeta rearrangements, with little or no direct Vbeta to Jbeta joining, despite 12/23 compatibility of Vbeta 23-RSSs and Jbeta12-RSSs. Here we use embryonic stem cells and mice with a modified T-cell receptor (TCR)beta locus containing only one Dbeta (Dbeta1) gene segment and one Jbeta (Jbeta1) gene cluster to show that the 5' Dbeta1 12-RSS, but not the Jbeta1 12-RSSs, targets rearrangement of a diverse Vbeta repertoire. This targeting is precise and position-independent. This additional restriction on V(D)J recombination has important implications for the regulation of variable region gene assembly and repertoire development.
    MeSH term(s) Alleles ; Animals ; Cell Line ; Chimera ; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor ; Hybridomas ; Mice ; Multigene Family ; Mutagenesis ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Recombination, Genetic ; Stem Cells
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta
    Language English
    Publishing date 2000-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/35014635
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  5. Article ; Online: Analysis of enzyme reactions using NMR techniques: A case study with α-methylacyl-CoA racemase (AMACR).

    Woodman, Timothy J / Lloyd, Matthew D

    Methods in enzymology

    2023  Volume 690, Page(s) 159–209

    Abstract: α-Methylacyl-CoA racemase (AMACR; P504S) catalyzes the conversion of R-2-methylacyl-CoA esters into their corresponding S-2-methylacyl-CoA epimers enabling their degradation by β-oxidation. The enzyme also catalyzes the key epimerization reaction in the ... ...

    Abstract α-Methylacyl-CoA racemase (AMACR; P504S) catalyzes the conversion of R-2-methylacyl-CoA esters into their corresponding S-2-methylacyl-CoA epimers enabling their degradation by β-oxidation. The enzyme also catalyzes the key epimerization reaction in the pharmacological activation pathway of ibuprofen and related drugs. AMACR protein levels and enzymatic activity are increased in prostate cancer, and the enzyme is a recognized drug target. Key to the development of novel treatments based on AMACR inhibition is the development of functional assays. Synthesis of substrates and purification of recombinant human AMACR are described. Incubation of R- or S-2-methylacyl-CoA esters with AMACR in vitro resulted in formation of epimers (at a near 1-1 ratio at equilibrium) via removal of their α-protons to form an enolate intermediate followed by reprotonation. Conversion can be conveniently followed by incubation in buffer containing
    MeSH term(s) Male ; Humans ; Racemases and Epimerases ; Esters ; Prostatic Neoplasms/metabolism ; Biomarkers, Tumor
    Chemical Substances alpha-methylacyl-CoA racemase (EC 5.1.99.4) ; Racemases and Epimerases (EC 5.1.-) ; Esters ; Biomarkers, Tumor
    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2023.07.005
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  6. Article ; Online: A comprehensive review of machine learning algorithms and their application in geriatric medicine: present and future.

    Woodman, Richard J / Mangoni, Arduino A

    Aging clinical and experimental research

    2023  Volume 35, Issue 11, Page(s) 2363–2397

    Abstract: The increasing access to health data worldwide is driving a resurgence in machine learning research, including data-hungry deep learning algorithms. More computationally efficient algorithms now offer unique opportunities to enhance diagnosis, risk ... ...

    Abstract The increasing access to health data worldwide is driving a resurgence in machine learning research, including data-hungry deep learning algorithms. More computationally efficient algorithms now offer unique opportunities to enhance diagnosis, risk stratification, and individualised approaches to patient management. Such opportunities are particularly relevant for the management of older patients, a group that is characterised by complex multimorbidity patterns and significant interindividual variability in homeostatic capacity, organ function, and response to treatment. Clinical tools that utilise machine learning algorithms to determine the optimal choice of treatment are slowly gaining the necessary approval from governing bodies and being implemented into healthcare, with significant implications for virtually all medical disciplines during the next phase of digital medicine. Beyond obtaining regulatory approval, a crucial element in implementing these tools is the trust and support of the people that use them. In this context, an increased understanding by clinicians of artificial intelligence and machine learning algorithms provides an appreciation of the possible benefits, risks, and uncertainties, and improves the chances for successful adoption. This review provides a broad taxonomy of machine learning algorithms, followed by a more detailed description of each algorithm class, their purpose and capabilities, and examples of their applications, particularly in geriatric medicine. Additional focus is given on the clinical implications and challenges involved in relying on devices with reduced interpretability and the progress made in counteracting the latter via the development of explainable machine learning.
    MeSH term(s) Humans ; Aged ; Artificial Intelligence ; Algorithms ; Machine Learning ; Geriatrics
    Language English
    Publishing date 2023-09-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-023-02552-2
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    Zs.A 3343: Show issues Location:
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  7. Book: Patients beyond borders

    Woodman, Josef

    everybody's guide to affordable, world-class medical tourism

    2007  

    Author's details Josef Woodman
    Language English
    Size XIII, 325 S.
    Publisher Healthy Travel Media
    Publishing place Chapel Hill, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT015084600
    ISBN 0-979-1079-0-3 ; 0-979-10790-3 ; 978-0-979-1079-0-0 ; 978-0-979-1079-0- ; 978-0-979-10790-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 4036 order for loan Magazin

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  8. Article ; Online: Using administrative data to assess early-life policies.

    Harron, Katie / Woodman, Jenny

    The Lancet. Public health

    2023  Volume 8, Issue 7, Page(s) e476–e477

    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Journal Article
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(23)00127-5
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  9. Article ; Online: Corrigendum to 'Inhalational induction in paediatric anaesthesia' [

    Sellers, C / Woodman, N

    BJA education

    2023  Volume 24, Issue 2, Page(s) 75

    Abstract: This corrects the article DOI: 10.1016/j.bjae.2022.10.002.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.bjae.2022.10.002.].
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2888911-3
    ISSN 2058-5357 ; 2058-5349
    ISSN (online) 2058-5357
    ISSN 2058-5349
    DOI 10.1016/j.bjae.2023.11.001
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  10. Article ; Online: Esomeprazole for subcutaneous infusion: compatibility with other alkaline medications.

    Woodman, Myles / Curtin, John / Howard, Paul

    BMJ supportive & palliative care

    2024  Volume 13, Issue e3, Page(s) e751–e753

    MeSH term(s) Humans ; Esomeprazole/therapeutic use ; Infusions, Intravenous ; Infusions, Subcutaneous
    Chemical Substances Esomeprazole (N3PA6559FT)
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Letter
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/spcare-2022-003936
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