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Article ; Online: Expression of pyroptosis-related genes are correlated with immune microenvironment and predict prognosis in ESCA.

Shi, Youmeng / Yang, Qiuxing / Tai, Guomei / Chen, Xudong

Journal of cancer research and clinical oncology

2023 Volume 149, Issue 12, Page(s) 10701–10713

Abstract: Objectives: Pyroptosis-related genes (PRGs) are abnormally expressed in a variety of gastrointestinal tumors, this study aimed to investigate the role of pyroptosis genes in assessing the prognosis of esophageal cancer (ESCA).: Methods: Through ... ...

Abstract	Objectives: Pyroptosis-related genes (PRGs) are abnormally expressed in a variety of gastrointestinal tumors, this study aimed to investigate the role of pyroptosis genes in assessing the prognosis of esophageal cancer (ESCA). Methods: Through consensus clustering, we identified two subtypes associated with PRGs. After Lasso regression and multivariate Cox regression analysis, a polygenic signature based on six prognostic PRGS was constructed. Afterwards, we combined the risk score with clinical predictors to construct and validate a PRGs-associated ESCA prognostic model. Results: Through analysis, we Successfully constructed and validated a PRGs-associated ESCA prognostic model that predicts ESCA survival and correlates with the tumor immune microenvironment. Conclusion: Based on PRGs features, we established a new ESCA hierarchical model. This model has important clinical implications for ESCA patients, both in terms of assessing prognosis and in terms of targeted and immunotherapy.
MeSH term(s)	Humans ; Pyroptosis/genetics ; Esophageal Neoplasms/genetics ; Prognosis ; Cluster Analysis ; Immunotherapy ; Tumor Microenvironment/genetics
Language	English
Publishing date	2023-06-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-04958-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High-intensity interval training in breast cancer patients: A systematic review and meta-analysis.

Chen, Xudong / Shi, Xuyuan / Yu, Zhiruo / Ma, Xuelei

Cancer medicine

2023 Volume 12, Issue 17, Page(s) 17692–17705

Abstract: Background: Women with breast cancer and improved survival often experience treatment-related impairments. High-intensity interval training (HIIT) has emerged as a promising exercise therapy modality for adult cancer patients. However, the overall ... ...

Abstract	Background: Women with breast cancer and improved survival often experience treatment-related impairments. High-intensity interval training (HIIT) has emerged as a promising exercise therapy modality for adult cancer patients. However, the overall effects of HIIT in breast cancer patients remain scarce and controversial. Therefore, we conducted a systematic review and meta-analysis to comprehensively evaluate the impact of HIIT on health-related outcomes in breast cancer patients. Methods: We searched the PubMed, Embase, and Web of Science from inception to November 7, 2022. Eligible studies included randomized controlled trials that compared HIIT interventions with usual care (UC) or MICT in breast cancer patients. The primary outcome assessed was physical fitness, and exploratory outcomes included body composition, blood-borne biomarkers, and patient-reported outcomes. Summary data were extracted, and standardized mean differences (SMD) were calculated for meta-analysis. For outcomes that could not be pooled, a systematic review was conducted. Results: Our analysis included 19 articles from 10 studies, encompassing 532 participants who met the inclusion criteria. Pooled results demonstrated that HIIT was superior to UC in improving peak oxygen uptake (VO Conclusions: HIIT is a time-efficient alternative to MICT for improving VO
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6387
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Article ; Online: The effect of team cultural tightness and transformational leadership on employee creative behavior: A cross-level moderated mediation model.

Shi, Kan / Song, Xudong / Zhou, Ruihua / Zhou, Wei

PsyCh journal

2023 Volume 12, Issue 5, Page(s) 657–669

Abstract: In recent years, "cultural tightness-looseness" refers to the strength of social norms and tolerance for deviant behaviors perceived by individuals in society, and team cultural tightness applied at the organizational level represents the strength of ... ...

Abstract	In recent years, "cultural tightness-looseness" refers to the strength of social norms and tolerance for deviant behaviors perceived by individuals in society, and team cultural tightness applied at the organizational level represents the strength of team norms. According to the cultural tightness-looseness theory, this study explores the influence of team cultural tightness on employee creative behavior, as well as the moderating role of transformational leadership and the mediating role of work engagement. A questionnaire method was used to survey five enterprise organizations in China through three stages, and 288 paired questionnaires were finally obtained from leaders and employees. The results found that team cultural tightness has a significant negative effect on employee creative behavior through the mediating effect of work engagement. In other words, the more the team culture in the workplace tends to be loose, the more it stimulates employee work engagement, which in turn promotes employee creative behavior. In addition, transformational leadership played a significant positive moderating role in the model. Under the influence of transformational leadership style, the negative impact of team cultural tightness on employee work engagement and creative behavior can be mitigated. The study enriches the understanding of the influence and action mechanism of the cultural tightness-looseness theory on employee creative behavior. In future research, the action mechanism of team cultural tightness interacting with different leadership styles to influence employee creative behavior will be explored more deeply.
MeSH term(s)	Humans ; Leadership ; Workplace ; Surveys and Questionnaires ; Work Engagement ; China
Language	English
Publishing date	2023-09-08
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2717141-3
ISSN	2046-0260 ; 2046-0252
ISSN (online)	2046-0260
ISSN	2046-0252
DOI	10.1002/pchj.678
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Article ; Online: Variation characteristics of rainfall erosivity in tropical China and its impact on river sediment load

Xudong Lu / Jiadong Chen / Jianchao Guo / Shi Qi

Frontiers in Environmental Science, Vol

2023 Volume 11

Abstract: Rainfall erosivity is one of the important factors leading to soil and water erosion, affecting the intensity of soil erosion and the variation of river sediment load. This work aimed to explore the distribution and variation characteristics of rainfall ... ...

Abstract	Rainfall erosivity is one of the important factors leading to soil and water erosion, affecting the intensity of soil erosion and the variation of river sediment load. This work aimed to explore the distribution and variation characteristics of rainfall erosivity in the Nandu River Basin in tropical China and to clarify the effect of rainfall erosivity on sediment load variation. The daily rainfall data of 13 meteorological stations in the Nandu River Basin during 1971–2020 were used to calculate the rainfall erosivity of the river basin by using the rainfall erosivity model based on the daily rainfall. The analyses were conducted using the Mann-Kendall non-parametric trend/abrupt test, wavelet analysis, inverse distance weighted interpolation and other research methods to determine the temporal and spatial fluctuation patterns of rainfall erosivity and sediment load. The annual mean rainfall erosivity in the Nandu River Basin during 1971–2020 was 16,497.67 MJ mm·ha−1·h−1, which showed an upward trend. The distribution of rainfall erosivity was concentrated from July to September. Except spring, the variation of rainfall erosivity in summer, autumn and winter showed an upward trend. Spatially, rainfall erosivity showed a decreasing trend from south to north. The variation coefficient of each meteorological station ranged from 0.24 to 0.43, showing high regional variability. The correlation between rainfall erosivity and erosive rainfall in the basin was the highest, followed by altitude and latitude. From 1980 to 2020, the sediment load in the Nandu River Basin showed an overall upward trend, with obvious periodic changes. The main change period was 25 years, and the sediment load had a large inter-annual variation. Taking the period before the inflection point of the double accumulation curve of sediment load and rainfall erosivity as the base period, since 2009, the river sediment load increased by 46.36% compared with the base period. The influence of the variation of rainfall erosivity on sediment load is ...
Keywords	rainfall erosivity ; sediment load ; temporal and spatial variation ; soil and water loss ; tropical basin ; erosive rainfall ; Environmental sciences ; GE1-350
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Mild magnetic hyperthermia-activated immuno-responses for primary bladder cancer therapy.

Qi, Fenggang / Bao, Qunqun / Hu, Ping / Guo, Yuedong / Yan, Yang / Yao, Xudong / Shi, Jianlin

Biomaterials

2024 Volume 307, Page(s) 122514

Abstract: Surgical intervention followed by chemotherapy is the principal treatment strategy for bladder cancer, which is hindered by significant surgical risks, toxicity from chemotherapy, and high rates of recurrence after surgery. In this context, a novel ... ...

Abstract	Surgical intervention followed by chemotherapy is the principal treatment strategy for bladder cancer, which is hindered by significant surgical risks, toxicity from chemotherapy, and high rates of recurrence after surgery. In this context, a novel approach using mild magnetic hyperthermia therapy (MHT) for bladder cancer treatment through the intra-bladder delivery of magnetic nanoparticles is presented for the first time. This method overcomes the limitations of low magnetic thermal efficiency, inadequate tumor targeting, and reduced therapeutic effectiveness associated with the traditional intravenous administration of magnetic nanoparticles. Core-shell Zn-CoFe
MeSH term(s)	Humans ; Urinary Bladder/metabolism ; Urinary Bladder/pathology ; Hyperthermia, Induced/methods ; Neoplasm Recurrence, Local ; Urinary Bladder Neoplasms/pathology ; Magnetic Phenomena ; Cell Line, Tumor
Language	English
Publishing date	2024-02-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2024.122514
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Article: Abnormal balance control mechanisms during dynamic reaching forward and quiet standing in patients with anterior cruciate ligament reconstruction.

Wang, Wei / Li, Xudong / Shi, Runxiu / Wang, Cheng / Zhang, Ke / Ren, Xiaomin / Wei, Hui

Frontiers in physiology

2023 Volume 14, Page(s) 1176222

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1176222
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Article ; Online: Zonotopic Fault Detection for 2-D Systems Under Event-Triggered Mechanism.

Wang, Xudong / Fei, Zhongyang / Shi, Peng / Yu, Jinyong

IEEE transactions on cybernetics

2022 Volume 52, Issue 5, Page(s) 3510–3518

Abstract: This article studies the problem of event-triggered fault detection (FD) for 2-D systems subjected to amplitude-bounded exogenous disturbance and measurement noise via a zonotopic residual evaluation mechanism. An event-triggered mechanism is introduced ... ...

Abstract	This article studies the problem of event-triggered fault detection (FD) for 2-D systems subjected to amplitude-bounded exogenous disturbance and measurement noise via a zonotopic residual evaluation mechanism. An event-triggered mechanism is introduced into the FD framework to save limited communication resources. A finite-frequency (FF) mixed l
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2020.3009118
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Article ; Online: LepR-expressing cells are a critical population in periodontal healing post periodontitis.

Xu, Chunmei / Xie, Xudong / Shi, Peilei / Xue, Kun / Li, Yue / Wu, Yafei / Wang, Jun

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2024 Volume 39, Issue 1, Page(s) 59–72

Abstract: Identification of promising seed cells plays a pivotal role in achieving tissue regeneration. This study demonstrated that LepR-expressing cells (LepR+ cells) are required for maintaining periodontal homeostasis at the adult stage. We further ... ...

Abstract	Identification of promising seed cells plays a pivotal role in achieving tissue regeneration. This study demonstrated that LepR-expressing cells (LepR+ cells) are required for maintaining periodontal homeostasis at the adult stage. We further investigated how LepR+ cells behave in periodontal healing using a ligature-induced periodontitis (PD) and a self-healing murine model with LepRCre/+; R26RtdTomato/+ mice. Lineage tracing experiments revealed that the largely suppressed osteogenic ability of LepR+ cells results from periodontal inflammation. Periodontal defects were partially recovered when the ligature was removed, in which the osteogenic differentiation of LepR+ cell lineage was promoted and contributed to the newly formed alveolar bone. A cell ablation model established with LepRCre/+; R26RtdTomato/+; R26RDTA/+ mice further proved that LepR+ cells are an important cell source of newly formed alveolar bone. Expressions of β-catenin and LEF1 in LepR+ cells were upregulated when the inflammatory stimuli were removed, which are consistent with the functional changes observed during periodontal healing. Furthermore, the conditional upregulation of WNT signaling or the application of sclerostin neutralized antibody promoted the osteogenic function of LepR+ cells. In contrast, the specific knockdown of β-catenin in LepR+ human periodontal ligament cells with small interfering RNA caused arrested osteogenic function. Our findings identified the LepR+ cell lineage as a critical cell population for endogenous periodontal healing post PD, which is regulated by the WNT signaling pathway, making it a promising seed cell population in periodontal tissue regeneration.
MeSH term(s)	Adult ; Mice ; Humans ; Animals ; Osteogenesis ; beta Catenin/metabolism ; Periodontitis ; Periodontal Ligament/metabolism ; Inflammation ; Wnt Signaling Pathway/physiology ; Cell Differentiation ; Cells, Cultured
Chemical Substances	beta Catenin
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1093/jbmr/zjad008
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Article ; Online: Carbon coated In

Shi, Yuchen / Su, Weiguang / Wei, Xinyu / Bai, Yonghui / Song, Xudong / Lv, Peng / Wang, Jiaofei / Yu, Guangsuo

Journal of colloid and interface science

2023 Volume 636, Page(s) 141–152

Abstract: ... ...

Abstract	CO
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.01.008
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Article ; Online: Observer-Based Adaptive NN Security Control for Switched Nonlinear Systems Against DoS Attacks: An ADT Approach.

Xie, Hongzhen / Zong, Guangdeng / Yang, Dong / Zhao, Xudong / Shi, Kaibo

IEEE transactions on cybernetics

2023 Volume 53, Issue 12, Page(s) 8024–8034

Abstract: In this article, a novel switched observer-based neural network (NN) adaptive control algorithm is established, which addresses the security control problem of switched nonlinear systems (SNSs) under denial-of-service (DoS) attacks. The considered SNSs ... ...

Abstract	In this article, a novel switched observer-based neural network (NN) adaptive control algorithm is established, which addresses the security control problem of switched nonlinear systems (SNSs) under denial-of-service (DoS) attacks. The considered SNSs are described in lower triangular form with external disturbances and unmodeled dynamics. Note that when an attack is launched in the sensor-controller channel, the controller will not receive any message, which makes the standard backstepping controller not workable. To tackle the challenge, a set of NN adaptive observers are designed under two different situations, which can switch adaptively depending on the DoS attack on/off. Further, an NN adaptive controller is constructed and the dynamic surface control method is borrowed to surmount the complexity explosion phenomenon. To eliminate double damage from DoS attacks and switches, a set of switching laws with average dwell time are designed via the multiple Lyapunov function method, which in combination with the proposed controllers, guarantees that all the signals in the closed-loop system are bounded. Finally, an illustrative example is offered to verify the availability of the proposed control algorithm.
Language	English
Publishing date	2023-11-29
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2023.3309292
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