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  1. Article ; Online: Endogenous opiates and behavior: 2022.

    Bodnar, Richard J

    Peptides

    2023  Volume 169, Page(s) 171095

    Abstract: This paper is the forty-fifth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2022 that studied the behavioral effects of molecular, pharmacological and ... ...

    Abstract This paper is the forty-fifth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2022 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
    MeSH term(s) Animals ; Humans ; Female ; Pregnancy ; Opioid Peptides/pharmacology ; Analgesics, Opioid ; Analgesia ; Analgesics, Non-Narcotic ; Drug Tolerance
    Chemical Substances Opioid Peptides ; Analgesics, Opioid ; Analgesics, Non-Narcotic
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2023.171095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Endogenous opiates and behavior: 2021.

    Bodnar, Richard J

    Peptides

    2023  Volume 164, Page(s) 171004

    Abstract: This paper is the forty-fourth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2021 that studied the behavioral effects of molecular, pharmacological and ...

    Abstract This paper is the forty-fourth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2021 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonizts and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
    MeSH term(s) Animals ; Humans ; Opioid Peptides/pharmacology ; Receptors, Opioid/physiology ; Analgesics, Opioid/pharmacology ; Learning/physiology ; Pain/drug therapy
    Chemical Substances Opioid Peptides ; Receptors, Opioid ; Analgesics, Opioid
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2023.171004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Endogenous opiates and behavior: 2020.

    Bodnar, Richard J

    Peptides

    2022  Volume 151, Page(s) 170752

    Abstract: This paper is the forty-third consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2020 that studied the behavioral effects of molecular, pharmacological and ... ...

    Abstract This paper is the forty-third consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2020 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
    MeSH term(s) Analgesics, Opioid/pharmacology ; Animals ; Female ; Learning/physiology ; Opioid Peptides/pharmacology ; Pain/drug therapy ; Pregnancy ; Receptors, Opioid/agonists
    Chemical Substances Analgesics, Opioid ; Opioid Peptides ; Receptors, Opioid
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2022.170752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endogenous opiates and behavior: 2019.

    Bodnar, Richard J

    Peptides

    2021  Volume 141, Page(s) 170547

    Abstract: This paper is the forty-second consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2019 that studied the behavioral effects of molecular, pharmacological and ...

    Abstract This paper is the forty-second consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2019 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
    MeSH term(s) Analgesics, Opioid/pharmacology ; Animals ; Cancer Pain/drug therapy ; Cancer Pain/genetics ; Chronic Pain/drug therapy ; Ethanol/pharmacology ; Female ; Humans ; Memory/drug effects ; Memory/physiology ; Opioid Peptides/pharmacology ; Opioid Peptides/physiology ; Pain, Postoperative/drug therapy ; Pregnancy ; Receptors, Opioid/agonists ; Receptors, Opioid/physiology ; Sexual Behavior/physiology ; Social Status ; Stress, Psychological/physiopathology ; Substance-Related Disorders/etiology ; Substance-Related Disorders/genetics
    Chemical Substances Analgesics, Opioid ; Opioid Peptides ; Receptors, Opioid ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2021-04-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2021.170547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: 2018 Gayle A. Olson And Richard D. Olson Prize Vladimir A. Kashkin.

    Bodnar, Richard J

    Peptides

    2020  Volume 126, Page(s) 170252

    MeSH term(s) Analgesics/history ; Analgesics/therapeutic use ; Awards and Prizes ; History, 21st Century ; Humans ; Morphine Dependence/prevention & control ; Peptide Fragments/history ; Peptide Fragments/therapeutic use
    Chemical Substances Analgesics ; Peptide Fragments
    Language English
    Publishing date 2020-01-10
    Publishing country United States
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2020.170252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Endogenous opiates and behavior: 2020

    Bodnar, Richard J.

    Peptides. 2022 May, v. 151

    2022  

    Abstract: This paper is the forty-third consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2020 that studied the behavioral effects of molecular, pharmacological and ... ...

    Abstract This paper is the forty-third consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2020 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
    Keywords alcohols ; analgesia ; analgesics ; behavior disorders ; drug abuse ; emotions ; gastrointestinal system ; genetic engineering ; locomotion ; memory ; narcotics ; opioid peptides ; pain ; pregnancy ; socioeconomic status ; thermoregulation
    Language English
    Dates of publication 2022-05
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2022.170752
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Endogenous Opiates and Behavior: 2018.

    Bodnar, Richard J

    Peptides

    2020  Volume 132, Page(s) 170348

    Abstract: This paper is the forty-first consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2018 that studied the behavioral effects of molecular, pharmacological and ... ...

    Abstract This paper is the forty-first consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2018 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (2), the roles of these opioid peptides and receptors in pain and analgesia in animals (3) and humans (4), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (5), opioid peptide and receptor involvement in tolerance and dependence (6), stress and social status (7), learning and memory (8), eating and drinking (9), drug abuse and alcohol (10), sexual activity and hormones, pregnancy, development and endocrinology (11), mental illness and mood (12), seizures and neurologic disorders (13), electrical-related activity and neurophysiology (14), general activity and locomotion (15), gastrointestinal, renal and hepatic functions (16), cardiovascular responses (17), respiration and thermoregulation (18), and immunological responses (19).
    MeSH term(s) Analgesics, Opioid/pharmacology ; Animals ; Behavior/drug effects ; Humans ; Learning/physiology ; Mental Disorders/drug therapy ; Mental Disorders/metabolism ; Narcotic Antagonists/pharmacology ; Opioid Peptides/agonists ; Opioid Peptides/antagonists & inhibitors ; Opioid Peptides/metabolism ; Opioid Peptides/pharmacology ; Pain/drug therapy ; Pain/metabolism ; Receptors, Opioid/agonists
    Chemical Substances Analgesics, Opioid ; Narcotic Antagonists ; Opioid Peptides ; Receptors, Opioid
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2020.170348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Opioid addiction.

    Bodnar, Richard J

    Peptides

    2019  Volume 116, Page(s) 68–70

    MeSH term(s) Analgesics, Opioid/therapeutic use ; Humans ; Opioid-Related Disorders/drug therapy ; Opioid-Related Disorders/physiopathology
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2019-05-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2019.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Endogenous opioid modulation of food intake and body weight: Implications for opioid influences upon motivation and addiction.

    Bodnar, Richard J

    Peptides

    2019  Volume 116, Page(s) 42–62

    Abstract: This review is part of a special issue dedicated to Opioid addiction, and examines the influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake and body weight control in rodents. This review postulates that opioid ... ...

    Abstract This review is part of a special issue dedicated to Opioid addiction, and examines the influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake and body weight control in rodents. This review postulates that opioid mediation of food intake was an example of "positive addictive" properties that provide motivational drives to maintain opioid-seeking behavior and that are not subject to the "negative addictive" properties associated with tolerance, dependence and withdrawal. Data demonstrate that opiate and opioid peptide agonists stimulate food intake through homeostatic activation of sensory, metabolic and energy-related In contrast, general, and particularly mu-selective, opioid receptor antagonists typically block these homeostatically-driven ingestive behaviors. Intake of palatable and hedonic food stimuli is inhibited by general, and particularly mu-selective, opioid receptor antagonists. The selectivity of specific opioid agonists to elicit food intake was confirmed through the use of opioid receptor antagonists and molecular knockdown (antisense) techniques incapacitating specific exons of opioid receptor genes. Further extensive evidence demonstrated that homeostatic and hedonic ingestive situations correspondingly altered the levels and expression of opioid peptides and opioid receptors. Opioid mediation of food intake was controlled by a distributed brain network intimately related to both the appetitive-consummatory sites implicated in food intake as well as sites intimately involved in reward and reinforcement. This emergent system appears to sustain the "positive addictive" properties providing motivational drives to maintain opioid-seeking behavior.
    MeSH term(s) Animals ; Body Weight/genetics ; Brain/metabolism ; Eating/genetics ; Feeding Behavior/drug effects ; Humans ; Motivation/genetics ; Narcotic Antagonists/therapeutic use ; Opioid Peptides/genetics ; Receptors, Opioid/genetics
    Chemical Substances Narcotic Antagonists ; Opioid Peptides ; Receptors, Opioid
    Language English
    Publishing date 2019-04-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2019.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Endogenous opiates and behavior: 2017.

    Bodnar, Richard J

    Peptides

    2019  Volume 124, Page(s) 170223

    Abstract: This paper is the fortieth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2017 that studied the behavioral effects of molecular, pharmacological and ... ...

    Abstract This paper is the fortieth consecutive installment of the annual anthological review of research concerning the endogenous opioid system, summarizing articles published during 2017 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides and receptors as well as effects of opioid/opiate agonists and antagonists. The review is subdivided into the following specific topics: molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors (1), the roles of these opioid peptides and receptors in pain and analgesia in animals (2) and humans (3), opioid-sensitive and opioid-insensitive effects of nonopioid analgesics (4), opioid peptide and receptor involvement in tolerance and dependence (5), stress and social status (6), learning and memory (7), eating and drinking (8), drug abuse and alcohol (9), sexual activity and hormones, pregnancy, development and endocrinology (10), mental illness and mood (11), seizures and neurologic disorders (12), electrical-related activity and neurophysiology (13), general activity and locomotion (14), gastrointestinal, renal and hepatic functions (15), cardiovascular responses (16), respiration and thermoregulation (17), and immunological responses (18).
    MeSH term(s) Analgesics, Opioid/pharmacology ; Animals ; Cancer Pain/drug therapy ; Chronic Pain/drug therapy ; Chronic Pain/genetics ; Eating/drug effects ; Emotions ; Female ; Humans ; Learning/drug effects ; Male ; Memory/drug effects ; Opioid Peptides/agonists ; Opioid Peptides/antagonists & inhibitors ; Opioid Peptides/pharmacology ; Opioid Peptides/physiology ; Opioid-Related Disorders/etiology ; Opioid-Related Disorders/prevention & control ; Pregnancy ; Receptors, Opioid/metabolism ; Stress, Physiological ; Substance-Related Disorders/etiology
    Chemical Substances Analgesics, Opioid ; Opioid Peptides ; Receptors, Opioid ; nociceptin receptor (DVO6VKD7IJ)
    Language English
    Publishing date 2019-12-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2019.170223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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