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  1. Article: Image acquisition in 2-D electrophoresis.

    Patton, W F / Lim, M J / Shepro, D

    Methods in molecular biology (Clifton, N.J.)

    1999  Volume 112, Page(s) 353–362

    MeSH term(s) Electrophoresis, Gel, Two-Dimensional/methods ; Humans ; Proteins/analysis ; Staining and Labeling/methods
    Chemical Substances Proteins
    Language English
    Publishing date 1999-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1064-3745
    ISSN 1064-3745
    DOI 10.1385/1-59259-584-7:353
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  2. Article ; Online: Thymic cancer in lynch syndrome: an unusual association.

    Pandey, Deepali / Shepro, David Scott

    BMJ case reports

    2020  Volume 13, Issue 4

    Abstract: Lynch syndrome has been associated with predominantly colorectal, endometrial, and ovarian cancer. We report hereby an unusual case of thymic carcinoma in a patient with Lynch syndrome. A 45-year-old Caucasian woman with a personal history of Lynch ... ...

    Abstract Lynch syndrome has been associated with predominantly colorectal, endometrial, and ovarian cancer. We report hereby an unusual case of thymic carcinoma in a patient with Lynch syndrome. A 45-year-old Caucasian woman with a personal history of Lynch syndrome (MLH1 heterozygous mutation) presented with dyspnea, chest pain, and dysphagia. CT chest showed a bulky anterior mediastinal mass, pulmonary nodules, and pericardial effusion. Lung biopsy demonstrated a poorly differentiated carcinoma with squamous features with extensive necrosis, favouring thymic origin. Genomic studies on the tumour revealed deficient mismatch repair status with a two-copy deletion of MLH1 at 3p22.2 and c-Kit mutation. She received carboplatin and paclitaxel, with initial clinical improvement, but then died within 3 months after diagnosis. This case highlights that thymic cancer may be one of the malignancies associated with Lynch syndrome, and MLH1 gene mutation may have a role in the pathogenesis of thymic cancer.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Carboplatin/therapeutic use ; Colorectal Neoplasms, Hereditary Nonpolyposis/drug therapy ; Colorectal Neoplasms, Hereditary Nonpolyposis/pathology ; Dasatinib/therapeutic use ; Dexamethasone/therapeutic use ; Diagnosis, Differential ; Drug Therapy, Combination ; Fatal Outcome ; Female ; Glucocorticoids/therapeutic use ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/secondary ; Middle Aged ; Paclitaxel/therapeutic use ; Thymus Neoplasms/drug therapy ; Thymus Neoplasms/secondary
    Chemical Substances Antineoplastic Agents ; Glucocorticoids ; Dexamethasone (7S5I7G3JQL) ; Carboplatin (BG3F62OND5) ; Paclitaxel (P88XT4IS4D) ; Dasatinib (RBZ1571X5H)
    Language English
    Publishing date 2020-04-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-230241
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  3. Article: Metabolites of the phospholipase D pathway regulate H2O2-induced filamin redistribution in endothelial cells.

    Hastie, L E / Patton, W F / Hechtman, H B / Shepro, D

    Journal of cellular biochemistry

    1998  Volume 68, Issue 4, Page(s) 511–524

    Abstract: ... rearrangement by reactive oxygen species may be related to specific activation of the phospholipase D (PLD ... phospholipase D. H2O2-induced cytoskeletal changes are prevented by inhibiting phospholipase D ...

    Abstract Hypoxia/reoxygenation injury to cultured endothelial cells results in cytoskeletal rearrangement and second messenger activation related to increased monolayer junctional permeability. Cytoskeletal rearrangement by reactive oxygen species may be related to specific activation of the phospholipase D (PLD) pathway. Human umbilical vein endothelial cell monolayers are exposed to H2O2 (100 microM) or metabolites of the PLD pathway for 1-60 min. Changes in cAMP levels, Ca2+ levels, PIP2 production, filamin distribution, and intercellular gap formation are then quantitated. H2O2-induced filamin translocation from the membrane to the cytosol occurs after 1-min H2O2 treatment, while intercellular gap formation significantly increases after 15 min. H2O2 and phosphatidic acid exposure rapidly decrease intracellular cAMP levels, while increasing PIP2 levels in a Ca2+-independent manner. H2O2-induced cAMP decreases are prevented by inhibiting phospholipase D. H2O2-induced cytoskeletal changes are prevented by inhibiting phospholipase D, phosphatidylinositol-4-phosphate kinase, phosphoinositide turnover, or by adding a synthetic peptide that binds PIP2. These data indicate that metabolites produced downstream of H2O2-induced PLD activation may mediate filamin redistribution and F-actin rearrangement.
    MeSH term(s) Calcium/metabolism ; Cells, Cultured ; Contractile Proteins/analysis ; Contractile Proteins/metabolism ; Cyclic AMP/metabolism ; Cytoskeleton/metabolism ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Enzyme Activation ; Filamins ; Gap Junctions/drug effects ; Gap Junctions/metabolism ; Humans ; Hydrogen Peroxide/pharmacology ; Microfilament Proteins/analysis ; Microfilament Proteins/metabolism ; Permeability ; Phosphatidic Acids/pharmacology ; Phosphatidylinositol Phosphates/metabolism ; Phospholipase D/antagonists & inhibitors ; Phospholipase D/metabolism ; Signal Transduction ; Subcellular Fractions/metabolism ; Umbilical Veins
    Chemical Substances Contractile Proteins ; Filamins ; Microfilament Proteins ; Phosphatidic Acids ; Phosphatidylinositol Phosphates ; Hydrogen Peroxide (BBX060AN9V) ; Cyclic AMP (E0399OZS9N) ; Phospholipase D (EC 3.1.4.4) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1998-03-15
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 392402-6
    ISSN 1097-4644 ; 0730-2312
    ISSN (online) 1097-4644
    ISSN 0730-2312
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  4. Article: Rapid Quantum Magnetic IL-6 Point-of-Care Assay in Patients Hospitalized with COVID-19.

    Atallah, Johnny / Archambault, Dakota / Randall, Jeffrey D / Shepro, Adam / Styskal, Lauren E / Glenn, David R / Connolly, Colin B / Katsis, Katelin / Gallagher, Kathleen / Ghebremichael, Musie / Mansour, Michael K

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 5

    Abstract: Interleukin-6 (IL-6) has been linked to several life-threatening disease processes. Developing a point-of-care testing platform for the immediate and accurate detection of IL-6 concentrations could present a valuable tool for improving clinical ... ...

    Abstract Interleukin-6 (IL-6) has been linked to several life-threatening disease processes. Developing a point-of-care testing platform for the immediate and accurate detection of IL-6 concentrations could present a valuable tool for improving clinical management in patients with IL-6-mediated diseases. Drawing on an available biobank of samples from 35 patients hospitalized with COVID-19, a novel quantum-magnetic sensing platform is used to determine plasma IL-6 concentrations. A strong correlation was observed between IL-6 levels measured by QDTI10x and the Luminex assay (r = 0.70, p-value < 0.001) and between QDTI80x and Luminex (r = 0.82, p-value < 0.001). To validate the non-inferiority of QDTI to Luminex in terms of the accuracy of IL-6 measurement, two clinical parameters—the need for intensive care unit admission and the need for mechanical intubation—were chosen. IL-6 concentrations measured by the two assays were compared with respect to these clinical outcomes. Results demonstrated a comparative predictive performance between the two assays with a significant correlation coefficient. Conclusion: In short, the QDTI assay holds promise for implementation as a potential tool for rapid clinical decision in patients with IL-6-mediated diseases. It could also reduce healthcare costs and enable the development of future various biomolecule point-of-care tests for different clinical scenarios.
    Language English
    Publishing date 2022-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12051164
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  5. Article: Editorial.

    Shepro, David

    Microvascular research

    2002  Volume 64, Issue 3, Page(s) 363–366

    MeSH term(s) Congresses as Topic/history ; History, 20th Century ; Microcirculation ; Publications/history ; United States
    Language English
    Publishing date 2002-11-25
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1006/mvre.2002.2467
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  6. Article: In memoriam. George Pearman Fulton, Jr. (1914-1998).

    Shepro, D

    Microvascular research

    1998  Volume 55, Issue 3, Page(s) 186–188

    MeSH term(s) Animals ; Hemorheology/history ; History, 20th Century ; Microcirculation ; United States
    Language English
    Publishing date 1998-05
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1006/mvre.1998.2090
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  7. Article ; Online: Rapid Quantum Magnetic IL-6 Point-of-Care Assay in Patients Hospitalized with COVID-19

    Johnny Atallah / Dakota Archambault / Jeffrey D. Randall / Adam Shepro / Lauren E. Styskal / David R. Glenn / Colin B. Connolly / Katelin Katsis / Kathleen Gallagher / Musie Ghebremichael / Michael K. Mansour

    Diagnostics, Vol 12, Iss 1164, p

    2022  Volume 1164

    Abstract: Interleukin-6 (IL-6) has been linked to several life-threatening disease processes. Developing a point-of-care testing platform for the immediate and accurate detection of IL-6 concentrations could present a valuable tool for improving clinical ... ...

    Abstract Interleukin-6 (IL-6) has been linked to several life-threatening disease processes. Developing a point-of-care testing platform for the immediate and accurate detection of IL-6 concentrations could present a valuable tool for improving clinical management in patients with IL-6-mediated diseases. Drawing on an available biobank of samples from 35 patients hospitalized with COVID-19, a novel quantum-magnetic sensing platform is used to determine plasma IL-6 concentrations. A strong correlation was observed between IL-6 levels measured by QDTI10x and the Luminex assay (r = 0.70, p -value < 0.001) and between QDTI80x and Luminex (r = 0.82, p -value < 0.001). To validate the non-inferiority of QDTI to Luminex in terms of the accuracy of IL-6 measurement, two clinical parameters—the need for intensive care unit admission and the need for mechanical intubation—were chosen. IL-6 concentrations measured by the two assays were compared with respect to these clinical outcomes. Results demonstrated a comparative predictive performance between the two assays with a significant correlation coefficient. Conclusion: In short, the QDTI assay holds promise for implementation as a potential tool for rapid clinical decision in patients with IL-6-mediated diseases. It could also reduce healthcare costs and enable the development of future various biomolecule point-of-care tests for different clinical scenarios.
    Keywords IL-6 ; COVID-19 ; diagnostics ; ICU ; mechanical ventilation ; Luminex ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: The American Microcirculatory Society Landis Award lecture. Endothelial cells, inflammatory edema, and the microvascular barrier: comments by a "free radical".

    Shepro, D

    Microvascular research

    1988  Volume 35, Issue 3, Page(s) 246–264

    MeSH term(s) Awards and Prizes ; Endothelium, Vascular/cytology ; History, 20th Century ; Inflammation/physiopathology ; Massachusetts ; Microcirculation ; Societies, Medical
    Language English
    Publishing date 1988-05
    Publishing country United States
    Document type Autobiography ; Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 80307-8
    ISSN 1095-9319 ; 0026-2862
    ISSN (online) 1095-9319
    ISSN 0026-2862
    DOI 10.1016/0026-2862(88)90080-5
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  9. Article: In vitro studies of aggregation of non-mammalian thrombocytes.

    Belamarich, F A / Fusari, M H / Shepro, D / Kien, M

    Nature

    2010  Volume 212, Issue 5070, Page(s) 1579–1580

    MeSH term(s) Animals ; Blood Platelets/cytology ; Centrifugation ; Chickens ; Dogfish ; In Vitro Techniques ; Platelet Aggregation ; Reptiles
    Language English
    Publishing date 2010-11-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/2121579a0
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  10. Article: Antimotility effect of cytochalasin B observed in Mammalian clot retraction.

    Shepro, D / Belamarich, F A / Robblee, L / Chao, F C

    The Journal of cell biology

    2009  Volume 47, Issue 2, Page(s) 544–547

    Language English
    Publishing date 2009-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.47.2.544
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