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Article ; Online: Targeting Eosinophils in Mouse Models of Asthma.

Guthier, Hope E / Zimmermann, Nives

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2506, Page(s) 211–222

Abstract: Eosinophils are bone marrow-derived hematopoietic cells that accumulate significantly in the lungs and bronchoalveolar lavage fluid in patients with asthma and models of allergic airway inflammation. Their role in the pathophysiology of asthma and other ... ...

Abstract	Eosinophils are bone marrow-derived hematopoietic cells that accumulate significantly in the lungs and bronchoalveolar lavage fluid in patients with asthma and models of allergic airway inflammation. Their role in the pathophysiology of asthma and other diseases can be studied using mouse models in which eosinophils are depleted. This review article focuses on two main approaches for depleting eosinophils in vivo, antibody-mediated and genetic models. Specific antibodies and genetic models are reviewed, along with their strengths and weaknesses.
MeSH term(s)	Animals ; Asthma ; Bronchoalveolar Lavage Fluid ; Disease Models, Animal ; Eosinophils ; Inflammation ; Leukocyte Count ; Lung ; Mice
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2364-0_15
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Article ; Online: Detection of Eosinophils in Tissue Sections by Immunohistochemistry.

Zhu, Xiang / Zimmermann, Nives

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2506, Page(s) 199–209

Abstract: Eosinophils are bone marrow-derived hematopoietic cells which represent a small subset in the peripheral blood, and under homeostatic conditions predominantly reside in certain organs, such as the gastrointestinal tract. However, eosinophil numbers ... ...

Abstract	Eosinophils are bone marrow-derived hematopoietic cells which represent a small subset in the peripheral blood, and under homeostatic conditions predominantly reside in certain organs, such as the gastrointestinal tract. However, eosinophil numbers increase both in the peripheral blood and tissues during allergic inflammation, parasitic infestation, drug reactions, vasculitides, as well as certain hematopoietic neoplasms. Their presence in tissues can be detected by hematoxylin and eosin staining; however, this may be challenging particularly at times of activation and/or degranulation, e.g., during allergic lung inflammation. Thus, detection of eosinophils and/or their released granule proteins is significantly enhanced by immunohistochemistry. This chapter describes methods for the detection of mouse or human eosinophils by using granule protein-specific antibodies in formalin-fixed paraffin-embedded tissue.
MeSH term(s)	Animals ; Blood Proteins/metabolism ; Eosinophil Granule Proteins/metabolism ; Eosinophils/metabolism ; Hematoxylin ; Humans ; Immunohistochemistry ; Inflammation/metabolism ; Leukocyte Count ; Mice ; Ribonucleases/metabolism
Chemical Substances	Blood Proteins ; Eosinophil Granule Proteins ; Ribonucleases (EC 3.1.-) ; Hematoxylin (YKM8PY2Z55)
Language	English
Publishing date	2022-06-30
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2364-0_14
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Article ; Online: Standardized Quantification of Mast Cells in the Gastrointestinal Tract in Adults.

Iding, Jared / Agarwal, Pooja / Zhang, Simin / Odin, Rachel / Bernstein, Jonathan A / Zimmermann, Nives

The journal of allergy and clinical immunology. In practice

2023 Volume 12, Issue 2, Page(s) 472–481

Abstract: Background: Current data on the normal quantity of mast cells throughout the adult gastrointestinal tract are limited in several domains. These include microanatomic localization of mast cells, standardization of staining and counting methods, and ... ...

Abstract	Background: Current data on the normal quantity of mast cells throughout the adult gastrointestinal tract are limited in several domains. These include microanatomic localization of mast cells, standardization of staining and counting methods, and reporting of microscope field of view. Objective: To address this lack of reliable reference ranges to facilitate the study of and diagnosis of emerging mast cell-mediated diseases. Methods: We examined biopsies obtained from the esophagus, stomach, duodenum, and colon from an unselected cohort. Mean and peak mast cell density were determined on slides stained for tryptase and CD117, and were expressed per high power field (hpf) and surface area (mm Results: For the most common hpf surface area (0.238 mm Conclusions: These data help standardize mast cell reference ranges throughout the gastrointestinal tract in adults, which can be used to determine whether abnormal levels of mast cells are present in patients with suspected mast cell-mediated disease. Our data show that the commonly used cutoff of 20 mast cells per hpf irrespective of the gastrointestinal tract segment is an underestimate of an appropriate cutoff in stomach, duodenum (crypt area), and colon.
MeSH term(s)	Adult ; Humans ; Mast Cells/pathology ; Tryptases/metabolism ; Gastrointestinal Tract/pathology ; Duodenum/pathology ; Mastocytosis/pathology
Chemical Substances	Tryptases (EC 3.4.21.59)
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2023.10.045
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Article ; Online: Biologic Therapy in Rare Eosinophil-Associated Disorders: Remaining Questions and Translational Research Opportunities.

Khoury, Paneez / Roufosse, Florence / Kuang, Fei Li / Ackerman, Steven J / Akuthota, Praveen / Bochner, Bruce S / Johansson, Mats W / Mathur, Sameer K / Ogbogu, Princess U / Spencer, Lisa A / Wechsler, Michael E / Zimmermann, Nives / Klion, Amy D

Journal of leukocyte biology

2024

Abstract: Rare eosinophil-associated disorders (EADs), including hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis and eosinophilic gastrointestinal disorders, are a heterogeneous group of conditions characterized by blood and/or tissue ... ...

Abstract	Rare eosinophil-associated disorders (EADs), including hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis and eosinophilic gastrointestinal disorders, are a heterogeneous group of conditions characterized by blood and/or tissue hypereosinophilia and eosinophil-related clinical manifestations. Although the recent availability of biologic therapies that directly and indirectly target eosinophils has the potential to dramatically improve treatment options for all EADs, clinical trials addressing their safety and efficacy in rare EADs have been relatively few. Consequently, patient access to therapy is limited for many biologics, and the establishment of evidence-based treatment guidelines has been extremely difficult. In this regard, multicenter retrospective collaborative studies focusing on disease manifestations and treatment responses in rare EADs have provided invaluable data for physicians managing patients with these conditions and helped identify important questions for future translational research. During the Clinical Pre-Meeting Workshop held in association with the July 2023 biennial meeting of the International Eosinophil Society in Hamilton, Ontario, Canada, the successes and limitations of pivotal multicenter retrospective studies in EADs were summarized, and unmet needs regarding the establishment of guidelines for use of biologics in rare EADs were discussed. Key topics of interest included: 1) clinical outcome measures, 2) minimally invasive biomarkers of disease activity, 3) predictors of response to biologic agents, and 4) long-term safety of eosinophil depletion. Herein, we report a summary of these discussions, presenting a state-of-the-art overview of data currently available for each of these topics, the limitations of the data, and avenues for future data generation through implementation of multidisciplinary and multicenter studies.
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1093/jleuko/qiae051
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Article ; Online: Perinatal Case of Fatal Simpson-Golabi-Behmel Syndrome with Hyperplasia of Seminiferous Tubules.

Zimmermann, Nives / Stanek, Jerzy

The American journal of case reports

2017 Volume 18, Page(s) 649–655

Abstract: BACKGROUND Simpson-Golabi-Behmel syndrome (SGBS) is a rare X-linked recessive syndrome characterized by fetal overgrowth. CASE REPORT We present a case of a male infant with SGBS. Abnormal prenatal ultrasound (including congenital diaphragmatic hernia) ... ...

Abstract	BACKGROUND Simpson-Golabi-Behmel syndrome (SGBS) is a rare X-linked recessive syndrome characterized by fetal overgrowth. CASE REPORT We present a case of a male infant with SGBS. Abnormal prenatal ultrasound (including congenital diaphragmatic hernia) prompted microarray testing of amniotic fluid cells, which showed deletion on chromosome Xq26.2 affecting the glypican-3 gene consistent with SGBS type I. The infant died six hours after birth and at autopsy showed features of SGBS, including macrosomia, organomegaly, diaphragmatic hernia with consequent pulmonary hypoplasia, cleft palate, large tongue with a midline groove, a supernumerary nipple, Meckel's diverticulum, and abnormal phalanges. Additionally, we observed features that have previously not been described in SGBS, including testes with hyperplastic seminiferous tubules and Mullerian remnants, and placenta with incipient fetal thrombotic vasculopathy. CONCLUSIONS While most patients with SGBS type I survive into childhood or even adulthood, the severe course in our patient was ascribed to pulmonary hypoplasia secondary to the bilateral diaphragmatic hernia.
MeSH term(s)	Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/genetics ; Chromosome Deletion ; Chromosomes, Human, X/genetics ; Fatal Outcome ; Genetic Diseases, X-Linked/diagnosis ; Genetic Diseases, X-Linked/genetics ; Gigantism/diagnosis ; Gigantism/genetics ; Glypicans/genetics ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/genetics ; Hernia, Diaphragmatic ; Humans ; Hyperplasia ; Infant, Newborn ; Intellectual Disability/diagnosis ; Intellectual Disability/genetics ; Lung/abnormalities ; Male ; Seminiferous Tubules/pathology
Chemical Substances	GPC3 protein, human ; Glypicans
Language	English
Publishing date	2017-06-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/ajcr.903964
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Article ; Online: Mechanism of enhanced eosinophil survival in inflammation.

Zimmermann, Nives / Rothenberg, Marc E

Blood

2015 Volume 125, Issue 25, Page(s) 3831–3832

MeSH term(s)	Animals ; Apoptosis/physiology ; Eosinophils/immunology ; Humans ; I-kappa B Proteins/immunology ; NF-kappa B/immunology ; bcl-X Protein/immunology
Chemical Substances	I-kappa B Proteins ; NF-kappa B ; bcl-X Protein
Language	English
Publishing date	2015-06-17
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2015-04-640623
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Eosinophilic esophagitis with extremely high esophageal eosinophil counts.

O'Shea, Kelly M / Rochman, Mark / Shoda, Tetsuo / Zimmermann, Nives / Caldwell, Julie / Rothenberg, Marc E

The Journal of allergy and clinical immunology

2020 Volume 147, Issue 1, Page(s) 409–412.e5

MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Eosinophilic Esophagitis/immunology ; Eosinophilic Esophagitis/pathology ; Eosinophils/immunology ; Eosinophils/pathology ; Esophagus/immunology ; Esophagus/pathology ; Female ; Humans ; Leukocyte Count ; Male
Language	English
Publishing date	2020-06-08
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2020.05.045
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Article ; Online: Previously Unreported Complication of Coronary Artery Bypass Grafting: Suture Rupture Resulting in Patient's Death.

Criss, Benjamin E / Zimmermann, Nives / Butler, Randall T

Journal of forensic sciences

2018 Volume 64, Issue 1, Page(s) 281–283

Abstract: Traditionally, the manner of death in most hospital autopsy cases is natural, in which death is due to the natural course of disease or reasonably anticipated outcomes of medical interventions. Some cases fall into a potential gray zone between natural ... ...

Abstract	Traditionally, the manner of death in most hospital autopsy cases is natural, in which death is due to the natural course of disease or reasonably anticipated outcomes of medical interventions. Some cases fall into a potential gray zone between natural and accident, including rare or unanticipated outcomes of medical interventions. We present a case of a patient postcoronary artery bypass graft. Autopsy revealed the proximal anastomosis of the aorta-to-first-diagonal-coronary-artery-to-second-obtuse-marginal-artery graft was detached from the aorta. A broken suture was present at the disconnected anastomosis, with intact knots but was broken along its length. In-hospital mortality rates of CABG range from 1% to 3%, with several autopsy studies identifying surgical complications as the cause of death in one-third of perioperative deaths. No publications were found that described suture rupture as directly relating to the cause of death. This case report describes a previously unreported complication of coronary artery bypass grafting.
MeSH term(s)	Anastomosis, Surgical/instrumentation ; Coronary Artery Bypass/adverse effects ; Equipment Failure ; Fatal Outcome ; Hemorrhage/pathology ; Humans ; Male ; Middle Aged ; Rupture ; Sutures/adverse effects
Language	English
Publishing date	2018-06-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
DOI	10.1111/1556-4029.13844
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Article ; Online: Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia.

Zimmermann, Nives / Wikenheiser-Brokamp, Kathryn A

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2018 Volume 121, Issue 2, Page(s) 179–185

Abstract: Objective: To describe key diagnostic considerations in patients with pulmonary infiltrates with eosinophilia, with a special emphasis on raising awareness of hypereosinophilic syndrome (HES), a disease that often involves the lungs and prompts ... ...

Abstract	Objective: To describe key diagnostic considerations in patients with pulmonary infiltrates with eosinophilia, with a special emphasis on raising awareness of hypereosinophilic syndrome (HES), a disease that often involves the lungs and prompts investigation for clonal neoplastic processes that determine prognosis and treatment. Data sources: Studies and review articles were selected from PubMed and Scopus for relevance to pertinent topics. Study selections: The literature was screened for studies that described lung eosinophilia and HES. Studies relevant to the topic were included in this review. Results: Pulmonary eosinophil infiltrates in lung biopsy specimens present a broad differential diagnosis, including eosinophilic pneumonia; hypersensitivity reactions, such as allergic bronchopulmonary fungal disease; and pulmonary manifestations of systemic diseases, such as eosinophilic granulomatosis with polyangiitis. An additional important consideration in the differential diagnosis is pulmonary involvement by HES. HES is a rare syndrome that comprises a heterogeneous group of conditions characterized by persistent blood and/or tissue eosinophilia associated with organ dysfunction. Approximately one-third of HES cases are caused by neoplastic diseases, with the remaining cases classified as reactive or idiopathic. Lung involvement is seen in up to 67% of cases and may be the presenting manifestation of the disorder. Conclusion: The differential diagnosis of pulmonary eosinophilia is broad and requires a multidisciplinary approach with clinicopathologic-radiologic correlation.
MeSH term(s)	Animals ; Churg-Strauss Syndrome/diagnosis ; Diagnosis, Differential ; Eosinophilia ; Eosinophils/immunology ; Humans ; Hypereosinophilic Syndrome/diagnosis ; Invasive Pulmonary Aspergillosis/diagnosis ; Lung/immunology ; Pulmonary Eosinophilia/diagnosis
Language	English
Publishing date	2018-05-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2018.05.014
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Article ; Online: Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci.

Zimmermann, Nives / Gibbons, William J / Homan, Shelli M / Prows, Daniel R

BMC genomics

2019 Volume 20, Issue 1, Page(s) 727

Abstract: Background: Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases with heart ... ...

Abstract	Background: Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases with heart complications is limited. We have discovered a mouse mutant, now maintained on an A/J inbred background, that spontaneously develops hypereosinophilia in multiple organs. Cellular infiltration into the heart causes an eosinophilic myocarditis, with affected mice of the mutant line (i.e., A/J Results: Maintaining the A/J Conclusions: These results indicate the HD trait in this mutant mouse model of eosinophilic myocarditis is oligogenic with variable penetrance, due to multiple segregating variants and possibly additional genetic or nongenetic factors. The A/J
MeSH term(s)	Animals ; Chromosome Mapping/methods ; Chromosomes, Mammalian/genetics ; Disease Models, Animal ; Eosinophilia/genetics ; Eosinophilia/mortality ; Female ; Genetic Linkage ; Genetic Loci ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mutation ; Myocarditis/genetics ; Myocarditis/mortality ; Penetrance
Language	English
Publishing date	2019-10-11
Publishing country	England
Document type	Journal Article
ISSN	1471-2164
ISSN (online)	1471-2164
DOI	10.1186/s12864-019-6108-0
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