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  1. Article: The journey of cardosin A in young Arabidopsis seedlings leads to evidence of a Golgi-independent pathway to the protein storage vacuole.

    Pereira, Cláudia / Vieira, Vanessa / Pissarra, José / Pereira, Susana

    Frontiers in plant science

    2023  Volume 14, Page(s) 1085898

    Abstract: The aspartic proteinase cardosin A is a vacuolar enzyme found to accumulate in protein storage and lytic vacuoles in the flowers and protein bodies in the seeds of the native plant cardoon. Cardosin A was first isolated several decades ago and has since ... ...

    Abstract The aspartic proteinase cardosin A is a vacuolar enzyme found to accumulate in protein storage and lytic vacuoles in the flowers and protein bodies in the seeds of the native plant cardoon. Cardosin A was first isolated several decades ago and has since been extensively characterized, both in terms of tissue distribution and enzyme biochemistry. In the native system, several roles have been attributed to cardosin A, such as reproduction, reserve mobilization, and membrane remodeling. To participate in such diverse events, cardosin A must accumulate and travel to different compartments within the cell: protein storage vacuoles, lytic vacuoles, and the cytoplasmic membrane (and eventually outside the cell). Several studies have approached the expression of cardosin A in
    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1085898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Neonatal Renal Failure Following Intrauterine Exposure to an Angiotensin-Converting Enzyme Inhibitor.

    Rodrigues, Inês / Quintela, Carolina / Jardim, Joana / Pinto, Helena / Pissarra, Susana / Soares, Henrique / Soares, Paulo

    Cureus

    2024  Volume 16, Issue 2, Page(s) e53833

    Abstract: The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the normal development of the fetal kidney. Late pregnancy blockage of the RAAS, through in-utero exposure to angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II ... ...

    Abstract The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in the normal development of the fetal kidney. Late pregnancy blockage of the RAAS, through in-utero exposure to angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers, is associated with poor fetal outcomes, including oligohydramnios, renal tubular dysplasia, postnatal anuric renal failure, and hypotension. The present case describes a 39-year-old primigravida that was referred to the emergency department, at 37 weeks, for the evaluation of intrauterine growth restriction and suspected coarctation of the aorta (CoA). She was medicated with enalapril since the 35th week of gestation. She delivered a male infant, weighing 2,110 g, with no apparent malformations. CoA was excluded. During his first day of life, the patient developed anuria, acute renal failure, and hypotension, requiring ionotropic support. Renal ultrasound appeared normal. Diuresis was reinitiated at 48 hours of life after continued supportive measures. Kidney function tests progressively normalized. Additional investigations revealed a low concentration of angiotensin-converting enzyme. The patient is currently 12 months old and has had a favorable evolution. This case highlights the fact that even brief exposure to enalapril in the third trimester may cause RAAS blocker fetopathy. As long-term sequelae of ACEI-exposed infants are poorly described, close follow-up of renal complications is essential. Physicians should be aware of the deleterious effects of RAAS blockers in pregnancy.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53833
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  3. Article ; Online: Long-acting paliperidone injection as a treatment option for interictal psychosis of epilepsy: A case report.

    Pinto-Gouveia, Carolina / Ventura, Fabiana / Carneiro, Mário / Mota, David / Renca, Susana / Pissarra, Celsa

    Psychiatry and clinical neurosciences

    2022  Volume 76, Issue 7, Page(s) 347–348

    MeSH term(s) Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Epilepsy/drug therapy ; Humans ; Injections/adverse effects ; Paliperidone Palmitate ; Psychotic Disorders/complications ; Psychotic Disorders/drug therapy
    Chemical Substances Antipsychotic Agents ; Paliperidone Palmitate (R8P8USM8FR)
    Language English
    Publishing date 2022-05-19
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13366
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  4. Article ; Online: How and when maternal viral infections can be a contraindication to breastfeeding

    Alexandra Pimentel / Susana Pissarra / Gustavo Rocha / Hercília Guimarães

    Journal of Pediatric and Neonatal Individualized Medicine, Vol 10, Iss 1, Pp e100130-e

    a narrative review

    2021  Volume 100130

    Abstract: The positive effects of breastfeeding on the health of infants and mothers are largely established. It is generally recommended that a mother should breastfeed exclusively for at least 6 months. Sometimes, however, this is not possible owing to a ... ...

    Abstract The positive effects of breastfeeding on the health of infants and mothers are largely established. It is generally recommended that a mother should breastfeed exclusively for at least 6 months. Sometimes, however, this is not possible owing to a maternal disease. The purpose of this review was to understand the possibility and the mechanisms of transmission of viral agents to breastfed infants when the mother is infected and to evaluate whether and when breastfeeding can be harmful and, therefore, a real contraindication exists. In order to produce this narrative review, an extensive literature search was conducted on PubMed. The query included “breastfeeding”, “mother to child” and “transmission” as keywords and a filter for publication date – from 2014 to 2019. Additionally, the bibliography of the selected articles was reviewed to identify further pertinent studies, which were then included. Only the following maternal infections were found to represent an absolute contraindication to breastfeeding: Human Immunodeficiency Virus and Human T-Lymphotropic Virus, because of their possible transmission via milk, and Ebola Virus, in which transmission to the child seems to be linked more to the close proximity relationship itself than the presence of the virus in human milk. Other viruses – Herpes Simplex Virus, Varicella Zoster Virus and Hepatitis C Virus – constituted a source of contraindication only in specific high-risk circumstances. To date, for the remaining viruses reviewed in this paper – including Severe Acute Respiratory Syndrome Coronavirus 2, no evidence exists that warrants contraindication of breastfeeding. Health professionals who deal with pregnant and puerperal women, such as obstetricians, pediatricians or family medicine doctors, must be aware of these particularities in the management of breastfeeding women in order to provide correct information and better take care of their patients and their respective infants.
    Keywords breastfeeding ; virus ; transmission ; newborn ; human milk ; prevention ; Medicine ; R ; Pediatrics ; RJ1-570
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Hygeia Press di Corridori Marinella
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Perinatal management of SARS-CoV-2 infection in a level III University Hospital.

    Pissarra, Susana / Rosário, Marta / Moucho, Marina / Soares, Henrique

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2020  Volume 35, Issue 15, Page(s) 2961–2964

    Abstract: Over the past 4 months, SARS-CoV-2 pandemic has spread all over the world. The lack of understanding of this pandemic epidemiological characteristics, clinical implications and long term consequences have raised concern among healthcare workers. Pregnant ...

    Abstract Over the past 4 months, SARS-CoV-2 pandemic has spread all over the world. The lack of understanding of this pandemic epidemiological characteristics, clinical implications and long term consequences have raised concern among healthcare workers. Pregnant women and newborns are a particularly worrisome population since data referring to real infection impact in these patients are scarce and management controversial. We report on the perinatal management of the first consecutive ten mother-infant dyads of SARS-CoV-2 infection complicated pregnancy. All mothers were included in newborn management planning prior to delivery and decided on separation from their newborns; nine decided on postponing breastfeeding until SARS-CoV-2 negativity while maintaining lactation stimulation. No evidence of vertical transmission was found (all NP swab and bronchial secretions SARS-CoV-2 RT-PCR were negative). No newborn developed clinical evidence of infection. In the face of current scientific uncertainty, decisions of perinatal management, such as mother-infant separation and breastfeeding, must involve parents in a process of shared decision making.
    MeSH term(s) COVID-19 ; Female ; Hospitals, University ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Pandemics ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/therapy ; Pregnancy Outcome ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2020.1786526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3510: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Coping with Abiotic Stress in Plants-An Endomembrane Trafficking Perspective.

    Sampaio, Miguel / Neves, João / Cardoso, Tatiana / Pissarra, José / Pereira, Susana / Pereira, Cláudia

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 3

    Abstract: Plant cells face many changes through their life cycle and develop several mechanisms to cope with adversity. Stress caused by environmental factors is turning out to be more and more relevant as the human population grows and plant cultures start to ... ...

    Abstract Plant cells face many changes through their life cycle and develop several mechanisms to cope with adversity. Stress caused by environmental factors is turning out to be more and more relevant as the human population grows and plant cultures start to fail. As eukaryotes, plant cells must coordinate several processes occurring between compartments and combine different pathways for protein transport to several cellular locations. Conventionally, these pathways begin at the ER, or endoplasmic reticulum, move through the Golgi and deliver cargo to the vacuole or to the plasma membrane. However, when under stress, protein trafficking in plants is compromised, usually leading to changes in the endomembrane system that may include protein transport through unconventional routes and alteration of morphology, activity and content of key organelles, as the ER and the vacuole. Such events provide the tools for cells to adapt and overcome the challenges brought on by stress. With this review, we gathered fragmented information on the subject, highlighting how such changes are processed within the endomembrane system and how it responds to an ever-changing environment. Even though the available data on this subject are still sparse, novel information is starting to untangle the complexity and dynamics of protein transport routes and their role in maintaining cell homeostasis under harsh conditions.
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11030338
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  7. Article ; Online: Plant-Specific Insert (PSI)-Mediated Vacuolar Sorting Is Not Disrupted in Arabidopsis Mutant with Abnormal ER Morphology

    Tatiana Cardoso / Miguel Sampaio / João Neves / Sofia Oliveira / Inês Moura / Ana Séneca / José Pissarra / Susana Pereira / Cláudia Pereira

    International Journal of Plant Biology, Vol 14, Iss 4, Pp 1034-

    2023  Volume 1050

    Abstract: The endomembrane system in plant cells enables the cell to manage and coordinate a variety of membranous compartments so that they and their contents arrive at the right location. The secretory pathway is an essential part of this complex network and has ...

    Abstract The endomembrane system in plant cells enables the cell to manage and coordinate a variety of membranous compartments so that they and their contents arrive at the right location. The secretory pathway is an essential part of this complex network and has its gateway at the Endoplasmic Reticulum. Therefore, alterations at the ER can affect how protein trafficking takes place and how cargo leaves this organelle. With this work, we assessed how abnormalities at the Endoplasmic Reticulum would interfere with protein sorting and trafficking. We used an Arabidopsis mutant— leb-2 GFP-h , presenting abnormal ER morphology, and evaluated the expression of aspartic proteinases and genes related to vacuolar transport along with the localization of a specific vacuolar sorting signal—plant-specific insert (PSI). Our results show that alterations in the leb-2 GFP-h mutant did not disrupt the transport of PSI–mCherry to the vacuole but influenced the expression of endogenous aspartic proteinases. Furthermore, the study of key endomembrane genes expression revealed an upregulation of the SNARE proteins AtVAMP722 and AtVAMP723 . The leb-2 mutant seems not to interfere with vacuolar routes but may be implicated in secretion events.
    Keywords Arabidopsis ; aspartic proteinases ; ER-bodies ; endomembranes ; plant-specific insert ; vacuolar sorting ; Science ; Q ; Biology (General) ; QH301-705.5
    Subject code 580
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Perinatal management of SARS-CoV-2 infection in a level III University Hospital

    Pissarra, Susana / Rosário, Marta / Moucho, Marina / Soares, Henrique

    The Journal of Maternal-Fetal & Neonatal Medicine

    2020  , Page(s) 1–4

    Keywords Obstetrics and Gynaecology ; Pediatrics, Perinatology, and Child Health ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ISSN 1476-7058
    DOI 10.1080/14767058.2020.1786526
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Abiotic Stress Triggers the Expression of Genes Involved in Protein Storage Vacuole and Exocyst-Mediated Routes.

    Neves, João / Sampaio, Miguel / Séneca, Ana / Pereira, Susana / Pissarra, José / Pereira, Cláudia

    International journal of molecular sciences

    2021  Volume 22, Issue 19

    Abstract: Adverse conditions caused by abiotic stress modulate plant development and growth by altering morphological and cellular mechanisms. Plants' responses/adaptations to stress often involve changes in the distribution and sorting of specific proteins and ... ...

    Abstract Adverse conditions caused by abiotic stress modulate plant development and growth by altering morphological and cellular mechanisms. Plants' responses/adaptations to stress often involve changes in the distribution and sorting of specific proteins and molecules. Still, little attention has been given to the molecular mechanisms controlling these rearrangements. We tested the hypothesis that plants respond to stress by remodelling their endomembranes and adapting their trafficking pathways. We focused on the molecular machinery behind organelle biogenesis and protein trafficking under abiotic stress conditions, evaluating their effects at the subcellular level, by looking at ultrastructural changes and measuring the expression levels of genes involved in well-known intracellular routes. The results point to a differential response of the endomembrane system, showing that the genes involved in the pathway to the Protein Storage Vacuole and the exocyst-mediated routes are upregulated. In contrast, the ones involved in the route to the Lytic Vacuole are downregulated. These changes are accompanied by morphological alterations of endomembrane compartments. The data obtained demonstrate that plants' response to abiotic stress involves the differential expression of genes related to protein trafficking machinery, which can be connected to the activation/deactivation of specific intracellular sorting pathways and lead to alterations in the cell ultrastructure.
    MeSH term(s) Arabidopsis/genetics ; Arabidopsis/growth & development ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Cell Wall/metabolism ; Cytoplasm/metabolism ; Gene Expression ; Intracellular Membranes/metabolism ; Organelle Biogenesis ; Organelles/genetics ; Organelles/metabolism ; Protein Transport/genetics ; Stress, Physiological/genetics ; Up-Regulation/genetics ; Vacuoles/genetics ; Vacuoles/metabolism ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism
    Chemical Substances Arabidopsis Proteins ; Vesicular Transport Proteins
    Language English
    Publishing date 2021-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms221910644
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  10. Article ; Online: A Rare Case of a Type IV Laryngotracheal Cleft in Association with VACTERL

    Rita Magalhães Moita / Susana Pissarra / Jorge Spratley / Inês Azevedo / Hercília Guimarães

    Portuguese Journal of Pediatrics, Vol 52, Iss

    2021  Volume 3

    Keywords Pediatrics ; RJ1-570 ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Sociedade Portuguesa de Pediatria
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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