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Article ; Online: Benign course of episodic dizziness disorders in childhood.

Huppert, Doreen / Langhagen, Thyra / Brandt, Thomas

2017 Volume 264, Issue Suppl 1, Page(s) 4–6

MeSH term(s)	Child ; Child, Preschool ; Disease Progression ; Dizziness/epidemiology ; Dizziness/physiopathology ; Female ; Humans ; Male
Language	English
Publishing date	2017-03-07
Publishing country	Germany
Document type	Letter
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-017-8408-0
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Article ; Online: Vertigo and dizziness in children.

Jahn, Klaus / Langhagen, Thyra / Heinen, Florian

Current opinion in neurology

2015 Volume 28, Issue 1, Page(s) 78–82

Abstract: Purpose of review: Vertigo and dizziness occur with considerable frequency in childhood and adolescence. Most causes are benign and treatable. This review aims to make physicians more alert to the frequent causes of dizziness in the young.: Recent ... ...

Abstract	Purpose of review: Vertigo and dizziness occur with considerable frequency in childhood and adolescence. Most causes are benign and treatable. This review aims to make physicians more alert to the frequent causes of dizziness in the young. Recent findings: Epidemiological data confirm that migraine-related syndromes are the most common cause of vertigo in children. Vestibular migraine and benign paroxysmal vertigo have now been defined by the International Classification of Headache Disorders. About half of the adolescents with vertigo and dizziness show psychiatric comorbidity and somatization. Vestibular paroxysmia has been described as a new entity in children that can be treated with low doses of carbamazepine. To assess vestibular deficits, video head impulses (for the semicircular canals) and vestibular-evoked myogenic potentials (for the otoliths) are increasingly being used. Summary: Pediatricians and neuro-otologists should be aware of the full spectrum of causes of vertigo and dizziness in children and adolescents. Vestibular function can reliably be tested nowadays. Although treatment for the common migraine-related syndromes can be done in analogy to the treatment of migraine in general, specific approaches are required for somatoform vertigo, the most frequent diagnosis in adolescent girls.
MeSH term(s)	Adolescent ; Child ; Dizziness/diagnosis ; Dizziness/etiology ; Dizziness/physiopathology ; Humans ; Migraine Disorders/complications ; Migraine Disorders/physiopathology ; Vertigo/diagnosis ; Vertigo/etiology ; Vertigo/physiopathology
Language	English
Publishing date	2015-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1182686-1
ISSN	1473-6551 ; 1350-7540
ISSN (online)	1473-6551
ISSN	1350-7540
DOI	10.1097/WCO.0000000000000157
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Article: Schwindel in der Kinderarztpraxis

Langhagen, Thyra / Heinen, Florian / Jahn, Klaus

Kinder- und Jugendarzt

2014 Volume -, Issue 8, Page(s) 415

Language	German
Document type	Article
ZDB-ID	1461570-8
ISSN	1436-9559 ; 0340-5877
Database	Current Contents Medicine

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Article: Vestibular migraine in children and adolescents: clinical findings and laboratory tests.

Langhagen, Thyra / Lehrer, Nicole / Borggraefe, Ingo / Heinen, Florian / Jahn, Klaus

Frontiers in neurology

2015 Volume 5, Page(s) 292

Abstract: Introduction: Vestibular migraine (VM) is the most common cause of episodic vertigo in children. We summarize the clinical findings and laboratory test results in a cohort of children and adolescents with VM. We discuss the limitations of current ... ...

Abstract	Introduction: Vestibular migraine (VM) is the most common cause of episodic vertigo in children. We summarize the clinical findings and laboratory test results in a cohort of children and adolescents with VM. We discuss the limitations of current classification criteria for dizzy children. Methods: A retrospective chart analysis was performed on 118 children with migraine related vertigo at a tertiary care center. Patients were grouped in the following categories: (1) definite vestibular migraine (dVM); (2) probable vestibular migraine (pVM); (3) suspected vestibular migraine (sVM); (4) benign paroxysmal vertigo (BPV); and (5) migraine with/without aura (oM) plus vertigo/dizziness according to the International Classification of Headache Disorders, 3rd edition (beta version). Results: The mean age of all patients was 12 ± 3 years (range 3-18 years, 70 females). 36 patients (30%) fulfilled criteria for dVM, 33 (28%) for pVM, 34 (29%) for sVM, 7 (6%) for BPV, and 8 (7%) for oM. Somatoform vertigo (SV) co-occurred in 27% of patients. Episodic syndromes were reported in 8%; the family history of migraine was positive in 65%. Mild central ocular motor signs were found in 24% (most frequently horizontal saccadic pursuit). Laboratory tests showed that about 20% had pathological function of the horizontal vestibulo-ocular reflex, and almost 50% had abnormal postural sway patterns. Conclusion: Patients with definite, probable, and suspected VM do not differ in the frequency of ocular motor, vestibular, or postural abnormalities. VM is the best explanation for their symptoms. It is essential to establish diagnostic criteria in clinical studies. In clinical practice, however, the most reasonable diagnosis should be made in order to begin treatment. Such a procedure also minimizes the fear of the parents and children, reduces the need to interrupt leisure time and school activities, and prevents the development of SV.
Language	English
Publishing date	2015-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2014.00292
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Article ; Online: Health-Related Quality of Life of Children/Adolescents with Vertigo: Retrospective Study from the German Center of Vertigo and Balance Disorders.

Deissler, Anna / Albers, Lucia / von Kries, Rüdiger / Weinberger, Raphael / Langhagen, Thyra / Gerstl, Lucia / Heinen, Florian / Jahn, Klaus / Schröder, A Sebastian

Neuropediatrics

2017 Volume 48, Issue 2, Page(s) 91–97

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Adolescent ; Age Factors ; Child ; Chronic Disease ; Female ; Germany/epidemiology ; Humans ; Male ; Quality of Life ; Retrospective Studies ; Self Report ; Socioeconomic Factors ; Vertigo/epidemiology ; Vertigo/psychology
Language	English
Publishing date	2017-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0037-1598645
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Article ; Online: Vestibular Migraine in Children and Adolescents.

Langhagen, Thyra / Landgraf, Mirjam N / Huppert, Doreen / Heinen, Florian / Jahn, Klaus

Current pain and headache reports

2016 Volume 20, Issue 12, Page(s) 67

Abstract: Purpose of review: The goal of this review is to provide an actualized overview on vestibular migraine in childhood and adolescence, with focus on the epidemiology and clinical presentation as well as its treatment.: Recent findings: Vertigo spells ... ...

Abstract	Purpose of review: The goal of this review is to provide an actualized overview on vestibular migraine in childhood and adolescence, with focus on the epidemiology and clinical presentation as well as its treatment. Recent findings: Vertigo spells in childhood can evolve into other periodic syndromes and/or migraine types and persist even into adulthood. Vestibular migraine (VM) and benign paroxysmal vertigo are the most common causes of vertigo in children and adolescents. The diagnostic criteria for VM are dizziness and vertigo, headache, phonophobia and photophobia, and visual aura. The prevention of attacks is the treatment for children and adolescents with VM, as is recommended for migraine with or without aura. Thus, non-pharmacological measures are the first-line option; when these measures fail or daily activities are notably affected, drugs are administrated. Psychological assessment and cognitive behavioral therapy are also important therapeutic measures in this patient group. There is still insufficient research on VM in children and adolescents; future studies on clinical presentation, evolvement, and specific treatment are necessary.
MeSH term(s)	Adolescent ; Child ; Female ; Humans ; Male ; Migraine Disorders ; Vestibular Diseases
Language	English
Publishing date	2016-11-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055062-5
ISSN	1534-3081 ; 1531-3433
ISSN (online)	1534-3081
ISSN	1531-3433
DOI	10.1007/s11916-016-0600-x
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Article ; Online: Self-reported neck and shoulder pain in adolescents is associated with episodic and chronic migraine.

Landgraf, Mirjam N / von Kries, Rüdiger / Heinen, Florian / Langhagen, Thyra / Straube, Andreas / Albers, Lucia

Cephalalgia : an international journal of headache

2016 Volume 36, Issue 8, Page(s) 807–811

Abstract: Aim: The aim of this study was to verify the association between self-reported neck/shoulder pain and migraine and to compare findings of chronic and episodic migraine in adolescents.: Methods: In this cross-sectional study, 601 secondary-school ... ...

Abstract	Aim: The aim of this study was to verify the association between self-reported neck/shoulder pain and migraine and to compare findings of chronic and episodic migraine in adolescents. Methods: In this cross-sectional study, 601 secondary-school students filled in questionnaires about headache appearance, type and frequency, neck and shoulder pain and lifestyle factors. Results: The adjusted strength of the association between reported neck and shoulder pain and migraine (assessed in multinomial regression models) increased with the frequency of migraine: less than once a week (OR = 1.40; 95% CI = (0.85-2.30)), weekly (OR = 2.14; 95% CI = (1.42-3.24)), and at least 15 days/month (OR = 7.27; 95% CI = (3.42-15.44)). Conclusion: In adolescents the association between self-reported neck and shoulder pain and migraine is most pronounced in migraine with a high attack frequency.
MeSH term(s)	Adolescent ; Child ; Chronic Pain/complications ; Cross-Sectional Studies ; Female ; Humans ; Male ; Migraine Disorders/complications ; Neck Pain/epidemiology ; Prevalence ; Self Report ; Shoulder Pain/epidemiology ; Surveys and Questionnaires ; Young Adult
Language	English
Publishing date	2016-07
Publishing country	England
Document type	Journal Article
ZDB-ID	604567-4
ISSN	1468-2982 ; 0333-1024
ISSN (online)	1468-2982
ISSN	0333-1024
DOI	10.1177/0333102415610875
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Zs.A 1645: Show issues

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Article ; Online: Vestibular paroxysmia in children: a treatable cause of short vertigo attacks.

Lehnen, Nadine / Langhagen, Thyra / Heinen, Florian / Huppert, Doreen / Brandt, Thomas / Jahn, Klaus

Developmental medicine and child neurology

2015 Volume 57, Issue 4, Page(s) 393–396

Abstract: Vestibular paroxysmia due to neurovascular compression is a syndrome consisting of frequent short episodes of vertigo in adults that can be easily treated. Here we describe the initial presentation and follow-up of three children (one female, 12y; two ... ...

Abstract	Vestibular paroxysmia due to neurovascular compression is a syndrome consisting of frequent short episodes of vertigo in adults that can be easily treated. Here we describe the initial presentation and follow-up of three children (one female, 12y; two males, 8y and 9y) who experienced typical, brief, vertiginous attacks several times a day. Nystagmus was observed during the episodes. Cranial magnetic resonance imaging revealed arterial compression of the eighth cranial nerve. The attacks ceased after administration of low-dose carbamazepine (2-4mg/kg daily). Vestibular paroxysmia must be considered in the differential diagnosis of children with brief vertiginous episodes.
MeSH term(s)	Anticonvulsants/administration & dosage ; Anticonvulsants/pharmacology ; Carbamazepine/administration & dosage ; Carbamazepine/pharmacology ; Child ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Nerve Compression Syndromes/complications ; Nerve Compression Syndromes/diagnosis ; Nystagmus, Pathologic/diagnosis ; Nystagmus, Pathologic/etiology ; Treatment Outcome ; Vertigo/diagnosis ; Vertigo/drug therapy ; Vertigo/etiology ; Vestibulocochlear Nerve/pathology ; Vestibulocochlear Nerve Diseases/complications ; Vestibulocochlear Nerve Diseases/pathology
Chemical Substances	Anticonvulsants ; Carbamazepine (33CM23913M)
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/dmcn.12563
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Article: Kopfschmerzen im Kindes- und Jugendalter - Schlüsselaspekte guter Praxis

Bonfert, Michaela / Landgraf, Mirjam N. / Hannibal, Iris / Langhagen, Thyra / Gerstl, Lucia / Kusser, Beate / Heinen, Florian

Kinder- und Jugendarzt

2016 Volume -, Issue 6, Page(s) 380

Language	German
Document type	Article
ZDB-ID	1461570-8
ISSN	1436-9559 ; 0340-5877
Database	Current Contents Medicine

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Article ; Online: Migraine-related vertigo and somatoform vertigo frequently occur in children and are often associated.

Langhagen, Thyra / Schroeder, A Sebastian / Rettinger, Nicole / Borggraefe, Ingo / Jahn, Klaus

Neuropediatrics

2013 Volume 44, Issue 1, Page(s) 55–58

Abstract: Migraine-related syndromes are a common cause of episodic vertigo and dizziness in children. Somatoform vertigo (SV) is an important cause of chronic dizziness, especially in adolescents. Our aim was to elucidate the comorbidity of migraine and SV. Three ...

Abstract	Migraine-related syndromes are a common cause of episodic vertigo and dizziness in children. Somatoform vertigo (SV) is an important cause of chronic dizziness, especially in adolescents. Our aim was to elucidate the comorbidity of migraine and SV. Three diagnostic groups were defined: migraine-related vertigo (MRV), SV, and combined migraine-related and SV (MSV). A retrospective analysis was performed on patient data (demographics, diagnosis, neuro-orthoptic and neurologic status, and results of vestibular and balance testing) from 168 patients who were presented to the German Center for Vertigo and Balance Disorders (IFB) over a 2.5-year period. Mean age of patients was 12 ± 4 years (range: 1.4 to 18 years). The most frequent diagnosis was MRV (28%), followed by MSV (19%) and SV (14%). MSV occurred most frequently in adolescent girls (25%). MRV was the most common cause of dizziness in our cohort. MSV ranked second overall but ranked first in adolescent girls, followed by isolated SV. SV was most prevalent in adolescent girls. MRV, MSV, and SV account for about 60% of diagnoses established in our tertiary referral center. Competent care of childhood migraine should include skill in detecting both the clinical symptoms of vertigo and overlapping somatoform symptoms.
MeSH term(s)	Adolescent ; Age Factors ; Child ; Child, Preschool ; Chronic Disease ; Cohort Studies ; Comorbidity ; Dizziness/etiology ; Female ; Humans ; Infant ; Male ; Migraine Disorders/complications ; Migraine Disorders/epidemiology ; Migraine Disorders/psychology ; Retrospective Studies ; Sex Factors ; Somatoform Disorders/epidemiology ; Somatoform Disorders/etiology ; Somatoform Disorders/psychology ; Vertigo/classification ; Vertigo/epidemiology ; Vertigo/etiology
Language	English
Publishing date	2013-02
Publishing country	Germany
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0032-1333433
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