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Article ; Online: Chagas Disease and the Kissing Bug: An Invisible Giant.

Gosling, Andre F / Gelape, Claudio L

Journal of cardiothoracic and vascular anesthesia

2019 Volume 33, Issue 8, Page(s) 2349–2350

MeSH term(s)	Aneurysm ; Animals ; Chagas Disease ; Triatoma
Language	English
Publishing date	2019-01-04
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2019.01.014
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Article: An Unusual Cause of End-Tidal Carbon Dioxide Rise During One-Lung Ventilation.

Boyle, Jason T / Gosling, Andre F / Wei, Benjamin / Abraham, Abey S / Nooli, Nishank

Cureus

2023 Volume 15, Issue 6, Page(s) e41034

Abstract: A relatively common problem that may arise during one-lung ventilation is elevation of end-tidal carbon dioxide (ETCO2), which has several potential etiologies. This case report describes a 69-year-old woman with carcinoid tumor undergoing a robotic left ...

Abstract	A relatively common problem that may arise during one-lung ventilation is elevation of end-tidal carbon dioxide (ETCO2), which has several potential etiologies. This case report describes a 69-year-old woman with carcinoid tumor undergoing a robotic left lower lobectomy complicated by an acute rise in ETCO2 during one-lung ventilation, without an immediately identifiable cause. Thorough evaluation revealed CO2 leak through an open bronchial lumen resulting in an artificially high ETCO2 reading. This case report demonstrates the importance of performing a comprehensive assessment during acute changes in ETCO2 while also considering changes in the surgical field, which may contribute to these findings.
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.41034
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Article: Perioperative Fluid Management.

Mladinov, Domagoj / Isaza, Erin / Gosling, Andre F / Clark, Adrienne L / Kukreja, Jasleen / Brzezinski, Marek

Anesthesiology clinics

2023 Volume 41, Issue 3, Page(s) 613–629

Abstract: The medical complexity of the geriatric patients has been steadily rising. Still, as outcomes of surgical procedures in the elderly are improving, centers are pushing boundaries. There is also a growing appreciation of the importance of perioperative ... ...

Abstract	The medical complexity of the geriatric patients has been steadily rising. Still, as outcomes of surgical procedures in the elderly are improving, centers are pushing boundaries. There is also a growing appreciation of the importance of perioperative fluid management on postoperative outcomes, especially in the elderly. Optimal fluid management in this cohort is challenging due to the combination of age-related physiological changes in organ function, increased comorbid burden, and larger fluid shifts during more complex surgical procedures. The current state-of-the-art approach to fluid management in the perioperative period is outlined.
MeSH term(s)	Aged ; Humans ; Perioperative Care ; Fluid Therapy
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2228899-5
ISSN	2210-3538 ; 1932-2275 ; 0889-8537
ISSN (online)	2210-3538
ISSN	1932-2275 ; 0889-8537
DOI	10.1016/j.anclin.2023.03.001
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Article ; Online: Renal-Resistive Index for Prediction of Acute Kidney Injury in the Setting of Aortic Insufficiency.

Gosling, Andre F / Andrew, Benjamin Y / Stafford-Smith, Mark / Nicoara, Alina / Cherry, Anne D

Journal of cardiothoracic and vascular anesthesia

2021 Volume 35, Issue 12, Page(s) 3819–3825

Abstract: Acute kidney injury (AKI) is a common postoperative complication after cardiac surgery with cardiopulmonary bypass (CPB), and leads to significant morbidity, mortality, and cost. Although early recognition and management of AKI may reduce the burden of ... ...

Abstract	Acute kidney injury (AKI) is a common postoperative complication after cardiac surgery with cardiopulmonary bypass (CPB), and leads to significant morbidity, mortality, and cost. Although early recognition and management of AKI may reduce the burden of renal disease, reliance on serum creatinine accumulation to confidently diagnose it leads to a significant and important delay (up to 48 hours). Hence, a search for earlier AKI biomarkers is warranted. The renal-resistive index (RRI) is a promising early AKI biomarker that reflects intrarenal arterial pulsatility as reflected by the peak systolic and end-diastolic blood velocities divided by the peak systolic velocity. During cardiac surgery, post-CPB elevation of RRI is correlated with renal injury. The RRI is influenced by intrarenal and extrarenal factors, as well as different hemodynamic states. Understanding its limitations may increase its usefulness as an early AKI biomarker. For example, tachycardia or aortic stenosis typically results in a lower RRI, whereas bradycardia or increased systemic pulse pressure (as seen with aortic insufficiency) are associated with a higher RRI, unrelated to any intrarenal effects. In this E-Challenge, the authors present two cases in which the RRI was used to evaluate a patient's risk of developing AKI.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Aortic Valve Insufficiency ; Cardiac Surgical Procedures/adverse effects ; Creatinine ; Humans ; Kidney
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2021-08-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2021.08.034
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Article ; Online: Correction to: Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis.

Nunez, Jose I / Gosling, Andre F / O'Gara, Brian / Kennedy, Kevin F / Rycus, Peter / Abrams, Darryl / Brodie, Daniel / Shaefi, Shahzad / Garan, A Reshad / Grandin, E Wilson

Intensive care medicine

2022 Volume 48, Issue 5, Page(s) 644–645

Language	English
Publishing date	2022-01-18
Publishing country	United States
Document type	Published Erratum
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-021-06605-w
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Article ; Online: The Role of Recipient Thyroid Hormone Supplementation in Primary Graft Dysfunction After Heart Transplantation: A Propensity-Adjusted Analysis.

Gosling, Andre F / Wright, Mary C / Cherry, Anne / Milano, Carmelo A / Patel, Chetan B / Schroder, Jacob N / DeVore, Adam / McCartney, Sharon / Kerr, Daryl / Bryner, Benjamin / Podgoreanu, Mihai / Nicoara, Alina

Journal of cardiothoracic and vascular anesthesia

2023 Volume 37, Issue 11, Page(s) 2236–2243

Abstract: Objectives: To investigate whether recipient administration of thyroid hormone (liothyronine [T3]) is associated with reduced rates of primary graft dysfunction (PGD) after orthotopic heart transplantation.: Design: Retrospective cohort study.: ... ...

Abstract	Objectives: To investigate whether recipient administration of thyroid hormone (liothyronine [T3]) is associated with reduced rates of primary graft dysfunction (PGD) after orthotopic heart transplantation. Design: Retrospective cohort study. Setting: Single-center, university hospital. Participants: Adult patients undergoing orthotopic heart transplantation. Interventions: A total of 609 adult heart transplant recipients were divided into 2 cohorts: patients who did not receive T3 (no T3 group, from 2009 to 2014), and patients who received T3 (T3 group, from 2015 to 2019). Propensity-adjusted logistic regression was performed to assess the association between T3 supplementation and PGD. Measurements and main results: After applying exclusion criteria and propensity-score analysis, the final cohort included 461 patients. The incidence of PGD was not significantly different between the groups (33.9% no T3 group v 40.8% T3 group; p = 0.32). Mortality at 30 days (3% no T3 group v 2% T3 group; p = 0.53) and 1 year (10% no T3 group v 12% T3 group; p = 0.26) were also not significantly different. When assessing the severity of PGD, there were no differences in the groups' rates of moderate PGD (not requiring mechanical circulatory support other than an intra-aortic balloon pump) or severe PGD (requiring mechanical circulatory support other than an intra-aortic balloon pump). However, segmented time regression analysis revealed that patients in the T3 group were less likely to develop severe PGD. Conclusions: These findings indicated that recipient single-dose thyroid hormone administration may not protect against the development of PGD, but may attenuate the severity of PGD.
MeSH term(s)	Adult ; Humans ; Retrospective Studies ; Primary Graft Dysfunction/diagnosis ; Primary Graft Dysfunction/epidemiology ; Primary Graft Dysfunction/etiology ; Heart Transplantation/adverse effects ; Thyroid Hormones ; Dietary Supplements
Chemical Substances	Thyroid Hormones
Language	English
Publishing date	2023-07-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2023.07.027
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Article ; Online: Interventional Pulmonology: A Brave New World.

Kalsi, Hardeep S / Thakrar, Ricky / Gosling, Andre F / Shaefi, Shahzad / Navani, Neal

Thoracic surgery clinics

2020 Volume 30, Issue 3, Page(s) 321–338

Abstract: Interventional pulmonology is a dynamic and evolving field in respiratory medicine. Advances have improved the ability to diagnose and manage diseases of the airways. A shift toward early detection of malignant disease has generated a focus on innovative ...

Abstract	Interventional pulmonology is a dynamic and evolving field in respiratory medicine. Advances have improved the ability to diagnose and manage diseases of the airways. A shift toward early detection of malignant disease has generated a focus on innovative diagnostic techniques. With patient populations living longer with malignant and benign diseases, the role for interventional bronchoscopy has grown. In cancer groups, novel immunotherapies have improved the prospects of clinical outcomes and reignited a focus on optimizing patient performance status to enable access to anticancer therapy. This review discusses current and emerging diagnostic modalities and therapeutic approaches available to manage airway diseases.
MeSH term(s)	Airway Obstruction/diagnostic imaging ; Airway Obstruction/surgery ; Bronchoscopy/methods ; Cone-Beam Computed Tomography ; Fluoroscopy ; Humans ; Laser Therapy ; Lung/diagnostic imaging ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Pulmonary Medicine/methods ; Stents ; Ultrasonography
Language	English
Publishing date	2020-06-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2149218-9
ISSN	1558-5069 ; 1547-4127
ISSN (online)	1558-5069
ISSN	1547-4127
DOI	10.1016/j.thorsurg.2020.04.001
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Article ; Online: Automated Spectral Doppler Profile Tracing.

Gosling, Andre F / Thalappillil, Richard / Ortoleva, Jamel / Datta, Pranav / Cobey, Frederick C

Journal of cardiothoracic and vascular anesthesia

2019 Volume 34, Issue 1, Page(s) 72–76

Abstract: Objective: The authors hypothesized that automated tracings of both pulsed wave (PW) and continuous wave (CW) Doppler correlate well with manual measurements performed by an experienced echocardiographer.: Design: The authors performed a ... ...

Abstract	Objective: The authors hypothesized that automated tracings of both pulsed wave (PW) and continuous wave (CW) Doppler correlate well with manual measurements performed by an experienced echocardiographer. Design: The authors performed a retrospective analysis of spectral Doppler profile measurements performed by automated software and an echocardiographer. Setting: University hospital, single institution. Participants: The authors reviewed transesophageal echocardiographic examinations from patients undergoing transcatheter aortic valve (AV) replacement procedures at their institution. Interventions: No interventions were performed solely for research purposes. Measurements and main results: PW and CW spectral envelopes at the left ventricular outflow tract (LVOT) and AV were analyzed. Blinded, a board-certified echocardiographer performed manual measurements of the identical spectral envelopes. Peak velocities, mean gradients, and velocity time integrals (VTI) were collected. A total of 33 PW as well as 33 CW Doppler spectral envelopes were evaluated. There was no significant difference between the measurements provided by the automated software and manual tracings. LVOT PW VTI automated versus manual: 18.2 cm versus 15.9 cm, p = 0.11. AV CW VTI automated versus manual: 65.8 cm versus 64.8 cm, p = 0.90. AV CW mean gradient automated versus manual: 24.3 mmHg versus 23.4 mmHg, p = 0.84. AV CW peak velocity automated versus manual: 3.00 m/s versus 2.98 m/s, p = 0.93. Correlation coefficients were all above 0.9. Conclusions: Automated measurements of peak velocities, mean gradients, and VTI of spectral Doppler correlate closely with manual measurements performed by an experienced echocardiographer.
MeSH term(s)	Aortic Valve Stenosis/surgery ; Blood Flow Velocity ; Echocardiography, Transesophageal ; Humans ; Retrospective Studies ; Transcatheter Aortic Valve Replacement ; Ultrasonography, Doppler
Language	English
Publishing date	2019-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2019.06.018
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Article ; Online: Perioperative Considerations for Tracheostomies in the Era of COVID-19.

Gosling, Andre F / Bose, Somnath / Gomez, Ernest / Parikh, Mihir / Cook, Charles / Sarge, Todd / Shaefi, Shahzad / Leibowitz, Akiva

Anesthesia and analgesia

2020 Volume 131, Issue 2, Page(s) 378–386

Abstract: The morbidity, mortality, and blistering pace of transmission of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an unprecedented worldwide health crisis. Coronavirus disease 2019 (COVID-19), the disease produced by ...

Abstract	The morbidity, mortality, and blistering pace of transmission of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an unprecedented worldwide health crisis. Coronavirus disease 2019 (COVID-19), the disease produced by SARS-CoV-2 infection, is remarkable for persistent, severe respiratory failure requiring mechanical ventilation that places considerable strain on critical care resources. Because recovery from COVID-19-associated respiratory failure can be prolonged, tracheostomy may facilitate patient management and optimize the use of mechanical ventilators. Several important considerations apply to plan tracheostomies for COVID-19-infected patients. After performing a literature review of tracheostomies during the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, we synthesized important learning points from these experiences and suggested an approach for perioperative teams involved in these procedures during the COVID-19 pandemic. Multidisciplinary teams should be involved in decisions regarding timing and appropriateness of the procedure. As the theoretical risk of disease transmission is increased during aerosol-generating procedures (AGPs), stringent infectious precautions are warranted. Personal protective equipment (PPE) should be available and worn by all personnel present during tracheostomy. The number of people in the room should be limited to those absolutely necessary. Using the most experienced available operators will minimize the total time that staff is exposed to an infectious aerosolized environment. An approach that secures the airway in the safest and quickest manner will minimize the time any part of the airway is open to the environment. Deep neuromuscular blockade (train-of-four ratio = 0) will facilitate surgical exposure and prevent aerosolization due to patient movement or coughing. For percutaneous tracheostomies, the bronchoscopist should be able to reintubate if needed. Closed-loop communication must occur at all times among members of the team. If possible, after tracheostomy is performed, waiting until the patient is virus-free before changing the cannula or downsizing may reduce the chances of health care worker infection. Tracheostomies in COVID-19 patients present themselves as extremely high risk for all members of the procedural team. To mitigate risk, systematic meticulous planning of each procedural step is warranted along with strict adherence to local/institutional protocols.
MeSH term(s)	Aerosols ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Infection Control ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Occupational Exposure/adverse effects ; Occupational Exposure/prevention & control ; Operative Time ; Pandemics ; Patient Care Team ; Perioperative Care ; Personal Protective Equipment ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Time Factors ; Tracheostomy/adverse effects ; Treatment Outcome
Chemical Substances	Aerosols
Keywords	covid19
Language	English
Publishing date	2020-05-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000005009
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Article: Impact of mental disorders on clinical outcomes of physical diseases: an umbrella review assessing population attributable fraction and generalized impact fraction.

World psychiatry : official journal of the World Psychiatric Association (WPA)

2023 Volume 22, Issue 1, Page(s) 86–104

Abstract: Empirical evidence indicates a significant bidirectional association between mental disorders and physical diseases, but the prospective impact of men-tal disorders on clinical outcomes of physical diseases has not been comprehensively outlined. In this ... ...

Abstract	Empirical evidence indicates a significant bidirectional association between mental disorders and physical diseases, but the prospective impact of men-tal disorders on clinical outcomes of physical diseases has not been comprehensively outlined. In this PRISMA- and COSMOS-E-compliant umbrella review, we searched PubMed, PsycINFO, Embase, and Joanna Briggs Institute Database of Systematic Reviews and Implementation Reports, up to March 15, 2022, to identify systematic reviews with meta-analysis that examined the prospective association between any mental disorder and clinical outcomes of physical diseases. Primary outcomes were disease-specific mortality and all-cause mortality. Secondary outcomes were disease-specific incidence, functioning and/or disability, symptom severity, quality of life, recurrence or progression, major cardiac events, and treatment-related outcomes. Additional inclusion criteria were further applied to primary studies. Random effect models were employed, along with I
Language	English
Publishing date	2023-01-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2236130-3
ISSN	2051-5545 ; 1723-8617
ISSN (online)	2051-5545
ISSN	1723-8617
DOI	10.1002/wps.21068
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