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  1. Article ; Online: Stroke volume variation remains accurate in the presence of proximal stenosis.

    Sakamoto, Hiroatsu / Kitaura, Atsuhiro / Tsukimoto, Shota / Yoshino, Yukari / Mino, Takashi / Yuasa, Haruyuki / Nakajima, Yasufumi

    JA clinical reports

    2024  Volume 10, Issue 1, Page(s) 13

    Language English
    Publishing date 2024-02-13
    Publishing country Germany
    Document type Letter
    ISSN 2363-9024
    ISSN (online) 2363-9024
    DOI 10.1186/s40981-024-00693-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intraoperative cardiac arrest caused by unexpected vasospastic angina requiring prolonged resuscitation using extracorporeal membrane oxygenation: a case report.

    Sugita, Shinji / Obata, Masanobu / Hasunuma, Fumihiko / Sakamoto, Atsuhiro

    JA clinical reports

    2023  Volume 9, Issue 1, Page(s) 77

    Abstract: Background: Vasospastic angina (VSA) occurring during surgery is rare but can lead to sudden intraoperative cardiac arrest.: Case presentation: A 77-year-old man with hypertension, and no history of coronary artery disease, displayed an abrupt ST- ... ...

    Abstract Background: Vasospastic angina (VSA) occurring during surgery is rare but can lead to sudden intraoperative cardiac arrest.
    Case presentation: A 77-year-old man with hypertension, and no history of coronary artery disease, displayed an abrupt ST-segment elevation on the electrocardiogram (ECG) during laparoscopic inguinal hernia surgery under general anesthesia. Subsequently, ventricular fibrillation (VF) occurred, with a finding suggesting ischemic myocardial contracture by transesophageal echocardiography. VF was refractory to cardiopulmonary resuscitation (CPR), and veno-arterial extracorporeal membrane oxygenation (VA ECMO) was introduced. Spontaneous circulation resumed 77 min post-cardiac arrest. VSA was confirmed through the patient's clinical course and coronary angiography. Subsequently, VA ECMO was terminated, and the patient was discharged uneventfully.
    Conclusions: Extracorporeal CPR may be a valuable alternative to extended resuscitation for refractory ventricular arrhythmias by VSA.
    Language English
    Publishing date 2023-11-09
    Publishing country Germany
    Document type Journal Article
    ISSN 2363-9024
    ISSN (online) 2363-9024
    DOI 10.1186/s40981-023-00667-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Unexpected abnormal positive pressure due to misconnection of excess gas tube.

    Kitaura, Atsuhiro / Sakamoto, Hiroatsu / Toho, Kensuke / Tsukimoto, Shota / Yuasa, Haruyuki / Nakajima, Yasufumi

    JA clinical reports

    2023  Volume 9, Issue 1, Page(s) 83

    Language English
    Publishing date 2023-12-01
    Publishing country Germany
    Document type Letter
    ISSN 2363-9024
    ISSN (online) 2363-9024
    DOI 10.1186/s40981-023-00677-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Increased extracellular release of microRNAs from dorsal root ganglion cells in a rat model of neuropathic pain caused by peripheral nerve injury.

    Ikuma, Yuko / Sakai, Atsushi / Sakamoto, Atsuhiro / Suzuki, Hidenori

    PloS one

    2023  Volume 18, Issue 1, Page(s) e0280425

    Abstract: microRNAs (miRNAs) are extracellularly released by cells for intercellular communication, while intracellularly, they inhibit the expression of specific genes. An increasing number of studies suggest that extracellular miRNAs have great potential as both ...

    Abstract microRNAs (miRNAs) are extracellularly released by cells for intercellular communication, while intracellularly, they inhibit the expression of specific genes. An increasing number of studies suggest that extracellular miRNAs have great potential as both therapeutic targets and disease-specific biomarkers in a variety of diseases, including pain disorders. However, little is known about miRNA release from dorsal root ganglion (DRG) neurons in neuropathic pain caused by peripheral nerve injury. In this study, we investigated the changes in the extracellular release of miRNAs from DRG neurons in a rat model of neuropathic pain induced by chronic constriction injury of the sciatic nerve. We found increased release of six miRNAs (let-7d, miR-21, miR-142-3p, miR-146b, miR-203-3p and miR-221) from primary cultured DRG neurons prepared from rats 7 days after nerve injury. Among these, miR-221 was also increased in serum from days 7 to 28 after nerve injury. In contrast, serum miR-221 levels and its release from DRG neurons were unchanged in an inflammatory pain model produced by intraplantar injection of complete Freund's adjuvant. These results suggest that the increased release of specific miRNAs by DRG neurons may be involved in the pathophysiology of neuropathic pain through extracellular as well as intracellular mechanisms. Furthermore, serum miR-221 may be useful as a biomarker of neuropathic pain caused by peripheral nerve injury.
    MeSH term(s) Rats ; Animals ; Ganglia, Spinal/metabolism ; Peripheral Nerve Injuries/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neuralgia/etiology ; Sciatic Nerve/injuries
    Chemical Substances MicroRNAs ; MIRN203 microRNA, rat ; mirn21 microRNA, rat
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0280425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lateral position does not cause an interhemicerebral difference of cerebral hemodynamic in healthy adult volunteers.

    Kamiya, Ichiro / Kim, Chol / Kageyama, Atsuko / Sakamoto, Atsuhiro

    Physiological reports

    2023  Volume 11, Issue 9, Page(s) e15685

    Abstract: Cerebral perfusion is maintained at a consistent value irrespective of changes in systemic blood pressure or disease-induced changes in general physical condition. This regulatory mechanism is effective despite postural changes, working even during ... ...

    Abstract Cerebral perfusion is maintained at a consistent value irrespective of changes in systemic blood pressure or disease-induced changes in general physical condition. This regulatory mechanism is effective despite postural changes, working even during changes in posture, such as those from sitting to standing or from the head-down to the head-up position. However, no study has addressed changes in perfusion separately in the left and right cerebral hemispheres, and there has been no specific investigation of the effect of the lateral decubitus position on perfusion in each hemisphere. Surgery, particularly respiratory surgery, is often performed with the patient in the lateral decubitus position, and since intraoperative anesthesia may also have an effect, it is important to ascertain the effect of the lateral decubitus position on perfusion in the left and right cerebral hemispheres in the absence of anesthesia. The effects of the lateral decubitus position on heart rate, blood pressure, and hemodynamic in the left and right cerebral hemispheres assessed by regional saturation of oxygen measured by near-infrared spectroscopy were investigated in healthy adult volunteers. Although the lateral decubitus position causes systemic circulatory changes, it may not cause any difference in hemodynamic between the left and right cerebral hemispheres.
    MeSH term(s) Humans ; Adult ; Posture/physiology ; Hemodynamics ; Blood Pressure/physiology ; Heart Rate ; Volunteers
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Remimazolam-Based Anesthesia in Patients with Heart Failure Due to Mitral Regurgitation and Low Left Ventricular Function: A Case Series.

    Kitaura, Atsuhiro / Sakamoto, Hiroatsu / Hamasaki, Shinichi / Tsukimoto, Shota / Nakajima, Yasufumi

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 12

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Mitral Valve Insufficiency/complications ; Mitral Valve Insufficiency/surgery ; Ventricular Function, Left/physiology ; Retrospective Studies ; Treatment Outcome ; Benzodiazepines ; Heart Failure/complications ; Heart Failure/drug therapy ; Anesthetics ; Anesthesia, General/adverse effects
    Chemical Substances remimazolam (7V4A8U16MB) ; Benzodiazepines (12794-10-4) ; Anesthetics
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59122136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Two Cases of Inadequate Response to Remimazolam.

    Kitaura, Atsuhiro / Hamasaki, Shinichi / Sakamoto, Hiroatsu / Tsukimoto, Shota / Nakajima, Yasufumi

    Cureus

    2023  Volume 15, Issue 7, Page(s) e42576

    Abstract: We report the inadequate efficacy of remimazolam in two patients undergoing long-term benzodiazepine analog therapy. Remimazolam is a recently developed ultrashort-acting benzodiazepine. It is primarily used as an anesthetic in surgical procedures, as it ...

    Abstract We report the inadequate efficacy of remimazolam in two patients undergoing long-term benzodiazepine analog therapy. Remimazolam is a recently developed ultrashort-acting benzodiazepine. It is primarily used as an anesthetic in surgical procedures, as it has minimal effect on cardiac function and antagonists are available. It is expected to become more widely used in the future. On the other hand, similar to other benzodiazepines, benzodiazepine tolerance can also pose a challenge with remimazolam. Herein, we report two cases who were taking long-term oral benzodiazepine analogs. One patient did not fall asleep despite a sufficient dose of remimazolam and required a change to propofol. The other patient required a high dose of remimazolam to fall asleep; however, multiple signs of arousal were noted intraoperatively. Our findings suggest that remimazolam may not be an ideal anesthetic in long-term benzodiazepine analog users. Comprehensive assessment of preoperative medications and careful monitoring of intraoperative sedation levels are necessary. Furthermore, it may be advisable to consider the use of alternative agents such as propofol.
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.42576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Remimazolam-Based Anesthesia in Patients with Heart Failure Due to Mitral Regurgitation and Low Left Ventricular Function

    Atsuhiro Kitaura / Hiroatsu Sakamoto / Shinichi Hamasaki / Shota Tsukimoto / Yasufumi Nakajima

    Medicina, Vol 59, Iss 12, p

    A Case Series

    2023  Volume 2136

    Abstract: Background and Objectives : Remimazolam is a new ultrashort-acting benzodiazepine anesthetic. Remimazolam appears to be useful in patients with severe valvular disease because of its minimal cardiovascular impact. In this retrospective case series study, ...

    Abstract Background and Objectives : Remimazolam is a new ultrashort-acting benzodiazepine anesthetic. Remimazolam appears to be useful in patients with severe valvular disease because of its minimal cardiovascular impact. In this retrospective case series study, we assessed the efficacy and safety of remimazolam for maintaining hemodynamic stability during anesthetic induction and maintenance. Cases : MitraClip was performed on 18 cases with severe mitral regurgitation with low left ventricular function who presented with heart failure, and remimazolam was administered for general anesthesia with induction (12 mg/kg/h) and maintenance (1 mg/kg/h). The impact of remimazolam on the hemodynamics at anesthetic induction and during anesthetic maintenance was investigated retrospectively using electronic medical records. Blood pressure decreased significantly during anesthetic induction with remimazolam (78.5 [72, 81.25] and 66.1 [62.2, 74.2], median [IQR], p = 0.0001), but only mildly, by about 10 mmHg. There was no significant change in the cardiac index (2.0 [1.8, 2.4] vs. 1.9 [1.8, 2.3], p = 0.57642) or pulse rate (73.5 ± 8.85 vs. 74.7 ± 11.7, mean ± SD, p = 0.0876) during anesthetic induction with remimazolam. All patients underwent MitraClip without major hemodynamic concerns, with no or small increases in inotropes. Conclusions: Remimazolam may be used safely in patients with severe mitral regurgitation and low left ventricular function presenting with heart failure.
    Keywords remimazolam ; MitraClip ; mitral regurgitation ; heart failure ; anesthesia ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Response to the letter: Research protocol and complementary results.

    Ishikawa, Masashi / Sakamoto, Atsuhiro

    Journal of clinical monitoring and computing

    2019  Volume 34, Issue 1, Page(s) 193–195

    MeSH term(s) Anesthesia, General ; Humans ; Postoperative Period ; Retrospective Studies
    Language English
    Publishing date 2019-07-25
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-019-00358-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Comparison of Gastric Emptying Time after the Ingestion of Whisky with Isocalorically Adjusted Glucose Solution.

    Okabe, Tadashi / Terashima, Hideo / Sakamoto, Atsuhiro

    Journal of nutrition and metabolism

    2022  Volume 2022, Page(s) 6137230

    Abstract: Previous studies have shown that the liquid gastric emptying mainly depended on energy content, regardless of compositional differences. But the gastric emptying of alcoholic beverages remains unclear. Therefore, we performed the present study to compare ...

    Abstract Previous studies have shown that the liquid gastric emptying mainly depended on energy content, regardless of compositional differences. But the gastric emptying of alcoholic beverages remains unclear. Therefore, we performed the present study to compare gastric emptying times between whisky mixed with water and glucose solution with uniform energy contents and volumes. As a crossover study, 10 healthy male volunteers ingested one of 3 test solutions with a uniform volume of 150 ml, i.e., whisky with water-containing whisky 30 ml (67 kcal), sugar water containing glucose 16.8 g (67 kcal), and water (0 kcal), and the gastric emptying time of each beverage was then assessed by ultrasound measurements of the gastric antral cross-sectional area. The gastric emptying pattern of whisky with water was faster than that of isocaloric sugar water, but slower than that of water. Each antral cross-sectional area 20, 30, and 40 min after the ingestion of sugar water was significantly larger than that of whisky with water. Antral cross-sectional areas 10 and 20 min after the ingestion of water were significantly smaller than those of whisky with water. In conclusion, the gastric emptying time of whisky would be faster than that of isocaloric glucose solution and slower than that of water. Unlike the other beverages, the gastric emptying time of alcohol drinks does not purely depend on the energy content because alcohol itself has no calorie before absorption. This study is registered with the University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN000034443).
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573563-9
    ISSN 2090-0732 ; 2090-0724
    ISSN (online) 2090-0732
    ISSN 2090-0724
    DOI 10.1155/2022/6137230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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