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Article ; Online: Integrative spatial analysis reveals a multi-layered organization of glioblastoma.

2024

Abstract: Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics, spatial proteomics, and computational approaches to define glioma cellular states and uncover their organization. We find three prominent modes of organization. ... ...

Abstract	Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics, spatial proteomics, and computational approaches to define glioma cellular states and uncover their organization. We find three prominent modes of organization. First, gliomas are composed of small local environments, each typically enriched with one major cellular state. Second, specific pairs of states preferentially reside in proximity across multiple scales. This pairing of states is consistent across tumors. Third, these pairwise interactions collectively define a global architecture composed of five layers. Hypoxia appears to drive the layers, as it is associated with a long-range organization that includes all cancer cell states. Accordingly, tumor regions distant from any hypoxic/necrotic foci and tumors that lack hypoxia such as low-grade IDH-mutant glioma are less organized. In summary, we provide a conceptual framework for the organization of cellular states in glioma, highlighting hypoxia as a long-range tissue organizer.
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2024.03.029
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Article ; Online: Association of Patient-Reported Outcomes With Subsequent Nonfatal Self-injury After a New Cancer Diagnosis.

Hallet, Julie / Sutradhar, Rinku / Isenberg-Grzeda, Elie / Noel, Christopher W / Mahar, Alyson L / Vigod, Simone N / Bolton, James / Deleemans, Julie / Chan, Wing C / Coburn, Natalie G / Eskander, Antoine

JAMA oncology

2022 Volume 8, Issue 5, Page(s) e220203

Abstract: Importance: Nonfatal self-injury (NFSI) is a patient-centered manifestation of severe distress occurring in 3 out of 1000 patients after cancer diagnosis. How to identify patients at risk for NFSI remains unknown.: Objective: To examine the ... ...

Abstract	Importance: Nonfatal self-injury (NFSI) is a patient-centered manifestation of severe distress occurring in 3 out of 1000 patients after cancer diagnosis. How to identify patients at risk for NFSI remains unknown. Objective: To examine the associations between patient-reported outcome measures and subsequent NFSI in patients with cancer. Design, setting, and participants: This population-based matched case-control study included adults with a new cancer diagnosis reporting an Edmonton Symptom Assessment System (ESAS) score within 36 months of diagnosis in Ontario, Canada, 2007 to 2019. Data analysis was performed January 2007 to December 2019. Main outcomes and measures: Cases included patients with NFSI, and controls were patients without NFSI. Cases and controls were matched 1:4. Multivariable conditional logistic regression assessed the association between moderate to severe ESAS symptom scores and total ESAS (t-ESAS, range 0-90) score with NFSI in the subsequent 180 days. Results: Of 408 858 patients reporting 1 or more ESAS assessments, 425 patients experienced NFSI and reported an ESAS score in the preceding 180 days. Of those, 406 cases were matched to 1624 control patients without an NFSI. Cases reported a higher proportion of moderate to severe symptoms and higher t-ESAS score than controls prior to the event. After adjustment, moderate to severe anxiety (odds ratio [OR], 1.61; 95% CI, 1.14-2.27), depression (OR, 1.66; 95% CI, 1.20-2.31), and shortness of breath (OR, 1.65; 95% CI, 1.18-2.31) and each 10-point increase in t-ESAS score (OR, 1.51; 95% CI, 1.40-1.63) were independently associated with higher odds of subsequent NFSI. Conclusions and relevance: In this case-control study, reporting moderate to severe anxiety, depression, and shortness of breath and an increasing t-ESAS score after cancer diagnosis were associated with higher odds of NFSI in the following 180 days. These data support the prospective use of routine ESAS screening as a means of identifying patients at higher risk for NFSI to improve supportive care.
MeSH term(s)	Adult ; Case-Control Studies ; Dyspnea ; Humans ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Ontario/epidemiology ; Patient Reported Outcome Measures ; Prospective Studies ; Retrospective Studies ; Self-Injurious Behavior ; Symptom Assessment
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2022.0203
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Article ; Online: Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy.

Fehlings, Darcy L / Zarrei, Mehdi / Engchuan, Worrawat / Sondheimer, Neal / Thiruvahindrapuram, Bhooma / MacDonald, Jeffrey R / Higginbotham, Edward J / Thapa, Ritesh / Behlim, Tarannum / Aimola, Sabrina / Switzer, Lauren / Ng, Pamela / Wei, John / Danthi, Prakroothi S / Pellecchia, Giovanna / Lamoureux, Sylvia / Ho, Karen / Pereira, Sergio L / de Rijke, Jill /

Sung, Wilson W L / Mowjoodi, Alireza / Howe, Jennifer L / Nalpathamkalam, Thomas / Manshaei, Roozbeh / Ghaffari, Siavash / Whitney, Joseph / Patel, Rohan V / Hamdan, Omar / Shaath, Rulan / Trost, Brett / Knights, Shannon / Samdup, Dawa / McCormick, Anna / Hunt, Carolyn / Kirton, Adam / Kawamura, Anne / Mesterman, Ronit / Gorter, Jan Willem / Dlamini, Nomazulu / Merico, Daniele / Hilali, Murto / Hirschfeld, Kyle / Grover, Kritika / Bautista, Nelson X / Han, Kara / Marshall, Christian R / Yuen, Ryan K C / Subbarao, Padmaja / Azad, Meghan B / Turvey, Stuart E / Mandhane, Piush / Moraes, Theo J / Simons, Elinor / Maxwell, George / Shevell, Michael / Costain, Gregory / Michaud, Jacques L / Hamdan, Fadi F / Gauthier, Julie / Uguen, Kevin / Stavropoulos, Dimitri J / Wintle, Richard F / Oskoui, Maryam / Scherer, Stephen W

Nature genetics

2024 Volume 56, Issue 4, Page(s) 585–594

Abstract: We performed whole-genome sequencing (WGS) in 327 children with cerebral palsy (CP) and their biological parents. We classified 37 of 327 (11.3%) children as having pathogenic/likely pathogenic (P/LP) variants and 58 of 327 (17.7%) as having variants of ... ...

Abstract	We performed whole-genome sequencing (WGS) in 327 children with cerebral palsy (CP) and their biological parents. We classified 37 of 327 (11.3%) children as having pathogenic/likely pathogenic (P/LP) variants and 58 of 327 (17.7%) as having variants of uncertain significance. Multiple classes of P/LP variants included single-nucleotide variants (SNVs)/indels (6.7%), copy number variations (3.4%) and mitochondrial mutations (1.5%). The COL4A1 gene had the most P/LP SNVs. We also analyzed two pediatric control cohorts (n = 203 trios and n = 89 sib-pair families) to provide a baseline for de novo mutation rates and genetic burden analyses, the latter of which demonstrated associations between de novo deleterious variants and genes related to the nervous system. An enrichment analysis revealed previously undescribed plausible candidate CP genes (SMOC1, KDM5B, BCL11A and CYP51A1). A multifactorial CP risk profile and substantial presence of P/LP variants combine to support WGS in the diagnostic work-up across all CP and related phenotypes.
MeSH term(s)	Humans ; Child ; DNA Copy Number Variations/genetics ; Cerebral Palsy/genetics ; Mutation ; Whole Genome Sequencing ; Genomics
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/s41588-024-01686-x
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Article ; Online: Towards a global partnership model in interprofessional education for cross-sector problem-solving.

Ganotice, Fraide / Zheng, Binbin / Ng, Pauline Yeung / Leung, Siu Chung / Barrett, Elizabeth Ann / Chan, Hoi Yan Celia / Chan, Chad W N / Chan, Kit Wa Sherry / Chan, Linda / Chan, M K Karen / Chan, Siu Ling Polly / Chan, So Ching Sarah / Chan, Esther W Y / Chen, Julie / Cheuk, Yuet Ying Jessica / Chong, Yin Kei Doris / Chow, Yin Man Amy / Chu, Kwok Pui Jody / Chung, Hon Yin Brian /

Ho, Shun Yee Amy / Jen, Julienne / Jin, Jingwen / Khoo, Ui Soon / Lam, Ho Yan Angie / Lam, May P S / Lam, Suk Fun Veronica / Lee, Pamela Pui-Wah / Lee, Jetty Chung-Yung / Leung, Chung Yin Feona / Leung, Anna K Y / Lin, Xiang / Liu, Rebecca K W / Lou, Wei Qun Vivian / Luk, Pauline / Ng, Lai Han Zoe / Ng, Yee Man Alina / Ng, Tin Wai Terry / See, Lok Man Mary / Shen, Jiangang / Shen, Xiaoai / Szeto, Grace / Tam, Eliza Y T / To, Kelvin Kai-Wang / Tso, Wan-Yee Winnie / Vackova, Dana / Wang, Ning / Wang, Runjia / Wong, Hoi Yan Gloria / Wong, K T Janet / Wong, M Y Anita / Wong, Yuen Ha Janet / Yuen, Kwan Yuk Jacqueline / Yuen, Wai Yee Grace / Orlu, Mine / Tipoe, George L

BMC medical education

2023 Volume 23, Issue 1, Page(s) 457

Abstract: Objectives: A partnership model in interprofessional education (IPE) is important in promoting a sense of global citizenship while preparing students for cross-sector problem-solving. However, the literature remains scant in providing useful guidance ... ...

Abstract	Objectives: A partnership model in interprofessional education (IPE) is important in promoting a sense of global citizenship while preparing students for cross-sector problem-solving. However, the literature remains scant in providing useful guidance for the development of an IPE programme co-implemented by external partners. In this pioneering study, we describe the processes of forging global partnerships in co-implementing IPE and evaluate the programme in light of the preliminary data available. Methods: This study is generally quantitative. We collected data from a total of 747 health and social care students from four higher education institutions. We utilized a descriptive narrative format and a quantitative design to present our experiences of running IPE with external partners and performed independent t-tests and analysis of variance to examine pretest and posttest mean differences in students' data. Results: We identified factors in establishing a cross-institutional IPE programme. These factors include complementarity of expertise, mutual benefits, internet connectivity, interactivity of design, and time difference. We found significant pretest-posttest differences in students' readiness for interprofessional learning (teamwork and collaboration, positive professional identity, roles, and responsibilities). We also found a significant decrease in students' social interaction anxiety after the IPE simulation. Conclusions: The narrative of our experiences described in this manuscript could be considered by higher education institutions seeking to forge meaningful external partnerships in their effort to establish interprofessional global health education.
MeSH term(s)	Humans ; Interprofessional Education ; Students, Health Occupations ; Learning ; Problem Solving ; Universities ; Interprofessional Relations ; Attitude of Health Personnel
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04290-5
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Article: Microbiome Preterm Birth DREAM Challenge: Crowdsourcing Machine Learning Approaches to Advance Preterm Birth Research.

Golob, Jonathan L / Oskotsky, Tomiko T / Tang, Alice S / Roldan, Alennie / Chung, Verena / Ha, Connie W Y / Wong, Ronald J / Flynn, Kaitlin J / Parraga-Leo, Antonio / Wibrand, Camilla / Minot, Samuel S / Andreoletti, Gaia / Kosti, Idit / Bletz, Julie / Nelson, Amber / Gao, Jifan / Wei, Zhoujingpeng / Chen, Guanhua / Tang, Zheng-Zheng /

Novielli, Pierfrancesco / Romano, Donato / Pantaleo, Ester / Amoroso, Nicola / Monaco, Alfonso / Vacca, Mirco / De Angelis, Maria / Bellotti, Roberto / Tangaro, Sabina / Kuntzleman, Abigail / Bigcraft, Isaac / Techtmann, Stephen / Bae, Daehun / Kim, Eunyoung / Jeon, Jongbum / Joe, Soobok / Theis, Kevin R / Ng, Sherrianne / Lee Li, Yun S / Diaz-Gimeno, Patricia / Bennett, Phillip R / MacIntyre, David A / Stolovitzky, Gustavo / Lynch, Susan V / Albrecht, Jake / Gomez-Lopez, Nardhy / Romero, Roberto / Stevenson, David K / Aghaeepour, Nima / Tarca, Adi L / Costello, James C / Sirota, Marina

medRxiv : the preprint server for health sciences

2023

Abstract: Globally, every year about 11% of infants are born preterm, defined as a birth prior to 37 weeks of gestation, with significant and lingering health consequences. Multiple studies have related the vaginal microbiome to preterm birth. We present a ... ...

Abstract	Globally, every year about 11% of infants are born preterm, defined as a birth prior to 37 weeks of gestation, with significant and lingering health consequences. Multiple studies have related the vaginal microbiome to preterm birth. We present a crowdsourcing approach to predict: (a) preterm or (b) early preterm birth from 9 publicly available vaginal microbiome studies representing 3,578 samples from 1,268 pregnant individuals, aggregated from raw sequences via an open-source tool, MaLiAmPi. We validated the crowdsourced models on novel datasets representing 331 samples from 148 pregnant individuals. From 318 DREAM challenge participants we received 148 and 121 submissions for our two separate prediction sub-challenges with top-ranking submissions achieving bootstrapped AUROC scores of 0.69 and 0.87, respectively. Alpha diversity, VALENCIA community state types, and composition (via phylotype relative abundance) were important features in the top performing models, most of which were tree based methods. This work serves as the foundation for subsequent efforts to translate predictive tests into clinical practice, and to better understand and prevent preterm birth.
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.07.23286920
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Article ; Online: Microbiome preterm birth DREAM challenge: Crowdsourcing machine learning approaches to advance preterm birth research.

Golob, Jonathan L / Oskotsky, Tomiko T / Tang, Alice S / Roldan, Alennie / Chung, Verena / Ha, Connie W Y / Wong, Ronald J / Flynn, Kaitlin J / Parraga-Leo, Antonio / Wibrand, Camilla / Minot, Samuel S / Oskotsky, Boris / Andreoletti, Gaia / Kosti, Idit / Bletz, Julie / Nelson, Amber / Gao, Jifan / Wei, Zhoujingpeng / Chen, Guanhua /

Tang, Zheng-Zheng / Novielli, Pierfrancesco / Romano, Donato / Pantaleo, Ester / Amoroso, Nicola / Monaco, Alfonso / Vacca, Mirco / De Angelis, Maria / Bellotti, Roberto / Tangaro, Sabina / Kuntzleman, Abigail / Bigcraft, Isaac / Techtmann, Stephen / Bae, Daehun / Kim, Eunyoung / Jeon, Jongbum / Joe, Soobok / Theis, Kevin R / Ng, Sherrianne / Lee, Yun S / Diaz-Gimeno, Patricia / Bennett, Phillip R / MacIntyre, David A / Stolovitzky, Gustavo / Lynch, Susan V / Albrecht, Jake / Gomez-Lopez, Nardhy / Romero, Roberto / Stevenson, David K / Aghaeepour, Nima / Tarca, Adi L / Costello, James C / Sirota, Marina

Cell reports. Medicine

2023 Volume 5, Issue 1, Page(s) 101350

Abstract: Every year, 11% of infants are born preterm with significant health consequences, with the vaginal microbiome a risk factor for preterm birth. We crowdsource models to predict (1) preterm birth (PTB; <37 weeks) or (2) early preterm birth (ePTB; <32 weeks) ...

Abstract	Every year, 11% of infants are born preterm with significant health consequences, with the vaginal microbiome a risk factor for preterm birth. We crowdsource models to predict (1) preterm birth (PTB; <37 weeks) or (2) early preterm birth (ePTB; <32 weeks) from 9 vaginal microbiome studies representing 3,578 samples from 1,268 pregnant individuals, aggregated from public raw data via phylogenetic harmonization. The predictive models are validated on two independent unpublished datasets representing 331 samples from 148 pregnant individuals. The top-performing models (among 148 and 121 submissions from 318 teams) achieve area under the receiver operator characteristic (AUROC) curve scores of 0.69 and 0.87 predicting PTB and ePTB, respectively. Alpha diversity, VALENCIA community state types, and composition are important features in the top-performing models, most of which are tree-based methods. This work is a model for translation of microbiome data into clinically relevant predictive models and to better understand preterm birth.
MeSH term(s)	Pregnancy ; Female ; Infant, Newborn ; Humans ; Premature Birth ; Crowdsourcing ; Phylogeny ; Vagina ; Microbiota/genetics
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2023.101350
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Article ; Online: Acute and chronic pain following craniotomy.

Flexman, Alana M / Ng, Julie L / Gelb, Adrian W

Current opinion in anaesthesiology

2010 Volume 23, Issue 5, Page(s) 551–557

Abstract: Purpose of review: The purpose of the review is to describe what is currently known about the mechanisms, incidence and risk factors for acute and chronic postcraniotomy pain. The review will also summarize the evidence supporting the prevention and ... ...

Abstract	Purpose of review: The purpose of the review is to describe what is currently known about the mechanisms, incidence and risk factors for acute and chronic postcraniotomy pain. The review will also summarize the evidence supporting the prevention and management of acute and chronic postcraniotomy pain. Recent findings: Current studies suggest acute and chronic pain is common in patients after craniotomy. Surgical and patient factors may influence the incidence and severity of pain and a multimodal approach to acute postcraniotomy pain is recommended. Although codeine and tramadol are frequently used in the postoperative period, research suggests morphine provides superior efficacy with a good safety profile. Local anesthesia with nerve blocks has not been shown to consistently reduce acute postoperative pain, though it has recently been demonstrated to dramatically reduce the incidence of chronic pain. Despite this, little is known about the mechanisms, prevention and treatment of chronic postcraniotomy pain. Summary: Acute and chronic pain following craniotomy is frequent and underrecognized. Several surgical and patient risk factors predispose patients to pain following neurosurgery. Further research is needed to determine the mechanisms, predictors, prevention and optimal treatment of acute and chronic pain following craniotomy.
MeSH term(s)	Acute Disease ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Anesthesia, Local ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Causality ; Chronic Disease ; Craniotomy/adverse effects ; Headache/epidemiology ; Headache/etiology ; Headache/physiopathology ; Headache/prevention & control ; Humans ; Pain, Postoperative/epidemiology ; Pain, Postoperative/physiopathology ; Pain, Postoperative/prevention & control ; Pain, Postoperative/therapy ; Risk Factors
Chemical Substances	Analgesics, Opioid ; Anti-Inflammatory Agents, Non-Steroidal
Language	English
Publishing date	2010-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645203-6
ISSN	1473-6500 ; 0952-7907
ISSN (online)	1473-6500
ISSN	0952-7907
DOI	10.1097/ACO.0b013e32833e15b9
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Article ; Online: Perioperative stroke in noncardiac, nonneurosurgical surgery.

Ng, Julie L W / Chan, Matthew T V / Gelb, Adrian W

Anesthesiology

2011 Volume 115, Issue 4, Page(s) 879–890

Abstract: Perioperative stroke after noncardiac, nonneurosurgical procedures is more common than generally acknowledged. It is reported to have an incidence of 0.05-7% of patients. Most are thrombotic in origin and are noted after discharge from the postanesthetic ...

Abstract	Perioperative stroke after noncardiac, nonneurosurgical procedures is more common than generally acknowledged. It is reported to have an incidence of 0.05-7% of patients. Most are thrombotic in origin and are noted after discharge from the postanesthetic care unit. Common predisposing factors include age, a previous stroke, atrial fibrillation, and vascular and metabolic diseases. The mortality is more than two times greater than in strokes occurring outside the hospital. Delayed diagnosis and a synergistic interaction between the inflammatory changes normally associated with stroke, and those normally occurring after surgery, may explain this increase. Intraoperative hypotension is an infrequent direct cause of stroke. Hypotension will augment the injury produced by embolism or other causes, and this may be especially important in the postoperative period, during which monitoring is not nearly as attentive as in the operating room. Increased awareness and management of predisposing risk factors with early detection should result in improved outcomes.
MeSH term(s)	Cardiac Surgical Procedures ; Comorbidity ; Humans ; Intraoperative Complications/epidemiology ; Intraoperative Complications/mortality ; Intraoperative Complications/therapy ; Perioperative Period ; Postoperative Complications/epidemiology ; Postoperative Complications/mortality ; Postoperative Complications/therapy ; Risk Assessment ; Risk Management ; Stroke/epidemiology ; Stroke/etiology ; Stroke/mortality ; Stroke/prevention & control ; Surgical Procedures, Operative
Language	English
Publishing date	2011-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0b013e31822e9499
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Article ; Online: Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex.

Lee, Brian R / Dalley, Rachel / Miller, Jeremy A / Chartrand, Thomas / Close, Jennie / Mann, Rusty / Mukora, Alice / Ng, Lindsay / Alfiler, Lauren / Baker, Katherine / Bertagnolli, Darren / Brouner, Krissy / Casper, Tamara / Csajbok, Eva / Donadio, Nicholas / Driessens, Stan L W / Egdorf, Tom / Enstrom, Rachel / Galakhova, Anna A /

Gary, Amanda / Gelfand, Emily / Goldy, Jeff / Hadley, Kristen / Heistek, Tim S / Hill, Dijon / Hou, Wen-Hsien / Johansen, Nelson / Jorstad, Nik / Kim, Lisa / Kocsis, Agnes Katalin / Kruse, Lauren / Kunst, Michael / León, Gabriela / Long, Brian / Mallory, Matthew / Maxwell, Michelle / McGraw, Medea / McMillen, Delissa / Melief, Erica J / Molnar, Gabor / Mortrud, Marty T / Newman, Dakota / Nyhus, Julie / Opitz-Araya, Ximena / Ozsvár, Attila / Pham, Trangthanh / Pom, Alice / Potekhina, Lydia / Rajanbabu, Ram / Ruiz, Augustin / Sunkin, Susan M / Szöts, Ildikó / Taskin, Naz / Thyagarajan, Bargavi / Tieu, Michael / Trinh, Jessica / Vargas, Sara / Vumbaco, David / Waleboer, Femke / Walling-Bell, Sarah / Weed, Natalie / Williams, Grace / Wilson, Julia / Yao, Shenqin / Zhou, Thomas / Barzó, Pál / Bakken, Trygve / Cobbs, Charles / Dee, Nick / Ellenbogen, Richard G / Esposito, Luke / Ferreira, Manuel / Gouwens, Nathan W / Grannan, Benjamin / Gwinn, Ryder P / Hauptman, Jason S / Hodge, Rebecca / Jarsky, Tim / Keene, C Dirk / Ko, Andrew L / Korshoej, Anders Rosendal / Levi, Boaz P / Meier, Kaare / Ojemann, Jeffrey G / Patel, Anoop / Ruzevick, Jacob / Silbergeld, Daniel L / Smith, Kimberly / Sørensen, Jens Christian / Waters, Jack / Zeng, Hongkui / Berg, Jim / Capogna, Marco / Goriounova, Natalia A / Kalmbach, Brian / de Kock, Christiaan P J / Mansvelder, Huib D / Sorensen, Staci A / Tamas, Gabor / Lein, Ed S / Ting, Jonathan T

Science (New York, N.Y.)

2023 Volume 382, Issue 6667, Page(s) eadf6484

Abstract: Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid-producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling plus Patch-seq ( ... ...

Abstract	Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid-producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling plus Patch-seq (patch-clamp electrophysiology plus single-cell RNA sequencing) sampling in human brain slices was used to reliably target and analyze GABAergic neuron subclasses and individual transcriptomic types. This characterization elucidated transitions between PVALB and SST subclasses, revealed morphological heterogeneity within an abundant transcriptomic type, identified multiple spatially distinct types of the primate-specialized double bouquet cells (DBCs), and shed light on cellular differences between homologous mouse and human neocortical GABAergic neuron types. These results highlight the importance of multimodal phenotypic characterization for refinement of emerging transcriptomic cell type taxonomies and for understanding conserved and specialized cellular properties of human brain cell types.
MeSH term(s)	Animals ; Humans ; Mice ; Electrophysiological Phenomena ; GABAergic Neurons/metabolism ; gamma-Aminobutyric Acid/metabolism ; Interneurons/metabolism ; Neocortex/cytology ; Neocortex/metabolism ; Patch-Clamp Techniques
Chemical Substances	gamma-Aminobutyric Acid (56-12-2)
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.adf6484
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Article ; Online: Enterovirus D68-Associated Acute Respiratory Illness ─ New Vaccine Surveillance Network, United States, July-November 2018-2020.

Shah, Melisa M / Perez, Ariana / Lively, Joana Y / Avadhanula, Vasanthi / Boom, Julie A / Chappell, James / Englund, Janet A / Fregoe, Wende / Halasa, Natasha B / Harrison, Christopher J / Hickey, Robert W / Klein, Eileen J / McNeal, Monica M / Michaels, Marian G / Moffatt, Mary E / Otten, Catherine / Sahni, Leila C / Schlaudecker, Elizabeth / Schuster, Jennifer E /

Selvarangan, Rangaraj / Staat, Mary A / Stewart, Laura S / Weinberg, Geoffrey A / Williams, John V / Ng, Terry Fan Fei / Routh, Janell A / Gerber, Susan I / McMorrow, Meredith L / Rha, Brian / Midgley, Claire M

MMWR. Morbidity and mortality weekly report

2021 Volume 70, Issue 47, Page(s) 1623–1628

Abstract: Enterovirus D68 (EV-D68) is associated with a broad spectrum of illnesses, including mild to severe acute respiratory illness (ARI) and acute flaccid myelitis (AFM). Enteroviruses, including EV-D68, are typically detected in the United States during late ...

Abstract	Enterovirus D68 (EV-D68) is associated with a broad spectrum of illnesses, including mild to severe acute respiratory illness (ARI) and acute flaccid myelitis (AFM). Enteroviruses, including EV-D68, are typically detected in the United States during late summer through fall, with year-to-year fluctuations. Before 2014, EV-D68 was infrequently reported to CDC (1). However, numbers of EV-D68 detection have increased in recent years, with a biennial pattern observed during 2014-2018 in the United States, after the expansion of surveillance and wider availability of molecular testing. In 2014, a national outbreak of EV-D68 was detected (2). EV-D68 was also reported in 2016 via local (3) and passive national (4) surveillance. EV-D68 detections were limited in 2017, but substantial circulation was observed in 2018 (5). To assess recent levels of circulation, EV-D68 detections in respiratory specimens collected from patients aged <18 years* with ARI evaluated in emergency departments (EDs) or admitted to one of seven U.S. medical centers
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Disease Outbreaks ; Enterovirus D, Human/genetics ; Enterovirus D, Human/isolation & purification ; Enterovirus Infections/epidemiology ; Enterovirus Infections/virology ; Female ; Humans ; Infant ; Male ; Population Surveillance/methods ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; United States/epidemiology
Language	English
Publishing date	2021-11-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	412775-4
ISSN	1545-861X ; 0149-2195
ISSN (online)	1545-861X
ISSN	0149-2195
DOI	10.15585/mmwr.mm7047a1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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