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Article ; Online: To build a plasma cell.

Allman, David

2021 Volume 303, Issue 1, Page(s) 5–7

MeSH term(s)	Plasma Cells
Language	English
Publishing date	2021-08-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.13017
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Article ; Online: Feasibility of an enhanced low-fidelity ear simulator for otomicroscopy training.

Allman, Megan / Owens, David

The Journal of laryngology and otology

2024 , Page(s) 1–3

Abstract: Objective: Otoscopic skills are essential for ENT doctors. Early-stage doctors develop skills whilst treating patients, with minimal teaching, potentially increasing risk to patients. Simulation allows skill development without patient risk; however, ... ...

Abstract	Objective: Otoscopic skills are essential for ENT doctors. Early-stage doctors develop skills whilst treating patients, with minimal teaching, potentially increasing risk to patients. Simulation allows skill development without patient risk; however, simulation often requires subjective expert review of technique. This study compared enhanced low-fidelity simulation with performance feedback against standard simulation using a basic otoscopy skills simulator. Methods: Two low-fidelity ear simulators were created: a basic model without feedback and an enhanced model which alarms when the aural instrument tip touches the canal wall. Participants were evaluated in a randomised crossover pilot study, using both models to assess whether objective feedback reduced tip touches. Results: The enhanced simulator reduced tip touches more than the control model, suggesting better and more sustained skill uptake. Participants reported that the enhanced model improved learning. Conclusion: Enhanced low-fidelity models provide a low-cost opportunity to improve otoscopy skills without patient risk or the need for subjective expert feedback.
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215123002359
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Article: John David Kuykendall, M.D. 1946-1979.

Allman, R

Radiology

1980 Volume 134, Issue 1, Page(s) 268

MeSH term(s)	History, 20th Century ; Radiology/history ; United States
Language	English
Publishing date	1980-01
Publishing country	United States
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiology.134.1.6985740
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Article ; Online: Biochemical coordination of plasma cell genesis.

Gaudette, Brian T / Allman, David

Immunological reviews

2021 Volume 303, Issue 1, Page(s) 52–61

Abstract: Antibody-secreting plasma cells are a central component of short- and long-term adaptive immunity. Yet, many fundamental questions about how activated B cells decide to yield functional plasma cells have yet to be answered. Likewise, the biochemical ... ...

Abstract	Antibody-secreting plasma cells are a central component of short- and long-term adaptive immunity. Yet, many fundamental questions about how activated B cells decide to yield functional plasma cells have yet to be answered. Likewise, the biochemical processes underpinning the ability of plasma cells to generate and secrete large numbers of antibodies, the capacity of some plasma cell to sustain antibody secretion, presumably without interruption, for decades, and the capacity of long-lived plasma cells to avoid apoptosis despite the high-energy demands associated with sustained robust antibody synthesis and secretion each remain mysterious processes. Our objective here is to review what is currently known about these processes with an emphasis on the earliest phases of plasma cell genesis. Along the way, we will work toward developing a model that ties the biochemistry of plasma cell function and survival. The chief idea imbedded in this model is that progress toward understanding plasma cell survival mechanisms may require increased focus on the unique cell autonomous processes inherent in plasma cell differentiation and function.
MeSH term(s)	Antibody Formation ; Antibody-Producing Cells ; B-Lymphocytes ; Cell Differentiation ; Lymphocyte Activation ; Plasma Cells
Language	English
Publishing date	2021-07-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.12992
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Article ; Online: The Proteasome Inhibitor Bortezomib Induces p53-Dependent Apoptosis in Activated B Cells.

Ochoa, Trini A / Rossi, Amy / Woodle, E Steve / Hildeman, David / Allman, David

Journal of immunology (Baltimore, Md. : 1950)

2023 Volume 212, Issue 1, Page(s) 154–164

Abstract: The proteasome inhibitor bortezomib (BTZ) is proposed to deplete activated B cells and plasma cells. However, a complete picture of the mechanisms underlying BTZ-induced apoptosis in B lineage cells remains to be established. In this study, using a ... ...

Abstract	The proteasome inhibitor bortezomib (BTZ) is proposed to deplete activated B cells and plasma cells. However, a complete picture of the mechanisms underlying BTZ-induced apoptosis in B lineage cells remains to be established. In this study, using a direct in vitro approach, we show that deletion of the tumor suppressor and cell cycle regulator p53 rescues recently activated mouse B cells from BTZ-induced apoptosis. Furthermore, BTZ treatment elevated intracellular p53 levels, and p53 deletion constrained apoptosis, as recently stimulated cells first transitioned from the G1 to S phase of the cell cycle. Moreover, combined inhibition of the p53-associated cell cycle regulators and E3 ligases MDM2 and anaphase-promoting complex/cyclosome induced cell death in postdivision B cells. Our results reveal that efficient cell cycle progression of activated B cells requires proteasome-driven inhibition of p53. Consequently, BTZ-mediated interference of proteostasis unleashes a p53-dependent cell cycle-associated death mechanism in recently activated B cells.
MeSH term(s)	Animals ; Mice ; Bortezomib/pharmacology ; Bortezomib/metabolism ; Proteasome Inhibitors/pharmacology ; Antineoplastic Agents/pharmacology ; Tumor Suppressor Protein p53/metabolism ; Cell Line, Tumor ; Proteasome Endopeptidase Complex/metabolism ; Apoptosis
Chemical Substances	Bortezomib (69G8BD63PP) ; Proteasome Inhibitors ; Antineoplastic Agents ; Tumor Suppressor Protein p53 ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.2300212
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Article ; Online: Bone marrow plasma cells require P2RX4 to sense extracellular ATP.

Ishikawa, Masaki / Hasanali, Zainul S / Zhao, Yongge / Das, Arundhoti / Lavaert, Marieke / Roman, Carly J / Londregan, Jennifer / Allman, David / Bhandoola, Avinash

Nature

2024 Volume 626, Issue 8001, Page(s) 1102–1107

Abstract: Plasma cells produce large quantities of antibodies and so play essential roles in immune ... ...

Abstract	Plasma cells produce large quantities of antibodies and so play essential roles in immune protection
MeSH term(s)	Animals ; Mice ; Adenosine Triphosphate/metabolism ; Autoantibodies/immunology ; Autoimmunity/immunology ; Bone Marrow Cells/cytology ; Bone Marrow Cells/metabolism ; Cell Lineage ; Connexins/genetics ; Connexins/metabolism ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Mutation ; Osteoblasts/metabolism ; Plasma Cells/cytology ; Plasma Cells/immunology ; Plasma Cells/metabolism ; Receptors, Purinergic P2X4/metabolism ; Signal Transduction
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Atf4 protein, mouse ; Autoantibodies ; Connexins ; Ddit3 protein, mouse ; P2rx4 protein, mouse ; pannexin 3 protein, mouse ; Receptors, Purinergic P2X4
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07047-2
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Article ; Online: Editorial overview: B cell shades of diversity and memory.

Khan, Wasif N / Allman, David

Current opinion in immunology

2019 Volume 57, Page(s) iii–vi

MeSH term(s)	Animals ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Differentiation ; Humans ; Immunity, Humoral ; Immunologic Memory ; Lymphocyte Activation
Language	English
Publishing date	2019-05-11
Publishing country	England
Document type	Editorial ; Introductory Journal Article ; Portrait
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2019.04.006
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Article ; Online: Systems map of interventions to improve dietary intake of pre-school aged children: A scoping review.

Chan, Jacqueline / Conroy, Patrick / Phongsavan, Philayrath / Raubenheimer, David / Allman-Farinelli, Margaret

Preventive medicine

2023 Volume 177, Page(s) 107727

Abstract: Implementation and sustaining impact of early childhood nutrition interventions in practice remains a challenge. An understanding of the extent to which determinants across multiple levels of the food system are being addressed may improve success. This ... ...

Abstract	Implementation and sustaining impact of early childhood nutrition interventions in practice remains a challenge. An understanding of the extent to which determinants across multiple levels of the food system are being addressed may improve success. This literature review aimed to synthesise the evidence on interventions targeting dietary intake and eating behaviours in preschool children using a systems approach. Eligible studies included intervention studies targeting the dietary intake of preschool children aged 2-5 years in high income countries, published in English after January 2000. Interventions were categorised to the Determinants of Nutrition and Eating (DONE) framework for children developed and evaluated by experts across multiple fields. The framework maps and ranks 411 factors driving eating behaviours and nutrition and can be used to systematically summarise determinants. DONE ranks each determinant for its perceived research priority. A total of 160 eligible studies were identified. Most interventions targeted interpersonal (n = 101, 63.1%) and individual (n = 85, 53.1%) level determinants, with fewer targeting environmental (n = 55, 34.4%) and policy level (n = 17, 10.6%) determinants. The most frequently addressed determinants were Parental Resources and Risk Factors (n = 85) and Children's Food Knowledge, Skills and Abilities (n = 67). These determinants had a Moderate research priority rating. Home Food Availability and Accessibility at the environmental level is classified as the highest research priority, however, only 15 of 160 interventions addressed this determinant. This review highlights home food availability and accessibility as potential leverage points for future interventions to improve children's dietary intake and eating behaviours.
MeSH term(s)	Child, Preschool ; Humans ; Eating ; Food ; Nutritional Status ; Feeding Behavior ; Parents ; Diet
Language	English
Publishing date	2023-10-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2023.107727
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Article ; Online: What B cell memories are made of.

Tomayko, Mary M / Allman, David

Current opinion in immunology

2019 Volume 57, Page(s) 58–64

Abstract: In many ways, memory B cells represent the ultimate outcome of humoral immunity. Many of these cells express exceptionally high affinity antigen-specific B cell receptors for antigen, and these cells are a critical source of the long-lived plasma cells ... ...

Abstract	In many ways, memory B cells represent the ultimate outcome of humoral immunity. Many of these cells express exceptionally high affinity antigen-specific B cell receptors for antigen, and these cells are a critical source of the long-lived plasma cells that secrete protective serum antibodies to protect against secondary exposure to pathogens and other life-threatening antigens. Evidence is now emerging that not all memory B cells are created via the same cellular pathways and molecular events. Similarly, it is becoming clear that different memory B cells can take on different functions, with some producing IgM rather than IgG antibodies upon reactivation, and others preferentially producing plasma cells rather than additional waves of memory B cells. With this review, we discuss the conceptual ides and early studies surrounding early work on B cell memory, then discuss the many pathways and functional attributes of subpopulations of memory B cells and current approaches to characterize these cells directly.
MeSH term(s)	Animals ; B-Lymphocyte Subsets/immunology ; B-Lymphocytes/immunology ; Cell Differentiation ; Humans ; Immune Tolerance ; Immunity, Humoral ; Immunoglobulin G/metabolism ; Immunoglobulin M/metabolism ; Immunologic Memory ; Lymphocyte Activation ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, B-Cell/metabolism
Chemical Substances	Immunoglobulin G ; Immunoglobulin M ; Receptors, Antigen, B-Cell
Language	English
Publishing date	2019-03-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2019.01.003
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Article ; Online: Novel therapeutic opportunities afforded by plasma cell biology in transplantation.

Agarwal, Divyansh / Allman, David / Naji, Ali

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2020 Volume 20, Issue 8, Page(s) 1984–1991

Abstract: Despite new immunotherapies aimed at B and T cells, plasma cells and their lifelong antibody secretion constitute a major immune barrier to long-term graft survival. In this mini-review, we survey the recent advances that have been made in the biology ... ...

Abstract	Despite new immunotherapies aimed at B and T cells, plasma cells and their lifelong antibody secretion constitute a major immune barrier to long-term graft survival. In this mini-review, we survey the recent advances that have been made in the biology and immunometabolism of long-lived plasma cells, and outline aspects of plasma cell function that can be exploited for clinical benefit in recipients of solid organ transplants. A handful of ongoing studies are already targeting plasma cells to achieve desensitization and reduce the alloantibody burden in individuals posttransplant. In reviewing the recent strides made in our understanding of the molecular basis of plasma cell survival, we will place our discussions in the context of existing preclinical and clinical studies.
MeSH term(s)	Graft Rejection/prevention & control ; Graft Survival ; Humans ; Isoantibodies ; Organ Transplantation ; Plasma Cells ; T-Lymphocytes
Chemical Substances	Isoantibodies
Language	English
Publishing date	2020-02-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.15813
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