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Article ; Online: Adverse effect propensity: A new feature of Gulf War illness predicted by environmental exposures.

Golomb, Beatrice A / Han, Jun Hee

iScience

2023 Volume 26, Issue 8, Page(s) 107363

Abstract: A third of 1990-1 Gulf-deployed personnel developed drug/chemical-induced multisymptom illness, "Gulf War illness" ( ...

Abstract	A third of 1990-1 Gulf-deployed personnel developed drug/chemical-induced multisymptom illness, "Gulf War illness" (
Language	English
Publishing date	2023-07-13
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107363
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Article: Chocolate Consumption and Sex-Interest.

Golomb, Beatrice A / Berg, Brinton K

Cureus

2021 Volume 13, Issue 2, Page(s) e13310

Abstract: Media and popular literature link chocolate and sex-interest in women, but there is little research examining their association. This cross-sectional analysis sought to address this gap by assessing the relation of chocolate-consumption frequency to self- ...

Abstract	Media and popular literature link chocolate and sex-interest in women, but there is little research examining their association. This cross-sectional analysis sought to address this gap by assessing the relation of chocolate-consumption frequency to self-rated interest in sex. Seven-hundred twenty-three (723) Southern California men and women, age >20, completed surveys providing chocolate-consumption frequency (Choc0, x/week) and interest in sex (rated 0-10). Regression (robust standard errors) examined the relationship of chocolate-consumption frequency (Choc0, x/week) to sex-interest, adjusted for potential confounders. Tests for gender and age interactions guided gender- and age-stratified analyses. The mean sex-interest was 7.0±3.0 overall; 5.7±3.1 in women and 7.4±2.8 in men. The reported chocolate frequency was 2.0±2.5x/week overall; 2.5±2.8x/week in women and 1.8±2.4x/week in men. Those who ate chocolate more frequently reported lower interest in sex. Significance was sustained with an adjustment: per-time-per-week chocolate was eaten, β=-0.11(SE=0.050), p=0.02. The gender interaction was significant (p=0.03). The gender-stratified analysis showed the effect was driven by the much stronger relation in women: full model, per time-per-week chocolate consumed, β=-0.26(SE=0.08), p=0.002. Chocolate-consumption frequency was the strongest assessed predictor of sex-interest in women. A relationship was not observed in men, though a trend was present in younger men. Women who ate chocolate more frequently reported less interest in sex, a finding not explained by assessed potential confounders. Popular portrayals in which chocolate is represented as substituting for sex and "satisfying" the need for sex in women represent one possible explanation for these findings.
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.13310
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Article ; Online: Bioenergetic impairment in Gulf War illness assessed via

Golomb, Beatrice Alexandra / Han, Jun Hee / Fung, Alexander / Berg, Brinton Keith / Miller, Bruce J / Hamilton, Gavin

Scientific reports

2024 Volume 14, Issue 1, Page(s) 7418

Abstract: Time for post-exercise phosphocreatine-recovery (PCr-R), deemed a robust index of mitochondrial function in vivo, was previously reported to be elevated (signifying impaired ATP production) in veterans with Gulf War illness (GWI). Here we sought to ... ...

Abstract	Time for post-exercise phosphocreatine-recovery (PCr-R), deemed a robust index of mitochondrial function in vivo, was previously reported to be elevated (signifying impaired ATP production) in veterans with Gulf War illness (GWI). Here we sought to replicate the finding and assess the impact of contravening previous eligibility requirements. The replication sample comprised white males. Cases reported ≥ moderate muscle-weakness to match the organ assessed to an organ affected; controls lacked recent headache or multiple symptoms. The expansion sample added cases without muscle-weakness, controls with recent headache, females, nonwhites. PCr-R, following pedal-depression-exercise, was compared in veterans with GWI versus controls (sample N = 38). In the replication sample, PCr-R results closely matched the prior report: PCr-R veterans with GWI mean(SD) = 47.7(16.5); control mean(SD) = 30.3(9.2), p = 0.017. (Prior-study PCr-R veterans with GWI mean(SD) = 46.1(17.9), control mean(SD) = 29.0(8.7), p = 0.023. Combined replication + prior samples: p = 0.001.) No case-control difference was observed in the expansion sample. In cases, PCr-R related to muscle-weakness: PCr-R = 29.9(7.1), 38.2(8.9), 47.8(15.2) for muscle-weakness rated none/low, intermediate, and high respectively (p for trend = 0.02), validating desirability of matching tissue assessed to tissue affected. In controls, headache/multiple symptoms, sex, and ethnicity each mattered (affecting PCr-R significantly). This study affirms mitochondrial/bioenergetic impairment in veterans with GWI. The importance of careful case/control selection is underscored.
MeSH term(s)	Male ; Female ; Humans ; Persian Gulf Syndrome/diagnosis ; Veterans ; Mitochondria ; Headache ; Paresis ; Energy Metabolism
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57725-4
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Article ; Online: COVID-19-associated rhabdomyolysis: A scoping review.

Preger, Anna / Wei, Rebecca / Berg, Brinton / Golomb, Beatrice A

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2023 Volume 136, Page(s) 115–126

Abstract: Objectives: SARS-CoV-2 infection ("COVID-19") and the hypoxemia that has attended some cases may predispose to rhabdomyolysis. We sought to identify reported cases of COVID-19-associated rhabdomyolysis, examining concurrent risk factors (RFs) and ... ...

Abstract	Objectives: SARS-CoV-2 infection ("COVID-19") and the hypoxemia that has attended some cases may predispose to rhabdomyolysis. We sought to identify reported cases of COVID-19-associated rhabdomyolysis, examining concurrent risk factors (RFs) and mortality outcomes. Methods: We searched PubMed for articles conveying individual-level information on COVID-19-associated rhabdomyolysis, published between January 2020 and July 2022, with an English-language abstract. Two independent parties performed the search, and then abstracted information on cases including rhabdomyolysis RFs and mortality. Results: In total, 117 individual reported cases of COVID-19-associated rhabdomyolysis were identified from 89 articles. A total of 80 cases (68.4%) had at least one reported non-COVID-19 RF (i.e. not considering COVID-19 or hypoxemia). On average, 1.27 additional RFs were reported, including age ≥65, metabolic syndrome features, hypothyroidism, previous rhabdomyolysis, hemoglobinopathy, trauma/compression, pregnancy, exertion, inborn errors of metabolism, concurrent (co-)infection, capillary leak syndrome, and selected rhabdomyolysis-associated medications. Concurrent RFs are understated, as many articles omitted comorbidities/medications. Of 109 cases with ascertainable survival status, 31 (28%) died. Conclusions: COVID-19 and hypoxemia confer risk of rhabdomyolysis, but additional rhabdomyolysis RFs are commonly present. Mortality is substantial irrespective of the presence of such RFs. Clinicians should be aware of COVID-19-associated rhabdomyolysis, and caution may be warranted in administering agents that may amplify rhabdomyolysis risk.
MeSH term(s)	Pregnancy ; Female ; Humans ; COVID-19/complications ; SARS-CoV-2 ; Rhabdomyolysis/epidemiology ; Rhabdomyolysis/etiology ; Hypoxia
Language	English
Publishing date	2023-09-19
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2023.09.002
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Article ; Online: Misinterpretation of trial evidence on statin adverse effects may harm patients.

Golomb, Beatrice A

European journal of preventive cardiology

2015 Volume 22, Issue 4, Page(s) 492–493

MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Comment ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1177/2047487314533085
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Zs.A 4686: Show issues

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Article: Statin Use in Relation to COVID-19 and Other Respiratory Infections: Muscle and Other Considerations.

Golomb, Beatrice A / Han, Jun Hee / Langsjoen, Peter H / Dinkeloo, Eero / Zemljic-Harpf, Alice E

Journal of clinical medicine

2023 Volume 12, Issue 14

Abstract: Statins have been widely advocated for use in COVID-19 based on large favorable observational associations buttressed by theoretical expected benefits. However, past favorable associations of statins to pre-COVID-19 infection outcomes (also buttressed by ...

Abstract	Statins have been widely advocated for use in COVID-19 based on large favorable observational associations buttressed by theoretical expected benefits. However, past favorable associations of statins to pre-COVID-19 infection outcomes (also buttressed by theoretical benefits) were unsupported in meta-analysis of RCTs, RR = 1.00. Initial RCTs in COVID-19 appear to follow this trajectory. Healthy-user/tolerator effects and indication bias may explain these disparities. Moreover, cholesterol drops in proportion to infection severity, so less severely affected individuals may be selected for statin use, contributing to apparent favorable statin associations to outcomes. Cholesterol transports fat-soluble antioxidants and immune-protective vitamins. Statins impair mitochondrial function in those most reliant on coenzyme Q10 (a mevalonate pathway product also transported on cholesterol)-i.e., those with existing mitochondrial compromise, whom data suggest bear increased risks from both COVID-19 and from statins. Thus, statin risks of adverse outcomes are amplified in those patients at risk of poor COVID-19 outcomes-i.e., those in whom adjunctive statin therapy may most likely be given. High reported rates of rhabdomyolysis in hospitalized COVID-19 patients underscore the notion that statin-related risks as well as benefits must be considered. Advocacy for statins in COVID-19 should be suspended pending clear evidence of RCT benefits, with careful attention to risk modifiers.
Language	English
Publishing date	2023-07-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12144659
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Article ; Online: A Standardized, 3-Tiered, Seizure Burden-Based Protocol for the Treatment of Neonatal Seizures.

Moeller, Ashley A / Stefanescu, Andrei R / Stefanescu, Beatrice M / Golomb, Meredith R / Boyle, Frances A / Buss, William F / Rose, Rebecca S / Wing, Sarah E

Journal of child neurology

2023 Volume 38, Issue 3-4, Page(s) 142–152

Abstract: Objective: To evaluate use of a standardized, 3-tiered, seizure burden-based protocol for treatment of all electroencephalography (EEG)-confirmed seizures in a level IV neonatal intensive care unit (NICU).: Study design: All infants admitted to the ... ...

Abstract	Objective: To evaluate use of a standardized, 3-tiered, seizure burden-based protocol for treatment of all electroencephalography (EEG)-confirmed seizures in a level IV neonatal intensive care unit (NICU). Study design: All infants admitted to the NICU with EEG-confirmed seizures over a 25-month period were enrolled in the study. We compared short-term outcomes before and after implementation of a standardized, 3-tiered protocol. Results: A total of 107 infants were enrolled in the study. Use of midazolam infusions was reduced by 53.7% ( Conclusion: Implementation of a standardized, 3-tiered protocol for treatment of neonatal seizures improved short-term outcomes. Although not measured directly, reductions in EEG duration and midazolam use are promising indicators of overall seizure burden. More research is needed to evaluate impact on long-term neurodevelopmental outcomes.
MeSH term(s)	Infant ; Infant, Newborn ; Humans ; Midazolam/therapeutic use ; Seizures/drug therapy ; Epilepsy ; Infant, Newborn, Diseases ; Electroencephalography
Chemical Substances	Midazolam (R60L0SM5BC)
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	639288-x
ISSN	1708-8283 ; 0883-0738
ISSN (online)	1708-8283
ISSN	0883-0738
DOI	10.1177/08830738231164704
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Zs.A 2301: Show issues

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Article ; Online: Radiation Exposure Predicts Reported Vaccine Adverse Effects in Veterans with Gulf War Illness.

Golomb, Beatrice A / Nguyen, Emily / Dinkeloo, Eero

International journal of environmental research and public health

2020 Volume 17, Issue 19

Abstract: Most people have no problems when administered vaccines; however, as with all drugs, reported adverse effects (rAEs) do occur. There is a need to better understand the potential predictors of reported vaccine AEs (rVaxAEs), including modifiable ( ... ...

Abstract	Most people have no problems when administered vaccines; however, as with all drugs, reported adverse effects (rAEs) do occur. There is a need to better understand the potential predictors of reported vaccine AEs (rVaxAEs), including modifiable (environmental) predictors. Gulf War Veterans (GWV) who have Gulf War illness (GWI) report increased experiences of drug and chemical rAEs, extending to rVaxAEs. GWV provide an opportunity to examine the relationship between their reported exposures and rAEs. Forty one GWV with GWI and 40 healthy controls reported exposure and rAEs to exposure, including for 14 vaccines. Individual and summed vaccine exposures, rVaxAEs, and reported Vaccine AE Propensity (summed rVaxAEs/summed vaccines exposures) were compared in cases vs. controls. Exposure-outcome assessments focused on GWV, using a multivariable regression with robust standard error. More designated vaccines were reported in cases than in controls: 9.0 (2.3) vs. 3.8 (2.3),
MeSH term(s)	Case-Control Studies ; Drug-Related Side Effects and Adverse Reactions ; Gulf War ; Humans ; Male ; Middle Aged ; Persian Gulf Syndrome ; Pesticides ; Radiation Exposure/adverse effects ; Vaccines/adverse effects ; Veterans
Chemical Substances	Pesticides ; Vaccines
Language	English
Publishing date	2020-09-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17197136
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Article ; Online: Too sweet to be real?-Reply.

Golomb, Beatrice A

Archives of internal medicine

2012 Volume 172, Issue 16, Page(s) 1270

Language	English
Publishing date	2012-09-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	211575-x
ISSN	1538-3679 ; 0003-9926 ; 0888-2479 ; 0730-188X
ISSN (online)	1538-3679
ISSN	0003-9926 ; 0888-2479 ; 0730-188X
DOI	10.1001/archinternmed.2012.3388
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Article ; Online: Susceptibility to radiation adverse effects in veterans with Gulf War illness and healthy civilians.

Golomb, Beatrice Alexandra / Berg, Brinton Keith / Han, Jun Hee

Scientific reports

2024 Volume 14, Issue 1, Page(s) 874

Abstract: We evaluated whether veterans with Gulf War illness (VGWI) report greater ionizing radiation adverse effects (RadAEs) than controls; whether radiation-sensitivity is tied to reported chemical-sensitivity; and whether environmental exposures are apparent ... ...

Abstract	We evaluated whether veterans with Gulf War illness (VGWI) report greater ionizing radiation adverse effects (RadAEs) than controls; whether radiation-sensitivity is tied to reported chemical-sensitivity; and whether environmental exposures are apparent risk factors for reported RadAEs (rRadAEs). 81 participants (41 VGWI, 40 controls) rated exposure to, and rRadAEs from, four radiation types. The relations of RadAE-propensity (defined as the ratio of rRadAEs to summed radiation exposures) to Gulf War illness (GWI) presence and severity, and to reported chemical-sensitivity were assessed. Ordinal logistic regression evaluated exposure prediction of RadAE-propensity in the full sample, in VGWI, and stratified by age and chemical-sensitivity. RadAE-propensity was increased in VGWI (vs. controls) and related to GWI severity (p < 0.01) and chemical-sensitivity (p < 0.01). Past carbon monoxide (CO) exposure emerged as a strong, robust predictor of RadAE-propensity on univariable and multivariable analyses (p < 0.001 on multivariable assessment, without and with adjustment for VGWI case status), retaining significance in age-stratified and chemical-sensitivity-stratified replication analyses. Thus, RadAE-propensity, a newly-described GWI-feature, relates to chemical-sensitivity, and is predicted by CO exposure-both features reported for nonionizing radiation sensitivity, consistent with shared mitochondrial/oxidative toxicity across radiation frequencies. Greater RadAE vulnerability fits an emerging picture of heightened drug/chemical susceptibility in VGWI.
MeSH term(s)	Humans ; Persian Gulf Syndrome/epidemiology ; Persian Gulf Syndrome/etiology ; Veterans ; Radiation Exposure ; Radiation Tolerance ; Carbon Monoxide ; Drug-Related Side Effects and Adverse Reactions
Chemical Substances	Carbon Monoxide (7U1EE4V452)
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50083-7
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