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  1. Article ; Online: Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

    Vaddi, Damodara Reddy / Piao, Lin / Khan, Shakil A / Wang, Ning / Prabhakar, Nanduri R / Nanduri, Jayasri

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0297301

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0215905.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0215905.].
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Transcriptomic Analysis of Postnatal Rat Carotid Body Development.

    Wang, Ning / Peng, Ying-Jie / Kang, Wenjun / Hildreth, Matthew / Prabhakar, Nanduri R / Nanduri, Jayasri

    Genes

    2024  Volume 15, Issue 3

    Abstract: The carotid body (CB), located bilaterally at the carotid artery bifurcations, is the primary sensory organ for monitoring arterial blood ... ...

    Abstract The carotid body (CB), located bilaterally at the carotid artery bifurcations, is the primary sensory organ for monitoring arterial blood O
    MeSH term(s) Rats ; Animals ; Carotid Body/metabolism ; Rats, Sprague-Dawley ; Gene Expression Profiling ; Hypoxia/metabolism ; Transcription Factors/metabolism
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes15030302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Carotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea.

    Prabhakar, Nanduri R / Peng, Ying-Jie / Nanduri, Jayasri

    The Journal of physiology

    2023  Volume 601, Issue 24, Page(s) 5481–5494

    Abstract: Carotid bodies are the principal sensory organs for detecting changes in arterial blood oxygen concentration, and the carotid body chemoreflex is a major regulator of the sympathetic tone, blood pressure and breathing. Intermittent hypoxia is a hallmark ... ...

    Abstract Carotid bodies are the principal sensory organs for detecting changes in arterial blood oxygen concentration, and the carotid body chemoreflex is a major regulator of the sympathetic tone, blood pressure and breathing. Intermittent hypoxia is a hallmark manifestation of obstructive sleep apnoea (OSA), which is a widespread respiratory disorder. In the first part of this review, we discuss the role of carotid bodies in heightened sympathetic tone and hypertension in rodents treated with intermittent hypoxia, and the underlying cellular, molecular and epigenetic mechanisms. We also present evidence for hitherto-uncharacterized role of carotid body afferents in triggering cellular and molecular changes induced by intermittent hypoxia. In the second part of the review, we present evidence for a contribution of a hypersensitive carotid body to OSA and potential therapeutic intervention to mitigate OSA in a murine model.
    MeSH term(s) Animals ; Mice ; Carotid Body/physiology ; Hypoxia ; Sleep Apnea Syndromes ; Hypertension ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284111
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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Editorial: Vascular pathophysiology in hypoxia.

    Das, Kusal K / Majid, Dewan S A / Prabhakar, Nanduri R

    Frontiers in physiology

    2023  Volume 14, Page(s) 1235383

    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1235383
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  5. Book: Translational research in environmental and occupational stress

    Singh, Shashi Bala / Prabhakar, Nanduri R. / Pentyala, Srinivas N.

    2014  

    Author's details Shashi Bala Singh ; Nanduri R. Prabhakar ; Srinivas N. Pentyala
    Keywords Science/Research ; Discoveries in science
    Subject code 001.4
    Language English
    Size XIV, 274 S. : Ill., graph. Darst., 26 cm
    Publisher Springer
    Publishing place New Delhi u.a.
    Publishing country India
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018436384
    ISBN 978-81-322-1927-9 ; 9788132219286 ; 81-322-1927-9 ; 8132219287
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2014 A 4037 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Gasotransmitter modulation of hypoglossal motoneuron activity.

    Browe, Brigitte M / Peng, Ying-Jie / Nanduri, Jayasri / Prabhakar, Nanduri R / Garcia, Alfredo J

    eLife

    2023  Volume 12

    Abstract: Obstructive sleep apnea (OSA) is characterized by sporadic collapse of the upper airway leading to periodic disruptions in breathing. Upper airway patency is governed by genioglossal nerve activity that originates from the hypoglossal motor nucleus. Mice ...

    Abstract Obstructive sleep apnea (OSA) is characterized by sporadic collapse of the upper airway leading to periodic disruptions in breathing. Upper airway patency is governed by genioglossal nerve activity that originates from the hypoglossal motor nucleus. Mice with targeted deletion of the gene
    MeSH term(s) Mice ; Animals ; Gasotransmitters ; Motor Neurons/physiology ; Respiration ; Medulla Oblongata/physiology ; Sleep Apnea, Obstructive ; Hypoglossal Nerve/physiology
    Chemical Substances Gasotransmitters
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.81978
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  7. Article ; Online: Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia.

    Wang, Ning / Prabhakar, Nanduri R / Nanduri, Jayasri

    American journal of physiology. Cell physiology

    2022  Volume 323, Issue 2, Page(s) C423–C431

    Abstract: We recently reported pheochromocytoma 12 (PC12) cells and rats subjected to intermittent hypoxia (IH), a hallmark manifestation of obstructive sleep apnea (OSA), exhibit reduced histone deacetylase activity and HDAC5 protein. Our study further suggested ... ...

    Abstract We recently reported pheochromocytoma 12 (PC12) cells and rats subjected to intermittent hypoxia (IH), a hallmark manifestation of obstructive sleep apnea (OSA), exhibit reduced histone deacetylase activity and HDAC5 protein. Our study further suggested that posttranslational modifications rather than transcriptional mechanism(s) mediate IH-induced HDAC5 degradation. These observations prompted our current study to investigate the mechanism(s) underlying HDAC5 degradation by IH in PC12 cell cultures. IH-induced HDAC5 degradation was blocked by an antioxidant, and reactive oxygen species (ROS) mimetics decreased HDAC5 protein, suggesting that ROS mediates HDAC5 degradation by IH. NADPH oxidases (NOX) 2 and 4 were identified as sources of ROS that mediate the effects of IH. HDAC5 degradation during IH was associated with dephosphorylation of HDAC5 at serine
    MeSH term(s) Animals ; Cell Hypoxia ; Histone Deacetylases/genetics ; Histone Deacetylases/metabolism ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Protein Phosphatase 1/metabolism ; Rats ; Reactive Oxygen Species/metabolism
    Chemical Substances Hypoxia-Inducible Factor 1, alpha Subunit ; Reactive Oxygen Species ; Protein Phosphatase 1 (EC 3.1.3.16) ; Hdac5 protein, rat (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00057.2022
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
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  8. Article: Adaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia.

    Prabhakar, Nanduri R / Peng, Ying-Jie / Nanduri, Jayasri

    Handbook of clinical neurology

    2022  Volume 188, Page(s) 103–123

    Abstract: This chapter reviews cardiorespiratory adaptations to chronic hypoxia (CH) experienced at high altitude and cardiorespiratory pathologies elicited by chronic intermittent hypoxia (CIH) occurring with obstructive sleep apnea (OSA). Short-term CH increases ...

    Abstract This chapter reviews cardiorespiratory adaptations to chronic hypoxia (CH) experienced at high altitude and cardiorespiratory pathologies elicited by chronic intermittent hypoxia (CIH) occurring with obstructive sleep apnea (OSA). Short-term CH increases breathing (ventilatory acclimatization to hypoxia) and blood pressure (BP) through carotid body (CB) chemo reflex. Hyperplasia of glomus cells, alterations in ion channels, and recruitment of additional excitatory molecules are implicated in the heightened CB chemo reflex by CH. Transcriptional activation of hypoxia-inducible factors (HIF-1 and 2) is a major molecular mechanism underlying respiratory adaptations to short-term CH. High-altitude natives experiencing long-term CH exhibit blunted hypoxic ventilatory response (HVR) and reduced BP due to desensitization of CB response to hypoxia and impaired processing of CB sensory information at the central nervous system. Ventilatory changes evoked by long-term CH are not readily reversed after return to sea level. OSA patients and rodents subjected to CIH exhibit heightened CB chemo reflex, increased hypoxic ventilatory response, and hypertension. Increased generation of reactive oxygen species (ROS) is a major cellular mechanism underlying CIH-induced enhanced CB chemo reflex and the ensuing cardiorespiratory pathologies. ROS generation by CIH is mediated by nontranscriptional, disrupted HIF-1 and HIF-2-dependent transcriptions as well as epigenetic mechanisms.
    MeSH term(s) Humans ; Hypoxia ; Reactive Oxygen Species ; Reflex ; Respiration ; Sleep Apnea, Obstructive
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2022-08-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 0072-9752
    ISSN 0072-9752
    DOI 10.1016/B978-0-323-91534-2.00009-6
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  9. Article ; Online: Correction

    Damodara Reddy Vaddi / Lin Piao / Shakil A Khan / Ning Wang / Nanduri R Prabhakar / Jayasri Nanduri

    PLoS ONE, Vol 19, Iss 1, p e

    Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

    2024  Volume 0297301

    Abstract: This corrects the article DOI:10.1371/journal.pone.0215905.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0215905.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: 2019 Nobel Prize in Physiology or Medicine.

    Prabhakar, Nanduri R

    Physiology (Bethesda, Md.)

    2020  Volume 35, Issue 2, Page(s) 81–83

    MeSH term(s) History, 21st Century ; Humans ; Hypoxia/genetics ; Hypoxia/metabolism ; Hypoxia/pathology ; Hypoxia-Inducible Factor 1/metabolism ; Medicine ; Nobel Prize ; Physiology/history ; Vascular Endothelial Growth Factor A/metabolism ; Von Hippel-Lindau Tumor Suppressor Protein/genetics ; Von Hippel-Lindau Tumor Suppressor Protein/metabolism
    Chemical Substances Hypoxia-Inducible Factor 1 ; Vascular Endothelial Growth Factor A ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27)
    Language English
    Publishing date 2020-02-02
    Publishing country United States
    Document type Editorial ; Historical Article
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00001.2020
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