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Article: Spontaneous signal generation by an excitable system for cell migration.

Matsuoka, Satomi / Iwamoto, Koji / Shin, Da Young / Ueda, Masahiro

Frontiers in cell and developmental biology

2024 Volume 12, Page(s) 1373609

Abstract: Eukaryotic cells exhibit random migration in the absence of extracellular directional cues. This random migration acts as basal motility for various migratory responses such as chemotaxis. The self-organization of random motility requires the internal ... ...

Abstract	Eukaryotic cells exhibit random migration in the absence of extracellular directional cues. This random migration acts as basal motility for various migratory responses such as chemotaxis. The self-organization of random motility requires the internal signals that determine the anterior side of the migrating cell be generated spontaneously from the intrinsic activities of intracellular signaling networks. Recent studies have identified an excitable system as the mechanism of the spontaneous signal generation. Here, we discuss how the excitable system of Ras, a small G protein, regulates signaling networks in
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2024.1373609
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regression of kaposiform lymphangiomatosis and chronic disseminated intravascular coagulation after inhaled budesonide-formoterol treatment.

Imamura, Masaru / Shin, Chansu / Ozeki, Michio / Matsuoka, Kentaro / Saitoh, Akihiko / Imai, Chihaya

Pediatric blood & cancer

2024 Volume 71, Issue 4, Page(s) e30907

MeSH term(s)	Humans ; Disseminated Intravascular Coagulation/drug therapy ; Bronchodilator Agents/therapeutic use ; Budesonide ; Formoterol Fumarate ; Administration, Inhalation ; Double-Blind Method
Chemical Substances	Bronchodilator Agents ; Budesonide (51333-22-3) ; Formoterol Fumarate (W34SHF8J2K)
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Letter
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30907
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Zs.A 1131: Show issues

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Book ; Online: Polymer Micelles

Yusa, Shin-ichi / Bahadur, Pratap / Matsuoka, Hideki / Sato, Takahiro

2018

Abstract: Classically, polymer micelles have been defined as aggregates formed by the self-association of amphiphilic polymers due to the hydrophobic interactions between polymer molecules in water. Practical applications of polymer micelles include as carriers in ...

Abstract	Classically, polymer micelles have been defined as aggregates formed by the self-association of amphiphilic polymers due to the hydrophobic interactions between polymer molecules in water. Practical applications of polymer micelles include as carriers in drug delivery systems, as solubilizers, and as associative thickeners. Polymer micelles that do not fall within the classical definition have recently been reported and reflect important developments in synthesis and analysis. For example, hydrophobic interactions are the classic force driving polymer association, whereas recently, micelles have been formed through interactions such as electrostatics, hydrogen bonds, and coordination bonds. Intermolecular association results in the formation of polymer micelles that are similar to micelles formed from low molecular weight surfactants, whereas unimolecular micelles formed by intramolecular association within a single polymer chain have also been reported, as have stimuli-responsive polymer micelles. It is therefore important to constantly update the information available and our knowledge of polymer micelles. This special issue covers synthesis, characterization, solution properties, association behavior, simulation, and the application of polymer micelles and polymer aggregates. The aim of this issue is to expand our knowledge of polymer micelles by gathering together the latest basic and applied information regarding these supramolecular structures
Keywords	Biochemistry
Size	1 electronic resource (VIII, 220 p.)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020098305
ISBN	9783038428077 ; 9783038428084 ; 3038428078 ; 3038428086
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The Effect of Block Ratio and Structure on the Thermosensitivity of Double and Triple Betaine Block Copolymers.

Lim, Jongmin / Matsuoka, Hideki / Kinoshita, Yusuke / Yusa, Shin-Ichi / Saruwatari, Yoshiyuki

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 2

Abstract: AB-type and BAB-type betaine block copolymers composed of a carboxybetaine methacrylate and a sulfobetaine methacrylate, PGLBT- ...

Abstract	AB-type and BAB-type betaine block copolymers composed of a carboxybetaine methacrylate and a sulfobetaine methacrylate, PGLBT-
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29020390
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Zs.MO 81: Show issues

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Article ; Online: Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals.

Okamoto, Chisato / Tsukamoto, Osamu / Hasegawa, Takuya / Matsuoka, Ken / Amaki, Makoto / Kanzaki, Hideaki / Izumi, Chisato / Takashima, Seiji / Ito, Shin / Kitakaze, Masafumi

JACC. Asia

2024 Volume 4, Issue 1, Page(s) 87–88

Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ISSN	2772-3747
ISSN (online)	2772-3747
DOI	10.1016/j.jacasi.2023.10.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Eagle jugular syndrome accompanied by de novo brainstem cavernous malformation: a case-based systematic review.

Motoyama, Yasushi / Sasaki, Hiromitsu / Nakajima, Tsukasa / Hayami, Hiromichi / Matsuoka, Ryuta / Fukutome, Kenji / Tei, Rinsei / Shin, Yasushi / Aketa, Shuta

Acta neurochirurgica

2024 Volume 166, Issue 1, Page(s) 20

Abstract: Background: Eagle jugular syndrome (EJS), recently identified as a cause of cerebrovascular disease (CVD) due to venous obstruction by an elongated styloid process (SP), is reported here alongside a case of concurrent de novo cerebral cavernous ... ...

Abstract	Background: Eagle jugular syndrome (EJS), recently identified as a cause of cerebrovascular disease (CVD) due to venous obstruction by an elongated styloid process (SP), is reported here alongside a case of concurrent de novo cerebral cavernous malformation (CCM). This study aims to explore the potential causal relationship between EJS and de novo CCM through a comprehensive literature review. Method: Systematic literature reviews, spanning from 1995 to 2023, focused on EJS cases with definitive signs and symptoms and de novo CCM cases with detailed clinical characteristics. Data on the pathophysiology and clinical manifestations of EJS, as well as potential risk factors preceding de novo CCM, were collected to assess the relationship between the two conditions. Result: Among 14 patients from 11 articles on EJS, the most common presentation was increased intracranial hypertension (IIH), observed in 10 patients (71.4%), followed by dural sinus thrombosis in four patients (28.6%). In contrast, 30 patients from 28 articles were identified with de novo CCM, involving 37 lesions. In these cases, 13 patients developed CCM subsequent to developmental venous anomalies (43%), seven following dural arteriovenous fistula (dAVF) (23%), and two after sinus thrombosis (6%). In a specific case of de novo brainstem CCM, the development of an enlarged condylar emissary vein, indicative of venous congestion due to IJV compression by the elongated SP, was noted before the emergence of CCM. Conclusion: This study underscores that venous congestion, a primary result of symptomatic EJS, might lead to the development of de novo CCM. Thus, EJS could potentially be an indicator of CCM development. Further epidemiological and pathophysiological investigations focusing on venous circulation are necessary to clarify the causal relationship between EJS and CCM.
MeSH term(s)	Humans ; Brain Stem/diagnostic imaging ; Hyperemia/epidemiology ; Ossification, Heterotopic/epidemiology ; Sinus Thrombosis, Intracranial/epidemiology ; Temporal Bone/abnormalities
Language	English
Publishing date	2024-01-17
Publishing country	Austria
Document type	Case Reports ; Journal Article ; Systematic Review
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-05900-x
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Uk I Zs.180: Show issues

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Article ; Online: Sphingomyelin metabolism underlies Ras excitability for efficient cell migration and chemotaxis.

Shin, Da Young / Takagi, Hiroaki / Hiroshima, Michio / Matsuoka, Satomi / Ueda, Masahiro

Cell structure and function

2023 Volume 48, Issue 2, Page(s) 145–160

Abstract: In eukaryotic motile cells, the active Ras (Ras-GTP)-enriched domain is generated in an asymmetric manner on the cell membrane through the excitable dynamics of an intracellular signaling network. This asymmetric Ras signaling regulates pseudopod ... ...

Abstract	In eukaryotic motile cells, the active Ras (Ras-GTP)-enriched domain is generated in an asymmetric manner on the cell membrane through the excitable dynamics of an intracellular signaling network. This asymmetric Ras signaling regulates pseudopod formation for both spontaneous random migration and chemoattractant-induced directional migration. While membrane lipids, such as sphingomyelin and phosphatidylserine, contribute to Ras signaling in various cell types, whether they are involved in the Ras excitability for cell motility is unknown. Here we report that functional Ras excitability requires the normal metabolism of sphingomyelin for efficient cell motility and chemotaxis. The pharmacological blockade of sphingomyelin metabolism by an acid-sphingomyelinase inhibitor, fendiline, and other inhibitors suppressed the excitable generation of the stable Ras-GTP-enriched domain. The suppressed excitability failed to invoke enough basal motility to achieve directed migration under shallow chemoattractant gradients. The fendiline-induced defects in Ras excitability, motility and stimulation-elicited directionality were due to an accumulation of sphingomyelin on the membrane, which could be recovered by exogenous sphingomyelinase or phosphatidylserine without changing the expression of Ras. These results indicate a novel regulatory mechanism of the excitable system by membrane lipids, in which sphingomyelin metabolism provides a membrane environment to ensure Ras excitation for efficient cellular motility and chemotaxis.Key words: cell polarity, cell migration, Ras, excitability, sphingomyelin.
MeSH term(s)	Chemotaxis/physiology ; Sphingomyelins ; Sphingomyelin Phosphodiesterase/metabolism ; Phosphatidylserines ; Fendiline ; Cell Movement ; Chemotactic Factors ; Guanosine Triphosphate
Chemical Substances	Sphingomyelins ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12) ; Phosphatidylserines ; Fendiline (S253D559A8) ; Chemotactic Factors ; Guanosine Triphosphate (86-01-1)
Language	English
Publishing date	2023-07-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	197293-5
ISSN	1347-3700 ; 0386-7196
ISSN (online)	1347-3700
ISSN	0386-7196
DOI	10.1247/csf.23045
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Zs.A 1294: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: Recognition of Uni-Stroke Characters with Hand Movements in 3D Space Using Convolutional Neural Networks.

Chang, Won-Du / Matsuoka, Akitaka / Kim, Kyeong-Taek / Shin, Jungpil

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 16

Abstract: Hand gestures are a common means of communication in daily life, and many attempts have been made to recognize them automatically. Developing systems and algorithms to recognize hand gestures is expected to enhance the experience of human-computer ... ...

Abstract	Hand gestures are a common means of communication in daily life, and many attempts have been made to recognize them automatically. Developing systems and algorithms to recognize hand gestures is expected to enhance the experience of human-computer interfaces, especially when there are difficulties in communicating vocally. A popular system for recognizing hand gestures is the air-writing method, where people write letters in the air by hand. The arm movements are tracked with a smartwatch/band with embedded acceleration and gyro sensors; a computer system then recognizes the written letters. One of the greatest difficulties in developing algorithms for air writing is the diversity of human hand/arm movements, which makes it difficult to build signal templates for air-written characters or network models. This paper proposes a method for recognizing air-written characters using an artificial neural network. We utilized uni-stroke-designed characters and presented a network model with inception modules and an ensemble structure. The proposed method was successfully evaluated using the data of air-written characters (Arabic numbers and English alphabets) from 18 people with 91.06% accuracy, which reduced the error rate of recent studies by approximately half.
MeSH term(s)	Algorithms ; Gestures ; Hand ; Humans ; Neural Networks, Computer ; Pattern Recognition, Automated/methods ; Stroke
Language	English
Publishing date	2022-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22166113
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inspiratory and expiratory CT analyses of the diaphragmatic crus in chronic obstructive pulmonary disease.

Wada, Shinji / Matsuoka, Shin / Mimura, Hidefumi

Japanese journal of radiology

2022 Volume 40, Issue 12, Page(s) 1257–1262

Abstract: Purpose: This study aimed to investigate the association between the results of pulmonary function tests (PFTs) in patients with chronic obstructive pulmonary disease (COPD) and the size of their diaphragmatic crus (DC) using inspiratory and expiratory ... ...

Abstract	Purpose: This study aimed to investigate the association between the results of pulmonary function tests (PFTs) in patients with chronic obstructive pulmonary disease (COPD) and the size of their diaphragmatic crus (DC) using inspiratory and expiratory CT. Materials and methods: Thirty-three patients who underwent inspiratory and expiratory CT and PFTs between July and December 2019 were studied retrospectively. The short axis, long axis, and cross-sectional area (CSA) of the bilateral DC were measured, and the percentage change of the DC after expiration (% change of DC) in the size was calculated. The correlation between the results of the PFTs (forced expiratory volume in 1 s [FEV Results: Significant correlations were observed between the short axis of the right and left DC at expiration and PFTs (FEV Conclusion: There were significant correlations between airflow limitation and the short axis of the bilateral DC at expiration, and the % change in the DC of the CSA. Certain CT measurements of the DC may reflect airflow limitation in patients with COPD.
MeSH term(s)	Humans ; Retrospective Studies ; Pulmonary Disease, Chronic Obstructive/diagnostic imaging ; Respiratory Function Tests ; Tomography, X-Ray Computed/methods ; Lung ; Forced Expiratory Volume ; Vital Capacity
Language	English
Publishing date	2022-07-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-022-01314-w
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Zs.A 2249: Show issues

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Article ; Online: American Sign Language Alphabet Recognition by Extracting Feature from Hand Pose Estimation.

Shin, Jungpil / Matsuoka, Akitaka / Hasan, Md Al Mehedi / Srizon, Azmain Yakin

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 17

Abstract: Sign language is designed to assist the deaf and hard of hearing community to convey messages and connect with society. Sign language recognition has been an important domain of research for a long time. Previously, sensor-based approaches have obtained ... ...

Abstract	Sign language is designed to assist the deaf and hard of hearing community to convey messages and connect with society. Sign language recognition has been an important domain of research for a long time. Previously, sensor-based approaches have obtained higher accuracy than vision-based approaches. Due to the cost-effectiveness of vision-based approaches, researchers have been conducted here also despite the accuracy drop. The purpose of this research is to recognize American sign characters using hand images obtained from a web camera. In this work, the media-pipe hands algorithm was used for estimating hand joints from RGB images of hands obtained from a web camera and two types of features were generated from the estimated coordinates of the joints obtained for classification: one is the distances between the joint points and the other one is the angles between vectors and 3D axes. The classifiers utilized to classify the characters were support vector machine (SVM) and light gradient boosting machine (GBM). Three character datasets were used for recognition: the ASL Alphabet dataset, the Massey dataset, and the finger spelling A dataset. The results obtained were 99.39% for the Massey dataset, 87.60% for the ASL Alphabet dataset, and 98.45% for Finger Spelling A dataset. The proposed design for automatic American sign language recognition is cost-effective, computationally inexpensive, does not require any special sensors or devices, and has outperformed previous studies.
MeSH term(s)	Algorithms ; Fingers ; Hand ; Humans ; Recognition, Psychology ; Sign Language ; United States
Language	English
Publishing date	2021-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21175856
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