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Article ; Online: Child Maltreatment and Vulnerable Narcissism: The Roles of Shame and Disavowed Need.

Van Buren, Brian R / Meehan, Kevin B

Journal of the American Psychoanalytic Association

2015 Volume 63, Issue 3, Page(s) 555–561

MeSH term(s)	Adaptation, Psychological ; Adolescent ; Adult ; Adult Survivors of Child Abuse/psychology ; Guilt ; Humans ; Narcissism ; Psychoanalytic Theory ; Shame ; Young Adult
Language	English
Publishing date	2015-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	219420-x
ISSN	1941-2460 ; 0003-0651
ISSN (online)	1941-2460
ISSN	0003-0651
DOI	10.1177/0003065115593058
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Article ; Online: Peritraumatic Tonic Immobility and Trauma-Related Symptoms in Adult Survivors of Childhood Sexual Abuse: The Role of Posttrauma Cognitions.

Van Buren, Brian R / Weierich, Mariann R

Journal of child sexual abuse

2015 Volume 24, Issue 8, Page(s) 959–974

Abstract: Tonic immobility is a set of involuntary motor responses elicited under conditions of extreme fear and perceived inescapability, and it is one type of peritraumatic distress reported by survivors of child sexual abuse. Experiencing tonic immobility ... ...

Abstract	Tonic immobility is a set of involuntary motor responses elicited under conditions of extreme fear and perceived inescapability, and it is one type of peritraumatic distress reported by survivors of child sexual abuse. Experiencing tonic immobility during child sexual abuse is associated with increased risk for developing symptoms of post-traumatic stress disorder, although less is known about relations between tonic immobility and other established risk factors for post-traumatic stress disorder. We investigated posttraumatic cognitions as a potential mediator of the relations between peritraumatic fear, perceptions of inescapability, tonic immobility, and post-traumatic stress disorder symptoms. Specifically, we tested posttraumatic negative beliefs about the self, the world, and self-blame as pathways that might increase risk for post-traumatic stress disorder symptoms in child sexual abuse survivors who had experienced tonic immobility. Forty-six women with a history of unwanted childhood sexual contact completed questionnaires measuring peritraumatic tonic immobility, posttraumatic cognitions, and current posttraumatic stress symptoms. Negative beliefs about the self independently mediated the relation between peritraumatic perceptions of inescapability and post-traumatic stress disorder symptoms, but the data did not support similar path model for the physical symptoms of tonic immobility and post-traumatic stress disorder. We discuss ways in which treatment of survivors and future research on CSA can benefit from attention to the impact of peritraumatic distress on posttraumatic beliefs.
MeSH term(s)	Adult ; Adult Survivors of Child Abuse/psychology ; Cognition ; Exposure to Violence/psychology ; Fear/psychology ; Female ; Humans ; Immobility Response, Tonic ; Male ; Self Concept ; Self Disclosure ; Stress Disorders, Post-Traumatic/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1158969-3
ISSN	1547-0679 ; 1053-8712
ISSN (online)	1547-0679
ISSN	1053-8712
DOI	10.1080/10538712.2015.1082003
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Article: A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies.

Li, Xihao / Chen, Han / Selvaraj, Margaret Sunitha / Van Buren, Eric / Zhou, Hufeng / Wang, Yuxuan / Sun, Ryan / McCaw, Zachary R / Yu, Zhi / Arnett, Donna K / Bis, Joshua C / Blangero, John / Boerwinkle, Eric / Bowden, Donald W / Brody, Jennifer A / Cade, Brian E / Carson, April P / Carlson, Jenna C / Chami, Nathalie /

Chen, Yii-Der Ida / Curran, Joanne E / de Vries, Paul S / Fornage, Myriam / Franceschini, Nora / Freedman, Barry I / Gu, Charles / Heard-Costa, Nancy L / He, Jiang / Hou, Lifang / Hung, Yi-Jen / Irvin, Marguerite R / Kaplan, Robert C / Kardia, Sharon L R / Kelly, Tanika / Konigsberg, Iain / Kooperberg, Charles / Kral, Brian G / Li, Changwei / Loos, Ruth J F / Mahaney, Michael C / Martin, Lisa W / Mathias, Rasika A / Minster, Ryan L / Mitchell, Braxton D / Montasser, May E / Morrison, Alanna C / Palmer, Nicholette D / Peyser, Patricia A / Psaty, Bruce M / Raffield, Laura M / Redline, Susan / Reiner, Alexander P / Rich, Stephen S / Sitlani, Colleen M / Smith, Jennifer A / Taylor, Kent D / Tiwari, Hemant / Vasan, Ramachandran S / Wang, Zhe / Yanek, Lisa R / Yu, Bing / Rice, Kenneth M / Rotter, Jerome I / Peloso, Gina M / Natarajan, Pradeep / Li, Zilin / Liu, Zhonghua / Lin, Xihong

bioRxiv : the preprint server for biology

2023

Abstract: Large-scale whole-genome sequencing (WGS) studies have improved our understanding of the contributions of coding and noncoding rare variants to complex human traits. Leveraging association effect sizes across multiple traits in WGS rare variant ... ...

Abstract	Large-scale whole-genome sequencing (WGS) studies have improved our understanding of the contributions of coding and noncoding rare variants to complex human traits. Leveraging association effect sizes across multiple traits in WGS rare variant association analysis can improve statistical power over single-trait analysis, and also detect pleiotropic genes and regions. Existing multi-trait methods have limited ability to perform rare variant analysis of large-scale WGS data. We propose MultiSTAAR, a statistical framework and computationally-scalable analytical pipeline for functionally-informed multi-trait rare variant analysis in large-scale WGS studies. MultiSTAAR accounts for relatedness, population structure and correlation among phenotypes by jointly analyzing multiple traits, and further empowers rare variant association analysis by incorporating multiple functional annotations. We applied MultiSTAAR to jointly analyze three lipid traits (low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides) in 61,861 multi-ethnic samples from the Trans-Omics for Precision Medicine (TOPMed) Program. We discovered new associations with lipid traits missed by single-trait analysis, including rare variants within an enhancer of
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.30.564764
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Article ; Online: Decentralized research technology use in multicenter clinical research studies based at U.S. academic research centers.

Cummins, Mollie R / Burr, Jeri / Young, Lisa / Yeatts, Sharon D / Ecklund, Dixie J / Bunnell, Brian E / Dwyer, Jamie P / VanBuren, John M

Journal of clinical and translational science

2023 Volume 7, Issue 1, Page(s) e250

Abstract: Introduction: During the COVID-19 pandemic, research organizations accelerated adoption of technologies that enable remote participation. Now, there's a pressing need to evaluate current decentralization practices and develop appropriate research, ... ...

Abstract	Introduction: During the COVID-19 pandemic, research organizations accelerated adoption of technologies that enable remote participation. Now, there's a pressing need to evaluate current decentralization practices and develop appropriate research, education, and operations infrastructure. The purpose of this study was to examine current adoption of decentralization technologies in a sample of clinical research studies conducted by academic research organizations (AROs). Methods: The setting was three data coordinating centers in the U.S. These centers initiated coordination of 44 clinical research studies during or after 2020, with national recruitment and enrollment, and entailing coordination between one and one hundred sites. We determined the decentralization technologies used in these studies. Results: We obtained data for 44/44 (100%) trials coordinated by the three centers. Three technologies have been adopted across nearly all studies (98-100%): eIRB, eSource, and Clinical Trial Management Systems. Commonly used technologies included e-Signature (32/44, 73%), Online Payments Portals (26/44, 59%), ePROs (23/44, 53%), Interactive Response Technology (22/44, 50%), Telemedicine (19/44, 43%), and eConsent (18/44, 41%). Wearables (7/44,16%) and Online Recruitment Portals (5/44,11%) were less common. Rarely utilized technologies included Direct-to-Patient Portals (1/44, 2%) and Home Health Nurse Portals (1/44, 2%). Conclusions: All studies incorporated some type of decentralization technology, with more extensive adoption than found in previous research. However, adoption may be strongly influenced by institution-specific IT and informatics infrastructure and support. There are inherent needs, responsibilities, and challenges when incorporating decentralization technology into a research study, and AROs must ensure that infrastructure and informatics staff are adequate.
Language	English
Publishing date	2023-11-08
Publishing country	England
Document type	Journal Article
ISSN	2059-8661
ISSN (online)	2059-8661
DOI	10.1017/cts.2023.678
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Article: Variability in drought gene expression datasets highlight the need for community standardization.

VanBuren, Robert / Nguyen, Annie / Marks, Rose A / Mercado, Catherine / Pardo, Anna / Pardo, Jeremy / Schuster, Jenny / Aubin, Brian St / Wilson, Mckena Lipham / Rhee, Seung Y

bioRxiv : the preprint server for biology

2024

Abstract: Physiologically relevant drought stress is difficult to apply consistently, and the heterogeneity in experimental design, growth conditions, and sampling schemes make it challenging to compare water deficit studies in plants. Here, we re-analyzed ... ...

Abstract	Physiologically relevant drought stress is difficult to apply consistently, and the heterogeneity in experimental design, growth conditions, and sampling schemes make it challenging to compare water deficit studies in plants. Here, we re-analyzed hundreds of drought gene expression experiments across diverse model and crop species and quantified the variability across studies. We found that drought studies are surprisingly uncomparable, even when accounting for differences in genotype, environment, drought severity, and method of drying. Many studies, including most Arabidopsis work, lack high-quality phenotypic and physiological datasets to accompany gene expression, making it impossible to assess the severity or in some cases the occurrence of water deficit stress events. From these datasets, we developed supervised learning classifiers that can accurately predict if RNA-seq samples have experienced a physiologically relevant drought stress, and suggest this can be used as a quality control for future studies. Together, our analyses highlight the need for more community standardization, and the importance of paired physiology data to quantify stress severity for reproducibility and future data analyses.
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.04.578814
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Article ; Online: Regulatory dynamics distinguishing desiccation tolerance strategies within resurrection grasses.

St Aubin, Brian / Wai, Ching Man / Kenchanmane Raju, Sunil K / Niederhuth, Chad E / VanBuren, Robert

Plant direct

2022 Volume 6, Issue 12, Page(s) e457

Abstract: Desiccation tolerance has evolved recurrently in grasses using two unique strategies of either protecting or dismantling the photosynthetic apparatus to minimize photooxidative damage under life without water (anhydrobiosis). Here, we surveyed chromatin ... ...

Abstract	Desiccation tolerance has evolved recurrently in grasses using two unique strategies of either protecting or dismantling the photosynthetic apparatus to minimize photooxidative damage under life without water (anhydrobiosis). Here, we surveyed chromatin architecture and gene expression during desiccation in two closely related grasses with distinguishing desiccation tolerance strategies to identify regulatory dynamics underlying these unique adaptations. In both grasses, we observed a strong association between nearby chromatin accessibility and gene expression in desiccated tissues compared to well-watered, reflecting an unusual chromatin stability under anhydrobiosis. Integration of chromatin accessibility (ATACseq) and expression data (RNAseq) revealed a core desiccation response across these two grasses. This includes many genes with binding sites for the core seed development transcription factor ABI5, supporting the long-standing hypothesis that vegetative desiccation tolerance evolved from rewiring seed pathways.
Language	English
Publishing date	2022-12-13
Publishing country	England
Document type	Journal Article
ISSN	2475-4455
ISSN (online)	2475-4455
DOI	10.1002/pld3.457
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Article ; Online: Novel Methylated DNA Markers Discriminate Advanced Neoplasia in Pancreatic Cysts: Marker Discovery, Tissue Validation, and Cyst Fluid Testing.

Majumder, Shounak / Taylor, William R / Yab, Tracy C / Berger, Calise K / Dukek, Brian A / Cao, Xiaoming / Foote, Patrick H / Wu, Chung Wah / Mahoney, Douglas W / Aslanian, Harry R / Fernández-Del Castillo, Carlos / Doyle, Leona A / Farrell, James J / Fisher, William E / Lee, Linda S / Lee, Yvonne N / Park, Walter / Rodrigues, Clifton / Gould Rothberg, Bonnie Elyssa /

Salem, Ronald R / Simeone, Diane M / Urs, Sumithra / Van Buren, George / Smyrk, Thomas C / Allawi, Hatim T / Lidgard, Graham P / Raimondo, Massimo / Chari, Suresh T / Kendrick, Michael L / Kisiel, John B / Topazian, Mark D / Ahlquist, David A

The American journal of gastroenterology

2019 Volume 114, Issue 9, Page(s) 1539–1549

Abstract: Objectives: Pancreatic cystic lesions (PCLs) may be precancerous. Those likely to harbor high-grade dysplasia (HGD) or pancreatic cancer (PC) are targets for surgical resection. Current algorithms to predict advanced neoplasia (HGD/PC) in PCLs lack ... ...

Abstract	Objectives: Pancreatic cystic lesions (PCLs) may be precancerous. Those likely to harbor high-grade dysplasia (HGD) or pancreatic cancer (PC) are targets for surgical resection. Current algorithms to predict advanced neoplasia (HGD/PC) in PCLs lack diagnostic accuracy. In pancreatic tissue and cyst fluid (CF) from PCLs, we sought to identify and validate novel methylated DNA markers (MDMs) that discriminate HGD/PC from low-grade dysplasia (LGD) or no dysplasia (ND). Methods: From an unbiased whole-methylome discovery approach using predefined selection criteria followed by multistep validation on case (HGD or PC) and control (ND or LGD) tissues, we identified discriminant MDMs. Top candidate MDMs were then assayed by quantitative methylation-specific polymerase chain reaction on archival CF from surgically resected PCLs. Results: Of 25 discriminant MDMs identified in tissue, 13 were selected for validation in 134 CF samples (21 cases [8 HGD, 13 PC], 113 controls [45 ND, 68 LGD]). A tree-based algorithm using 2 CF-MDMs (TBX15, BMP3) achieved sensitivity and specificity above 90%. Discrimination was significantly better by this CF-MDM panel than by mutant KRAS or carcinoembryonic antigen, with areas under the receiver operating characteristic curve of 0.93 (95% confidence interval: 0.86-0.99), 0.71 (0.57-0.85), and 0.72 (0.60-0.84), respectively. Cutoffs for the MDM panel applied to an independent CF validation set (31 cases, 56 controls) yielded similarly high discrimination, areas under the receiver operating characteristic curve = 0.86 (95% confidence interval: 0.77-0.94, P = 0.2). Discussion: Novel MDMs discovered and validated in tissue accurately identify PCLs harboring HGD/PC. A panel of 2 MDMs assayed in CF yielded results with potential to enhance current risk prediction algorithms. Prospective studies are indicated to optimize and further evaluate CF-MDMs for clinical use.
MeSH term(s)	Aged ; Bone Morphogenetic Protein 3/genetics ; Carcinoembryonic Antigen/metabolism ; Carcinoma, Pancreatic Ductal/diagnosis ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Cyst Fluid/metabolism ; Cystadenoma, Serous/diagnosis ; Cystadenoma, Serous/genetics ; Cystadenoma, Serous/pathology ; DNA Methylation/genetics ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Pancreatic Cyst/diagnosis ; Pancreatic Cyst/genetics ; Pancreatic Cyst/pathology ; Pancreatic Intraductal Neoplasms/diagnosis ; Pancreatic Intraductal Neoplasms/genetics ; Pancreatic Intraductal Neoplasms/pathology ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Polymerase Chain Reaction ; Precancerous Conditions/diagnosis ; Precancerous Conditions/genetics ; Precancerous Conditions/pathology ; Proto-Oncogene Proteins p21(ras)/genetics ; Reproducibility of Results ; Sensitivity and Specificity ; T-Box Domain Proteins/genetics
Chemical Substances	BMP3 protein, human ; Bone Morphogenetic Protein 3 ; Carcinoembryonic Antigen ; KRAS protein, human ; T-Box Domain Proteins ; TBX15 protein, human ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
Language	English
Publishing date	2019-07-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	390122-1
ISSN	1572-0241 ; 0002-9270
ISSN (online)	1572-0241
ISSN	0002-9270
DOI	10.14309/ajg.0000000000000284
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Article ; Online: Decentralized research technology use in multicenter clinical research studies based at U.S. academic research centers

Mollie R. Cummins / Jeri Burr / Lisa Young / Sharon D. Yeatts / Dixie J. Ecklund / Brian E. Bunnell / Jamie P. Dwyer / John M. VanBuren

Journal of Clinical and Translational Science, Vol

2023 Volume 7

Abstract: Abstract Introduction: During the COVID-19 pandemic, research organizations accelerated adoption of technologies that enable remote participation. Now, there’s a pressing need to evaluate current decentralization practices and develop appropriate ... ...

Abstract	Abstract Introduction: During the COVID-19 pandemic, research organizations accelerated adoption of technologies that enable remote participation. Now, there’s a pressing need to evaluate current decentralization practices and develop appropriate research, education, and operations infrastructure. The purpose of this study was to examine current adoption of decentralization technologies in a sample of clinical research studies conducted by academic research organizations (AROs). Methods: The setting was three data coordinating centers in the U.S. These centers initiated coordination of 44 clinical research studies during or after 2020, with national recruitment and enrollment, and entailing coordination between one and one hundred sites. We determined the decentralization technologies used in these studies. Results: We obtained data for 44/44 (100%) trials coordinated by the three centers. Three technologies have been adopted across nearly all studies (98–100%): eIRB, eSource, and Clinical Trial Management Systems. Commonly used technologies included e-Signature (32/44, 73%), Online Payments Portals (26/44, 59%), ePROs (23/44, 53%), Interactive Response Technology (22/44, 50%), Telemedicine (19/44, 43%), and eConsent (18/44, 41%). Wearables (7/44,16%) and Online Recruitment Portals (5/44,11%) were less common. Rarely utilized technologies included Direct-to-Patient Portals (1/44, 2%) and Home Health Nurse Portals (1/44, 2%). Conclusions: All studies incorporated some type of decentralization technology, with more extensive adoption than found in previous research. However, adoption may be strongly influenced by institution-specific IT and informatics infrastructure and support. There are inherent needs, responsibilities, and challenges when incorporating decentralization technology into a research study, and AROs must ensure that infrastructure and informatics staff are adequate.
Keywords	Biomedical research ; clinical research informatics ; informatics ; data coordinating centers ; decentralized trials ; decentralized research ; digital health ; Medicine ; R
Subject code	690
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Adherence to behavioral targets and treatment attendance during a pediatric weight control trial.

Theim, Kelly R / Sinton, Meghan M / Goldschmidt, Andrea B / Van Buren, Dorothy J / Doyle, Angela C / Saelens, Brian E / Stein, Richard I / Epstein, Leonard H / Wilfley, Denise E

Obesity (Silver Spring, Md.)

2013 Volume 21, Issue 2, Page(s) 394–397

Abstract: Objective: Better weight loss outcomes are achieved in adults and youth who adhere to obesity treatment regimens (i.e., session attendance and prescribed changes in weight control behaviors). However, more research is needed regarding children's ... ...

Abstract	Objective: Better weight loss outcomes are achieved in adults and youth who adhere to obesity treatment regimens (i.e., session attendance and prescribed changes in weight control behaviors). However, more research is needed regarding children's adherence to a range of behaviors relevant for weight maintenance over long-term follow-up. Design and methods: Overweight children (N = 101, aged 7-12 years), along with an overweight parent, participated in a 20-week family-based behavioral weight loss treatment (FBT) and were then assigned to either a behaviorally focused or socially focused 16-week weight maintenance treatment (MT). Treatment attendance and child and parent adherence (i.e., reported use of skills targeted within treatment) were examined in relation to child percent overweight change from baseline to post-FBT, post-MT, and 2-year follow-up. Results: Higher attendance predicted better child weight outcomes at post-MT, but not at 2-year follow-up. Adherence to self-regulatory skills/goal-setting skills predicted child weight outcomes at 2-year follow-up among the behaviorally focused MT group. Conclusions: Future research is needed to examine mediators of change within family-based weight control interventions, including behavioral and socially based targets. Incorporating self-regulatory weight maintenance skills into a comprehensive MT may maximize children's sustained weight control.
MeSH term(s)	Child ; Feeding Behavior ; Female ; Follow-Up Studies ; Health Behavior ; Humans ; Male ; Motor Activity ; Obesity/therapy ; Overweight/therapy ; Parents ; Patient Compliance ; Social Support ; Weight Loss
Language	English
Publishing date	2013-05-08
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.20281
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Article ; Online: The use of biosimulation in the design of a novel multilevel weight loss maintenance program for overweight children.

Wilfley, Denise E / Van Buren, Dorothy J / Theim, Kelly R / Stein, Richard I / Saelens, Brian E / Ezzet, Farkad / Russian, Angela C / Perri, Michael G / Epstein, Leonard H

Obesity (Silver Spring, Md.)

2010 Volume 18 Suppl 1, Page(s) S91–8

Abstract: Weight loss outcomes achieved through conventional behavior change interventions are prone to deterioration over time. Basic learning laboratory studies in the area of behavioral extinction and renewal and multilevel models of weight control offer clues ... ...

Abstract	Weight loss outcomes achieved through conventional behavior change interventions are prone to deterioration over time. Basic learning laboratory studies in the area of behavioral extinction and renewal and multilevel models of weight control offer clues as to why newly acquired weight loss skills are prone to relapse. According to these models, current clinic-based interventions may not be of sufficient duration or scope to allow for the practice of new skills across the multiple community contexts necessary to promote sustainable weight loss. Although longer, more intensive interventions with greater reach may hold the key to improving weight loss outcomes, it is difficult to test these assumptions in a time efficient and cost-effective manner. A research design tool that has been increasingly utilized in other fields (e.g., pharmaceuticals) is the use of biosimulation analyses. The present study describes our research team's use of computer simulation models to assist in designing a study to test a novel, comprehensive socio-environmental treatment approach to weight loss maintenance in children ages 7-12 years. Weight outcome data from the weight loss, weight maintenance, and follow-up phases of a recently completed randomized controlled trial (RCT) were used to describe the time course of a proposed, extended multilevel treatment program. Simulations were then conducted to project the expected changes in child percent overweight (POW) trajectories in the proposed study. A 12.9% decrease in POW at 30 months was estimated based upon the midway point between models of "best-case" and "worst-case" weight maintenance scenarios. Preliminary data and further analyses, including biosimulation projections, suggest that our socio-environmental approach to weight loss maintenance treatment is promising and warrants evaluation in a large-scale RCT. Biosimulation techniques may have utility in the design of future community-level interventions for the treatment and prevention of childhood overweight.
MeSH term(s)	Child ; Child Behavior ; Computer Simulation ; Female ; Health Behavior ; Health Promotion/methods ; Humans ; Life Style ; Male ; Overweight/prevention & control ; Overweight/psychology ; Overweight/therapy ; Psychology, Child ; Recurrence ; Risk Reduction Behavior ; Social Support ; Weight Loss/physiology
Language	English
Publishing date	2010-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1038/oby.2009.437
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