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  1. Article ; Online: Efficient Inhibition of SmNACE by Coordination Complexes Is Abolished by S. mansoni Sequestration of Metal.

    Muller-Steffner, Hélène / Jacques, Sylvain A / Kuhn, Isabelle / Schultz, Michael D / Botta, Davide / Osswald, Paul / Maechling, Clarisse / Lund, Frances E / Kellenberger, Esther

    ACS chemical biology

    2017  Volume 12, Issue 7, Page(s) 1787–1795

    Abstract: SmNACE is a NAD catabolizing enzyme expressed on the outer tegument of S. mansoni, a human parasite ...

    Abstract SmNACE is a NAD catabolizing enzyme expressed on the outer tegument of S. mansoni, a human parasite that is one of the major agents of the neglected tropical disease schistosomiasis. Recently, we identified aroylhydrazone derivatives capable of inhibiting the recombinant form of the enzyme with variable potency (IC
    MeSH term(s) Animals ; Coordination Complexes/pharmacology ; Enzyme Activation/drug effects ; Enzyme Activation/physiology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Inhibitory Concentration 50 ; Metals/metabolism ; Molecular Structure ; Schistosoma mansoni/enzymology ; Schistosoma mansoni/metabolism ; Zinc/chemistry
    Chemical Substances Coordination Complexes ; Enzyme Inhibitors ; Metals ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2017--21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.7b00186
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  2. Article ; Online: Probing conformational changes during activation of ASIC1a by an optical tweezer and by methanethiosulfonate-based cross-linkers.

    Vaithia, Anand / Kellenberger, Stephan

    PloS one

    2022  Volume 17, Issue 7, Page(s) e0270762

    Abstract: Acid-sensing ion channels (ASICs) are neuronal, proton-gated, Na+-selective ion channels. They are involved in various physiological and pathological processes such as neurodegeneration after stroke, pain sensation, fear behavior and learning. To obtain ... ...

    Abstract Acid-sensing ion channels (ASICs) are neuronal, proton-gated, Na+-selective ion channels. They are involved in various physiological and pathological processes such as neurodegeneration after stroke, pain sensation, fear behavior and learning. To obtain information on the activation mechanism of ASIC1a, we attempted in this study to impose distance constraints between paired residues in different channel domains by using cross-linkers reacting with engineered Cys residues, and we measured how this affected channel function. First, the optical tweezer 4'-Bis(maleimido)azobenzene (BMA) was used, whose conformation changes depending on the wavelength of applied light. After exposure of channel mutants to BMA, an activation of the channel by light was only observed with a mutant containing a Cys mutation in the extracellular pore entry, I428C. Western blot analysis indicated that BMA did not cross-link Cys428 residues. Extracellular application of methanethiosulfonate (MTS) cross-linkers of different lengths changed the properties of several Cys mutants, in many cases likely without cross-linking two Cys residues. Our observations suggest that intersubunit cross-linking occurred in the wrist mutant A425C and intrasubunit cross-linking in the acidic pocket mutant D237C/I312C. In these mutants, exposure to cross-linkers favored a non-conducting channel conformation and induced an acidic shift of the pH dependence and a decrease of the maximal current amplitude. Overall, the cross-linking approaches appeared to be inefficient, possibly due to the geometrical requirements for successful reactions of the two ends of the cross-linking compound.
    MeSH term(s) Acid Sensing Ion Channels/metabolism ; Hydrogen-Ion Concentration ; Mesylates ; Optical Tweezers ; Protein Structure, Tertiary
    Chemical Substances Acid Sensing Ion Channels ; Mesylates ; methanethiosulfonate (44059-82-7)
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0270762
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  3. Article ; Online: Hydrogen Sulfide Upregulates Acid-sensing Ion Channels

    Peng, Zhong / Kellenberger, Stephan

    Function (Oxford, England)

    2021  Volume 2, Issue 2, Page(s) zqab007

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    Language English
    Publishing date 2021-02-19
    Publishing country England
    Document type Journal Article
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqab007
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  4. Article ; Online: Galvani Offset Potential and Constant-pH Simulations of Membrane Proteins.

    Bignucolo, Olivier / Chipot, Christophe / Kellenberger, Stephan / Roux, Benoît

    The journal of physical chemistry. B

    2022  Volume 126, Issue 36, Page(s) 6868–6877

    Abstract: A central problem in computational biophysics is the treatment of titratable residues in molecular dynamics simulations of large biological macromolecular systems. Conventional simulation methods ascribe a fixed ionization state to titratable residues in ...

    Abstract A central problem in computational biophysics is the treatment of titratable residues in molecular dynamics simulations of large biological macromolecular systems. Conventional simulation methods ascribe a fixed ionization state to titratable residues in accordance with their p
    MeSH term(s) Hydrogen-Ion Concentration ; Membrane Proteins ; Molecular Dynamics Simulation ; Water/chemistry
    Chemical Substances Membrane Proteins ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.2c04593
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  5. Article ; Online: Meta-learning to address diverse Earth observation problems across resolutions

    Rußwurm, Marc / Wang, Sherrie / Kellenberger, Benjamin / Roscher, Ribana / Tuia, Devis

    Communications Earth and Environment

    2024  Volume 5, Issue 1

    Abstract: Earth scientists study a variety of problems with remote sensing data, but they most often consider them in isolation from each other, which limits information flows across disciplines. In this work, we present METEOR, a meta-learning methodology for ... ...

    Abstract Earth scientists study a variety of problems with remote sensing data, but they most often consider them in isolation from each other, which limits information flows across disciplines. In this work, we present METEOR, a meta-learning methodology for Earth observation problems across different resolutions. METEOR is an adaptive deep meta-learning model with several modifications that allow it to ingest images with a variable number of spectral channels and to predict a varying number of classes per downstream task. It uses knowledge mined from land cover information worldwide to adapt to new unseen target problems with few training examples. METEOR outperforms competing self-supervised approaches on five downstream tasks, showing its relevance to addressing novel and impactful geospatial problems with only a handful of labels.
    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Online
    ISSN 2662-4435
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Stay close, but not too close: aerial image analysis reveals patterns of social distancing in seal colonies.

    Hoekendijk, J P A / Grundlehner, A / Brasseur, S / Kellenberger, B / Tuia, D / Aarts, G

    Royal Society open science

    2023  Volume 10, Issue 8, Page(s) 230269

    Abstract: Many species aggregate in dense colonies. Species-specific spatial patterns provide clues about how colonies are shaped by various (a)biotic factors, including predation, temperature regulation or disease transmission. Using aerial imagery, we examined ... ...

    Abstract Many species aggregate in dense colonies. Species-specific spatial patterns provide clues about how colonies are shaped by various (a)biotic factors, including predation, temperature regulation or disease transmission. Using aerial imagery, we examined these patterns in colonies on land of two sympatric seal species: the harbour seal and grey seal. Results show that the density of grey seals on land is twice as high as that of harbour seals. Furthermore, the nearest neighbour distance (NND) of harbour seals (median = 1.06 m) is significantly larger than that of grey seals (median = 0.53 m). Avoidance at small distances (i.e. social distancing) was supported by spatial simulation: when the observed seal locations were shuffled slightly, the frequency of the smallest NNDs (0-25 cm) increased, while the most frequently observed NNDs decreased. As harbour seals are more prone to infectious diseases, we hypothesize that the larger NNDs might be a behavioural response to reduce pathogen transmission. The approach presented here can potentially be used as a practical tool to differentiate between harbour and grey seals in remote sensing applications, particularly in low to medium resolution imagery (e.g. satellite imagery), where morphological characteristics alone are insufficient to differentiate between species.
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.230269
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  7. Article ; Online: A molecular view of the function and pharmacology of acid-sensing ion channels.

    Vullo, Sabrina / Kellenberger, Stephan

    Pharmacological research

    2019  Volume 154, Page(s) 104166

    Abstract: The pH in the different tissues and organs of our body is kept within tight limits. Local pH changes occur, however, temporarily under physiological conditions, as for example in synapses during neuronal activity. In pathological situations, such as in ... ...

    Abstract The pH in the different tissues and organs of our body is kept within tight limits. Local pH changes occur, however, temporarily under physiological conditions, as for example in synapses during neuronal activity. In pathological situations, such as in ischemia, inflammation, and tumor growth, long-lasting acidification develops. Acid-sensing ion channels (ASICs) are low pH-activated Na
    MeSH term(s) Acid Sensing Ion Channel Blockers/pharmacology ; Acid Sensing Ion Channels/chemistry ; Acid Sensing Ion Channels/physiology ; Animals ; Humans
    Chemical Substances Acid Sensing Ion Channel Blockers ; Acid Sensing Ion Channels
    Language English
    Publishing date 2019-02-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2019.02.005
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    Zs.A 721: Show issues Location:
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  8. Article: Changes in H

    Alijevic, Omar / Peng, Zhong / Kellenberger, Stephan

    Frontiers in cellular neuroscience

    2021  Volume 15, Page(s) 732869

    Abstract: Acid-sensing ion channels (ASICs) are activated by extracellular acidification. Because ASIC currents are transient, these channels appear to be ideal sensors for detecting the onset of rapid pH changes. ASICs are involved in neuronal death after ... ...

    Abstract Acid-sensing ion channels (ASICs) are activated by extracellular acidification. Because ASIC currents are transient, these channels appear to be ideal sensors for detecting the onset of rapid pH changes. ASICs are involved in neuronal death after ischemic stroke, and in the sensation of inflammatory pain. Ischemia and inflammation are associated with a slowly developing, long-lasting acidification. Recent studies indicate however that ASICs are unable to induce an electrical signaling activity under standard experimental conditions if pH changes are slow. In situations associated with slow and sustained pH drops such as high neuronal signaling activity and ischemia, the extracellular K
    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2021.732869
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  9. Article ; Online: Does Magnetic Resonance Imaging Distinguish Juvenile Idiopathic Arthritis From Other Causes of Progressive Temporomandibular Joint Destruction?

    Bousquet, Bradley / Kellenberger, Christian J / Caprio, Ryan M / Jindal, Snigdha / Resnick, Cory M

    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

    2023  Volume 81, Issue 7, Page(s) 820–830

    Abstract: Purpose: Similarities in initial presentations of temporomandibular joint (TMJ) involvement from juvenile idiopathic arthritis (JIA), idiopathic condylar resorption, and other forms of progressive TMJ destruction in children create diagnostic confusion. ...

    Abstract Purpose: Similarities in initial presentations of temporomandibular joint (TMJ) involvement from juvenile idiopathic arthritis (JIA), idiopathic condylar resorption, and other forms of progressive TMJ destruction in children create diagnostic confusion. Treatment pathways, however, depend on determination of etiology. The purpose of this study was to compare TMJ magnetic resonance images (MRIs) of patients with joint degeneration localized to the TMJs to those with JIA and TMJ involvement.
    Study design, setting, sample: This is a retrospective cross-sectional study including subjects younger than 18 years that presented from February 2008 to October 2019 with clinical TMJ degeneration, a gadolinium-enhanced TMJ MRI and a negative pediatric rheumatologic workup (non-JIA group), and a series of age and sex-matched subjects with TMJ degeneration on gadolinium-enhanced MRI and JIA (JIA group). MRIs were evaluated in a blinded fashion by 1 pediatric radiologist. The primary outcome variable was the radiologist's accuracy in predicting study grouping, assessed in 1 randomly-selected joint per patient. Secondary outcome variables included MRI characteristics of inflammation, osseous damage and articular disc morphology. Independent samples t-tests, sensitivity/specificity, Fisher's exact and Mann-Whitney tests were computed as applicable, and P < .05 was considered significant.
    Results: The sample included 34 subjects: 16 non-JIA (75% female, age 13.9 ± 2.8 years) and 18 JIA (77% female, age 13.6 ± 2.8 years) (P ≥ .738). The radiologist correctly classified 64.7% of subjects as non-JIA or JIA (P = .078, sensitivity = 94.4%, specificity = 31.3%). Inflammatory and osseous findings were similar between groups (P ≥ .073). The disc was anteriorly displaced in 9 non-JIA and 0 JIA joints (P < .001, sensitivity = 100%, specificity = 100%) and flattened in 3 non-JIA and 14 JIA joints (P = .006, sensitivity = 38.9%, specificity = 90.6%).
    Conclusion and relevance: Inflammatory and osseous findings on gadolinium-enhanced TMJ MRIs are insufficient to determine the etiology of progressive TMJ destruction. Disc characteristics, however, significantly differ between JIA and non-JIA etiologies and may be important in differentiating these conditions.
    MeSH term(s) Child ; Humans ; Female ; Adolescent ; Male ; Arthritis, Juvenile/diagnostic imaging ; Arthritis, Juvenile/complications ; Retrospective Studies ; Temporomandibular Joint Disorders/diagnostic imaging ; Temporomandibular Joint Disorders/etiology ; Gadolinium ; Cross-Sectional Studies ; Temporomandibular Joint/diagnostic imaging ; Temporomandibular Joint/pathology ; Magnetic Resonance Imaging/methods
    Chemical Substances Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392404-x
    ISSN 1531-5053 ; 0278-2391
    ISSN (online) 1531-5053
    ISSN 0278-2391
    DOI 10.1016/j.joms.2023.03.016
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    Ul III Zs.113: Show issues Location:
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  10. Article ; Online: New viruses of

    Jaccard, Augustine / Dubuis, Nathalie / Kellenberger, Isabelle / Brodard, Justine / Schnee, Sylvain / Gindro, Katia / Schumpp, Olivier

    The Journal of general virology

    2023  Volume 104, Issue 8

    Abstract: Despite the fact ... ...

    Abstract Despite the fact that
    MeSH term(s) Cladosporium/genetics ; Fungal Viruses/genetics ; RNA Viruses/genetics ; Capsid Proteins/genetics ; Fungi ; RNA-Dependent RNA Polymerase/genetics
    Chemical Substances Capsid Proteins ; RNA-Dependent RNA Polymerase (EC 2.7.7.48)
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001879
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