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  1. Article ; Online: Not all that is corpus restricted is necessarily autoimmune.

    Lahner, Edith / Dilaghi, Emanuele / Dottori, Ludovica / Annibale, Bruno

    Gut

    2023  Volume 72, Issue 12, Page(s) 2384–2385

    MeSH term(s) Humans ; Gastritis ; Risk Factors ; Helicobacter Infections ; Helicobacter pylori ; Metaplasia ; Gastric Mucosa ; Stomach Neoplasms
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2022-328959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
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  2. Article ; Online: Update on Serum Biomarkers in Autoimmune Atrophic Gastritis.

    Dottori, Ludovica / Pivetta, Giulia / Annibale, Bruno / Lahner, Edith

    Clinical chemistry

    2023  Volume 69, Issue 10, Page(s) 1114–1131

    Abstract: Background: Autoimmune atrophic gastritis (AAG) is a persistent, corpus-restricted immune-mediated destruction of the gastric corpus oxyntic mucosa with reduced gastric acid and intrinsic factor secretion, leading to iron deficiency and pernicious ... ...

    Abstract Background: Autoimmune atrophic gastritis (AAG) is a persistent, corpus-restricted immune-mediated destruction of the gastric corpus oxyntic mucosa with reduced gastric acid and intrinsic factor secretion, leading to iron deficiency and pernicious anemia as a consequence of iron and cobalamin malabsorption. Positivity toward parietal cell (PCA) and intrinsic factor (IFA) autoantibodies is very common. AAG may remain asymptomatic for many years, thus making its diagnosis complex and often delayed. Due to the increased risk of gastric neoplasms, a timely diagnosis of AAG is clinically important.
    Content: The gold standard for AAG diagnosis is histopathological assessment of gastric biopsies obtained during gastroscopy, but noninvasive, preendoscopic serological screening may be useful in some clinical scenarios. Serum biomarkers for AAG may be divided into 2 groups: gastric autoimmunity-related biomarkers, such as PCA and IFA, and gastric corpus atrophy/reduced gastric acid secretion-related biomarkers, such as serum gastrin and pepsinogens. The present review focuses on the clinical significance and pitfalls of serum biomarkers related to gastric autoimmunity and gastric corpus atrophy, including some discussion of analytical methods.
    Summary: Serum assays for PCA, IFA, gastrin, and pepsinogen I show good diagnostic accuracy for noninvasive diagnostic work-up of AAG. Diagnostic performance may increase by combining >1 of these tests, overcoming the problem of seronegative AAG. However, appropriately designed, comparative studies with well-characterized patient cohorts are needed to better define the reliability of these biomarkers in the diagnosis of patients with AAG. Currently, positive serum tests should always be followed by the state-of-art diagnostic test, that is, histopathological assessment of gastric biopsies obtained during gastroscopy to definitively confirm or rule out AAG and eventually neoplastic complications.
    MeSH term(s) Humans ; Gastritis, Atrophic/diagnosis ; Gastritis, Atrophic/pathology ; Gastrins ; Intrinsic Factor ; Reproducibility of Results ; Atrophy ; Biomarkers ; Helicobacter pylori
    Chemical Substances Gastrins ; Intrinsic Factor (9008-12-2) ; Biomarkers
    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvad082
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Systematic review and meta-analysis: Risk of gastric cancer in patients with first-degree relatives with gastric cancer.

    Ligato, Irene / Dottori, Ludovica / Sbarigia, Caterina / Dilaghi, Emanuele / Annibale, Bruno / Lahner, Edith / Esposito, Gianluca

    Alimentary pharmacology & therapeutics

    2024  Volume 59, Issue 5, Page(s) 606–615

    Abstract: Background: Gastric cancer ranks fourth in terms of global cancer-related deaths. Timely identification of high-risk populations is crucial to reduce mortality. Although a family history of gastric cancer increases risk, European and British guidelines ... ...

    Abstract Background: Gastric cancer ranks fourth in terms of global cancer-related deaths. Timely identification of high-risk populations is crucial to reduce mortality. Although a family history of gastric cancer increases risk, European and British guidelines report weak recommendations and low-quality evidence about the management of these patients.
    Aim: To quantify the association in case-control studies of patients with gastric cancer with first-degree relatives with gastric cancer compared to those who do not.
    Methods: We conducted a systematic review and meta-analysis of case-control studies up to November 2023. Data extraction was performed independently by two reviewers. The heterogeneity of effects across studies was quantified by I
    Results: We included 30 studies in the systematic review. In all studies, a first-degree family history of gastric cancer represented a risk factor for gastric cancer. We included 21 studies on the risk of gastric cancer. There was a significantly increased association between gastric cancer and having first-degree relative(s) with gastric cancer, but with significant heterogeneity among studies (OR = 2.92; 95% CI 2.402-3.552; p < 0.001; I
    Conclusion: This meta-analysis highlights the relevance of patients' family history of gastric cancer and the importance of this risk factor for the early detection of neoplastic conditions.
    MeSH term(s) Humans ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/genetics ; Risk Factors ; Case-Control Studies
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17872
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2206: Show issues Location:
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  4. Article: No Danger for Medical Interest and Awareness towards Celiac Disease. Reply to Greenaway et al. Why Is There Medical Inertia and Nihilism to Celiac Disease? Comment on "Pivetta et al. In Elderly Anemic Patients without Endoscopic Signs of Bleeding Are Duodenal Biopsies Always Necessary to Rule Out Celiac Disease?

    Pivetta, Giulia / Dilaghi, Emanuele / Lahner, Edith

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 7

    Abstract: We would like to thank Greenaway et al. [ ... ]. ...

    Abstract We would like to thank Greenaway et al. [...].
    Language English
    Publishing date 2022-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12071511
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  5. Article ; Online: Editorial: Dissecting the immunological, pathological, and clinical aspects of autoimmune gastritis and its neoplastic complications.

    Lenti, Marco Vincenzo / Annibale, Bruno / Di Sabatino, Antonio / Lahner, Edith

    Frontiers in immunology

    2022  Volume 13, Page(s) 1070250

    MeSH term(s) Humans ; Gastritis ; Precancerous Conditions
    Language English
    Publishing date 2022-10-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1070250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: No Danger for Medical Interest and Awareness towards Celiac Disease. Reply to Greenaway et al. Why Is There Medical Inertia and Nihilism to Celiac Disease? Comment on “Pivetta et al. In Elderly Anemic Patients without Endoscopic Signs of Bleeding Are Duodenal Biopsies Always Necessary to Rule Out Celiac Disease? Diagnostics 2022, 12 , 678”

    Giulia Pivetta / Emanuele Dilaghi / Edith Lahner

    Diagnostics, Vol 12, Iss 1511, p

    2022  Volume 1511

    Abstract: We would like to thank Greenaway et al. [.] ...

    Abstract We would like to thank Greenaway et al. [.]
    Keywords n/a ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Comparison of Clinical, Biochemical and Histological Features between Adult Celiac Patients with High and Low Anti-Transglutaminase IgA Titer at Diagnosis and Follow-Up.

    Galli, Gloria / Carabotti, Marilia / Conti, Laura / Scalamonti, Silvia / Annibale, Bruno / Lahner, Edith

    Nutrients

    2023  Volume 15, Issue 9

    Abstract: In adults, celiac disease (CD) diagnosis is based on specific serology (anti-transglutaminase IgA-anti-tTG) and duodenal histology. Evidence is raising the possibility of perform CD diagnosis based only on high anti-tTG titer in children. We aimed to ... ...

    Abstract In adults, celiac disease (CD) diagnosis is based on specific serology (anti-transglutaminase IgA-anti-tTG) and duodenal histology. Evidence is raising the possibility of perform CD diagnosis based only on high anti-tTG titer in children. We aimed to evaluate clinical, histological and biochemical differences between adult patients with high tTG IgA titer (HT) and those with low titer (LT) at CD diagnosis and follow-up. This retrospective study included consecutive adult CD patients divided into two groups: HT (anti-tTG > 10 × ULN) and LT (anti-tTG < 10 × ULN). Clinical, biochemical and histological features were compared between groups at CD diagnosis and at follow-up. A total of 291 patients were included (HT: 47.1%; LT: 52.9%). At CD diagnosis, HT patients showed a non 'classical' presentation (
    MeSH term(s) Child ; Humans ; Adult ; Follow-Up Studies ; Retrospective Studies ; Celiac Disease/diagnosis ; Diet, Gluten-Free ; Transglutaminases ; Immunoglobulin A
    Chemical Substances Transglutaminases (EC 2.3.2.13) ; Immunoglobulin A
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15092151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Endoscopic diagnosis of gastric intestinal metaplasia in patients with autoimmune gastritis using narrow-band imaging: does pseudopyloric metaplasia muddy the waters?

    Dilaghi, Emanuele / Esposito, Gianluca / Pivetta, Giulia / Galli, Gloria / Pilozzi, Emanuela / Annibale, Bruno / Lahner, Edith

    Endoscopy international open

    2022  Volume 10, Issue 4, Page(s) E434–E440

    Abstract: Background and study ... ...

    Abstract Background and study aims
    Language English
    Publishing date 2022-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2761052-4
    ISSN 2196-9736 ; 2364-3722
    ISSN (online) 2196-9736
    ISSN 2364-3722
    DOI 10.1055/a-1776-7628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Common Pitfalls in the Management of Patients with Micronutrient Deficiency: Keep in Mind the Stomach.

    Carabotti, Marilia / Annibale, Bruno / Lahner, Edith

    Nutrients

    2021  Volume 13, Issue 1

    Abstract: Micronutrient deficiencies are relatively common, in particular iron and cobalamin deficiency, and may potentially lead to life-threatening clinical consequences when not promptly recognized and treated, especially in elderly patients. The stomach plays ... ...

    Abstract Micronutrient deficiencies are relatively common, in particular iron and cobalamin deficiency, and may potentially lead to life-threatening clinical consequences when not promptly recognized and treated, especially in elderly patients. The stomach plays an important role in the homeostasis of some important hematopoietic micronutrients like iron and cobalamin, and probably in others equally important such as ascorbic acid, calcium, and magnesium. A key role is played by the corpus oxyntic mucosa composed of parietal cells whose main function is gastric acid secretion and intrinsic factor production. Gastric acid secretion is necessary for the digestion and absorption of cobalamin and the absorption of iron, calcium, and probably magnesium, and is also essential for the absorption, secretion, and activation of ascorbic acid. Several pathological conditions such as
    MeSH term(s) Achlorhydria/etiology ; Achlorhydria/metabolism ; Animals ; Biomarkers ; Bone Density ; Calcium/metabolism ; Deficiency Diseases/diagnosis ; Deficiency Diseases/etiology ; Deficiency Diseases/therapy ; Digestive System Surgical Procedures/adverse effects ; Disease Management ; Disease Susceptibility ; Dysbiosis ; Gastric Acid/metabolism ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Hemorrhage/complications ; Humans ; Micronutrients/deficiency ; Stomach Diseases/complications ; Vitamin B 12/metabolism ; Vitamin B 12 Deficiency
    Chemical Substances Biomarkers ; Micronutrients ; Vitamin B 12 (P6YC3EG204) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13010208
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  10. Article ; Online: A current clinical overview of atrophic gastritis.

    Annibale, Bruno / Esposito, Gianluca / Lahner, Edith

    Expert review of gastroenterology & hepatology

    2020  Volume 14, Issue 2, Page(s) 93–102

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Gastritis, Atrophic/complications ; Gastritis, Atrophic/diagnosis ; Gastritis, Atrophic/etiology ; Gastritis, Atrophic/therapy ; Humans ; Risk Factors
    Language English
    Publishing date 2020-01-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1080/17474124.2020.1718491
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    In stock of ZB MED Cologne/Königswinter

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