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Article: Concentration Polarization Enabled Reactive Coating of Nanofiltration Membranes with Zwitterionic Hydrogel.

May, Patrick / Laghmari, Soraya / Ulbricht, Mathias

2021 Volume 11, Issue 3

Abstract: In this study, the bottleneck challenge of membrane fouling is addressed via establishing a scalable concentration polarization (CP) enabled and surface-selective hydrogel coating using zwitterionic cross-linkable macromolecules as building blocks. First, ...

Abstract	In this study, the bottleneck challenge of membrane fouling is addressed via establishing a scalable concentration polarization (CP) enabled and surface-selective hydrogel coating using zwitterionic cross-linkable macromolecules as building blocks. First, a novel methacrylate-based copolymer with sulfobetain and methacrylate side groups was prepared in a simple three-step synthesis. Polymer gelation initiated by a redox initiator system (ammonium persulfate and tetramethylethylenediamine) for radical cross-linking was studied in bulk in order to identify minimum ("critical") concentrations to obtain a hydrogel. In situ reactive coating of a polyamide nanofiltration membrane was achieved via filtration of a mixture of the reactive compounds, utilizing CP to meet critical gelation conditions solely within the boundary layer. Because the feasibility was studied and demonstrated in dead-end filtration mode, the variable extent of CP was estimated in the frame of the film model, with an iterative calculation using experimental data as input. This allowed to discuss the influence of parameters such as solution composition or filtration rate on the actual polymer concentration and resulting hydrogel formation at the membrane surface. The zwitterionic hydrogel-coated membranes exhibited lower surface charge and higher flux during protein filtration, both compared to pristine membranes. Salt rejection was found to remain unchanged. Results further reveal that the hydrogel coating thickness and consequently the reduction in membrane permeance due to the coating can be tuned by variation of filtration time and polymer feed concentration, illustrating the novel modification method's promising potential for scale-up to real applications.
Language	English
Publishing date	2021-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2614641-1
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes11030187
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Article ; Online: Spontaneous spinal epidural hematoma in a toddler presenting with torticollis: case report and literature review.

Hajhouji, Farouk / Benyaich, Zakariae / Laghmari, Mehdi / Ghannane, Houssine / Ait Benali, Said

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2023 Volume 39, Issue 7, Page(s) 1935–1939

Abstract: Introduction: Spontaneous spinal epidural hematoma (SSEH) is a rare entity, especially in toddlers and infants. The nonspecificity of its presenting symptoms in children may be a source of delayed diagnosis.: Case description: We report the case of a ...

Abstract	Introduction: Spontaneous spinal epidural hematoma (SSEH) is a rare entity, especially in toddlers and infants. The nonspecificity of its presenting symptoms in children may be a source of delayed diagnosis. Case description: We report the case of a 20-month-old young boy without medical history who presented with irreducible torticollis, worsened a few days later by severe tetraplegia and respiratory distress. Spinal magnetic resonance imaging (MRI) showed a posterior epidural hematoma, extending from C3 to T1 and compressing the spinal cord. An urgent decompressive surgery via an extensive laminectomy and evacuation of the clot was performed. The patient demonstrated a partial neurological recovery on follow-up. Conclusion: SSEH is a rare and serious condition that may compromise the functional and vital prognosis of the patient, hence the importance of prompt diagnosis and urgent treatment.
MeSH term(s)	Male ; Infant ; Humans ; Child, Preschool ; Laminectomy/methods ; Hematoma, Epidural, Spinal/complications ; Hematoma, Epidural, Spinal/diagnostic imaging ; Hematoma, Epidural, Spinal/surgery ; Torticollis/diagnostic imaging ; Torticollis/etiology ; Magnetic Resonance Imaging/adverse effects ; Spinal Cord/surgery
Language	English
Publishing date	2023-02-04
Publishing country	Germany
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-023-05870-y
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Article ; Online: Arachnoiditis Ossificans of the Lumbar Spine: A Rare Cause of Progressive Cauda Equina Syndrome.

Benyaich, Zakariae / Laghmari, Mehdi / Ait Benali, Said

World neurosurgery

2021 Volume 148, Page(s) 116–117

Abstract: Arachnoiditis ossificans of the spine is a rare entity defined as an ossification of the leptomeninges resulting in neurologic decline. We describe the case of a 42-year-old woman, without any obvious predisposing factor, who presented with a progressive ...

Abstract	Arachnoiditis ossificans of the spine is a rare entity defined as an ossification of the leptomeninges resulting in neurologic decline. We describe the case of a 42-year-old woman, without any obvious predisposing factor, who presented with a progressive cauda equina syndrome. The imaging findings on magnetic resonance imaging were confusing by showing an atypical intraspinal lesion extending from L1 to S1. The computed tomography scan was more specific by showing suggestive images of a huge arachnoiditis ossificans of the lumbar spine. The patient underwent a large lumbar laminectomy with an incomplete resection of the ossified arachnoid. The histologic study confirmed the bony nature of the lesion. This illustrative case highlights the importance of helical computed tomography scan with multiplanar reconstruction for the diagnosis of arachnoiditis ossificans.
Language	English
Publishing date	2021-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2021.01.057
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Article ; Online: Choroidal granuloma secondary to tuberculosis in an immunocompromised patient.

Boubnan, Yousra / Lezrek, Omar / Laghmari, Mina / Cherkaoui, Ouafa

Journal francais d'ophtalmologie

2019 Volume 42, Issue 6, Page(s) e245–e246

MeSH term(s)	Adult ; Choroid Diseases/microbiology ; Female ; Granuloma/microbiology ; Humans ; Immunocompromised Host ; Tuberculosis/complications
Language	English
Publishing date	2019-05-06
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2018.11.021
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Article ; Online: Ruptured intraventricular tuberculous brain abscess mimicking cystic neoplasm: a case report.

Benyaich, Zakariae / Hajhoui, Farouk / Laghmari, Mehdi / Ghannane, Houssine / Benali, Said Ait

The Pan African medical journal

2021 Volume 39, Page(s) 122

Abstract: Central nervous system (CNS) tuberculosis is a potentially life-threatening condition that may manifest in different forms and simulate other pathologies. It rarely involves the ventricles and the occurrence of primary intraventricular tuberculous brain ... ...

Abstract	Central nervous system (CNS) tuberculosis is a potentially life-threatening condition that may manifest in different forms and simulate other pathologies. It rarely involves the ventricles and the occurrence of primary intraventricular tuberculous brain abscess (TBA) has exceptionally been reported. As far as we know, ruptured intraventricular TBA has not been described before. An immunocompetent 56-years-old man was admitted for sub-acute intracranial hypertension with behaviour disorders. Cranial magnetic resonance imaging (MRI) showed a cystic lesion of the third ventricle containing fluid-fluid level with biventricular hydrocephalus and debris in the occipital horns. A ruptured cystic neoplasm was first considered. The patient underwent surgery via a right transcortical transventricular approach, combining both microscope and endoscope. The puncture of the lesion brought pus and the Ziehl-Neelson (ZN) staining demonstrated acid-fast bacilli. Intraventricular tuberculous abscess is an extremely rare condition that can take an unusual radiological appearance. This observation highlights the consideration of tuberculosis within the list of differential diagnosis of intraventricular cystic lesions in immunocompetent hosts.
MeSH term(s)	Brain/diagnostic imaging ; Brain/pathology ; Brain Abscess/diagnosis ; Brain Abscess/surgery ; Brain Neoplasms/diagnosis ; Diagnosis, Differential ; Humans ; Hydrocephalus/etiology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Tuberculoma, Intracranial/diagnosis ; Tuberculoma, Intracranial/surgery
Language	English
Publishing date	2021-06-12
Publishing country	Uganda
Document type	Case Reports
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2021.39.122.29369
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Article ; Online: A rare complication of cervical disc herniation surgery: Cerebral ischemia.

Bouaré, F / Mpando, D / Lmejjati, M / Laghmari, M / Ghannane, H / Ait Benali, S

Neuro-Chirurgie

2020 Volume 67, Issue 2, Page(s) 214–215

Language	English
Publishing date	2020-06-02
Publishing country	France
Document type	Letter
ZDB-ID	207146-0
ISSN	1773-0619 ; 0028-3770 ; 0150-9586
ISSN (online)	1773-0619
ISSN	0028-3770 ; 0150-9586
DOI	10.1016/j.neuchi.2020.04.002
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Article ; Online: Cornea plana : à propos d’un cas et revue de la littérature.

Jaja, Z / Lezrek, O / Laghmari, M / Daoudi, R

Journal francais d'ophtalmologie

2017 Volume 40, Issue 2, Page(s) e45–e47

Title translation	Cornea plana: Case report and review of the literature.
MeSH term(s)	Child, Preschool ; Cornea/abnormalities ; Corneal Diseases/diagnosis ; Eye Diseases, Hereditary/diagnosis ; Humans ; Male
Language	French
Publishing date	2017-01-05
Publishing country	France
Document type	Case Reports ; Letter ; Review
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2015.10.015
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Article ; Online: Glaucome uvéitique dans la maladie de Behçet : quand tout se complique….

Belkhadir, K / Boutimzine, N / Tachfouti, S / Laghmari, M / Amazouzi, A / Cherkaoui, O

Journal francais d'ophtalmologie

2020 Volume 43, Issue 7, Page(s) 635–641

Abstract: Introduction: Behçet's disease is a systemic disease of unknown etiology. Its ocular manifestations are multiple and polymorphic, with uveitis at the top of the list. Classically, uveitis in Behçet's disease does not cause elevation of intraocular ... ...

Title translation	Uveitic glaucoma in Behçet's disease: When everything gets complicated.
Abstract	Introduction: Behçet's disease is a systemic disease of unknown etiology. Its ocular manifestations are multiple and polymorphic, with uveitis at the top of the list. Classically, uveitis in Behçet's disease does not cause elevation of intraocular pressure. However, this may be found in 10 to 20% of cases, secondary to trabeculitis, trabecular obstruction by inflammatory cells, anterior or posterior synechiae, or induced by prolonged use of corticosteroids. Its occurrence is a major complication, the management of which is especially delicate when glaucoma occurs. The purpose of this study was to study the factors predictive of glaucoma in Behçet's disease. Materials and methods: This is a retrospective study of all the charts of patients consecutively hospitalized for Behçet's disease over a period of 8years in the ophthalmology A department of the specialty hospital of Rabat university medical center. Results: Fifty patients were treated for Behçet's disease during the study period. There were 41 men (82%), and 9 women (18%). Glaucoma was diagnosed in 11 patients (22%). The mean age of this subgroup was 31years, with a gender ratio of 6 women/5 men. The glaucoma was associated with anterior synechiae in 4 cases, primary open-angle glaucoma in 5 cases, neovascular glaucoma in 1 case and seclusio pupillae in 1 case. Therapeutically, all patients were on glaucoma eye drops, and five underwent filtering surgery. Statistically, on univariate analysis, ocular hypertension was observed particularly in patients with low initial visual acuity (less than 1/10) (P=0.001), with severe posterior segment involvement, especially retinal vasculitis (29% vs. 6%, P=0.04), macular edema (40% vs. 4%, P=0.001), and optic disc edema (50% vs. 15%, P=0.02). A high number of recurrences was also associated with glaucoma (1.0 vs. 3.0, P<0.0001). On multivariate analysis, low baseline visual acuity, presence of retinal vasculitis, and high number of recurrences were independent risk factors for ocular hypertension in our patients followed for Behçet's disease. Conclusion: Glaucoma can complicate the management of Behçet's disease. This glaucoma will be more difficult to manage in this delicate pathological context. It requires special vigilance in patients with severe posterior segment inflammation, to institute effective management to avoid its potentially blinding complications.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adult ; Behcet Syndrome/complications ; Behcet Syndrome/drug therapy ; Behcet Syndrome/epidemiology ; Female ; Glaucoma/drug therapy ; Glaucoma/epidemiology ; Glaucoma/etiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Morocco/epidemiology ; Prevalence ; Retrospective Studies ; Uveitis/drug therapy ; Uveitis/epidemiology ; Uveitis/etiology ; Vision, Ocular/drug effects ; Young Adult
Chemical Substances	Adrenal Cortex Hormones ; Immunosuppressive Agents
Language	French
Publishing date	2020-07-01
Publishing country	France
Document type	Journal Article
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2019.12.005
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Article ; Online: Chromone-isoxazole hybrids molecules: synthesis, spectroscopic, MEDT, ELF, antibacterial, ADME-Tox, molecular docking and MD simulation investigations.

Kanzouai, Youssra / Laghmari, Mustapha / Yamari, Imane / Bouzammit, Rachid / Bahsis, Lahoucine / Benali, Taoufiq / Chtita, Samir / Bakhouch, Mohamed / Akhazzane, Mohamed / El Kouali, M'hammed / Hammani, Khalil / Al Houari, Ghali

Journal of biomolecular structure & dynamics

2023 , Page(s) 1–15

Abstract: A mechanistic study was performed within the molecular electron density theory at the B3LYP/6-311G (d,p) computational level to explain the regioselectivity observed. An electron localization function analysis was also performed, and the results confirm ... ...

Abstract	A mechanistic study was performed within the molecular electron density theory at the B3LYP/6-311G (d,p) computational level to explain the regioselectivity observed. An electron localization function analysis was also performed, and the results confirm the zwitterionic-type (zw-type) mechanism of the cycloaddition reactions between nitrile oxide and alkylated 4
Language	English
Publishing date	2023-10-10
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2023.2266022
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Article ; Online: Penetrating head trauma: 03 rare cases and literature review.

Fahde, Youssef / Laghmari, Mehdi / Skoumi, Mohamed

The Pan African medical journal

2017 Volume 28, Page(s) 305

Abstract: Penetrating head trauma (PHT) include all open head injuries with foreign object in the brain. Although less common than closed head trauma, penetrating head trauma carry a worse prognosis. We received three unusual cases of penetrating head injuries ... ...

Abstract	Penetrating head trauma (PHT) include all open head injuries with foreign object in the brain. Although less common than closed head trauma, penetrating head trauma carry a worse prognosis. We received three unusual cases of penetrating head injuries whose prognosis was different according to clinical presentation and initial management of the patient. Treatment of penetrating head trauma aims at controlling bleeding, controlling intracranial pressure and preventing infections. Despite the efforts made by national authorities as well as the adequate management in hospitals, penetrating head injuries are still frequent with significant mortality and morbidity.
MeSH term(s)	Adolescent ; Child, Preschool ; Female ; Foreign Bodies/complications ; Head Injuries, Penetrating/therapy ; Humans ; Intracranial Hemorrhage, Traumatic/therapy ; Intracranial Pressure ; Male ; Prognosis
Language	English
Publishing date	2017
Publishing country	Uganda
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2017.28.305.10376
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