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Article ; Online: Borna disease in an adult free-ranging Eurasian beaver (Castor fiber albicus).

Ellenberger, Christin / Heenemann, Kristin / Vahlenkamp, Thomas W / Grothmann, Pierre / Herden, Christiane / Heinrich, Anja

Journal of comparative pathology

2024 Volume 209, Page(s) 31–35

Abstract: Borna disease (BD) associated with a peracute bacterial septicaemia with Escherichia coli was diagnosed in an adult female, naturally infected, free-ranging Eurasian beaver of the subspecies Castor fiber albicus, clinically characterized by weight loss, ... ...

Abstract	Borna disease (BD) associated with a peracute bacterial septicaemia with Escherichia coli was diagnosed in an adult female, naturally infected, free-ranging Eurasian beaver of the subspecies Castor fiber albicus, clinically characterized by weight loss, depression, weakness and gurgled peristaltic sounds. The beaver was euthanized humanely. Necropsy and light microscopy revealed a non-purulent meningoencephalitis with typical mononuclear perivascular cuffs and parenchymal infiltrates. The diagnosis of BD was confirmed by detection of viral antigen and RNA by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). The PCR product was sequenced and cluster analysis revealed a close relationship between endemic clusters in Saxony-Anhalt. This is the first report of naturally occurring BD in a free-ranging Eurasian beaver.
MeSH term(s)	Female ; Animals ; Borna Disease ; Antigens, Viral ; Autopsy/veterinary ; Meningoencephalitis/veterinary ; Sepsis/veterinary
Chemical Substances	Antigens, Viral
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	390920-7
ISSN	1532-3129 ; 0021-9975
ISSN (online)	1532-3129
ISSN	0021-9975
DOI	10.1016/j.jcpa.2024.01.003
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Article ; Online: [A world beyond SARS-CoV-2, as well

Michael Sieg / Thomas W. Vahlenkamp

Berliner und Münchener Tierärztliche Wochenschrift, Vol

Coronaviruses in zoo and wildlife animals]

2021 Volume 134

Abstract: The family of Coronaviridae comprises numerous virus species, some of which play an outstanding role in veterinary medicine. In addition to infections of the respiratory and/or the gastrointestinal tract, which are usually mild, severe systemic ... ...

Abstract	[The family of Coronaviridae comprises numerous virus species, some of which play an outstanding role in veterinary medicine. In addition to infections of the respiratory and/or the gastrointestinal tract, which are usually mild, severe systemic infections and even fatal outcomes can occur. Wild and zoo animals are just as affected by coronavirus infections as their domesticated counterparts. In many cases, however, other virus species or virus variants are found in wild animals, which so far have not been characterized in detail. Knowledge of the virus reservoirs, the transmission mechanisms, the virus evolution and the underlying pathomechanisms is a basic requirement for combating relevant infections in pets and farm animals. In the area of coronaviruses in zoo and wild animals, there is still a considerable need for research in order to be able to answer pestering questions regarding the zoonotic potential and possible cross-species transmissions between wild and domesticated animals.] Die Familie der Coronaviridae umfasst zahlreiche Virusspezies, die im Tierreich teils von großer Bedeutung sind. Neben Infektionen der Atemwege und/oder des Magen-Darm-Traktes, welche in der Regel mild verlaufen, können auch schwere systemische Infektionen bis hin zu tödlichen Krankheitsverläufen vorkommen. Wild- und Zootiere sind dabei von Infektionen mit Coronaviren genauso betroffen wie deren domestizierte Artgenossen. Allerdings findet man in wild lebenden Tieren in vielen Fällen noch weitere Virusspezies oder Virusvarianten, welche bis dato schlecht oder kaum charakterisiert sind. Dabei ist die Kenntnis des Virusreservoirs, der Übertragungsmechanismen, der Virusevolution und der zugrunde liegenden Pathomechanismen Grundvoraussetzung zur Bekämpfung entsprechender Infektionen bei Haus- und Nutztieren. Hinsichtlich der Coronaviren von Zoo- und Wildtieren besteht hierbei noch erheblicher Forschungsbedarf, um wichtige Fragen bezüglich des zoonotischen Potenzials und möglicher Spezies-Übertritte zwischen Wild- und ...
Keywords	reservoir ; zoonosis ; enteritis ; respiratory infections ; Veterinary medicine ; SF600-1100
Subject code	801
Language	German
Publishing date	2021-04-01T00:00:00Z
Publisher	Schlütersche Fachmedien GmbH
Document type	Article ; Online
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Article: Case Series of Disseminated Xanthogranulomatosis in Red-crowned Parakeets (

Konicek, Cornelia / Heenemann, Kristin / Cramer, Kerstin / Vahlenkamp, Thomas W / Schmidt, Volker

Animals : an open access journal from MDPI

2022 Volume 12, Issue 18

Abstract: Xanthogranulomatosis is a common dermatological disease in birds. This form of inflammation, possibly associated with lipometabolic disorders, can also be seen in visceral organs, which as yet has only rarely been described in avian medicine. In general, ...

Abstract	Xanthogranulomatosis is a common dermatological disease in birds. This form of inflammation, possibly associated with lipometabolic disorders, can also be seen in visceral organs, which as yet has only rarely been described in avian medicine. In general, diseases related to impaired lipid metabolism are frequently reported in avian medicine, with hepatic steatosis and atherosclerosis being the most common. In human medicine, infectious agents-especially some strains of adenovirus-were implicated in contributing to lipometabolic disorders; this has also been described for chicken. Here, a case series of six Red-crowned Parakeets (
Language	English
Publishing date	2022-09-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12182316
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Article ; Online: Seroprevalence of Infection with Feline Morbilliviruses Is Associated with FLUTD and Increased Blood Creatinine Concentrations in Domestic Cats.

Busch, Johannes / Heilmann, Romy M / Vahlenkamp, Thomas W / Sieg, Michael

Viruses

2021 Volume 13, Issue 4

Abstract: Feline morbilliviruses (FeMV) are fairly newly discovered paramyxoviruses found in cats. The first description indicated an association with widely distributed chronic kidney disease (CKD) in the host species. In various studies, a global prevalence and ... ...

Abstract	Feline morbilliviruses (FeMV) are fairly newly discovered paramyxoviruses found in cats. The first description indicated an association with widely distributed chronic kidney disease (CKD) in the host species. In various studies, a global prevalence and a further genotype, designated FeMV-2, and the involvement of other organ systems in infected individuals were shown. Using an immunofluorescence assay, we detected an overall seroprevalence of FeMV in almost half of the cats investigated (
MeSH term(s)	Animals ; Animals, Domestic/virology ; Cats ; Creatinine/blood ; Female ; Genotype ; Kidney/virology ; Male ; Morbillivirus/genetics ; Morbillivirus/immunology ; Morbillivirus Infections/immunology ; Morbillivirus Infections/veterinary ; Phylogeny ; Prevalence ; RNA, Viral/genetics ; Renal Insufficiency, Chronic/veterinary ; Renal Insufficiency, Chronic/virology ; Seroepidemiologic Studies ; Urologic Diseases/veterinary ; Urologic Diseases/virology
Chemical Substances	RNA, Viral ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2021-03-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13040578
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Article ; Online: Avian leukosis virus (ALV) is highly prevalent in fancy-chicken flocks in Saxony.

Freick, Markus / Schreiter, Ruben / Weber, Jim / Vahlenkamp, Thomas W / Heenemann, Kristin

Archives of virology

2022 Volume 167, Issue 4, Page(s) 1169–1174

Abstract: The current prevalence of avian leukosis virus (ALV) in fancy chickens in Germany is unknown. Therefore, 537 cloacal swabs from 50 purebred fancy-chicken flocks in Saxony were tested for the presence of the ALV p27 protein using a commercial antigen- ... ...

Abstract	The current prevalence of avian leukosis virus (ALV) in fancy chickens in Germany is unknown. Therefore, 537 cloacal swabs from 50 purebred fancy-chicken flocks in Saxony were tested for the presence of the ALV p27 protein using a commercial antigen-capture ELISA. The detection rate was 28.7% at the individual-animal level and 56.0% at the flock level. Phylogenetic analysis of PCR products obtained from 22 different flocks revealed the highest similarity to ALV subtype K. When classifying breeds by their origin, ALV detection rates differed significantly. Evaluation of questionnaire data revealed no significant differences between ALV-positive and negative flocks regarding mortality.
MeSH term(s)	Animals ; Avian Leukosis/epidemiology ; Avian Leukosis Virus/genetics ; Chickens ; Germany/epidemiology ; Phylogeny
Language	English
Publishing date	2022-03-17
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-022-05404-y
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Article ; Online: Mutated Measles Virus Matrix and Fusion Protein Influence Viral Titer In Vitro and Neuro-Invasion in Lewis Rat Brain Slice Cultures.

Busch, Johannes / Chey, Soroth / Sieg, Michael / Vahlenkamp, Thomas W / Liebert, Uwe G

Viruses

2021 Volume 13, Issue 4

Abstract: Measles virus (MV) can cause severe acute diseases as well as long-lasting clinical deteriorations due to viral-induced immunosuppression and neuronal manifestation. How the virus enters the brain and manages to persist in neuronal tissue is not fully ... ...

Abstract	Measles virus (MV) can cause severe acute diseases as well as long-lasting clinical deteriorations due to viral-induced immunosuppression and neuronal manifestation. How the virus enters the brain and manages to persist in neuronal tissue is not fully understood. Various mutations in the viral genes were found in MV strains isolated from patient brains. In this study, reverse genetics was used to introduce mutations in the fusion, matrix and polymerase genes of MV. The generated virus clones were characterized in cell culture and used to infect rat brain slice cultures. A mutation in the carboxy-terminal domain of the matrix protein (R293Q) promoted the production of progeny virions. This effect was observed in Vero cells irrespective of the expression of the signaling lymphocyte activation molecule (SLAM). Furthermore, a mutation in the fusion protein (I225M) induced syncytia formation on Vero cells in the absence of SLAM and promoted viral spread throughout the rat brain slices. In this study, a solid ex vivo model was established to elucidate the MV mutations contributing to neural manifestation.
MeSH term(s)	Animals ; Brain/virology ; Chlorocebus aethiops ; HEK293 Cells ; Humans ; In Vitro Techniques ; Measles/virology ; Measles virus/genetics ; Measles virus/pathogenicity ; Measles virus/physiology ; Mutation ; Neurons/virology ; Rats, Inbred Lew ; Reverse Genetics ; Signaling Lymphocytic Activation Molecule Family Member 1/genetics ; Signaling Lymphocytic Activation Molecule Family Member 1/metabolism ; Vero Cells ; Viral Fusion Proteins/genetics ; Viral Proteins/genetics ; Viral Tropism/genetics ; Rats
Chemical Substances	Viral Fusion Proteins ; Viral Proteins ; Signaling Lymphocytic Activation Molecule Family Member 1 (169535-43-7)
Language	English
Publishing date	2021-04-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13040605
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Article ; Online: Seroprevalence and Risk Factors for Equine West Nile Virus Infections in Eastern Germany, 2020.

Ganzenberg, Stefanie / Sieg, Michael / Ziegler, Ute / Pfeffer, Martin / Vahlenkamp, Thomas W / Hörügel, Uwe / Groschup, Martin H / Lohmann, Katharina L

Viruses

2022 Volume 14, Issue 6

Abstract: West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study's overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and ... ...

Abstract	West Nile virus (WNV) infections were first detected in Germany in 2018, but information about WNV seroprevalence in horses is limited. The study's overall goal was to gather information that would help veterinarians, horse owners, and veterinary-, and public health- authorities understand the spread of WNV in Germany and direct protective measures. For this purpose, WNV seroprevalence was determined in counties with and without previously registered WNV infections in horses, and risk factors for seropositivity were estimated. The cohort consisted of privately owned horses from nine counties in Eastern Germany. A total of 940 serum samples was tested by competitive panflavivirus ELISA (cELISA), and reactive samples were further tested by WNV IgM capture ELISA and confirmed by virus neutralization test (VNT). Information about potential risk factors was recorded by questionnaire and analyzed by logistic regression. A total of 106 serum samples showed antibodies against flaviviruses by cELISA, of which six tested positive for WNV IgM. The VNT verified a WNV infection for 54 samples (50.9%), while 35 sera neutralized tick-borne encephalitis virus (33.0%), and eight sera neutralized Usutu virus (7.5%). Hence, seroprevalence for WNV infection was 5.8% on average and was significantly higher in counties with previously registered infections (
MeSH term(s)	Animals ; Antibodies, Viral ; Encephalitis Viruses, Tick-Borne ; Enzyme-Linked Immunosorbent Assay ; Horse Diseases/epidemiology ; Horses ; Humans ; Immunoglobulin M ; Risk Factors ; Seroepidemiologic Studies ; West Nile Fever/epidemiology ; West Nile Fever/veterinary ; West Nile virus
Chemical Substances	Antibodies, Viral ; Immunoglobulin M
Language	English
Publishing date	2022-05-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14061191
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Article: The mycotoxin deoxynivalenol (DON) can deteriorate vaccination efficacy against porcine reproductive and respiratory syndrome virus (PRRSV) at subtoxic levels.

Rückner, Antje / Plagge, Lisa / Heenemann, Kristin / Harzer, Maxi / Thaa, Bastian / Winkler, Janine / Dänicke, Sven / Kauffold, Johannes / Vahlenkamp, Thomas W

Porcine health management

2022 Volume 8, Issue 1, Page(s) 13

Abstract: Background: Feedgrain contamination with mycotoxins, including deoxynivalenol (DON, "vomitoxin") is relatively frequently encountered. Pigs are particularly sensitive to the toxicity of DON. To assess the interplay between DON and porcine reproductive ... ...

Abstract	Background: Feedgrain contamination with mycotoxins, including deoxynivalenol (DON, "vomitoxin") is relatively frequently encountered. Pigs are particularly sensitive to the toxicity of DON. To assess the interplay between DON and porcine reproductive and respiratory syndrome virus (PRRSV), we performed an experimental DON exposure-PRRSV vaccination-challenge infection trial. Three-week-old piglets were divided into four groups. Groups I, II and III (10 animals/group) were vaccinated with a PRRSV modified live vaccine and 2 weeks later challenged with a heterologous field strain. While group I was not supplemented with DON, animals in groups II and III received DON for 4 weeks prior to challenge infection at levels that can be encountered in pig feed, employing a low-dose or high-dose regime (group II: 40 µg DON/kg body weight per day; group III: 80 µg DON/kg body weight per day, corresponding to approx. 1 or 2 mg DON/kg feed, respectively). Eight animals (group IV; unvaccinated, not DON exposed) served as control animals for the challenge infection. Results: We assessed clinical signs, virus load in serum and various organs as well as antibody titres in the animals. All vaccinated animals mounted an efficient PRRSV-specific antibody response within 2 weeks, except for 20% of the animals receiving the higher DON dose. Upon virus challenge, the vaccinated animals in group I were protected from clinical signs. Vaccinated DON-exposed animals in group II and III were protected from clinical signs to a lesser extent. Clinical signs in group III receiving the higher dose of DON were as severe as in the (unvaccinated, not DON exposed) control group IV. The animals of group III also displayed lower antibody titres compared with the animals in group I and II. Conclusions: The experimental vaccination/challenge study therefore revealed that exposure of pigs to DON for a period of 4 weeks deteriorates the efficacy of vaccination against clinical signs of PRRS.
Language	English
Publishing date	2022-03-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2835354-7
ISSN	2055-5660
ISSN	2055-5660
DOI	10.1186/s40813-022-00254-1
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Article: Avian leukosis virus (ALV) is highly prevalent in fancy-chicken flocks in Saxony

Freick, Markus / Schreiter, Ruben / Weber, Jim / Vahlenkamp, Thomas W. / Heenemann, Kristin

Archives of virology. 2022 Apr., v. 167, no. 4

2022

Abstract	The current prevalence of avian leukosis virus (ALV) in fancy chickens in Germany is unknown. Therefore, 537 cloacal swabs from 50 purebred fancy-chicken flocks in Saxony were tested for the presence of the ALV p27 protein using a commercial antigen-capture ELISA. The detection rate was 28.7% at the individual-animal level and 56.0% at the flock level. Phylogenetic analysis of PCR products obtained from 22 different flocks revealed the highest similarity to ALV subtype K. When classifying breeds by their origin, ALV detection rates differed significantly. Evaluation of questionnaire data revealed no significant differences between ALV-positive and negative flocks regarding mortality.
Keywords	Avian leukosis virus ; cloaca ; flocks ; mortality ; phylogeny ; purebreds ; questionnaires ; virology ; Germany
Language	English
Dates of publication	2022-04
Size	p. 1169-1174.
Publishing place	Springer Vienna
Document type	Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-022-05404-y
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Horses as sentinels for the circulation of flaviviruses in eastern-central Germany

Gothe, Leonard M. R. / Ganzenberg, Stefanie / Ziegler, Ute / Obiegala, Anna / Lohmann, Katharina L. / Sieg, Michael / Vahlenkamp, Thomas W. / Hörügel, Uwe / Pfeffer, Martin*

2023

Keywords	abstract_or_summary ; Text ; ddc:570 ; vector-borne zoonoses -- specific antibodies -- risk factors -- Usutu- ; West Nile- and Tick-Borne Encephalitis-Virus
Language	English
Publishing date	2023-10-09
Publisher	MDPI AG
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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