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  1. Book ; Thesis: Mittelfristige Ergebnisse des lateralen unikondylären Kniegelenkersatzes mit mobiler Inlaykomponente

    Zahn, Niklas / Gotterbarm, Tobias

    eine Multicenter Studie

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Niklas Zahn ; Doktorvater: Prof. Dr. med. Tobias Gotterbarm
    Language German
    Size 118 Blätter, Illustrationen, Diagramme
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021370148
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2022 E 561 order for loan Magazin

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  2. Book ; Online ; Thesis: Untersuchung zur Häufigkeit diagnostischer und therapeutischer Maßnahmen bei Krankenhauspatient:innen am Lebensende

    Franke, Rafael Tobias [Verfasser] / Zahn, Peter [Gutachter] / Frey, Ulrich [Gutachter]

    2023  

    Author's details Rafael Tobias Franke ; Gutachter: Peter Zahn, Ulrich Frey ; Medizinische Fakultät
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Ruhr-Universität Bochum
    Publishing place Bochum
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Book ; Online: Unlocking the Potential of Collaborative AI -- On the Socio-technical Challenges of Federated Machine Learning

    Müller, Tobias / Zahn, Milena / Matthes, Florian

    2023  

    Abstract: The disruptive potential of AI systems roots in the emergence of big data. Yet, a significant portion is scattered and locked in data silos, leaving its potential untapped. Federated Machine Learning is a novel AI paradigm enabling the creation of AI ... ...

    Abstract The disruptive potential of AI systems roots in the emergence of big data. Yet, a significant portion is scattered and locked in data silos, leaving its potential untapped. Federated Machine Learning is a novel AI paradigm enabling the creation of AI models from decentralized, potentially siloed data. Hence, Federated Machine Learning could technically open data silos and therefore unlock economic potential. However, this requires collaboration between multiple parties owning data silos. Setting up collaborative business models is complex and often a reason for failure. Current literature lacks guidelines on which aspects must be considered to successfully realize collaborative AI projects. This research investigates the challenges of prevailing collaborative business models and distinct aspects of Federated Machine Learning. Through a systematic literature review, focus group, and expert interviews, we provide a systemized collection of socio-technical challenges and an extended Business Model Canvas for the initial viability assessment of collaborative AI projects.

    Comment: Accepted for Publication at the 31st European Conference on Information Systems (ECIS 2023)
    Keywords Computer Science - Artificial Intelligence
    Subject code 670
    Publishing date 2023-04-26
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Etablierung einer stabilen in vitro-Kultur für Fagus sylvatica - Ein erster Schritt hin zur Genomeditierung in Buchen

    Zahn, Virginia / Sievers, Alice-Jeannine / Fladung, Matthias / Brügmann, Tobias

    2023  

    Keywords Text ; ddc:630
    Language German
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Fixed-bearing is superior to mobile-bearing in lateral unicompartmental knee replacement: a retrospective matched-pairs analysis.

    Hariri, Mustafa / Zahn, Niklas / Mick, Paul / Jaber, Ayham / Reiner, Tobias / Renkawitz, Tobias / Innmann, Moritz / Walker, Tilman

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

    2023  Volume 31, Issue 9, Page(s) 3947–3955

    Abstract: Purpose: Due to low incidence of isolated lateral osteoarthritis (OA), there are limited data on whether a fixed-bearing (FB) or a mobile-bearing (MB) design is superior for lateral unicompartmental knee replacement (UKR). The aim of this matched-pairs ... ...

    Abstract Purpose: Due to low incidence of isolated lateral osteoarthritis (OA), there are limited data on whether a fixed-bearing (FB) or a mobile-bearing (MB) design is superior for lateral unicompartmental knee replacement (UKR). The aim of this matched-pairs analysis was to compare both designs in terms of implant survival and clinical outcome.
    Methods: Patients who received MB-UKR (Group A) and FB-UKR (Group B) at a single centre were matched according to gender, age at time of surgery and body mass index (BMI). Survivorship analysis was performed with the endpoint set as "revision for any reason". Clinical outcome was assessed using the Oxford knee score (OKS), visual analogue scale for pain (VAS), patients' satisfaction, University of California Los Angeles activity scale (UCLA) and the Tegner activity score (TAS).
    Results: A total of 60 matched pairs were included with a mean follow-up (FU) of 3.4 ± 1.3 (range 1.2-5.0) years in Group A and 2.7 ± 1.2 (range 1.0-5.0) years in Group B. Survivorship between both groups differed significantly (Group A: 78.7%; Group B: 98.3%, p = 0.003) with bearing dislocation being the most common reason for revision in Group A (46.2%). The relative and absolute risk reduction were 92.2% and 20%, respectively, with 5 being the number needed to treat. There were no differences in OKS (Group A: 41.6 ± 6.5; Group B: 40.4 ± 7.7), VAS (Group A: 2.9 ± 3.2; Group B: 1.6 ± 2.2), UCLA (Group A: 5.7 ± 1.3; Group B: 5.9 ± 1.8) and TAS (Group A: 3.0 ± 1.0; Group B: 3.1 ± 1.2) between both groups on follow-up.
    Conclusion: Despite modern prosthesis design and surgical technique, implant survival of lateral MB-UKR is lower than that of FB-UKR on the short- to mid-term due to bearing dislocation as the most common cause of failure. Since clinical results are equivalent in both groups, FB-UKR should be preferred in treatment of isolated lateral OA.
    Level of evidence: Retrospective case-control study, Level III.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Knee/methods ; Knee Prosthesis ; Retrospective Studies ; Case-Control Studies ; Osteoarthritis, Knee/surgery ; Osteoarthritis, Knee/etiology ; Reoperation ; Prosthesis Design ; Joint Dislocations/surgery ; Pain/surgery ; Treatment Outcome ; Knee Joint/surgery
    Language English
    Publishing date 2023-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1159064-6
    ISSN 1433-7347 ; 0942-2056
    ISSN (online) 1433-7347
    ISSN 0942-2056
    DOI 10.1007/s00167-023-07417-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3742: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The Effect of Cytokine Adsorption on Leukocyte and Platelet Activation after Extracorporeal Cardiopulmonary Resuscitation.

    Zahn, Timm / Schanze, Nancy / Staudacher, Dawid L / Wengenmayer, Tobias / Maier, Sven / Benk, Christoph / Gauchel, Nadine / Duerschmied, Daniel / Supady, Alexander

    Thrombosis and haemostasis

    2024  

    Abstract: Background:  Post-cardiac arrest syndrome (PCAS) is a frequent complication following successful cardiopulmonary resuscitation and correlates with poor outcome. PCAS is characterized by an excessive inflammatory response to whole-body ischemia and ... ...

    Abstract Background:  Post-cardiac arrest syndrome (PCAS) is a frequent complication following successful cardiopulmonary resuscitation and correlates with poor outcome. PCAS is characterized by an excessive inflammatory response to whole-body ischemia and reperfusion. Cytokine adsorption was suggested as an adjunctive treatment option for the removal of cytokines from the patients' blood to restore the physiological equilibrium of pro- and anti-inflammatory activity and thus mitigate hemodynamic instability and end-organ complications.
    Material and methods:  To better understand the cellular effects of cytokine adsorption in patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) after in- and out-of-hospital cardiac arrest, we compared the activation status of neutrophils, monocytes, and platelets as well as the formation of platelet-leukocyte complexes in intravenous whole blood samples from an exploratory subgroup (
    Result:  At 48 hours after initiation of ECPR, flow cytometry analyses did neither reveal significant differences in neutrophil (CD11b, CD66b, L-selectin, and PSGL-1) and monocyte (CD11b, L-selectin, and PSGL-1) surface molecule expression nor in circulating platelet-monocyte complexes between patients receiving cytokine adsorption and those without.
    Conclusion:  Data did not show a relevant effect of cytokine adsorption on neutrophil and monocyte activation during the first 48 hours after initiation of ECPR.
    Language English
    Publishing date 2024-01-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-2225-5173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 433: Show issues

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  7. Conference proceedings: Mobile-bearing vs. fixed bearing im lateralen unikondylären Gelenkersatz – eine retrospektive Matched pair Studie

    Hariri, Mustafa / Zahn, Niklas / Mick, Paul / Jaber, Ayham / Reiner, Tobias / Renkawitz, Tobias / Innmann, Moritz / Walker, Tilman

    2023  , Page(s) AB35–3047

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2023); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2023
    Keywords Medizin, Gesundheit ; unikondylärer Gelenkersatz ; Schlittenprothese ; lateral ; Valgusgonarthrose
    Publishing date 2023-10-23
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dkou147
    Database German Medical Science

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  8. Article ; Online: Combining bacterial and viral elements for efficient gene targeting in poplar

    Zahn, Virginia / Brügmann, Tobias / Fladung, Matthias

    2022  

    Keywords Text ; abstract_or_summary ; ddc:570
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Diverse mutation patterns include large deletions in a CRISPR/nCas9 double nicking approach poplar

    Brügmann, Tobias / Zebbedies, Stefan / Zahn, Virginia / Fladung, Matthias

    2022  

    Keywords Text ; abstract_or_summary ; ddc:570
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Diverse mutation patterns include large deletions in a CRISPR/nCas9 double nicking approach poplar

    Brügmann, Tobias / Zebbedies, Stefan / Zahn, Virginia / Fladung, Matthias

    2022  

    Keywords Text ; abstract_or_summary ; ddc:570
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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