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  1. Article: Real-Life Comparison of Four JAK Inhibitors in Rheumatoid Arthritis (ELECTRA-

    Benucci, Maurizio / Li Gobbi, Francesca / Damiani, Arianna / Russo, Edda / Guiducci, Serena / Manfredi, Mariangela / Lari, Barbara / Grossi, Valentina / Infantino, Maria

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Non-medical switching: save today and pay tomorrow.

    Benucci, Maurizio / Cantini, Fabrizio

    Journal of medical economics

    2019  Volume 22, Issue 11, Page(s) 1160–1161

    MeSH term(s) Arthritis, Rheumatoid ; Biosimilar Pharmaceuticals ; Costs and Cost Analysis ; Etanercept ; Humans ; United Kingdom
    Chemical Substances Biosimilar Pharmaceuticals ; Etanercept (OP401G7OJC)
    Language English
    Publishing date 2019-09-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2270945-9
    ISSN 1941-837X ; 1369-6998
    ISSN (online) 1941-837X
    ISSN 1369-6998
    DOI 10.1080/13696998.2019.1651132
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  3. Article ; Online: Testing for isotypes does not help differentiating rheumatoid arthritis from other rheumatoid factor positive diseases.

    Infantino, Maria / Palterer, Boaz / Benucci, Maurizio / Grossi, Valentina / Pancani, Silvia / Manfredi, Mariangela / Bizzaro, Nicola

    Immunologic research

    2023  Volume 71, Issue 6, Page(s) 883–886

    Abstract: Rheumatoid factors (RFs) are useful for diagnosis and classification of rheumatoid arthritis (RA). Nephelometric and turbidimetric techniques, which detect total RF but do not reveal the antibody isotype, are common diagnostic methods in clinical routine. ...

    Abstract Rheumatoid factors (RFs) are useful for diagnosis and classification of rheumatoid arthritis (RA). Nephelometric and turbidimetric techniques, which detect total RF but do not reveal the antibody isotype, are common diagnostic methods in clinical routine. Given the recent development of isotype-specific immunoassays, the detection of IgG, IgM, and IgA RFs represents an interesting challenge. The aim of the study was to evaluate whether specific RF tests performed as a second step after traditional nephelometry could help differentiating RA from other RF-positive diseases. We tested 117 consecutive serum samples that were RF-positive at nephelometry (BNII nephelometric analyzer, Siemens) for IgA, IgG, and IgM RF isotypes by a fluoroimmunoenzymatic assay (FEIA) on the Phadia 250 instrument (ThermoFisher). Fifty-five subjects had RA and 62 presented non-RA diagnoses. Eighteen sera (15.4%) were positive only by nephelometry, two were positive only for IgA RF, and the remaining 97 sera were all positive for IgM RF isotype (with or without IgG and IgA RF). Positive findings did not correlate with RA or non-RA diagnosis. Spearman rho correlation coefficient between nephelometric total RF and IgM isotype was moderate (0.657), and weak between total RF and IgA (0.396) and IgG (0.360) isotypes. Despite its low specificity, measurement of total RF by nephelometry still seems to be the method that performs best. As IgM, IgA, and IgG RF isotypes showed only a moderate correlation with total RF measurement, their diagnostic use as a second level test remains controversial.
    MeSH term(s) Humans ; Rheumatoid Factor ; Immunoglobulin G ; Arthritis, Rheumatoid ; Immunoglobulin A ; Immunoglobulin M ; Enzyme-Linked Immunosorbent Assay/methods
    Chemical Substances Rheumatoid Factor (9009-79-4) ; Immunoglobulin G ; Immunoglobulin A ; Immunoglobulin M
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632857-x
    ISSN 1559-0755 ; 0257-277X
    ISSN (online) 1559-0755
    ISSN 0257-277X
    DOI 10.1007/s12026-023-09402-3
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  4. Article ; Online: Lack of comparability of immunoassays for rheumatoid factor isotypes.

    Infantino, Maria / Palterer, Boaz / Pancani, Silvia / Benucci, Maurizio / Grossi, Valentina / Manfredi, Mariangela / Bizzaro, Nicola

    Clinical chemistry and laboratory medicine

    2023  Volume 61, Issue 9, Page(s) 1619–1622

    Abstract: Objectives: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by the presence of autoantibodies that are used for classification of the disease. Though routine diagnostics is commonly restricted to measuring rheumatoid factor (RF) ...

    Abstract Objectives: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by the presence of autoantibodies that are used for classification of the disease. Though routine diagnostics is commonly restricted to measuring rheumatoid factor (RF) and anti-citrullinated protein antibodies, detection of RF IgM, IgG and IgA isotypes, may increase the power of RA serodiagnosis by reducing the number of seronegative patients as well as provide prognostic information. The agglutination-based RF assays, such as nephelometry or turbidimetry, are unable to differentiate isotypes. We compared three different immunoassays used in current laboratory practice to detect RF isotypes.
    Methods: We tested 117 consecutive serum samples that were positive for total RF at nephelometry, from 55 RA and 62 non-RA subjects. IgA, IgG, and IgM isotypes of RF were tested by immunoenzymatic (ELISA, Technogenetics), fluoroenzymatic (FEIA, ThermoFisher) and chemiluminescence (CLIA, YHLO Biotech Co.) immunoassays.
    Results: Diagnostic performance differed considerably between the assays, especially with regard to RF IgG isotype. Agreement among methods by Cohen's kappa ranged from 0.05 (RF IgG CLIA vs. FEIA) to 0.846 (RF IgM CLIA vs. FEIA).
    Conclusions: The poor agreement observed in this study indicates substantial lack of comparability among assays for RF isotypes. Harmonization of these tests requires further efforts before their measurement can be used in clinical practice.
    MeSH term(s) Humans ; Rheumatoid Factor ; Immunoglobulin Isotypes ; Arthritis, Rheumatoid/diagnosis ; Autoantibodies ; Enzyme-Linked Immunosorbent Assay ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulin A
    Chemical Substances Rheumatoid Factor (9009-79-4) ; Immunoglobulin Isotypes ; Autoantibodies ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulin A
    Language English
    Publishing date 2023-04-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-0109
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    Zs.A 121: Show issues Location:
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  5. Article ; Online: Additional comment to: 'Switching from the bio-originators to biosimilar: is it premature to recommend this procedure?' by Scherlinger and Schaeverbeke.

    Cantini, Fabrizio / Benucci, Maurizio

    Annals of the rheumatic diseases

    2018  Volume 78, Issue 4, Page(s) e25

    MeSH term(s) Antirheumatic Agents ; Arthritis, Psoriatic ; Biosimilar Pharmaceuticals ; Consensus ; Humans ; Rheumatic Diseases
    Chemical Substances Antirheumatic Agents ; Biosimilar Pharmaceuticals
    Language English
    Publishing date 2018-02-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2018-213044
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  6. Article ; Online: Mandatory, cost-driven switching from originator etanercept to its biosimilar SB4: possible fallout on non-medical switching.

    Cantini, Fabrizio / Benucci, Maurizio

    Annals of the rheumatic diseases

    2018  Volume 79, Issue 2, Page(s) e13

    MeSH term(s) Antirheumatic Agents ; Biosimilar Pharmaceuticals ; Etanercept ; Humans ; Registries ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Biosimilar Pharmaceuticals ; Etanercept (OP401G7OJC)
    Language English
    Publishing date 2018-11-28
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2018-214757
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  7. Article ; Online: A case of dermatomyositis induced by SARS-CoV-2 infection.

    Aimo, Cristina / Mariotti, Elena B / Corrà, Alberto / Quintarelli, Lavinia / Ruffo DI Calabria, Valentina / Bianchi, Beatrice / Del Bianco, Elena / Verdelli, Alice / Benucci, Maurizio / Caproni, Marzia

    Italian journal of dermatology and venereology

    2024  Volume 159, Issue 2, Page(s) 214–215

    MeSH term(s) Humans ; Dermatomyositis/etiology ; Dermatomyositis/complications ; COVID-19/complications ; SARS-CoV-2 ; Female ; Male ; Middle Aged
    Language English
    Publishing date 2024-03-04
    Publishing country Italy
    Document type Case Reports ; Letter ; Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.24.07807-1
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  8. Article: Correction: Benucci et al. Predicting Loss of Efficacy after Non-Medical Switching: Correlation between Circulating TNF-α Levels and SB4 in Etanercept to SB4 Switchers and Naïve Patients with Rheumatic Disease.

    Benucci, Maurizio / Damiani, Arianna / Bandinelli, Francesca / Russo, Edda / Li Gobbi, Francesca / Grossi, Valentina / Amedei, Amedeo / Infantino, Maria / Manfredi, Mariangela

    Journal of personalized medicine

    2023  Volume 13, Issue 2

    Abstract: The authors wish to make the following correction to this paper [ ... ]. ...

    Abstract The authors wish to make the following correction to this paper [...].
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13020168
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  9. Article ; Online: Answer to Vieira et al. "Cytokine profile as a prognostic tool in coronavirus disease 2019". Joint Bone Spine 2020. Doi:10.1016/j.jbspin.2020.09.006.

    Quartuccio, Luca / Benucci, Maurizio / De Vita, Salvatore

    Joint bone spine

    2020  Volume 88, Issue 1, Page(s) 105076

    MeSH term(s) COVID-19 ; Cytokines ; Humans ; Inflammation ; Prognosis ; SARS-CoV-2
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2020.09.008
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  10. Article ; Online: Biomarkers and pharmacoeconomics in rheumatoid arthritis: a good marriage.

    Benucci, Maurizio / Infantino, Maria / Manfredi, Mariangela

    Journal of medical economics

    2020  Volume 23, Issue 9, Page(s) 923–925

    MeSH term(s) Antirheumatic Agents/economics ; Antirheumatic Agents/pharmacokinetics ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Biomarkers/blood ; Cost-Benefit Analysis ; Economics, Pharmaceutical ; Humans ; Quality-Adjusted Life Years
    Chemical Substances Antirheumatic Agents ; Biomarkers
    Language English
    Publishing date 2020-05-21
    Publishing country England
    Document type Editorial
    ZDB-ID 2270945-9
    ISSN 1941-837X ; 1369-6998
    ISSN (online) 1941-837X
    ISSN 1369-6998
    DOI 10.1080/13696998.2020.1767630
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