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  1. Article: Bacillary angiomatosis in a solid organ transplant recipient.

    Helleberg, Marie

    IDCases

    2019  Volume 18, Page(s) e00649

    Language English
    Publishing date 2019-10-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2019.e00649
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  2. Article ; Online: Second stage human African Trypanosomiasis with Trypanosoma brucei rhodesiense treated with fexinidazole.

    Helleberg, Barbara Brask / Gudmundsson, Katrine Snorradottir Steen / Kurtzhals, Jørgen Anders Lindholm / Helleberg, Marie

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 11, Page(s) e505

    MeSH term(s) Animals ; Humans ; Trypanosomiasis, African/drug therapy ; Trypanosoma brucei rhodesiense ; Nitroimidazoles/therapeutic use ; Trypanocidal Agents/therapeutic use
    Chemical Substances fexinidazole (306ERL82IR) ; Nitroimidazoles ; Trypanocidal Agents
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00358-4
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    Zs.A 5743: Show issues Location:
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  3. Article: Upsurge in cases of travellers' malaria ex Zanzibar indicates that malaria is on the rebound in the archipelago.

    Florescu, Simin Aysel / Larsen, Carsten Schade / Helleberg, Marie / Marin, Alexandru / Popescu, Corneliu Petru / Schlagenhauf, Patricia

    New microbes and new infections

    2024  Volume 57, Page(s) 101226

    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2024.101226
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  4. Article ; Online: [Vaccination against herpes zoster].

    Larsen, Carsten Schade / Helleberg, Marie

    Ugeskrift for laeger

    2021  Volume 183, Issue 47

    Abstract: During their lifetime, 25% of Danes will experience an episode of herpes zoster (HZ). In 15-20% of these 25% HZ will be complicated by postherpetic neuralgia (PHN). The European Medicines Agency has approved two vaccines against HZ, a live attenuated ... ...

    Abstract During their lifetime, 25% of Danes will experience an episode of herpes zoster (HZ). In 15-20% of these 25% HZ will be complicated by postherpetic neuralgia (PHN). The European Medicines Agency has approved two vaccines against HZ, a live attenuated vaccine (ZLV) and a recombinant adjuvanted vaccine (RZV). The efficacy of ZLV against HZ is moderate (51%), age-dependent and declines in 5-8 years. RZV has shown greater-than 90% protection against HZ and PHN across age groups for ≥ 9 years as summarised in this review. Vaccination of everybody > 50 years of age and immunocompromised patients > 18 years of age against HZ with RZV is recommend in several countries and should also be considered in Denmark.
    MeSH term(s) Child ; Child, Preschool ; Herpes Zoster/prevention & control ; Herpes Zoster Vaccine ; Herpesvirus 3, Human ; Humans ; Neuralgia, Postherpetic/prevention & control ; Vaccination
    Chemical Substances Herpes Zoster Vaccine
    Language Danish
    Publishing date 2021-11-30
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  5. Article ; Online: Mucorales

    Herbst, Isabella / Helleberg, Marie / Overgaard-Steensen, Christian / Holmgaard, Rikke

    BMJ case reports

    2023  Volume 16, Issue 11

    Abstract: A previously fit and well man in his 50s was rescued from a burning apartment with Glasgow Coma Scale 3 and admitted to the burn intensive care unit with 18% mixed dermal and full thickness burns and inhalation injury. He received standardised acute burn ...

    Abstract A previously fit and well man in his 50s was rescued from a burning apartment with Glasgow Coma Scale 3 and admitted to the burn intensive care unit with 18% mixed dermal and full thickness burns and inhalation injury. He received standardised acute burn treatment according to the Emergency Management of Severe Burn guidelines and was found to have acute kidney injury requiring dialysis and cerebral watershed infarcts. The burns were deep especially on the left leg that was deemed unsalvageable and on day 8, he underwent a mid-femoral amputation.A wound swab on day 8 grew mould and with progression of skin necrosis,
    MeSH term(s) Male ; Humans ; Wound Healing ; Mucormycosis/therapy ; Mucormycosis/microbiology ; Skin Transplantation ; Renal Dialysis ; Debridement ; Soft Tissue Injuries/surgery ; Mucorales ; Necrosis
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-253879
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  6. Article ; Online: Cutaneous leishmaniasis with secondary mucosal disease in a traveller due to Leishmania (Viannia) braziliensis.

    Crone, Cornelia Geisler / Helleberg, Marie

    Journal of travel medicine

    2019  Volume 27, Issue 1

    MeSH term(s) Amphotericin B/administration & dosage ; Animals ; Antiprotozoal Agents/administration & dosage ; Communicable Diseases, Imported/diagnosis ; Ear ; Humans ; Leishmania braziliensis/isolation & purification ; Leishmaniasis, Mucocutaneous/diagnosis ; Leishmaniasis, Mucocutaneous/drug therapy ; Male ; Middle Aged ; Phosphorylcholine/administration & dosage ; Phosphorylcholine/analogs & derivatives ; Travel
    Chemical Substances Antiprotozoal Agents ; liposomal amphotericin B ; Phosphorylcholine (107-73-3) ; miltefosine (53EY29W7EC) ; Amphotericin B (7XU7A7DROE)
    Language English
    Publishing date 2019-11-27
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taz093
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    Zs.A 4120: Show issues Location:
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  7. Article ; Online: Superinfections in COVID-19 patients receiving extracorporeal membrane oxygenation support.

    Andersen, Harald V / Jørgensen, Vibeke R L / Steensen, Morten / Pedersen, Finn M / Helleberg, Marie

    Acta anaesthesiologica Scandinavica

    2023  Volume 67, Issue 6, Page(s) 755–761

    Abstract: Background: The risk of superinfections and associations with mortality among patients with corona virus disease 2019 (COVID-19) receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO) is poorly elucidated.: Method: We identified all ... ...

    Abstract Background: The risk of superinfections and associations with mortality among patients with corona virus disease 2019 (COVID-19) receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO) is poorly elucidated.
    Method: We identified all patients with COVID-19 treated with VV-ECMO >24 h at Rigshospitalet, Denmark from March 2020 to December 2021. Data were obtained by review of medical files. Associations between superinfections and mortality were assessed by logistic regression analyses adjusted for sex and age.
    Results: Fifty patients, median age 53 years (interquartile range [IQR] 45-59), 66% male, were included. Median time on VV-ECMO was 14.5 days (IQR 6.3-23.5), 42% were discharged from hospital alive. Bacteremia, ventilator associated pneumonia (VAP), invasive candidiasis, pulmonary aspergillosis, herpes simplex virus, and cytomegalovirus (CMV) were detected in 38%, 42%, 12%, 12%, 14%, and 20% of patients, respectively. No patients with pulmonary aspergillosis survived. CMV was associated with increased risk of death, odds ratio 12.6 (95% confidence interval 1.9-257, p = .05), whereas we found no associations between other superinfections and risk of death.
    Conclusion: Bacteremia and VAP are common but does not seem to affect mortality, whereas pulmonary aspergillosis and CMV are associated with poor prognosis among COVID-19 patients treated with VV-ECMO.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; COVID-19/complications ; COVID-19/therapy ; Extracorporeal Membrane Oxygenation/adverse effects ; Superinfection/etiology ; Pulmonary Aspergillosis/etiology ; Cytomegalovirus Infections/etiology ; Retrospective Studies
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 80002-8
    ISSN 1399-6576 ; 0001-5172
    ISSN (online) 1399-6576
    ISSN 0001-5172
    DOI 10.1111/aas.14228
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    Zs.A 22: Show issues Location:
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  8. Article ; Online: Invasive Aspergillosis among Lung Transplant Recipients during Time Periods with Universal and Targeted Antifungal Prophylaxis-A Nationwide Cohort Study.

    Crone, Cornelia Geisler / Wulff, Signe Marie / Ledergerber, Bruno / Helweg-Larsen, Jannik / Bredahl, Pia / Arendrup, Maiken Cavling / Perch, Michael / Helleberg, Marie

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 11

    Abstract: The optimal prevention strategy for invasive aspergillosis (IA) in lung transplant recipients (LTXr) is unknown. In 2016, the Danish guidelines were changed from universal to targeted IA prophylaxis. Previously, we found higher rates of adverse events in ...

    Abstract The optimal prevention strategy for invasive aspergillosis (IA) in lung transplant recipients (LTXr) is unknown. In 2016, the Danish guidelines were changed from universal to targeted IA prophylaxis. Previously, we found higher rates of adverse events in the universal prophylaxis period. In a Danish nationwide study including LTXr, for 2010-2019, we compared IA rates in time periods with universal vs. targeted prophylaxis and during person-time with vs. person-time without antifungal prophylaxis. IA hazard rates were analyzed in multivariable Cox models with adjustment for time after LTX. Among 295 LTXr, antifungal prophylaxis was initiated in 183/193 and 6/102 during the universal and targeted period, respectively. During the universal period, 62% discontinued prophylaxis prematurely. The median time on prophylaxis was 37 days (IQR 11-84). IA was diagnosed in 27/193 (14%) vs. 15/102 (15%) LTXr in the universal vs. targeted period, with an adjusted hazard ratio (aHR) of 0.94 (95% CI 0.49-1.82). The aHR of IA during person-time with vs. person-time without antifungal prophylaxis was 0.36 (95% CI 0.12-1.02). No difference in IA was found during periods with universal vs. targeted prophylaxis. Prophylaxis was protective of IA when taken. Targeted prophylaxis may be preferred over universal due to comparable IA rates and lower rates of adverse events.
    Language English
    Publishing date 2023-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9111079
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  9. Article ; Online: Associations between invasive aspergillosis and cytomegalovirus in lung transplant recipients: a nationwide cohort study.

    Wulff, Signe Marie / Perch, Michael / Helweg-Larsen, Jannik / Bredahl, Pia / Arendrup, Maiken Cavling / Lundgren, Jens / Helleberg, Marie / Crone, Cornelia Geisler

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2023  Volume 131, Issue 11, Page(s) 574–583

    Abstract: Cytomegalovirus (CMV) and invasive aspergillosis (IA) cause morbidity among lung transplant recipients (LTXr). Early diagnosis and treatment could improve outcomes. We examined rates of CMV after IA and vice versa to assess whether screening for one ... ...

    Abstract Cytomegalovirus (CMV) and invasive aspergillosis (IA) cause morbidity among lung transplant recipients (LTXr). Early diagnosis and treatment could improve outcomes. We examined rates of CMV after IA and vice versa to assess whether screening for one infection is warranted after detecting the other. All Danish LTXr, 2010-2019, were followed for IA and CMV for 2 years after transplantation. IA was defined using ISHLT criteria. Adjusted incidence rate ratios (aIRR) were estimated by Poisson regression adjusted for time after transplantation. We included 295 LTXr, among whom CMV and IA were diagnosed in 128 (43%) and 48 (16%). The risk of CMV was high the first 3 months after IA, IR 98/100 person-years of follow-up (95% CI 47-206). The risk of IA was significantly increased in the first 3 months after CMV, aIRR 2.91 (95% CI 1.32-6.44). Numbers needed to screen to diagnose one case of CMV after IA, and one case of IA after CMV was approximately seven and eight, respectively. Systematic screening for CMV following diagnosis of IA, and vice versa, may improve timeliness of diagnosis and outcomes for LTXr.
    MeSH term(s) Humans ; Cytomegalovirus ; Cohort Studies ; Transplant Recipients ; Risk Factors ; Aspergillosis/epidemiology ; Aspergillosis/etiology ; Lung ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/complications ; Invasive Fungal Infections ; Antiviral Agents ; Retrospective Studies
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-04-24
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13317
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  10. Article ; Online: Empirical carbapenems or piperacillin/tazobactam for infections in intensive care: An international retrospective cohort study.

    Meier, Nick / Munch, Marie Warrer / Granholm, Anders / Perner, Anders / Hertz, Frederik Boëtius / Venkatesh, Balasubramanian / Hammond, Naomi E / Li, Qiang / De Bus, Liesbet / De Waele, Jan / Kauzonas, Evaldas / Sjövall, Fredrik / Møller, Morten Hylander / Helleberg, Marie

    Acta anaesthesiologica Scandinavica

    2024  

    Abstract: Background: Critically ill patients in intensive care units (ICU) are frequently administered broad-spectrum antibiotics (e.g., carbapenems or piperacillin/tazobactam) for suspected or confirmed infections. This retrospective cohort study aimed to ... ...

    Abstract Background: Critically ill patients in intensive care units (ICU) are frequently administered broad-spectrum antibiotics (e.g., carbapenems or piperacillin/tazobactam) for suspected or confirmed infections. This retrospective cohort study aimed to describe the use of carbapenems and piperacillin/tazobactam in two international, prospectively collected datasets.
    Methods: We conducted a post hoc analysis of data from the "Adjunctive Glucocorticoid Therapy in Patients with Septic Shock" (ADRENAL) trial (n = 3713) and the "Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure" (DIANA) study (n = 1488). The primary outcome was the proportion of patients receiving initial antibiotic treatment with carbapenems and piperacillin/tazobactam. Secondary outcomes included mortality, days alive and out of ICU and ICU length of stay at 28 days.
    Results: In the ADRENAL trial, carbapenems were used in 648 out of 3713 (17%), whereas piperacillin/tazobactam was used in 1804 out of 3713 (49%) participants. In the DIANA study, carbapenems were used in 380 out of 1480 (26%), while piperacillin/tazobactam was used in 433 out of 1488 (29%) participants. Mortality at 28 days was 23% for patients receiving carbapenems and 24% for those receiving piperacillin/tazobactam in ADRENAL and 23% and 19%, respectively, in DIANA. We noted variations in secondary outcomes; in DIANA, patients receiving carbapenems had a median of 13 days alive and out of ICU compared with 18 days among those receiving piperacillin/tazobactam. In ADRENAL, the median hospital length of stay was 27 days for patients receiving carbapenems and 21 days for those receiving piperacillin/tazobactam.
    Conclusions: In this post hoc analysis of ICU patients with infections, we found widespread initial use of carbapenems and piperacillin/tazobactam in international ICUs, with the latter being more frequently used. Randomized clinical trials are needed to assess if the observed variations in outcomes may be drug-related effects or due to confounders.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80002-8
    ISSN 1399-6576 ; 0001-5172
    ISSN (online) 1399-6576
    ISSN 0001-5172
    DOI 10.1111/aas.14419
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