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  1. Article: Biofilm-Related Infections in Healthcare: Moving towards New Horizons.

    Di Domenico, Enea Gino / Oliva, Alessandra / Guembe, María

    Microorganisms

    2024  Volume 12, Issue 4

    Abstract: In this Special Issue, titled "Biofilm-Related Infections in Healthcare", we have reported considerable progress in understanding the physiology and pathology of biofilms [ ... ]. ...

    Abstract In this Special Issue, titled "Biofilm-Related Infections in Healthcare", we have reported considerable progress in understanding the physiology and pathology of biofilms [...].
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12040784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Enterobacteriaceae antimicrobial agents and resistance: relationship with the therapeutic approach, volume II.

    Mascellino, Maria Teresa / Biswas, Silpak / Oliva, Alessandra

    Frontiers in cellular and infection microbiology

    2024  Volume 14, Page(s) 1356413

    MeSH term(s) Humans ; Enterobacteriaceae ; Enterobacteriaceae Infections/drug therapy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2024.1356413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Did the updated Duke criteria missed

    Volpicelli, Lorenzo / Oliva, Alessandra / Venditti, Mario

    Le infezioni in medicina

    2023  Volume 31, Issue 4, Page(s) 425–428

    Abstract: Infectious endocarditis is a severe condition still characterized by a high morbidity and mortality rate. An early diagnosis may positively impact the outcome, so we need our diagnostic tools to match with the ever-changing epidemiologic and ... ...

    Abstract Infectious endocarditis is a severe condition still characterized by a high morbidity and mortality rate. An early diagnosis may positively impact the outcome, so we need our diagnostic tools to match with the ever-changing epidemiologic and microbiologic landscape of infectious diseases. We read with great interest the update to the Modified Duke Criteria for the diagnosis of Infectious Endocarditis recently proposed by the International Society for Cardiovascular Infectious Diseases and decided to propose the addition of
    Language English
    Publishing date 2023-12-01
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-3104-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5576: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Reply to Chen and Vitetta.

    Violi, Francesco / Pignatelli, Pasquale / Oliva, Alessandra / Cammisotto, Vittoria

    Clinical and translational gastroenterology

    2022  Volume 13, Issue 1, Page(s) e00448

    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.14309/ctg.0000000000000448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Progress in the evaluation of modified vaccinia Ankara vaccine against mpox.

    Mazzotta, Valentina / Matusali, Giulia / Oliva, Alessandra / Maggi, Fabrizio / Antinori, Andrea

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 11, Page(s) 1214–1215

    MeSH term(s) Humans ; Vaccinia/prevention & control ; Mpox (monkeypox) ; Vaccinia virus ; Viral Vaccines
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00369-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Acute bacterial skin and skin structure infections in pediatric patients: potential role of dalbavancin.

    Volpicelli, Lorenzo / Venditti, Mario / Oliva, Alessandra

    Expert review of anti-infective therapy

    2023  Volume 21, Issue 4, Page(s) 329–341

    Abstract: Introduction: Acute bacterial skin and skin structure infections (ABSSSIs) are a subtype of skin and soft tissue infections (SSTI), usually sustained by Gram-positive bacteria, whose incidence is high among children. ABSSSIs are responsible for a ... ...

    Abstract Introduction: Acute bacterial skin and skin structure infections (ABSSSIs) are a subtype of skin and soft tissue infections (SSTI), usually sustained by Gram-positive bacteria, whose incidence is high among children. ABSSSIs are responsible for a considerable number of hospitalizations. Moreover, as multidrug resistant (MDR) pathogens become widespread, the pediatric category seems burdened with an increased risk of resistance and treatment failure.
    Areas covered: To obtain a view on the status of the field, we describe the clinical, epidemiological, and microbiological aspects of ABSSSI in children. Old and new treatment options were critically revised with a focus on the pharmacological characteristics of dalbavancin. Evidence on the use of dalbavancin in children was collected, analyzed, and summarized.
    Expert opinion: Many of the therapeutic options available at the moment are characterized by the need for hospitalization or repeated intravenous infusions, safety issues, possible drug-drug interactions, and reduced efficacy on MDRs. Dalbavancin, the first long-acting molecule with strong activity against methicillin-resistant and also many vancomycin-resistant pathogens represents a game changer for adult ABSSSI. In pediatric settings, the available literature is still limited, but a growing body of evidence supports dalbavancin use in children with ABSSSI, demonstrating this drug to be safe and highly efficacious.
    MeSH term(s) Adult ; Humans ; Child ; Anti-Bacterial Agents/adverse effects ; Skin Diseases, Bacterial/drug therapy ; Skin Diseases, Bacterial/microbiology ; Teicoplanin ; Soft Tissue Infections/drug therapy ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/epidemiology
    Chemical Substances dalbavancin (808UI9MS5K) ; Anti-Bacterial Agents ; Teicoplanin (61036-62-2)
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2023.2182769
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Genome-Based Retrospective Analysis of a

    Capitani, Valerio / Arcari, Gabriele / Oliva, Alessandra / Sacco, Federica / Menichincheri, Gaia / Fenske, Linda / Polani, Riccardo / Raponi, Giammarco / Antonelli, Guido / Carattoli, Alessandra

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: Providencia ... ...

    Abstract Providencia stuartii
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12050943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Uveitis: Insights into pathogenesis and treatment.

    Soriano, Alessandra / Soriano, Marco / Oliva, Rocco / Smith, Wendy M

    Frontiers in medicine

    2022  Volume 9, Page(s) 1033817

    Language English
    Publishing date 2022-11-24
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1033817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Multi-Site MRI Data Harmonization with an Adversarial Learning Approach

    Federico Campo / Alessandra Retico / Sara Calderoni / Piernicola Oliva

    Applied Sciences, Vol 13, Iss 6486, p

    Implementation to the Study of Brain Connectivity in Autism Spectrum Disorders

    2023  Volume 6486

    Abstract: Magnetic resonance imaging (MRI) nowadays plays an important role in the identification of brain underpinnings in a wide range of neuropsychiatric disorders, including Autism Spectrum Disorders (ASD). Characterizing the hallmarks in these pathologies is ... ...

    Abstract Magnetic resonance imaging (MRI) nowadays plays an important role in the identification of brain underpinnings in a wide range of neuropsychiatric disorders, including Autism Spectrum Disorders (ASD). Characterizing the hallmarks in these pathologies is not a straightforward task and machine learning (ML) is certainly one of the most promising tools for addressing complex and non-linear problems. ML algorithms and, in particular, deep neural networks (DNNs), need large datasets in order to be properly trained and thus ensure generalization capabilities on new data. Large datasets can be obtained by collecting images from different centers, thus bringing unavoidable biases in the analysis due to differences in hardware and scanning protocols between different centers. In this work, we dealt with the issue of multicenter MRI data harmonization by comparing two different approaches: the analytical ComBat-GAM procedure, whose effectiveness is already documented in the literature, and an originally developed site-adversarial deep neural network (ad-DNN). The latter aims to perform a classification task while simultaneously searching for site-relevant patterns in order to make predictions free from site-related biases. As a case study, we implemented DNN and ad-DNN classifiers to distinguish subjects with ASD with respect to typical developing controls based on functional connectivity measures derived from data of the multicenter ABIDE collection. The classification performance of the proposed ad-DNN, measured in terms of the area under the ROC curve (AUC), achieved the value of AUC = <semantics> 0.70 ± 0.03 </semantics> , which is comparable to that obtained by a DNN on data harmonized according to the analytical procedure (AUC = <semantics> 0.71 ± 0.01 </semantics> ). The relevant functional connectivity alterations identified by both procedures showed an agreement between each other and with the patterns of neuroanatomical alterations previously detected in the same cohort of subjects.
    Keywords brain connectivity ; machine learning ; adversarial learning ; autism spectrum disorders (ASD) ; multi-site harmonization ; explainable AI (XAI) ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 006
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: The Current Knowledge on the Pathogenesis of Tissue and Medical Device-Related Biofilm Infections.

    Di Domenico, Enea Gino / Oliva, Alessandra / Guembe, María

    Microorganisms

    2022  Volume 10, Issue 7

    Abstract: Biofilm is the trigger for the majority of infections caused by the ability of microorganisms to adhere to tissues and medical devices. Microbial cells embedded in the biofilm matrix are highly tolerant to antimicrobials and escape the host immune system. ...

    Abstract Biofilm is the trigger for the majority of infections caused by the ability of microorganisms to adhere to tissues and medical devices. Microbial cells embedded in the biofilm matrix are highly tolerant to antimicrobials and escape the host immune system. Thus, the refractory nature of biofilm-related infections (BRIs) still represents a great challenge for physicians and is a serious health threat worldwide. Despite its importance, the microbiological diagnosis of a BRI is still difficult and not routinely assessed in clinical microbiology. Moreover, biofilm bacteria are up to 100-1000 times less susceptible to antibiotics than their planktonic counterpart. Consequently, conventional antibiograms might not be representative of the bacterial drug susceptibility in vivo. The timely recognition of a BRI is a crucial step to directing the most appropriate biofilm-targeted antimicrobial strategy.
    Language English
    Publishing date 2022-06-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10071259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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