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  1. Article ; Online: Marijuana-induced toxic myocarditis: a case report and a review of the literature.

    Prota, Costantina / Ravera, Amelia / Caleo, Oliviero / Campanile, Alfonso

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2022  Volume 23, Issue 12, Page(s) 814–818

    MeSH term(s) Humans ; Myocarditis/chemically induced ; Myocarditis/diagnostic imaging ; Cannabis/adverse effects
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Incorporation of Testicular Ultrasonography and Hair Steroid Concentrations in Bull Breeding Soundness Evaluation.

    Cotticelli, Alessio / Navas, Luigi / Calabria, Alfonso / Bifulco, Giovanna / Campanile, Giuseppe / Peric, Tanja / Prandi, Alberto / D'Occhio, Michael J / Russo, Marco

    Veterinary sciences

    2023  Volume 10, Issue 6

    Abstract: Testicular ultrasonography and steroid concentrations (cortisol, dehydroepiandrosterone sulfate (DHEA-S), cortisol/DHEA-S ratio, testosterone) in hair were examined for their utility in the bull breeding soundness evaluation (BBSE). Beef and dairy bulls ( ...

    Abstract Testicular ultrasonography and steroid concentrations (cortisol, dehydroepiandrosterone sulfate (DHEA-S), cortisol/DHEA-S ratio, testosterone) in hair were examined for their utility in the bull breeding soundness evaluation (BBSE). Beef and dairy bulls (
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci10060373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adding the value of the Charlson Comorbidity Index to the GRACE score for mortality prediction in acute coronary syndromes.

    Campanile, Alfonso / Prota, Costantina / Tedeschi, Michele / Giano, Angelo / Pianese, Biancamaria / Cristiano, Mario / Pompa, Antonella / Sorrentino, Rosanna / Vigorito, Francesco / Ravera, Amelia

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2023  Volume 25, Issue 2, Page(s) 114–122

    Abstract: Background: Scarce and conflicting data still exist about the role of the Charlson Comorbidity Index (CCI) when added to the traditional Global Registry of Acute Coronary Events (GRACE) risk score for outcome prediction in patients with acute coronary ... ...

    Abstract Background: Scarce and conflicting data still exist about the role of the Charlson Comorbidity Index (CCI) when added to the traditional Global Registry of Acute Coronary Events (GRACE) risk score for outcome prediction in patients with acute coronary syndrome (ACS).
    Methods: All consecutive admissions due to ACS, from 1 January 2018 to 31 December 2020 were retrospectively reviewed from an internal database of a tertiary cardiac center in Salerno (Italy). Logistic and Cox proportional regression analyses were performed in order to assess the contribution of the CCI on 30-day and long-term mortality. The CCI adding value to the GRACE score was analyzed with several measures of improvement in discrimination: increase in the area under the receiver-operating characteristic curve (AUC), the integrated discrimination improvement (IDI), and the categorical and continuous net reclassification improvement (cNRI) more than 0. Robustness of the results was assessed through an internal validation procedure with bootstrapping.
    Results: One thousand three hundred and ten patients were identified. The median age was 68 (58-78) years. One hundred and twenty (9.2%) and 113 (9.5%) deaths occurred, respectively, during the first 30 days from admission and during long-term follow-up (median follow-up time: 13 months; interquartile range: 9-24). After multivariate regression analysis, the CCI was not associated with short-term mortality, while it was significantly and independently associated with long-term mortality along with the GRACE score (hazard ratio: 1.34, 95% confidence interval: 1.22-1.47; P  < 0.001). An additive effect of CCI with the GRACE risk score was observed in predicting long-term mortality: AUC from 0.768 to 0.819 ( P  = 0.003), category-based NRI: 0.215, cNRI>0: 0.669 ( P  < 0.001), IDI: 0.066 ( P  < 0.001).
    Conclusion: The CCI is a predictor of long-term mortality and improves risk stratification of patients with ACS over the GRACE risk score.
    MeSH term(s) Humans ; Aged ; Acute Coronary Syndrome ; Risk Assessment ; Retrospective Studies ; Risk Factors ; Prognosis ; Comorbidity ; Registries
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Incorporation of Testicular Ultrasonography and Hair Steroid Concentrations in Bull Breeding Soundness Evaluation

    Alessio Cotticelli / Luigi Navas / Alfonso Calabria / Giovanna Bifulco / Giuseppe Campanile / Tanja Peric / Alberto Prandi / Michael J. D’Occhio / Marco Russo

    Veterinary Sciences, Vol 10, Iss 373, p

    2023  Volume 373

    Abstract: Testicular ultrasonography and steroid concentrations (cortisol, dehydroepiandrosterone sulfate (DHEA-S), cortisol/DHEA-S ratio, testosterone) in hair were examined for their utility in the bull breeding soundness evaluation (BBSE). Beef and dairy bulls ( ...

    Abstract Testicular ultrasonography and steroid concentrations (cortisol, dehydroepiandrosterone sulfate (DHEA-S), cortisol/DHEA-S ratio, testosterone) in hair were examined for their utility in the bull breeding soundness evaluation (BBSE). Beef and dairy bulls ( n = 16; 2.7 ± 0.4 years old; body condition score 3.2 ± 0.1) of five breeds were maintained under the same conditions at an accredited semen collection center. Bulls underwent routine semen collection twice weekly for 12 weeks and semen was processed and cryopreserved. Ultrasonography and hair sampling were undertaken at the last semen collection. Bulls with homogeneous testicular parenchyma ( n = 8) had a higher ( p < 0.05) percentage of motile sperm post-thawing compared with bulls with heterogeneous parenchyma ( n = 8). There were no differences ( p > 0.05) in the hair concentrations of cortisol, DHEA-S, and testosterone between bulls with homogeneous and heterogeneous parenchyma. In bulls with homogeneous parenchyma, hair DHEA-S concentration was positively correlated with percentage motile sperm (R 2 = 0.76), progressively motile sperm (R 2 = 0.70), and motility yield (R 2 = 0.71). The findings indicate that the integration of testicular ultrasonography and hair DHEA-S status in the BBSE could provide a more comprehensive assessment of indicative fertility in bulls. Additionally, ultrasonography can be used in the BBSE when the evaluation of semen parameters is not available.
    Keywords testicular ultrasonography ; hair steroids ; semen ; bull ; Veterinary medicine ; SF600-1100
    Subject code 630 ; 333
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Sacubitril/Valsartan vs. Standard Medical Therapy on Exercise Capacity in HFrEF Patients.

    Campanile, Alfonso / Visco, Valeria / De Carlo, Stefania / Ferruzzi, Germano Junior / Mancusi, Costantino / Izzo, Carmine / Mongiello, Felice / Di Pietro, Paola / Virtuoso, Nicola / Ravera, Amelia / Bonadies, Domenico / Vecchione, Carmine / Ciccarelli, Michele

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: Sacubitril/valsartan (Sac/Val) reduces mortality in patients with heart failure with reduced ejection fraction (HFrEF) compared to enalapril. However, its effects on functional capacity remain uncertain; consequently, we sought to compare Sac/Val vs. ... ...

    Abstract Sacubitril/valsartan (Sac/Val) reduces mortality in patients with heart failure with reduced ejection fraction (HFrEF) compared to enalapril. However, its effects on functional capacity remain uncertain; consequently, we sought to compare Sac/Val vs. standard medical therapy, in terms of effects on prognostically significant CPET parameters, in HFrEF patients during a long follow-up period. We conducted a single-center, observational study in an HF clinic; specifically, we retrospectively identified that 12 patients switched to Sac/Val and 13 patients that managed with standard, optimal medical therapy (control group). At each visit, baseline, and follow-up (median time: 16 months; IQ range: 11.5-22), we collected demographic information, medical history, vital signs, cardiopulmonary exercise testing, standard laboratory data, pharmacological treatment information, and echocardiographic parameters. The study's primary end-point was the change from baseline in peak VO
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13051174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Primary percutaneous coronary intervention during ST elevation myocardial infarction in prosthetic valve endocarditis: a case report.

    Campanile, Alfonso / Tavazzi, Guido / Caprioglio, Francesco / Rigo, Fausto

    BMC cardiovascular disorders

    2018  Volume 18, Issue 1, Page(s) 28

    Abstract: Background: Infective endocarditis (IE) is still a condition with high mortality and morbidity, especially in the elderly, and in patients with prosthetic valves. The concept of "time-to-therapy" plays a key role for the prompt management of IE and ... ...

    Abstract Background: Infective endocarditis (IE) is still a condition with high mortality and morbidity, especially in the elderly, and in patients with prosthetic valves. The concept of "time-to-therapy" plays a key role for the prompt management of IE and related complications, and the currently available multimodality imaging may play a key role in this setting. Myocardial ischemia due to extrinsic coronary compression from an aortic abscess is an extremely rare condition where the optimal therapeutic strategy has not been defined yet. We present herein the first case of a patient with ST elevation myocardial infarction caused by an aortic root abscess treated with percutaneous stent implantation.
    Case presentation: An 82-year-old woman with a history of atrial fibrillation, chronic renal failure, anemia and a bioprosthetic aortic valve replacement performed in 2014, was admitted to hospital with profound asthenia and a pyrexia of unknown origin. Because of high clinical suspicion of endocarditis, a trans-esophageal echocardiogram was performed. Empirical broad-spectrum antimicrobial therapy was initiated, followed by targeted treatment based on the results of blood cultures (Staphylococcus aureus). The echocardiogram did not show vegetations and the patient was managed conservatively. She suddenly deteriorated, due to an acute coronary syndrome (ACS) with anterior ST segment elevation. An urgent angiogram was performed, and extrinsic compression of the left coronary system, due to an aortic root abscess, was suspected. After discussion with the surgical team, percutaneous revascularization was attempted, aiming to restore satisfactory hemodynamics, in order to plan surgery. Unfortunately, the patient rapidly developed cardiogenic shock, with multi organ failure, and died in less than 24 h.
    Conclusions: Patients with fever, and significant risk factors for endocarditis, who develop ACS, need a prompt diagnostic work up, including trans-esophageal echocardiography. At present, the specific timing of echocardiographic follow-up and surgical intervention is still a matter of debate, and our case aims to highlight the importance of this aspect in the management of endocarditis, in order to avoid severe complications that adversely affect patient prognosis.
    MeSH term(s) Abscess/diagnosis ; Abscess/microbiology ; Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/etiology ; Acute Coronary Syndrome/therapy ; Aged, 80 and over ; Coronary Angiography ; Echocardiography, Transesophageal ; Electrocardiography ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/microbiology ; Fatal Outcome ; Female ; Heart Valve Prosthesis/adverse effects ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation ; Humans ; Percutaneous Coronary Intervention ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/microbiology ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/etiology ; ST Elevation Myocardial Infarction/therapy ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/microbiology ; Treatment Outcome
    Language English
    Publishing date 2018--09
    Publishing country England
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-018-0750-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Exploring the Link between ADHD and Obesity: A Focus on Temperament.

    Porfirio, Maria Cristina / Campanile, Roberta / Masi, Gabriele / Purper-Ouakil, Diane / Giovinazzo, Silvia / Ascenzi, Alessandra / Troisi, Alfonso / Mazzone, Luigi

    Brain sciences

    2022  Volume 12, Issue 12

    Abstract: Multiple studies support the relationship between ADHD and overweight/obesity in youth. Different mechanisms may be involved, such as temperamental and psychopathological factors. The aim of this study was to test the hypothesis that specific ... ...

    Abstract Multiple studies support the relationship between ADHD and overweight/obesity in youth. Different mechanisms may be involved, such as temperamental and psychopathological factors. The aim of this study was to test the hypothesis that specific temperamental and psychopathological dimensions could mediate the relationship between ADHD and obesity. The sample included 100 children and adolescents (78 males and 22 females; age range 6 to 18 years; mean age 9.90 ± 2.5 years). The assessment procedure included Conners' Parent Rating Scale-Long (CPRS-R:L) as the inclusion criterion for ADHD diagnosis, the Child Behavior Checklist (CBCL), a dimensional measure for psychopathology, and the Junior Temperament and Character Inventory, which describes four temperamental dimensions: novelty seeking (NS), harm avoidance (HA), reward dependence (RD), and persistence (P). While in the whole ADHD sample, the highest scores were found in NS and the lowest in P, ADHD with overweight/obesity, compared to ADHD with normal weight, showed higher HA and RD, lower NS, and higher CBCL Internalizing scores. These findings suggest that ADHD youth with overweight/obesity present specific temperamental and psychopathological features compared to those without overweight/obesity. If confirmed in larger samples, using a control group without ADHD, these temperamental and psychological features may be helpful for an earlier recognition of ADHD patients at higher risk for obesity, and may represent possible targets for temperament-based preventive interventions and tailored treatment programs. These features should be included in the routine assessment of children and adolescents with ADHD and/or are overweight/obese.
    Language English
    Publishing date 2022-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci12121631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Predictors of complications in initially haemodynamically stable patients admitted in a modern coronary care unit.

    Campanile, Alfonso / Ciccarelli, Michele / Galasso, Gennaro / Dell'Aquila, Ferruccio / Procaccini, Vincenza / Vigorito, Francesco / Vecchione, Carmine / Ravera, Amelia

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2021  Volume 22, Issue 7, Page(s) 553–559

    Abstract: Aims: Resource optimization in the intensive cardiac care unit (ICCU) is, nowadays, of great importance because of the increasing number of acute cardiovascular patients requiring high-intensity level-of-care. Because of natural limits in ICCU bed ... ...

    Abstract Aims: Resource optimization in the intensive cardiac care unit (ICCU) is, nowadays, of great importance because of the increasing number of acute cardiovascular patients requiring high-intensity level-of-care. Because of natural limits in ICCU bed availability, understanding, which patients will really benefit from in a such a critical care setting, is of paramount importance. In our study, we analysed a heterogeneous ICCU population with initially stable haemodynamic conditions, in order to find potential predictors of severe complications.
    Methods: Nine hundred and fifty patients admitted to our ICCU during the year 2019 were screened in order to detect those with a stable haemodynamic condition at admission. Data were extrapolated from an internal database. Comorbidity burden was expressed by the Charlson Comorbidity Index (CCI). Our primary end point was defined by a combination of severe complications requiring critical care, and in-hospital death.
    Results: Ninety-eight patients (14.1% of 695 stable patients identified) developed severe complications. After a multivariable logistic regression analysis, four predictors were identified: signs of congestive heart failure [OR: 9.25, 95% confidence interval (CI): 5.61-15.25; P < 0.001], SBP 120 mmHg or less (OR: 2.10, 95% CI: 1.27-3.47; P = 0.004), haemoglobin level 13 g/dl or less (OR: 1.75, 95% CI: 1.03-2.95; P = 0.037), and the CCI above 3 (OR: 2.27, 95% CI: 1.13-4.56; P = 0.022).
    Conclusion: In our study, 73% of patients showed a stable haemodynamic condition on admission. Severe complications occurred in 14.1% of these patients, and signs of heart failure were the main determinants of the outcome. SBP, haemoglobin level, and the CCI concurred in the prediction of severe complications during the hospital stay.
    MeSH term(s) Aged ; Comorbidity ; Coronary Care Units/methods ; Coronary Care Units/organization & administration ; Diagnostic Tests, Routine/methods ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/physiopathology ; Heart Failure/therapy ; Hemodynamics ; Hospital Mortality ; Humans ; Italy/epidemiology ; Male ; Medical Overuse/prevention & control ; Outcome and Process Assessment, Health Care ; Patient Selection ; Predictive Value of Tests ; Prognosis ; Triage/methods ; Triage/standards
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Persistent Unexplained Dyspnea: A Case of Hepatopulmonary Syndrome.

    Campanile, Alfonso / Colombo, Alessandro / Del Pinto, Maurizio / Cavallini, Claudio

    Case reports in cardiology

    2017  Volume 2017, Page(s) 1469893

    Abstract: Regarding a patient with dyspnea, the history and physical examination often lead to the correct diagnosis. In some circumstances, when more than one underlying disease is present, the diagnostic process can be more challenging. We describe an unusual ... ...

    Abstract Regarding a patient with dyspnea, the history and physical examination often lead to the correct diagnosis. In some circumstances, when more than one underlying disease is present, the diagnostic process can be more challenging. We describe an unusual case of dyspnea and persistent hypoxemia related to a hepatopulmonary syndrome in a 53-year-old patient with known heart failure and chronic liver disease. Initially managed with intravenous diuretic therapy, due to signs of lung and peripheral congestion, our patient did not improve as expected; therefore we performed more advanced studies with a chest-abdomen CT scan and a right heart catheterization. They showed, respectively, no signs of parenchymal and vasculature lung disease, a cirrhotic liver disease, splenomegaly, signs of portal hypertension, and high cardiac output with normal pulmonary vascular resistance. These results, along with the association of hypoxemia and chronic liver disease, suggested a hepatopulmonary syndrome. The diagnosis was confirmed by the demonstration of an intrapulmonary vascular dilatation with right to left shunt during a microbubble transthoracic echocardiography and a lung perfusion scan. Liver transplantation is the only successful treatment for this syndrome; however, the patient became soon unsuitable for this strategy, due to a rapid clinical deterioration.
    Language English
    Publishing date 2017-08-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627627-6
    ISSN 2090-6412 ; 2090-6404
    ISSN (online) 2090-6412
    ISSN 2090-6404
    DOI 10.1155/2017/1469893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Permanent diabetes insipidus in a patient with mesothelioma treated with immunotherapy.

    Brilli, Lucia / Calabrò, Luana / Campanile, Michele / Pilli, Tania / Agostinis, Cristina / Cerase, Alfonso / Maio, Michele / Castagna, Maria Grazia

    Archives of endocrinology and metabolism

    2020  Volume 64, Issue 4, Page(s) 483–486

    Abstract: Checkpoint inhibitors have substantially improved the prognosis for patients with advanced malignancy. Treatment with immunomodulants has the ability to reactivate the immune system against tumor cells, but can also trigger the development of immune- ... ...

    Abstract Checkpoint inhibitors have substantially improved the prognosis for patients with advanced malignancy. Treatment with immunomodulants has the ability to reactivate the immune system against tumor cells, but can also trigger the development of immune-related adverse events that reflects a loss of tolerance of the immune system for self-antigens. Regarding the endocrine system, thyroid and pituitary are the most frequent glands involved; in particular hypophysitis is commonly observed with anti-CTLA4 with a variable impaired anterior pituitary dysfunction (mainly ACTH and TSH dysregulation) while a posterior pituitary dysfunction has been rarely described. A 68-year-old man with a diagnosis of metastatic mesothelioma started in September 2016 first-line treatment with tremelimumab and durvalumab. After 3 cycles he presented sudden onset of polydipsia and polyuria without other symptoms. Diagnostic work-up, including a water deprivation test, established a diagnosis of central diabetes insipidus. Patient started sublingual desmopressin 60 mcg three times a day, that was subsequently increased up to 480 mcg/die. At magnetic resonance imaging the posterior lobe of pituitary gland did not show high signal intensity on T1-weighted images. After regression of diabetes insipidus symptoms under desmopressin, patient restarted cancer treatment and received additional 10 doses without worsening of endocrinological toxicity or further treatment-related toxicities, maintaining the same desmopressin dosage. Posterior pituitary dysfunction has been rarely observed in patients treated with immunomodulants. To our knowledge, this is the first observation of permanent central diabetes insipidus in patients treated with combined immune checkpoint inhibitors (tremelimumab and durvalumab).
    MeSH term(s) Aged ; Diabetes Insipidus, Neurogenic/complications ; Humans ; Immunotherapy ; Lung Neoplasms ; Magnetic Resonance Imaging ; Male ; Mesothelioma/complications ; Mesothelioma/therapy
    Language English
    Publishing date 2020-04-06
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ISSN 2359-4292
    ISSN (online) 2359-4292
    DOI 10.20945/2359-3997000000221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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