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Article: Cultural stress and immigrant well-being: The role of sense of purpose.

Hill, Patrick L / Beatty, Jennifer F / Toprakkiran, Selin / Wolk, Megan W

Cultural diversity & ethnic minority psychology

2024

Abstract: Objectives: Immigrants face multiple forms of cultural stress that hold pernicious influences on their psychological well-being, including everyday discrimination, bicultural stressors, and negative context of reception from others. Research thus is ... ...

Abstract	Objectives: Immigrants face multiple forms of cultural stress that hold pernicious influences on their psychological well-being, including everyday discrimination, bicultural stressors, and negative context of reception from others. Research thus is needed to consider potential buffers and mitigating factors that may help immigrant adults in the face of cultural stress. The present studies evaluated a sense of purpose as one potential buffer. Method: Study 1 asked immigrant adults in the Unites States to complete measures of the three cultural stress indicators in addition to sense of purpose and measures of well-being (depressive symptoms, anxiety, stress, self-esteem, self-rated health). Multiple regression analyses examined whether sense of purpose moderated the influence of cultural stress on immigrant well-being. Study 2 randomly assigned immigrant participants receive an experimental condition that asked participants to imagine a common cultural stressor faced by immigrants. Multiple regression analyses tested whether sense of purpose operated differently on postscenario affect across the control and experimental conditions. Results: Study 1 found that all cultural stress indicators negatively correlated with psychological well-being and sense of purpose. However, sense of purpose did not significantly moderate these associations. Study 2 found that imagining the cultural stressor led to worse momentary affective well-being, whereas sense of purpose was associated with better well-being. Again, sense of purpose did not interact with the condition to predict the postscenario affect. Conclusions: Sense of purpose was consistently associated with better psychological well-being. However, little evidence was found that sense of purpose mitigates the ill effects of cultural stress for immigrant adults. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463411-9
ISSN	1939-0106 ; 1099-9809
ISSN (online)	1939-0106
ISSN	1099-9809
DOI	10.1037/cdp0000666
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Article ; Online: Are language-cognition interactions bigger than a breadbox? Integrative modeling and design space thinking temper simplistic questions about causally dense phenomena.

Titone, Debra / Hernández-Rivera, Esteban / Iniesta, Antonio / Beatty-Martínez, Anne L / Gullifer, Jason W

The Behavioral and brain sciences

2024 Volume 47, Page(s) e60

Abstract: We affirm the utility of integrative modeling, according to which it is advantageous to move beyond "one-at-a-time binary paradigms" through studies that position themselves within realistic multidimensional design spaces. We extend the integrative ... ...

Abstract	We affirm the utility of integrative modeling, according to which it is advantageous to move beyond "one-at-a-time binary paradigms" through studies that position themselves within realistic multidimensional design spaces. We extend the integrative modeling approach to a target domain with which we are familiar, the consequences of bilingualism on mind and brain, often referred to as the "bilingual advantage." In doing so, we highlight work from our group consistent with integrative modeling.
MeSH term(s)	Humans ; Cognition ; Language ; Multilingualism
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	423721-3
ISSN	1469-1825 ; 0140-525X
ISSN (online)	1469-1825
ISSN	0140-525X
DOI	10.1017/S0140525X23002145
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Zs.A 1470: Show issues

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Article ; Online: Inflammatory networks cultivate cancer cell metastasis to the liver.

Lee, Jae W / Beatty, Gregory L

Cell cycle (Georgetown, Tex.)

2020 Volume 19, Issue 6, Page(s) 642–651

Abstract: The liver is the most frequent site of metastatic spread in malignancies that arise from the digestive system, including pancreatic ductal adenocarcinoma (PDAC). Metastasis to the liver is a major cause of morbidity and mortality in cancer patients, yet ... ...

Abstract	The liver is the most frequent site of metastatic spread in malignancies that arise from the digestive system, including pancreatic ductal adenocarcinoma (PDAC). Metastasis to the liver is a major cause of morbidity and mortality in cancer patients, yet mechanisms that govern this process remain poorly understood. Until recently, liver tropism of metastasis was believed to be driven by mechanical factors that direct the passive flow of circulating cancer cells to the liver. However, emerging evidence now shows that liver metastasis is a dynamic process that is, at least in part, dependent on the formation of a "pro-metastatic niche". Key features of this niche are myeloid cells and fibrosis that support cancer cell colonization and growth. Inflammatory responses that are mounted early during primary tumor development are critical for the recruitment of myeloid cells and the deposition of extracellular matrix (ECM) proteins within the liver. Intriguingly, the inflammatory processes that direct the formation of a pro-metastatic niche share remarkable resemblance to mechanisms of liver injury and regeneration, suggesting that cancer co-opts physiological liver functions to support metastasis. Therefore, therapeutic strategies that target key elements of liver inflammation that form the basis of a pro-metastatic niche may lead to effective treatments for metastatic cancer.
MeSH term(s)	Animals ; Carcinoma, Pancreatic Ductal/pathology ; Colorectal Neoplasms/pathology ; Extracellular Matrix/metabolism ; Extracellular Matrix Proteins/metabolism ; Humans ; Liver/metabolism ; Liver Cirrhosis/complications ; Liver Neoplasms/complications ; Liver Neoplasms/metabolism ; Liver Neoplasms/secondary ; Myeloid Cells/metabolism ; Neoplastic Stem Cells/metabolism ; Pancreatic Neoplasms/pathology ; Tumor Microenvironment
Chemical Substances	Extracellular Matrix Proteins
Language	English
Publishing date	2020-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2020.1728013
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Zs.A 5881: Show issues

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Article: Hepatocytes prepare the soil for liver metastasis.

Lee, Jae W / Beatty, Gregory L

Molecular & cellular oncology

2019 Volume 6, Issue 5, Page(s) e1632686

Abstract: The liver is the most common organ site of cancer metastasis. Molecular determinants of this organotropism, though, are poorly understood. We recently showed that hepatocytes regulate the formation of a "pro-metastatic" niche in the liver via their ... ...

Abstract	The liver is the most common organ site of cancer metastasis. Molecular determinants of this organotropism, though, are poorly understood. We recently showed that hepatocytes regulate the formation of a "pro-metastatic" niche in the liver via their release of serum amyloid proteins.
Language	English
Publishing date	2019-06-24
Publishing country	United States
Document type	Journal Article
ISSN	2372-3556
ISSN	2372-3556
DOI	10.1080/23723556.2019.1632686
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Article ; Online: New specimens and species of the Oligocene toothed baleen whale Coronodon from South Carolina and the origin of Neoceti

Robert W. Boessenecker / Brian L. Beatty / Jonathan H. Geisler

PeerJ, Vol 11, p e

2023 Volume 14795

Abstract: Baleen whales (Mysticeti) are gigantic filter-feeding cetaceans possessing the unique soft tissue structure baleen and lacking adult teeth; Oligocene fossils have revealed a wealth of early diverging tooth-bearing mysticetes highlighting the transition ... ...

Abstract	Baleen whales (Mysticeti) are gigantic filter-feeding cetaceans possessing the unique soft tissue structure baleen and lacking adult teeth; Oligocene fossils have revealed a wealth of early diverging tooth-bearing mysticetes highlighting the transition from archaeocete ancestors to early toothless baleen-bearing eomysticetid whales. The archaeocete-like, toothed mysticete Coronodon havensteini from the lower Oligocene Ashley Formation of South Carolina possesses a number of peculiar aspects of feeding morphology suggesting dental filter-feeding in the earliest diverging mysticete lineage. New fossils of Coronodon are described in detail, including (1) supplementary description of the holotype skull and skeleton of Coronodon havensteini; (2) description of two new juvenile skulls of C. havensteini and a partial skull and postcranial skeleton of an adult; (3) description of the new species Coronodon planifrons n.sp.; and (4) description of the new species Coronodon newtonorum. New specimens of Coronodon havensteini include a partial adult skeleton preserving new elements for the species including incisors, numerous upper premolars and molars, lower m4, scapula, lumbar, and caudal vertebrae, and two juvenile skulls with tympanoperiotics and teeth. Fossils from the overlying unit, the Chandler Bridge Formation, represent two new species: Coronodon newtonorum n. sp. and Coronodon planifrons n. sp. Coronodon newtonorum possesses a concave-up alveolar profile, a mandibular condyle elevated far above the toothrow, and a gracile periotic resembling those of juvenile C. havensteini. Coronodon planifrons n. sp. possesses a horizontal supraorbital process, successively smaller upper molars, massively inflated periotic, and longer intertemporal region. Coronodon planifrons n. sp. preserves one of the most complete vertebral columns among toothed mysticetes, indicating nine thoracic vertebrae, ten lumbar vertebrae, and at least 20 caudal vertebrae. The column exhibits a somewhat stabilized caudal peduncle with enlarged ...
Keywords	Mysticeti ; Neoceti ; Cetacea ; Oligocene ; North Atlantic ; Phylogeny ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Trypanosoma cruzi

Torhorst, Carson W / Ledger, Kimberly J / White, Zoe S / Milleson, Michael P / Corral, Catalina C / Beatty, Norman L / Wisely, Samantha M

International journal for parasitology. Parasites and wildlife

2023 Volume 21, Page(s) 237–245

Abstract: In Latin America, synanthropic mammalian reservoirs ... ...

Abstract	In Latin America, synanthropic mammalian reservoirs maintain
Language	English
Publishing date	2023-06-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2715239-X
ISSN	2213-2244
ISSN	2213-2244
DOI	10.1016/j.ijppaw.2023.06.009
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Article ; Online: Increased pituitary volumes in patients with Sanfilippo syndrome (mucopolysaccharidosis type 3, MPS III).

Huang, Shiwei / Beatty, Zachary J / Mckinney, Alexander M / Nascene, David R

Neuroradiology

2023 Volume 65, Issue 9, Page(s) 1381–1386

Abstract: ... volume calculation method (π/6 × L × W × H). Convexity along the upper pituitary margin (Elster's grade ...

Abstract	Purpose: To evaluate apparent pituitary gland enlargement in patients with Sanfilippo syndrome observed at our institution. Methods: Twelve patients with Sanfilippo syndrome with brain MRI were studied. Anterior, posterior, and whole pituitary volumes were estimated using the prolate ellipsoid volume calculation method (π/6 × L × W × H). Convexity along the upper pituitary margin (Elster's grade) was also measured. These values were compared to two age- and sex-matched groups (normal controls and patients with Hurler syndrome) using one-way ANOVA followed by Tukey's post hoc analysis for multiple comparisons. Results: In the Sanfilippo cohort, the mean whole pituitary volume was 529.9 mm, the mean anterior pituitary volume was 333.4 mm, and the mean posterior pituitary volume was 59.1 mm with Elster's grade of 4.2. In the control cohort, the mean whole pituitary volume was 217.4 mm, the mean anterior pituitary volume was 154.8 mm, and the mean posterior pituitary volume was 28.4 mm with Elster's grade of 2.5. In the Hurler syndrome cohort, the mean whole pituitary volume was 310.0 mm, the mean anterior pituitary volume was 178.2 mm, and the mean posterior pituitary volume was 35.4 mm with Elster's grade of 3.5. Conclusion: In our cohort of patients with Sanfilippo syndrome, whole, anterior, and posterior pituitary volumes and degree of convexity along the upper pituitary border were all significantly greater than controls. The cause of these morphological changes is unclear, as is clinical correlation of the findings.
MeSH term(s)	Humans ; Mucopolysaccharidosis III ; Mucopolysaccharidosis I ; Pituitary Gland/diagnostic imaging
Language	English
Publishing date	2023-05-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-023-03157-2
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Zs.A 658: Show issues

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Article ; Online: The Prostate Cancer Active Lifestyle Study (PALS): A randomized controlled trial of diet and exercise in overweight and obese men on active surveillance.

Wright, Jonathan L / Schenk, Jeannette M / Gulati, Roman / Beatty, Sarah J / VanDoren, Matthew / Lin, Daniel W / Porter, Michael P / Morrissey, Colm / Dash, Atreya / Gore, John L / Etzioni, Ruth / Plymate, Stephen R / Neuhouser, Marian L

Cancer

2024

Abstract: Background: Active surveillance (AS) is increasingly used to monitor patients with lower risk prostate cancer (PCa). The Prostate Cancer Active Lifestyle Study (PALS) was a randomized controlled trial to determine whether weight loss improves obesity ... ...

Abstract	Background: Active surveillance (AS) is increasingly used to monitor patients with lower risk prostate cancer (PCa). The Prostate Cancer Active Lifestyle Study (PALS) was a randomized controlled trial to determine whether weight loss improves obesity biomarkers on the causal pathway to progression in patients with PCa on AS. Methods: Overweight/obese men (body mass index >25 kg/m Results: Among 117 men who were randomized, 100 completed the trial. The mean percentage weight loss was 7.1% and 1.8% in the intervention and control arms, respectively (adjusted between-group mean difference, -6.0 kg; 95% confidence interval, -8.0, -4.0). Mean percentage changes from baseline for insulin, C-peptide, and homeostatic model assessment for insulin resistance in the intervention arm were -23%, -16%, and -25%, respectively, compared with +6.9%, +7.5%, and +6.4%, respectively, in the control arm (all p for intervention effects ≤ .003). No significant between-arm differences were detected for the other biomarkers. Conclusions: Overweight/obese men with PCa undergoing AS who participated in a lifestyle-based weight loss intervention successfully met weight loss goals with this reproducible lifestyle intervention and experienced improvements in glucose-regulation biomarkers associated with PCa progression.
Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.35241
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Article ; Online: Integrated pest management strategies targeting the Florida kissing bug,

Beatty, Norman L / Bhosale, Chanakya R / Torhorst, Carson W / Burkett-Cadena, Nathan D / Oi, Faith M / Forsyth, Colin J / Wisely, Samantha M

Current research in parasitology & vector-borne diseases

2023 Volume 4, Page(s) 100144

Abstract: Triatomines (Hemiptera: Reduviidae: Triatominae), commonly called "kissing bugs", are blood-sucking pests and vectors of the protozoan ... ...

Abstract	Triatomines (Hemiptera: Reduviidae: Triatominae), commonly called "kissing bugs", are blood-sucking pests and vectors of the protozoan parasite
Language	English
Publishing date	2023-09-28
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2667-114X
ISSN (online)	2667-114X
DOI	10.1016/j.crpvbd.2023.100144
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Article ; Online: Nasal Lymphoma with Low Mitotic Index in Three Cats Treated with Chlorambucil and Prednisolone.

Ng, Karen W L / Beatty, Julia A / Tse, May P Y / Giuliano, Antonio

Veterinary sciences

2022 Volume 9, Issue 9

Abstract: Lymphoma is the most common tumor of the nasal cavity in cats. Commonly used treatment modalities are radiotherapy and chemotherapy, or both. Typical chemotherapy protocols used in cats with nasal lymphoma are COP (cyclophosphamide, vincristine ... ...

Abstract	Lymphoma is the most common tumor of the nasal cavity in cats. Commonly used treatment modalities are radiotherapy and chemotherapy, or both. Typical chemotherapy protocols used in cats with nasal lymphoma are COP (cyclophosphamide, vincristine prednisolone) and CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone). Thus far, the use of single-agent chlorambucil in nasal lymphoma has been evaluated in a single case report. We report a case series of three cats with B cell nasal lymphoma, two cats with intermediate cell, and one large cell, all with a low mitotic index (MI) of less than 5 mitotic figures per ×400 field, treated with chlorambucil and prednisolone. Two of the cases achieved a long disease-free interval, while the one with the highest MI did not. Protocols using chlorambucil and prednisolone may have potential as a first-line therapy for feline nasal lymphoma cases with a very low mitotic index.
Language	English
Publishing date	2022-09-01
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2768971-2
ISSN	2306-7381 ; 2306-7381
ISSN (online)	2306-7381
ISSN	2306-7381
DOI	10.3390/vetsci9090472
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