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Buch ; Dissertation / Habilitation: Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis

Hoeger-Schäfer, Janine Katrin

2017

Verfasserangabe	vorgelegt von Janine Katrin Hoeger-Schäfer, geb. Hoeger
Sprache	Englisch
Umfang	15 ungezählte Seiten, Diagramme
Erscheinungsort	Aachen
Erscheinungsland	Deutschland
Dokumenttyp	Buch ; Dissertation / Habilitation
Dissertation / Habilitation	Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2017
Anmerkung	Die Dissertation wurde zuvor 2015 als Aufsatz in der Zeitschrift "Biometals" (2015:28(4) veröffentlicht; DOI: 10.1007/s10534-015-9858-4
HBZ-ID	HT019370667
Datenquelle	Katalog ZB MED Medizin, Gesundheit

Verfügbar in ZB MED Köln/Königswinter

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2017 D 991	bestellbar zur Ausleihe	Magazin

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Artikel ; Online: An unprecedented cluster of Australian bat lyssavirus in Pteropus conspicillatus indicates pre-flight flying fox pups are at risk of mass infection.

Barrett, Janine / Höger, Alison / Agnihotri, Kalpana / Oakey, Jane / Skerratt, Lee F / Field, Hume E / Meers, Joanne / Smith, Craig

Zoonoses and public health

2020 Band 67, Heft 4, Seite(n) 435–442

Abstract: In November 2017, two groups of P. conspicillatus pups from separate locations in Far North Queensland presented with neurological signs consistent with Australian bat lyssavirus (ABLV) infection. These pups (n = 11) died over an 11-day period and were ... ...

Abstract	In November 2017, two groups of P. conspicillatus pups from separate locations in Far North Queensland presented with neurological signs consistent with Australian bat lyssavirus (ABLV) infection. These pups (n = 11) died over an 11-day period and were submitted to a government laboratory for testing where ABLV infection was confirmed. Over the next several weeks, additional ABLV cases in flying foxes in Queensland were also detected. Brain tissue from ABLV-infected flying foxes during this period, as well as archived brain tissue, was selected for next-generation sequencing. Phylogenetic analysis suggests that the two groups of pups were each infected from single sources. They were likely exposed while in crèche at night as their dams foraged. This study identifies crèche-age pups at a potentially heightened risk for mass ABLV infection.
Mesh-Begriff(e)	Animals ; Chiroptera/virology ; Disease Outbreaks/veterinary ; Genome, Viral ; Lyssavirus/genetics ; Lyssavirus/isolation & purification ; Queensland/epidemiology ; Rhabdoviridae Infections/epidemiology ; Rhabdoviridae Infections/veterinary ; Rhabdoviridae Infections/virology
Sprache	Englisch
Erscheinungsdatum	2020-04-20
Erscheinungsland	Germany
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2271118-1
ISSN	1863-2378 ; 1863-1959
ISSN (online)	1863-2378
ISSN	1863-1959
DOI	10.1111/zph.12703
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: An unprecedented cluster of Australian bat lyssavirus in Pteropus conspicillatus indicates pre‐flight flying fox pups are at risk of mass infection

Barrett, Janine / Höger, Alison / Agnihotri, Kalpana / Oakey, Jane / Skerratt, Lee F / Field, Hume E / Meers, Joanne / Smith, Craig

Zoonoses and public health. 2020 June, v. 67, no. 4

2020

Abstract	In November 2017, two groups of P. conspicillatus pups from separate locations in Far North Queensland presented with neurological signs consistent with Australian bat lyssavirus (ABLV) infection. These pups (n = 11) died over an 11‐day period and were submitted to a government laboratory for testing where ABLV infection was confirmed. Over the next several weeks, additional ABLV cases in flying foxes in Queensland were also detected. Brain tissue from ABLV‐infected flying foxes during this period, as well as archived brain tissue, was selected for next‐generation sequencing. Phylogenetic analysis suggests that the two groups of pups were each infected from single sources. They were likely exposed while in crèche at night as their dams foraged. This study identifies crèche‐age pups at a potentially heightened risk for mass ABLV infection.
Schlagwörter	Australian bat lyssavirus ; Pteropus ; brain ; foxes ; phylogeny ; public health ; risk ; zoonoses ; Queensland
Sprache	Englisch
Erscheinungsverlauf	2020-06
Umfang	p. 435-442.
Erscheinungsort	John Wiley & Sons, Ltd
Dokumenttyp	Artikel
Anmerkung	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	2271118-1
ISSN	1863-2378 ; 1863-1959
ISSN (online)	1863-2378
ISSN	1863-1959
DOI	10.1111/zph.12703
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: Persistent low serum zinc is associated with recurrent sepsis in critically ill patients - A pilot study.

Hoeger, Janine / Simon, Tim-Philipp / Beeker, Thorben / Marx, Gernot / Haase, Hajo / Schuerholz, Tobias

PloS one

2017 Band 12, Heft 5, Seite(n) e0176069

Abstract: Zinc is an essential trace element for both pathogens and hosts. Hypozincemia is a well known phenomenon in sepsis patients and represents the innate immune systems attempt to deprive pathogens of zinc. However little is known about course, restitution ... ...

Abstract	Zinc is an essential trace element for both pathogens and hosts. Hypozincemia is a well known phenomenon in sepsis patients and represents the innate immune systems attempt to deprive pathogens of zinc. However little is known about course, restitution and prognostic value of serum zinc levels in sepsis patients. We performed a prospective observational single-center study set in a tertiary care university hospital intensive care unit. Serum zinc levels were singularly measured of healthy controls and sequentially of surgical sepsis patients and surgical patients over a 8-day period. Throughout the study period, we report significantly decreased serum zinc levels in surgical and surgical sepsis patients compared to healthy controls. Lower serum zinc levels in surgical sepsis patients were associated with a higher susceptibility to a recurrent sepsis episode. Furthermore, surgical sepsis patients with a higher number of organ dysfunctions and increased in-hospital mortality at day 28 and 90 showed lower serum zinc levels at admission. We report serum zinc levels as a promising biomarker in the diagnosis and evaluation of sepsis patients. However, it is still unclear whether these findings are caused by an over-amplified redistribution of zinc during acute-phase response, or whether the critically ill patients were zinc deficient before sepsis.
Mesh-Begriff(e)	Aged ; Critical Illness ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Recurrence ; Sepsis/blood ; Zinc/blood
Chemische Substanzen	Zinc (J41CSQ7QDS)
Sprache	Englisch
Erscheinungsdatum	2017-05-04
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0176069
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Persistent low serum zinc is associated with recurrent sepsis in critically ill patients - A pilot study.

Janine Hoeger / Tim-Philipp Simon / Thorben Beeker / Gernot Marx / Hajo Haase / Tobias Schuerholz

PLoS ONE, Vol 12, Iss 5, p e

2017 Band 0176069

Abstract	Zinc is an essential trace element for both pathogens and hosts. Hypozincemia is a well known phenomenon in sepsis patients and represents the innate immune systems attempt to deprive pathogens of zinc. However little is known about course, restitution and prognostic value of serum zinc levels in sepsis patients. We performed a prospective observational single-center study set in a tertiary care university hospital intensive care unit. Serum zinc levels were singularly measured of healthy controls and sequentially of surgical sepsis patients and surgical patients over a 8-day period. Throughout the study period, we report significantly decreased serum zinc levels in surgical and surgical sepsis patients compared to healthy controls. Lower serum zinc levels in surgical sepsis patients were associated with a higher susceptibility to a recurrent sepsis episode. Furthermore, surgical sepsis patients with a higher number of organ dysfunctions and increased in-hospital mortality at day 28 and 90 showed lower serum zinc levels at admission. We report serum zinc levels as a promising biomarker in the diagnosis and evaluation of sepsis patients. However, it is still unclear whether these findings are caused by an over-amplified redistribution of zinc during acute-phase response, or whether the critically ill patients were zinc deficient before sepsis.
Schlagwörter	Medicine ; R ; Science ; Q
Thema/Rubrik (Code)	610 ; 616
Sprache	Englisch
Erscheinungsdatum	2017-01-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: The Human Host Defense Ribonucleases 1, 3 and 7 Are Elevated in Patients with Sepsis after Major Surgery--A Pilot Study.

Martin, Lukas / Koczera, Patrick / Simons, Nadine / Zechendorf, Elisabeth / Hoeger, Janine / Marx, Gernot / Schuerholz, Tobias

International journal of molecular sciences

2016 Band 17, Heft 3, Seite(n) 294

Abstract: Sepsis is the most common cause of death in intensive care units and associated with widespread activation of host innate immunity responses. Ribonucleases (RNases) are important components of the innate immune system, however the role of RNases in ... ...

Abstract	Sepsis is the most common cause of death in intensive care units and associated with widespread activation of host innate immunity responses. Ribonucleases (RNases) are important components of the innate immune system, however the role of RNases in sepsis has not been investigated. We evaluated serum levels of RNase 1, 3 and 7 in 20 surgical sepsis patients (Sepsis), nine surgical patients (Surgery) and 10 healthy controls (Healthy). RNase 1 and 3 were elevated in Sepsis compared to Surgery (2.2- and 3.1-fold, respectively; both p < 0.0001) or compared to Healthy (3.0- and 15.5-fold, respectively; both p < 0.0001). RNase 1 showed a high predictive value for the development of more than two organ failures (AUC 0.82, p = 0.01). Patients with renal dysfunction revealed higher RNase 1 levels than without renal dysfunction (p = 0.03). RNase 1 and 3 were higher in respiratory failure than without respiratory failure (p < 0.0001 and p = 0.02, respectively). RNase 7 was not detected in Healthy patients and only in two patients of Surgery, however RNase 7 was detected in 10 of 20 Sepsis patients. RNase 7 was higher in renal or metabolic failure than without failure (p = 0.04 and p = 0.02, respectively). In conclusion, RNase 1, 3 and 7 are secreted into serum under conditions with tissue injury, such as major surgery or sepsis. Thus, RNases might serve as laboratory parameters to diagnose and monitor organ failure in sepsis.
Mesh-Begriff(e)	Aged ; Autoantigens/blood ; Biomarkers/blood ; Case-Control Studies ; Eosinophil Cationic Protein/blood ; Female ; Humans ; Male ; Middle Aged ; Ribonuclease P/blood ; Ribonucleases/blood ; Sepsis/blood ; Sepsis/etiology ; Surgical Wound Infection/blood ; Surgical Wound Infection/complications
Chemische Substanzen	Autoantigens ; Biomarkers ; POP7 protein, human ; Ribonucleases (EC 3.1.-) ; Ribonuclease P (EC 3.1.26.5) ; Eosinophil Cationic Protein (EC 3.1.27.-) ; Ribonuclease 7 (EC 3.1.27.-)
Sprache	Englisch
Erscheinungsdatum	2016-02-26
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms17030294
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The Human Host Defense Ribonucleases 1, 3 and 7 Are Elevated in Patients with Sepsis after Major Surgery—A Pilot Study

Lukas Martin / Patrick Koczera / Nadine Simons / Elisabeth Zechendorf / Janine Hoeger / Gernot Marx / Tobias Schuerholz

International Journal of Molecular Sciences, Vol 17, Iss 3, p

2016 Band 294

Abstract	Sepsis is the most common cause of death in intensive care units and associated with widespread activation of host innate immunity responses. Ribonucleases (RNases) are important components of the innate immune system, however the role of RNases in sepsis has not been investigated. We evaluated serum levels of RNase 1, 3 and 7 in 20 surgical sepsis patients (Sepsis), nine surgical patients (Surgery) and 10 healthy controls (Healthy). RNase 1 and 3 were elevated in Sepsis compared to Surgery (2.2- and 3.1-fold, respectively; both p < 0.0001) or compared to Healthy (3.0- and 15.5-fold, respectively; both p < 0.0001). RNase 1 showed a high predictive value for the development of more than two organ failures (AUC 0.82, p = 0.01). Patients with renal dysfunction revealed higher RNase 1 levels than without renal dysfunction (p = 0.03). RNase 1 and 3 were higher in respiratory failure than without respiratory failure (p < 0.0001 and p = 0.02, respectively). RNase 7 was not detected in Healthy patients and only in two patients of Surgery, however RNase 7 was detected in 10 of 20 Sepsis patients. RNase 7 was higher in renal or metabolic failure than without failure (p = 0.04 and p = 0.02, respectively). In conclusion, RNase 1, 3 and 7 are secreted into serum under conditions with tissue injury, such as major surgery or sepsis. Thus, RNases might serve as laboratory parameters to diagnose and monitor organ failure in sepsis.
Schlagwörter	human RNases ; host-defense protein ; sepsis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Thema/Rubrik (Code)	616
Sprache	Englisch
Erscheinungsdatum	2016-02-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis.

Hoeger, Janine / Simon, Tim-Philipp / Doemming, Sabine / Thiele, Christoph / Marx, Gernot / Schuerholz, Tobias / Haase, Hajo

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

2015 Band 28, Heft 4, Seite(n) 693–700

Abstract: Zinc is crucial for immune function. In addition, the redistribution of zinc and other nutrients due to infection is an integral part of the host immune response to limit availability to pathogens. However, the major zinc binding protein albumin is down ... ...

Abstract	Zinc is crucial for immune function. In addition, the redistribution of zinc and other nutrients due to infection is an integral part of the host immune response to limit availability to pathogens. However, the major zinc binding protein albumin is down regulated during the acute phase response, implicating a decrease in zinc binding capacity. A prospective animal study with eight female German landrace pigs was conducted to investigate alterations in zinc binding capacity, total serum zinc and free zinc levels in the initial phase of sepsis. Sepsis was induced by instillation of autologous feces via midline laparotomy. Total serum zinc declined significantly after 1 h (10.89 ± 0.42 µM vs. 7.67 ± 0.41 µM, p < 0.001), total serum copper and iron reached a significant reduction at 4 h. Urinary excretion of zinc declined in line with total serum zinc. In comparison to total serum zinc, free zinc levels declined to a lesser, though significant, extent. Zinc binding capacity of serum decreased over time, whereby free zinc levels after addition of zinc correlated negatively with total serum protein and albumin levels. In addition IL-6 and TNF-α concentrations were measured and increased significantly 2 h after induction of sepsis. Hence, total serum zinc was the first marker of inflammation in our experiment, and might therefore be a promising biomarker for the early diagnosis of sepsis. Furthermore the observation of a substantially different serum free zinc homeostasis during sepsis provides valuable information for a potential therapeutic zinc supplementation, which has to take buffering capacity by serum proteins into account.
Mesh-Begriff(e)	Albumins/analysis ; Animals ; Binding Sites ; Biomarkers/analysis ; Biomarkers/blood ; Biomarkers/metabolism ; Blood Proteins/analysis ; Copper/analysis ; Copper/blood ; Copper/metabolism ; Cytokines/blood ; Disease Models, Animal ; Female ; Inflammation/blood ; Inflammation/metabolism ; Iron/analysis ; Iron/blood ; Iron/metabolism ; Sepsis/blood ; Sepsis/diagnosis ; Sepsis/metabolism ; Sepsis/surgery ; Swine ; Zinc/analysis ; Zinc/blood ; Zinc/metabolism
Chemische Substanzen	Albumins ; Biomarkers ; Blood Proteins ; Cytokines ; Copper (789U1901C5) ; Iron (E1UOL152H7) ; Zinc (J41CSQ7QDS)
Sprache	Englisch
Erscheinungsdatum	2015-08
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	1112688-7
ISSN	1572-8773 ; 0966-0844
ISSN (online)	1572-8773
ISSN	0966-0844
DOI	10.1007/s10534-015-9858-4
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum.

Martin, Lukas / Schmitz, Susanne / De Santis, Rebecca / Doemming, Sabine / Haase, Hajo / Hoeger, Janine / Heinbockel, Lena / Brandenburg, Klaus / Marx, Gernot / Schuerholz, Tobias

PloS one

2015 Band 10, Heft 5, Seite(n) e0127584

Abstract: Myocardial dysfunction in sepsis has been linked to inflammation caused by pathogen-associated molecular patterns (PAMPs) as well as by host danger-associated molecular patterns (DAMPs). These include soluble heparan sulfate (HS), which triggers the ... ...

Abstract	Myocardial dysfunction in sepsis has been linked to inflammation caused by pathogen-associated molecular patterns (PAMPs) as well as by host danger-associated molecular patterns (DAMPs). These include soluble heparan sulfate (HS), which triggers the devastating consequences of the pro-inflammatory cascades in severe sepsis and septic shock. Thus, there is increasing interest in the development of anti-infective agents, with effectiveness against both PAMPs and DAMPs. We hypothesized that a synthetic antimicrobial peptide (peptide 19-2.5) inhibits inflammatory response in murine cardiomyocytes (HL-1 cells) stimulated with PAMPs, DAMPs or serum from patients with septic shock by reduction and/or neutralization of soluble HS. In the current study, our data indicate that the treatment with peptide 19-2.5 decreases the inflammatory response in HL-1 cells stimulated with either PAMPs or DAMPs. Furthermore, our work shows that soluble HS in serum from patients with Gram-negative or Gram-positive septic shock induces a strong pro-inflammatory response in HL-1 cells, which can be effectively blocked by peptide 19-2.5. Based on these findings, peptide 19-2.5 is a novel anti-inflammatory agent interacting with both PAMPs and DAMPs, suggesting peptide 19-2.5 may have the potential for further development as a broad-spectrum anti-inflammatory agent in sepsis-induced myocardial inflammation and dysfunction.
Mesh-Begriff(e)	Aged ; Animals ; Antimicrobial Cationic Peptides/chemical synthesis ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/pharmacology ; Cell Line ; Female ; Heparitin Sulfate/toxicity ; Humans ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Male ; Mice ; Middle Aged ; Myocytes, Cardiac ; Sepsis/blood ; Serum
Chemische Substanzen	Antimicrobial Cationic Peptides ; Heparitin Sulfate (9050-30-0)
Sprache	Englisch
Erscheinungsdatum	2015
Erscheinungsland	United States
Dokumenttyp	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0127584
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum.

Lukas Martin / Susanne Schmitz / Rebecca De Santis / Sabine Doemming / Hajo Haase / Janine Hoeger / Lena Heinbockel / Klaus Brandenburg / Gernot Marx / Tobias Schuerholz

PLoS ONE, Vol 10, Iss 5, p e

2015 Band 0127584

Abstract	Myocardial dysfunction in sepsis has been linked to inflammation caused by pathogen-associated molecular patterns (PAMPs) as well as by host danger-associated molecular patterns (DAMPs). These include soluble heparan sulfate (HS), which triggers the devastating consequences of the pro-inflammatory cascades in severe sepsis and septic shock. Thus, there is increasing interest in the development of anti-infective agents, with effectiveness against both PAMPs and DAMPs. We hypothesized that a synthetic antimicrobial peptide (peptide 19-2.5) inhibits inflammatory response in murine cardiomyocytes (HL-1 cells) stimulated with PAMPs, DAMPs or serum from patients with septic shock by reduction and/or neutralization of soluble HS. In the current study, our data indicate that the treatment with peptide 19-2.5 decreases the inflammatory response in HL-1 cells stimulated with either PAMPs or DAMPs. Furthermore, our work shows that soluble HS in serum from patients with Gram-negative or Gram-positive septic shock induces a strong pro-inflammatory response in HL-1 cells, which can be effectively blocked by peptide 19-2.5. Based on these findings, peptide 19-2.5 is a novel anti-inflammatory agent interacting with both PAMPs and DAMPs, suggesting peptide 19-2.5 may have the potential for further development as a broad-spectrum anti-inflammatory agent in sepsis-induced myocardial inflammation and dysfunction.
Schlagwörter	Medicine ; R ; Science ; Q
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsdatum	2015-01-01T00:00:00Z
Verlag	Public Library of Science (PLoS)
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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