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  1. Article: New 132-epi-Phaeophorbide a Ethyl Ester from Lantana camara

    Sousa, E. O / R. Braz-Filho / H. D. M. Coutinho / I. R. A. Menezes / F. F. G. Rodrigues / J. G. M. Costa

    Chemistry of natural compounds. 2018 Nov., v. 54, no. 6

    2018  

    Abstract: ... A ethyl ester (1). Its structure was established based on spectroscopic methods, mainly IR spectroscopy ...

    Abstract This study presents the isolation of a new compound from the Lantana genus: 13²-epi-phaeophorbide A ethyl ester (1). Its structure was established based on spectroscopic methods, mainly IR spectroscopy and 1D and 2D NMR, and comparison with literature data.
    Keywords Lantana camara ; chemistry ; infrared spectroscopy ; nuclear magnetic resonance spectroscopy
    Language English
    Dates of publication 2018-11
    Size p. 1114-1117.
    Publishing place Springer US
    Document type Article
    ZDB-ID 213866-9
    ISSN 0009-3130
    ISSN 0009-3130
    DOI 10.1007/s10600-018-2567-9
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    Zs.A 3107: Show issues Location:
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  2. Article: Furo-fused BINOL based crown as a fluorescent chiral sensor for enantioselective recognition of phenylethylamine and ethyl ester of valine.

    Upadhyay, Sunil P / Pissurlenkar, Raghuvir R S / Coutinho, Evans C / Karnik, Anil V

    The Journal of organic chemistry

    2007  Volume 72, Issue 15, Page(s) 5709–5714

    Abstract: ... for phenylethylamine and ethyl ester of valine. Fusion of furan to BINOL has resulted in a highly stereo-discriminating ... of ethyl ester of valine. The ratio of association constants for two diastereomeric complexes of two ... enantiomers of phenylethylamine was found to be 11.30, and the ratio for two enantiomers of ethyl ester ...

    Abstract A furo-fused BINOL based chiral crown was developed as an enantioselective chiral sensor for phenylethylamine and ethyl ester of valine. Fusion of furan to BINOL has resulted in a highly stereo-discriminating backbone for the chiral crown developed. This chiral crown exhibited a fluorescence enhancement difference of 2.97 times between two enantiomers of phenylethylamine and 2.55 times between two enantiomers of ethyl ester of valine. The ratio of association constants for two diastereomeric complexes of two enantiomers of phenylethylamine was found to be 11.30, and the ratio for two enantiomers of ethyl ester of valine was 7.02.
    MeSH term(s) Crown Ethers/chemistry ; Esters ; Fluorescent Dyes/chemistry ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Models, Molecular ; Phenethylamines/chemistry ; Spectrometry, Fluorescence ; Stereoisomerism ; Valine/chemistry
    Chemical Substances Crown Ethers ; Esters ; Fluorescent Dyes ; Phenethylamines ; phenethylamine (327C7L2BXQ) ; Valine (HG18B9YRS7)
    Language English
    Publishing date 2007-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo070850y
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  3. Article ; Online: Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II.

    Pojoga, Luminita H / Romero, Jose R / Yao, Tham M / Loutraris, Paul / Ricchiuti, Vincent / Coutinho, Patricia / Guo, Christine / Lapointe, Nathalie / Stone, James R / Adler, Gail K / Williams, Gordon H

    Endocrinology

    2010  Volume 151, Issue 3, Page(s) 1236–1246

    Abstract: ... in rodents that relies on treatment with N-omega-nitro-l-arginine methyl ester (L-NAME (nitric oxide synthase ...

    Abstract Caveolae are the major cellular membrane structure through which extracellular mediators transmit information to intracellular signaling pathways. In vascular tissue (but not ventricular myocardium), caveolin-1 (cav-1) is the main component of caveolae; cav-1 modulates enzymes and receptors, such as the endothelial nitric oxide synthase and the angiotensin II (AngII) type 1 receptor. Evidence suggests that AngII and aldosterone (ALDO) are important mediators of ventricular injury. We have described a model of biventricular damage in rodents that relies on treatment with N-omega-nitro-l-arginine methyl ester (L-NAME (nitric oxide synthase inhibitor)) and AngII. This damage initiated at the vascular level and was observed only in the presence of ALDO and an activated mineralocorticoid receptor (MR). We hypothesize that cav-1 modulates the adverse cardiac effects mediated by ALDO in this animal model. To test this hypothesis, we assessed the ventricular damage and measures of inflammation, in wild-type (WT) and cav-1 knockout (KO) mice randomized to either placebo or L-NAME/AngII treatment. Despite displaying cardiac hypertrophy at baseline and higher blood pressure responses to L-NAME/AngII, cav-1 KO mice displayed, as compared with WT, decreased treatment-induced biventricular damage as well as decreased transcript levels of the proinflammatory marker plasminogen activator inhibitor-1. Additionally, L-NAME/AngII induced an increase in cardiac MR levels in WT but not cav-1-ablated mice. Moreover and despite similar circulating ALDO levels in both genotypes, the myocardial damage (as determined histologically and by plasminogen activator inhibitor-1 mRNA levels) was less sensitive to ALDO levels in cav-1 KO vs. WT mice, consistent with decreased MR signaling in the cav-1 KO. Thus, we conclude that the L-NAME/AngII-induced biventricular damage is mediated by a mechanism partially dependent on cav-1 and signaling via MR/ALDO.
    MeSH term(s) Aldosterone/blood ; Amino Acid Sequence ; Angiotensin II/metabolism ; Animals ; Blood Pressure ; Cardiomegaly/chemically induced ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Caveolin 1/deficiency ; Endothelial Cells/metabolism ; Male ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Myocardium/pathology ; NG-Nitroarginine Methyl Ester ; Nitric Oxide Synthase Type III/metabolism ; Receptor, Angiotensin, Type 1/metabolism ; Receptors, Mineralocorticoid/metabolism ; Signal Transduction
    Chemical Substances Caveolin 1 ; Receptor, Angiotensin, Type 1 ; Receptors, Mineralocorticoid ; Angiotensin II (11128-99-7) ; Aldosterone (4964P6T9RB) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
    Language English
    Publishing date 2010-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2009-0514
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  4. Article: Maternal-Autoantibody-Related (MAR) Autism: Identifying Neuronal Antigens and Approaching Prospects for Intervention.

    Marks, Katya / Vincent, Angela / Coutinho, Ester

    Journal of clinical medicine

    2020  Volume 9, Issue 8

    Abstract: Recent studies indicate the existence of a maternal-autoantibody-related subtype of autism spectrum disorder (ASD). To date, a large number of studies have focused on describing patterns of brain-reactive serum antibodies in maternal-autoantibody-related ...

    Abstract Recent studies indicate the existence of a maternal-autoantibody-related subtype of autism spectrum disorder (ASD). To date, a large number of studies have focused on describing patterns of brain-reactive serum antibodies in maternal-autoantibody-related (MAR) autism and some have described attempts to define the antigenic targets. This article describes evidence on MAR autism and the various autoantibodies that have been implicated. Among other possibilities, antibodies to neuronal surface protein Contactin Associated Protein 2 (CASPR2) have been found more frequently in mothers of children with neurodevelopmental disorders or autism, and two independent experimental studies have shown pathogenicity in mice. The N-methyl-D-aspartate receptor (NMDAR) is another possible target for maternal antibodies as demonstrated in mice. Here, we discuss the growing evidence, discuss issues regarding biomarker definition, and summarise the therapeutic approaches that might be used to reduce or prevent the transfer of pathogenic maternal antibodies.
    Language English
    Publishing date 2020-08-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9082564
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  5. Article ; Online: Real-world experience of assessing antibodies against the N-methyl-D-aspartate receptor (NMDAR-IgG) in psychiatric patients. A retrospective single-centre study.

    Ariño, Helena / Coutinho, Ester / Pollak, Thomas A / Stewart, Robert

    Brain, behavior, and immunity

    2021  Volume 98, Page(s) 330–336

    Abstract: Objective: To evaluate the frequency of anti-NMDAR encephalitis in a secondary mental health service and investigate the challenges of its diagnosis in routine clinical practice.: Methods: Patients whose electronic health records registered an ... ...

    Abstract Objective: To evaluate the frequency of anti-NMDAR encephalitis in a secondary mental health service and investigate the challenges of its diagnosis in routine clinical practice.
    Methods: Patients whose electronic health records registered an indication for NMDAR-IgG assessment were selected and seropositive patients were reviewed.
    Results: In 1661 patients assessed for NMDAR-IgG over 12 years, the positivity rate was 3.79% (95% confidence interval [CI]: 2.87-4.70%). The working diagnosis at assessment was new onset psychosis in 38.7% and a chronic psychotic syndrome in 34.0%. Among seropositive patients, 30 (47.6%, 95%CI: 35.8-59.7%) had a final alternative diagnosis different from encephalitis after a median period of 49 months from onset. Patients with a final diagnosis of encephalitis were more frequently female (27/35 vs 13/30, p = 0.011) than other seropositive patients and had more frequently an acute (34/35 vs 11/30, p < 0.001), fluctuating (21/23 vs 4/27, p < 0.001) or agitated (32/32 vs 10/26, p < 0.001) presentation. Nine encephalitic patients received specialized follow-up for chronic neuropsychiatric problems including learning disabilities, organic personality disorder, anxiety, fatigue, obsessive-compulsive and autism-like disorder.
    Conclusions: In a psychiatric setting, NMDAR-IgG seropositivity rates were low with a positive predictive value for encephalitis around 50% when screened patients had chronic presentations and absence of other diagnostic criteria for encephalitis or psychosis of autoimmune origin. Chronic neuropsychiatric problems in anti-NMDAR encephalitis are not uncommon, so better diagnostic and treatment strategies are still needed.
    MeSH term(s) Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications ; Autoantibodies ; Female ; Humans ; Immunoglobulin G ; Receptors, N-Methyl-D-Aspartate ; Retrospective Studies
    Chemical Substances Autoantibodies ; Immunoglobulin G ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2021-09-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2021.08.233
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  6. Article ; Online: Maternal-Autoantibody-Related (MAR) Autism

    Katya Marks / Angela Vincent / Ester Coutinho

    Journal of Clinical Medicine, Vol 9, Iss 2564, p

    Identifying Neuronal Antigens and Approaching Prospects for Intervention

    2020  Volume 2564

    Abstract: Recent studies indicate the existence of a maternal-autoantibody-related subtype of autism spectrum disorder (ASD). To date, a large number of studies have focused on describing patterns of brain-reactive serum antibodies in maternal-autoantibody-related ...

    Abstract Recent studies indicate the existence of a maternal-autoantibody-related subtype of autism spectrum disorder (ASD). To date, a large number of studies have focused on describing patterns of brain-reactive serum antibodies in maternal-autoantibody-related (MAR) autism and some have described attempts to define the antigenic targets. This article describes evidence on MAR autism and the various autoantibodies that have been implicated. Among other possibilities, antibodies to neuronal surface protein Contactin Associated Protein 2 (CASPR2) have been found more frequently in mothers of children with neurodevelopmental disorders or autism, and two independent experimental studies have shown pathogenicity in mice. The N-methyl-D-aspartate receptor (NMDAR) is another possible target for maternal antibodies as demonstrated in mice. Here, we discuss the growing evidence, discuss issues regarding biomarker definition, and summarise the therapeutic approaches that might be used to reduce or prevent the transfer of pathogenic maternal antibodies.
    Keywords autism ; neurodevelopmental disorder ; autoantibodies ; autoimmunity ; pregnancy ; placental antibody transfer ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Mental health outcomes of encephalitis: An international web-based study.

    Butler, Matt / Abdat, Yasmin / Zandi, Michael / Michael, Benedict D / Coutinho, Ester / Nicholson, Timothy R / Easton, Ava / Pollak, Thomas A

    European journal of neurology

    2023  Volume 31, Issue 1, Page(s) e16083

    Abstract: Background and purpose: Acute encephalitis is associated with psychiatric symptoms. Despite this, the extent of mental health problems following encephalitis has not been systematically reported.: Methods: We recruited adults who had been diagnosed ... ...

    Abstract Background and purpose: Acute encephalitis is associated with psychiatric symptoms. Despite this, the extent of mental health problems following encephalitis has not been systematically reported.
    Methods: We recruited adults who had been diagnosed with encephalitis of any aetiology to complete a web-based questionnaire.
    Results: In total, 445 respondents from 31 countries (55.1% UK, 23.1% USA) responded. Infectious encephalitis constituted 65.4% of cases, autoimmune 29.7%. Mean age was 50.1 years, 65.8% were female, and median time since encephalitis diagnosis was 7 years. The most common self-reported psychiatric symptoms were anxiety (75.2%), sleep problems (64.4%), mood problems (62.2%), and unexpected crying (35.2%). Self-reported psychiatric diagnoses were common: anxiety (44.0%), depression (38.6%), panic disorder (15.7%), and posttraumatic stress disorder (PTSD; 21.3%). Severe mental illnesses such as psychosis (3.3%) and bipolar affective disorder (3.1%) were reported. Self-reported diagnosis rates were broadly consistent with results from the Psychiatric Diagnostic Screening Questionnaire. Many respondents also reported they had symptoms of anxiety (37.5%), depression (28.1%), PTSD (26.8%), or panic disorder (20.9%) that had not been diagnosed. Rates of psychiatric symptoms did not differ between autoimmune and infectious encephalitis. In total, 37.5% respondents had thought about suicide, and 4.4% had attempted suicide, since their encephalitis diagnosis. More than half of respondents (53.5%) reported they had no, or substandard, access to appropriate mental health care. High rates of sensory hypersensitivities (>75%) suggest a previously unreported association.
    Conclusions: This large international survey indicates that psychiatric symptoms following encephalitis are common and that mental health care provision may be inadequate. We highlight a need for proactive psychiatric input.
    MeSH term(s) Adult ; Humans ; Female ; Middle Aged ; Male ; Anxiety Disorders ; Encephalitis ; Infectious Encephalitis ; Outcome Assessment, Health Care ; Internet
    Language English
    Publishing date 2023-10-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16083
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    Zs.MO 592: Show issues

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  8. Article ; Online: Suicidal and self-injurious behavior following adalimumab reference-to-generic biosimilar switch.

    Ward, Catherine / Farag, Mena / Pollak, Thomas A / Coutinho, Ester / Posporelis, Sotiris

    Psychiatry and clinical neurosciences

    2021  Volume 76, Issue 2, Page(s) 59–62

    MeSH term(s) Adalimumab ; Adult ; Biosimilar Pharmaceuticals ; Drug Substitution ; Drugs, Generic ; Humans ; Male ; Self-Injurious Behavior ; Suicidal Ideation
    Chemical Substances Biosimilar Pharmaceuticals ; Drugs, Generic ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2021-12-07
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1292906-2
    ISSN 1440-1819 ; 1323-1316
    ISSN (online) 1440-1819
    ISSN 1323-1316
    DOI 10.1111/pcn.13315
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  9. Article ; Online: Both C57BL/KsJ (H2d haplotype) and CB10-H2 (H2b haplotype) mice are highly susceptible to congenital toxoplasmosis

    Coutinho, Loyane Bertagnolli / de Oliveira, Mário Cézar / Araujo, Ester Cristina Borges / França, Flávia Batista Ferreira / Almeida, Marcos Paulo Oliveira / Cariaco, Yusmaris / Czarnewski, Paulo / Silva, Neide Maria

    Acta Tropica. 2023 Dec., v. 248 p.107022-

    2023  

    Abstract: Congenital toxoplasmosis may cause abortion, neonatal death, or foetal abnormalities. Despite little information from human studies, a genetic influence over congenital disease was demonstrated and, host genome have been implicated to resistance/ ... ...

    Abstract Congenital toxoplasmosis may cause abortion, neonatal death, or foetal abnormalities. Despite little information from human studies, a genetic influence over congenital disease was demonstrated and, host genome have been implicated to resistance/susceptibility to Toxoplasma gondii infection in both human and mice. It was previously shown that BALB/c mice (H2ᵈ) were more resistant to congenital toxoplasmosis than C57BL/6 mice (H2ᵇ). However, it is unclear whether these differences are attributable to the MHC haplotype or to other components of the mouse's genetic background. Therefore, in this work, we intend to address this question by investigating the pregnancy outcome in H2ᵈ -congenic C57BL/6 mice (C57BL/KsJ-H2ᵈ) and H2ᵇ-congenic BALB/c mice (CB10-H2-H2ᵇ). For this, animals were infected by intragastric route on the first day of pregnancy and examined on days 8 (8dP/8dI) or 18 (18dP/18dI) of gestation and infection. The pregnancy outcome, parasite burden, systemic cytokine profile and antibody response to infection were evaluated. Infected mice showed adverse pregnancy outcomes, in parallel low parasite detection in the uterus/placenta, being that the C57BL/KsJ showed the worst results in relation to CB10-H2 mice. Both mouse lineages showed an increase in IFN-γ and TNF levels systemically on 8dP/8dI and on 18dP/18dI, and C57BL/KsJ showed an increase in IL-6 levels in both gestation/infection periods. Additionally, C57BL/KsJ showed 7- and 7-fold increase in IL-6, 4- and 2.5-fold increase in IFN-γ and, 6- and 4-fold increase in TNF production on 8dP/8dI and 18dP/18dI, respectively in association with 1.5-fold decrease in TGF-β levels on 8dP/8dI compared to CB10-H2 mice. In conclusion, the high IFN-γ and TNF serum levels observed in C57BL/KsJ (H2ᵈ) and CB10-H2 (H2ᵇ) mice were involved in the poor pregnancy outcomes in congenital toxoplasmosis. In addition, the higher IFN‐γ, IL‐6 and TNF levels detected in C57BL/KsJ in relation to CB10‐H2 mice on 8dP/8dI seem to be related to the genetic background of C57BL/6J mice that may have contributed to the worse pregnancy outcome in this mouse lineage.
    Keywords Toxoplasma gondii ; antibody formation ; blood serum ; congenital abnormalities ; death ; genetic background ; genome ; haplotypes ; humans ; interleukin-6 ; mice ; parasites ; placenta ; pregnancy outcome ; toxoplasmosis ; uterus ; Congenital toxoplasmosis ; C57BL/KsJ ; CB10-H2 ; Congenic mice ; CBA ; dI ; DNA ; dP ; ELISA ; GAPDH ; H2O2 ; HLA ; IFN ; Ig ; IL ; MHC ; mRNA ; NI ; OD ; PBMC ; PBS ; qPCR ; REBIR-UFU ; SAG-1 ; SD ; SEM ; STAg ; TGF ; Th ; TNF ; Treg
    Language English
    Dates of publication 2023-12
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2023.107022
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  10. Article ; Online: Both C57BL/KsJ (H2

    Coutinho, Loyane Bertagnolli / de Oliveira, Mário Cézar / Araujo, Ester Cristina Borges / França, Flávia Batista Ferreira / Almeida, Marcos Paulo Oliveira / Cariaco, Yusmaris / Czarnewski, Paulo / Silva, Neide Maria

    Acta tropica

    2023  Volume 248, Page(s) 107022

    Abstract: Congenital toxoplasmosis may cause abortion, neonatal death, or foetal abnormalities. Despite little information from human studies, a genetic influence over congenital disease was demonstrated and, host genome have been implicated to resistance/ ... ...

    Abstract Congenital toxoplasmosis may cause abortion, neonatal death, or foetal abnormalities. Despite little information from human studies, a genetic influence over congenital disease was demonstrated and, host genome have been implicated to resistance/susceptibility to Toxoplasma gondii infection in both human and mice. It was previously shown that BALB/c mice (H2
    MeSH term(s) Animals ; Female ; Humans ; Mice ; Pregnancy ; Disease Susceptibility ; Haplotypes ; Interleukin-6/genetics ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Toxoplasma/genetics ; Toxoplasmosis, Animal/parasitology ; Toxoplasmosis, Congenital/genetics ; Histocompatibility
    Chemical Substances Interleukin-6
    Language English
    Publishing date 2023-09-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2023.107022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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