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  1. Article ; Online: Demenz-Screening- und testpsychologische Untersuchungen in deutschen Haus- und Facharztpraxen unter Bedingungen der Corona Pandemie.

    Bohlken, Jens / Michalowsky, Bernhard / Kostev, Karel

    Psychiatrische Praxis

    2023  Volume 50, Issue 6, Page(s) 321–325

    Abstract: Objective: To analyse changes in frequencies of test psychology examinations (TPE) relevant to detect change in dementia diagnosis in general (GP) and neuropsychiatric (NP) practices during the Covid 19 pandemic.: Methods: Cross-sectional study ... ...

    Title translation Dementia Screening and Test Psychology in German General and Specialist Practices under Conditions of the Corona Pandemic.
    Abstract Objective: To analyse changes in frequencies of test psychology examinations (TPE) relevant to detect change in dementia diagnosis in general (GP) and neuropsychiatric (NP) practices during the Covid 19 pandemic.
    Methods: Cross-sectional study analysis comparing the number of patients aged ≥ 70 with at least one TPE in 908 GP and 107 NP-practices in 2018-2019 (prepandemic) and 2020-2021 (pandemic) using descriptive statisics and correlations.
    Results: While there was a large decrease in TPE between 2018-2019 and 2020-2021 (- 18.4%) conducted in NP-practices, it remained stable in GP-practices (+ 2.6%). In both GP and NP, there was a strong correlation between the number of patients tested and newly diagnosed with dementia.
    Conclusion: TPE in performing in GP practices appears less susceptible to a pandemic-related decline in the provision compared to NP practices. Further research is needed to reveal the reasons for these differences.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Pandemics ; COVID-19/epidemiology ; Germany ; Dementia/diagnosis ; Dementia/epidemiology ; Dementia/psychology
    Language German
    Publishing date 2023-05-09
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-2043-9939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Medical care services provision and stress experience in urologists during all waves of the COVID-19 pandemic in Germany.

    Paffenholz, Pia / Platen, Moritz / Kostev, Karel / Loosen, Sven H / Bohlken, Jens / Michalowsky, Bernhard

    Frontiers in medicine

    2024  Volume 11, Page(s) 1320489

    Abstract: Purpose: Urologists' practices reported decreasing medical care provision and increasing stress experience in the first wave of the COVID-19 pandemic. However, long-term effects of the pandemic are unknown.: Methods: Medical record data of n = 127 ... ...

    Abstract Purpose: Urologists' practices reported decreasing medical care provision and increasing stress experience in the first wave of the COVID-19 pandemic. However, long-term effects of the pandemic are unknown.
    Methods: Medical record data of n = 127 urologists were used to assess changes in healthcare provision, comparing the pandemic with the pre-pandemic period. An online survey among n = 101 urologists was conducted to assess the physicians' perceptions of the identified healthcare provision and organizational changes and experiences of anxiety, stress, and support needs during the pandemic waves. Urologists consultations, specialists' referrals, hospital admissions, documented cancer diagnoses, urologists' perceptions of causes for these changes and experienced stress, anxiety and support needs. Results were demonstrated using descriptive statistics.
    Results: Over the first two years of the pandemic, there was a slight decline in consultations (-0,94%), but more intensive reduction in hospital admissions (-13,6%) and identified cancer diagnoses (-6,2%). Although patients' behavior was seen as the main reason for the changes, 71 and 61% of consultations of high-risk patients or urgent surgeries were canceled. Telemedical approaches were implemented by 58% of urologists, and 88% stated that the reduced cancer detection rate would negatively affect patients' outcomes. Urologists reported higher anxiety, stress, and need for support during all waves of the pandemic than other disciplines, especially females.
    Conclusion: The pandemic tremendously affects urologists' health care provision and stress experience, possibly causing long-term consequences for patients and physicians.
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1320489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Demenzdiagnosen in deutschen Hausarztpraxen – Ein Vergleich mit der Prävalenzschätzung für das Jahr 2021.

    Bohlken, Jens / Riedel-Heller, Steffi G / Kostev, Karel / Michalowsky, Bernhard

    Psychiatrische Praxis

    2023  Volume 51, Issue 1, Page(s) 45–48

    Abstract: Background: A current prevalence estimate predicted the number of people with dementia (PwD) with 1.8 million in 2021. This estimation is based on data from different sources especially from field studies and does not reflect the recognized and ... ...

    Title translation Comparison of the Documented Dementia Diagnoses in German Primary Care with the Prevalence Estimate for 2021.
    Abstract Background: A current prevalence estimate predicted the number of people with dementia (PwD) with 1.8 million in 2021. This estimation is based on data from different sources especially from field studies and does not reflect the recognized and documented cases in primary care. We, therefore, aim to compare the prevalence of diagnosed PwD in general practitioner (GP) practices with these estimates of the general population.
    Methods: The number of diagnosed PwD in 946 GP practices with 2.8 million patients in 2021 was compared with the prevalence estimate of the German Alzheimer Society for 83 million inhabitants in Germany.
    Results:   Dementia diagnoses were documented less frequently in GP practices compared to the prevalence estimate (1.88% vs 2.16%), especially the age groups 80+years were less likely present in GP practices prevalence.
    Discussion: There is still potential for optimizing dementia diagnostics in primary care, especially in patients 80 or older.
    MeSH term(s) Humans ; Aged, 80 and over ; Dementia/diagnosis ; Dementia/epidemiology ; Prevalence ; Germany/epidemiology ; General Practitioners ; Primary Health Care
    Language German
    Publishing date 2023-10-09
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-2160-2864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association Between Low- and High-Value Medication and Hospital Referrals by General Practitioners in Patients Living with Dementia.

    Michalowsky, Bernhard / Platen, Moritz / Bohlken, Jens / Kostev, Karel

    Journal of Alzheimer's disease reports

    2022  Volume 6, Issue 1, Page(s) 641–650

    Abstract: Background: Previous studies revealed that low-value medication (LvM), drugs that provide little or no benefit but have the potential to cause harm, are associated with hospitalizations in dementia. Recommended medications, referred to as high-value ... ...

    Abstract Background: Previous studies revealed that low-value medication (LvM), drugs that provide little or no benefit but have the potential to cause harm, are associated with hospitalizations in dementia. Recommended medications, referred to as high-value medication (HvM), can be used alternately. However, the effect of LvM and HvM on hospitalizations is uncertain.
    Objective: To determine the prevalence of LvM and HvM in hospitalized and non-hospitalized patients living with dementia (PwD) and the odds for hospital referrals in PwD receiving LvM or HvM.
    Methods: The analysis was based on 47,446 PwD who visited a general practitioner practice between 2017 and 2019. Different guidelines were used to elicit LvM and HvM, resulting in 185 LvM and HvM related recommendations. Of these, 117 recommendations (83 for LvM, 34 for HvM) were categorized into thirteen therapy classes. The association of hospital referrals issued by general practitioners and receiving LvM or HvM was assessed using multiple logistic regression models.
    Results: 20.4% of PWD received LvM. Most frequently prescribed LvM were non-recommended sedatives and hypnotics, analgesics, and antidepressants. Recommended HvM were 3.4 (69.9%) more frequently prescribed than LvM. Most commonly prescribed HvM were recommended antihypertensives, antiplatelet agents, and antiarrhythmics. Both receiving LvM and receiving HvM were associated with higher odds for hospital referrals. When receiving LvM were compared to HvM, no significant differences could be found in hospital referrals.
    Conclusion: LvM is highly prevalent but did not cause more likely hospital referrals than HvM. Further research should focus on acute hospitalizations, not only on planned hospital referrals.
    Language English
    Publishing date 2022-10-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-220004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pre-diagnostic presentations of Multiple System Atrophy case control study in a primary care dataset.

    Schrag, Anette / Bohlken, Jens / Kostev, Karel

    Parkinsonism & related disorders

    2022  Volume 99, Page(s) 101–104

    Abstract: Background: We here report the pre-diagnostic clinical presentations of patients with Multiple System Atrophy (MSA) from analysis of a large routine clinical care database.: Methods: Data were extracted from a primary care database in the German ... ...

    Abstract Background: We here report the pre-diagnostic clinical presentations of patients with Multiple System Atrophy (MSA) from analysis of a large routine clinical care database.
    Methods: Data were extracted from a primary care database in the German healthcare system for the period between January 2000 and December 2020. We identified 250 patients with new diagnosis of MSA and 250 controls matched for age, sex, and index year. Logistic regression analyses were conducted to assess association between MSA and predefined diagnoses.
    Results: The greatest rate increase in the 2 years preceding diagnosis of MSA was seen for hypotension and balance impairment but rates of memory problems, urinary dysfunction, dizziness and depression rates were also markedly increased, and ataxia was solely identified in those with a later diagnosis of MSA. Up to 5 years before diagnosis similar patterns were seen, but >5 years before diagnosis only depression rates were increased with a trend for increase in constipation.
    Conclusions: Presentations that were significantly more common in patients with MSA in the pre-diagnostic phase than in controls were autonomic complaints such as postural hypotension, urinary and bowel dysfunction, and early balance impairment. However, the study also highlights that memory complaints and depression may be early features of MSA years before diagnosis.
    MeSH term(s) Autonomic Nervous System ; Case-Control Studies ; Humans ; Hypotension, Orthostatic ; Multiple System Atrophy/complications ; Multiple System Atrophy/diagnosis ; Primary Health Care
    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2022.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association Between Ginkgo Biloba Extract Prescriptions and Dementia Incidence in Outpatients with Mild Cognitive Impairment in Germany: A Retrospective Cohort Study.

    Bohlken, Jens / Peters, Oliver / Kostev, Karel

    Journal of Alzheimer's disease : JAD

    2022  Volume 86, Issue 2, Page(s) 703–709

    Abstract: Background: Clinical trials have demonstrated a significant effectiveness of Ginkgo biloba therapy versus placebo in patients with dementia.: Objective: The present study aims to analyze the impact of Ginkgo biloba drug prescriptions on dementia ... ...

    Abstract Background: Clinical trials have demonstrated a significant effectiveness of Ginkgo biloba therapy versus placebo in patients with dementia.
    Objective: The present study aims to analyze the impact of Ginkgo biloba drug prescriptions on dementia incidence in patients with mild cognitive impairment (MCI) in a real-world setting.
    Methods: This retrospective study was based on the IQVIA Disease Analyzer database and included patients aged 65 or older with a first diagnosis of MCI from January 2000 to December 2019. Each patient was followed for up to 20 years after MCI diagnosis until February 2021. Date of the first diagnosis of dementia or loss to follow-up, whichever occurred first, was noted. To estimate the association between Ginkgo biloba prescriptions during the follow-up and dementia incidence, a multivariable Cox regression analysis was performed, adjusted for age, sex, health insurance, documented co-diagnoses, and prescription of cholinesterase inhibitors.
    Results: Overall, 24,483 MCI patients (mean age: 77.0 years, 56.3% women) were included. It was found that > 2 prescriptions of Ginkgo biloba were significantly associated with a reduced dementia incidence (HR: 0.71 (95% CI: 0.55-0.91), p = 0.007), as compared with no Ginkgo biloba prescription. The effect of receiving > 3 Ginkgo biloba prescriptions was even stronger, with an HR of 0.64 (95% CI: 0.48-0.86), p = 0.003), while for > 4 prescriptions the HR was 0.58 (95% CI: 0.41-0.82) (p = 0.002).
    Conclusion: All-cause dementia incidence decreased with higher numbers of Ginkgo biloba prescriptions in MCI patients.
    MeSH term(s) Aged ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/epidemiology ; Dementia/drug therapy ; Dementia/epidemiology ; Female ; Ginkgo biloba ; Humans ; Incidence ; Male ; Outpatients ; Phytotherapy ; Plant Extracts/therapeutic use ; Prescriptions ; Retrospective Studies
    Chemical Substances Plant Extracts ; Ginkgo biloba extract (19FUJ2C58T)
    Language English
    Publishing date 2022-04-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-215348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Gerontopsychiatrische Versorgung durch Fachärzte. Bericht vom 17. Kongress der DGGPP in Essen

    Bohlken, Jens

    Neurotransmitter

    2017  Volume 28, Issue 12, Page(s) 14

    Language German
    Document type Article
    ZDB-ID 1362825-2
    ISSN 1436-123X
    Database Current Contents Medicine

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  8. Article: [No title information]

    Bohlken, Jens / Michalowsky, Bernhard / Kostev, Karel

    Psychiatrische Praxis

    2023  Volume 50, Issue 06, Page(s) 321–325

    Abstract: Ziel: Häufigkeitsvergleich der testpsychologischen Untersuchungen (TPU) in Haus- und Facharztpraxen (HA, FA) vor und während der Covid-19-Pandemie.: Methoden: Deskriptiver Vergleich der durchschnittlichen ... ...

    Abstract Ziel: Häufigkeitsvergleich der testpsychologischen Untersuchungen (TPU) in Haus- und Facharztpraxen (HA, FA) vor und während der Covid-19-Pandemie.
    Methoden: Deskriptiver Vergleich der durchschnittlichen Anzahl von Patienten im Alter von≥70Jahren mit mindestens einer TPU in 908 HA- und 107 FA-Praxen aus der IQVIA Disease Analyzer Datenbank zwischen den Jahren 2018–2019 (Prä-Pandemie) und 2020–2021 (Pandemie).
    Ergebnisse: In FA Praxen zeigte sich ein Rückgang (-18,4%) von TPU von 2018–2019 zu 2020–2021. In HA-Praxen war dies nicht der Fall (+ 2.6%). Sowohl bei HA als auch bei FA bestand eine starke Korrelation zwischen der Anzahl der Patienten mit TPU und neu diagnostizierter Demenz.
    Schlussfolgerung: Die Durchführung von Testungen in HA-Praxen zeigte keinen Pandemie bedingten Leistungsrückgang, welcher in FA-Praxen deutlich zu sehen war. Weitere Untersuchungen müssen folgen, um mögliche Ursachen aufzuklären.
    Keywords Covid-19-Pandemie ; Demenz ; Demenz-Screening ; Hausarzt ; Facharzt ; COVID-19 pandemic ; dementia ; dementia screening ; primary care physician ; specialist
    Language German
    Publishing date 2023-05-09
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 124981-2
    ISSN 1439-0876 ; 0303-4259
    ISSN (online) 1439-0876
    ISSN 0303-4259
    DOI 10.1055/a-2043-9939
    Database Thieme publisher's database

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  9. Article ; Online: Discontinuation of Antihypertensive Therapy and Dementia Incidence in the United Kingdom.

    Kostev, Karel / Bohlken, Jens

    Journal of the American Medical Directors Association

    2019  Volume 20, Issue 6, Page(s) 790–791

    MeSH term(s) Antihypertensive Agents ; Cognition ; Dementia ; Humans ; Hypertension ; Incidence ; United Kingdom
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2019-04-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2171030-2
    ISSN 1538-9375 ; 1525-8610
    ISSN (online) 1538-9375
    ISSN 1525-8610
    DOI 10.1016/j.jamda.2019.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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