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Book: Person-centered, outcomes-driven treatment

Harris, Stewart B.

a new paradigm for type 2 diabetes in primary care

(Diabetes ; [69, 8, Beilage])

2020

Author's details	contributing authors Stewart B. Harris, CM, MD; Alice Y.Y. Cheng, MD; Melanie J. Davies, CBE, MBChB, MD; Hertzel C. Gerstein, MD, MSc; Jennifer B. Green, MD; Neil Skolnik, MD
Series title	Diabetes ; [69, 8, Beilage]
Collection
Language	English
Size	28 Seiten, Illustrationen
Publisher	American Diabetes Association
Publishing place	Arlington, VA
Publishing country	United States
Document type	Book
HBZ-ID	HT020646040
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Uh III Zs 175 -[69,8,Beil.]-	verfügbar in Königswinter	Königswinter

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Article ; Online: [No title information]

Harris, Stewart B / Bari, Basel / Gilbert, Jeremy

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2024 Volume 196, Issue 9, Page(s) E325–E326

Title translation	Surveillance du glucose en continu.
MeSH term(s)	Humans ; Continuous Glucose Monitoring ; Blood Glucose Self-Monitoring ; Blood Glucose
Chemical Substances	Blood Glucose
Language	French
Publishing date	2024-03-10
Publishing country	Canada
Document type	Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.230572-f
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Ua VI Zs.136: Show issues

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Article ; Online: Continuous glucose monitoring.

Harris, Stewart B / Bari, Basel / Gilbert, Jeremy

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2023 Volume 195, Issue 44, Page(s) E1509

MeSH term(s)	Humans ; Blood Glucose ; Blood Glucose Self-Monitoring ; Diabetes Mellitus, Type 1 ; Hypoglycemia/diagnosis
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-11-14
Publishing country	Canada
Document type	Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.230572
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Article ; Online: Exploring quality improvement for diabetes care in First Nations communities in Canada: a multiple case study.

Fournie, Meghan / Sibbald, Shannon L / Harris, Stewart B

BMC health services research

2023 Volume 23, Issue 1, Page(s) 462

Abstract: Background: Indigenous peoples in Canada experience higher rates of diabetes and worse outcomes than non-Indigenous populations in Canada. Strategies are needed to address underlying health inequities and improve access to quality diabetes care. As part ...

Abstract	Background: Indigenous peoples in Canada experience higher rates of diabetes and worse outcomes than non-Indigenous populations in Canada. Strategies are needed to address underlying health inequities and improve access to quality diabetes care. As part of the national FORGE AHEAD Research Program, this study explores two primary healthcare teams' quality improvement (QI) process of developing and implementing strategies to improve the quality of diabetes care in First Nations communities in Canada. Methods: This study utilized a community-based participatory and qualitative case study methodology. Multiple qualitative data sources were analyzed to understand: (1) how knowledge and information was used to inform the teams' QI process; (2) how the process was influenced by the context of primary care services within communities; and (3) the factors that supported or hindered their QI process. Results: The findings of this study demonstrate how teams drew upon multiple sources of knowledge and information to inform their QI work, the importance of strengthening relationships and building relationships with the community, the influence of organizational support and capacity, and the key factors that facilitated QI efforts. Conclusions: This study contributes to the ongoing calls for research in understanding the process and factors affecting the implementation of QI strategies, particularly within Indigenous communities. The knowledge generated may help inform community action and the future development, implementation and scale-up of QI programs in Indigenous communities in Canada and globally.
MeSH term(s)	Humans ; Canada ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Indigenous Peoples ; Quality Improvement ; Indigenous Canadians
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-023-09442-3
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Article ; Online: Use of the FreeStyle Libre system and diabetes treatment progression in T2DM: Results from a retrospective cohort study using a Canadian private payer claims database.

Harris, Stewart B / Levrat-Guillen, Fleur

Diabetes, obesity & metabolism

2023 Volume 25, Issue 6, Page(s) 1704–1713

Abstract: Background: Up to one-third of Canadians are estimated to be living with prediabetes or diabetes. A retrospective study using Canadian private drug claims data was conducted to investigate whether flash glucose monitoring using the FreeStyle Libre ... ...

Abstract	Background: Up to one-third of Canadians are estimated to be living with prediabetes or diabetes. A retrospective study using Canadian private drug claims data was conducted to investigate whether flash glucose monitoring using the FreeStyle Libre system (FSL) among people with type 2 diabetes mellitus (T2DM) in Canada can be associated with changes in treatment intensification when compared with blood glucose monitoring (BGM) alone. Materials and methods: Using a Canadian national private drug claims database comprising approximately 50% coverage of insured individuals in Canada, cohorts of people with T2DM using FSL or BGM were identified algorithmically based on treatment history and followed over a 24-month study period, tracking their progression in diabetes treatment therapy. The Andersen-Gill model for recurrent time-to-event data was used to evaluate whether the rate of treatment progression differs between the FSL and BGM treatment cohorts. The survival function was used to calculate comparative treatment progression probabilities between the cohorts. Results: In total, 373 871 people with T2DM met the inclusion criteria. Across treatment (FSL) and control (BGM) groups, people using FSL had a higher probability of treatment progression compared with BGM alone, with a relative risk ranging between 1.86 and 2.81 (p < .001). A higher probability of treatment progression was independent of the diabetes treatment at the enrolment date (index date) or the patient status, and independent of whether patients were treatment naïve or on established diabetes therapy. Assessment of the ending treatment relative to the starting therapy indicated that dynamic treatment changes were most evident for patients in the FSL cohort and that the FSL cohort had a much greater portion of patients who ended with insulin treatment (when they started with non-insulin treatment) compared with the BGM cohort. Conclusions: People with T2DM using FSL had a greater probability for treatment progression compared with BGM alone, irrespective of the starting therapy, which may suggest that FSL can be used to support escalation of diabetes therapy to improve therapeutic inertia in T2DM.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Retrospective Studies ; Blood Glucose Self-Monitoring/methods ; Blood Glucose ; Canada/epidemiology
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15025
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Zs.A 5442: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Clinical Use of Insulin Glargine 300 U/mL in Adults with Type 2 Diabetes: Hypothetical Case Studies.

Harris, Stewart B / Parente, Erika B / Karalliedde, Janaka

Diabetes therapy : research, treatment and education of diabetes and related disorders

2022 Volume 13, Issue 5, Page(s) 913–930

Abstract: Type 2 diabetes (T2D) is a progressive disease, with many individuals eventually requiring basal insulin therapy to maintain glycaemic control. However, there exists considerable therapeutic inertia to the prompt initiation and optimal titration of basal ...

Abstract	Type 2 diabetes (T2D) is a progressive disease, with many individuals eventually requiring basal insulin therapy to maintain glycaemic control. However, there exists considerable therapeutic inertia to the prompt initiation and optimal titration of basal insulin therapy due to barriers that include fear of injections, hypoglycaemia, weight gain, and burdensome regimens. Hypoglycaemia is thought to be a major barrier to optimal glycaemic control and is associated with significant morbidity and mortality. Newer second-generation basal insulin analogues provide comparable glycaemic control with lower risk of hypoglycaemia compared with first-generation basal insulin analogues. The present review article discusses clinical evidence for one such second-generation basal insulin analogue, insulin glargine 300 U/mL (Gla-300), in the context of hypothetical case studies that are representative of individuals who may attend routine clinical practice. These case studies discuss individualised treatment needs for people with T2D who are insulin-naïve or pre-treated. Clinical characteristics such as older age, frequent nocturnal hypoglycaemia, and renal impairment, which are known risk factors for hypoglycaemia, are also considered.
Language	English
Publishing date	2022-03-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2566702-6
ISSN	1869-6961 ; 1869-6953
ISSN (online)	1869-6961
ISSN	1869-6953
DOI	10.1007/s13300-022-01247-7
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Article ; Online: Sphingomonas paucimobilis bloodstream infection is a predominantly community-onset disease with significant lethality.

Laupland, Kevin B / Paterson, David L / Stewart, Adam G / Edwards, Felicity / Harris, Patrick N A

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 119, Page(s) 172–177

Abstract: Background: Small case series and reports suggest that Sphingomonas paucimobilis is predominantly a cause of nosocomial bloodstream infections (BSI) with very low associated mortality. Our objective was to describe the epidemiology and outcome of ... ...

Abstract	Background: Small case series and reports suggest that Sphingomonas paucimobilis is predominantly a cause of nosocomial bloodstream infections (BSI) with very low associated mortality. Our objective was to describe the epidemiology and outcome of Sphingomonas species BSI in a large Australian population. Methods: We included all residents of Queensland, Australia, with BSI because of Sphingomonas species identified within the publicly funded system from 2000 to 2019. Results: A total of 282 incident episodes of Sphingomonas species BSI were identified for an age- and sex-adjusted incidence of 3.2 per million population annually. Incidence rates were highest in the tropical regions of the state. Most (94%) of the isolates were confirmed as Sphingomonas paucimobilis. In addition, 77% of the infections were community-onset, of which 48% were community-associated, and 30% were healthcare-associated. The very young, the old, and male patients were at the highest risk. Patients with community-associated disease were, on average, younger, had fewer co-morbidities, and were less likely to have polymicrobial infections. At least 1 co-morbidity was identified in 62% of patients, with malignancy, diabetes, and lung disease most prevalent. The overall all-cause 30-day case-fatality rate was 6%. Conclusion: Sphingomonas paucimobilis BSI is a predominantly community-onset disease associated with a significant risk of death.
MeSH term(s)	Australia ; Bacteremia/epidemiology ; Cross Infection/epidemiology ; Humans ; Male ; Sepsis ; Sphingomonas
Language	English
Publishing date	2022-04-06
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2022.03.060
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Zs.A 4516: Show issues

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Article ; Online: Culture-based determinants and outcome of Staphylococcus aureus bloodstream infections.

Laupland, Kevin B / Harris, Patrick N A / Stewart, Adam G / Edwards, Felicity / Paterson, David L

Diagnostic microbiology and infectious disease

2022 Volume 104, Issue 3, Page(s) 115772

Abstract: Background: The objective of this study was to examine the occurrence, determinants, and outcome of S. aureus bloodstream infections (BSI) diagnosed based on single versus multiple positive initial cultures.: Methods: All adults with first episodes ... ...

Abstract	Background: The objective of this study was to examine the occurrence, determinants, and outcome of S. aureus bloodstream infections (BSI) diagnosed based on single versus multiple positive initial cultures. Methods: All adults with first episodes of mono-microbial S. aureus BSI in Queensland during 2000-2019 were included. Results: 10,855 (67%) and 5,421 (33%) were diagnosed based on one and multiple positive initial cultures, respectively. Patients with multiple positive initial cultures were significantly younger, more likely to have community-associated disease, have a shorter time to culture positivity, less likely to have methicillin-resistant S. aureus BSI, and have a different distribution of comorbid medical illnesses and clinical foci. The 30-day all-cause case-fatality rate was 18% and single positive initial culture was an independent risk factor for death. Conclusions: Among patients with S. aureus BSI, those diagnosed by single positive initial blood cultures have different clinical features and a higher risk for death.
MeSH term(s)	Adult ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Risk Factors ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcus aureus
Language	English
Publishing date	2022-07-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2022.115772
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Zs.A 1845: Show issues

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Article ; Online: Scedosporium species and Lomentospora prolificans fungaemia is uniformly fatal in patients with haematological malignancy.

Stewart, Adam G / Heney, Claire / Paterson, David L / Harris, Patrick N A / Edwards, Felicity / Laupland, Kevin B

Internal medicine journal

2023 Volume 53, Issue 8, Page(s) 1489–1491

Abstract: Scedosporium and Lomentospora species are environmental moulds that are virulent in immunocompromised hosts and rarely cause bloodstream infection (BSI). Patients with Scedosporium and Lomentospora species BSI were identified by the state public ... ...

Abstract	Scedosporium and Lomentospora species are environmental moulds that are virulent in immunocompromised hosts and rarely cause bloodstream infection (BSI). Patients with Scedosporium and Lomentospora species BSI were identified by the state public laboratory service in Queensland, Australia, over a 20-year period. Twenty-two incident episodes occurred among 21 residents; one patient had a second episode 321 days following the first. Of these, 18 were Lomentospora prolificans, three were Scedosporium apiospermum complex and one was a nonspeciated Scedosporium species. Seventeen (81%) patients died during their index admission, and all-cause mortality at 30, 90 and 365 days was 73%, 82% and 91% respectively. All 20 patients with haematological malignancy died within 365 days of follow-up with a median time to death of 9 days (interquartile range, 6-20 days) following diagnoses of BSI.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Australia/epidemiology ; Fungemia/diagnosis ; Fungemia/epidemiology ; Fungemia/microbiology ; Fungemia/mortality ; Immunocompromised Host ; Leukemia/epidemiology ; Leukemia/mortality ; Scedosporium/isolation & purification ; Scedosporium/pathogenicity
Language	English
Publishing date	2023-08-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.16198
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Zs.MO 424: Show issues

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Article ; Online: Morganella morganii, an Emerging Cause of Bloodstream Infections.

Laupland, Kevin B / Paterson, David L / Edwards, Felicity / Stewart, Adam G / Harris, Patrick N A

Microbiology spectrum

2022 Volume 10, Issue 3, Page(s) e0056922

Abstract: Although recent reports of extensively antibiotic-resistant strains have highlighted the importance of Morganella morganii as an emerging pathogen, the epidemiology of serious infections due to this organism is not well defined. The objective of this ... ...

Abstract	Although recent reports of extensively antibiotic-resistant strains have highlighted the importance of Morganella morganii as an emerging pathogen, the epidemiology of serious infections due to this organism is not well defined. The objective of this study was to determine the incidence, determinants, and outcomes of Morganella morganii bloodstream infections (BSIs). Retrospective, population-based surveillance for Morganella morganii BSIs was conducted in Queensland, Australia, in 2000 to 2019; 709 cases were identified, for an annual incidence of 9.2 cases per million population. Most cases were of community onset, with 280 (39.5%) community-associated cases and 226 (31.9%) health care-associated cases. Morganella morganii BSIs were rare in children and young adults, and the incidence increased markedly with advancing age. The most common foci of infection were skin and soft tissue (131 cases [18.5%]), genitourinary (97 cases [13.7%]), and intraabdominal (90 cases [12.7%]). Most patients (580 cases [81.8%]) had at least one comorbid medical illness, with diabetes mellitus (250 cases [35.3%]), renal disease (208 cases [29.3%]), and congestive heart failure (167 cases [23.6%]) being most prevalent. Resistance to one or more of quinolones, co-trimoxazole, aminoglycosides, or carbapenems was observed in 67 cases (9.5%), and this did not change significantly over the study. The 30-day all-cause case fatality rate was 21.2%, and increasing age, nonfocal infection, heart failure, dementia, and cancer were independently associated with increased risk of death. Morganella morganii BSIs are increasing in our population, and elderly male subjects and individuals with comorbidities are at highest risk. Although antibiotic resistance is not a major contributor to the current burden in Queensland, ongoing surveillance is warranted.
MeSH term(s)	Aged ; Anti-Bacterial Agents/pharmacology ; Australia ; Child ; Enterobacteriaceae Infections/epidemiology ; Humans ; Male ; Morganella morganii ; Retrospective Studies ; Sepsis
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00569-22
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