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  1. Article ; Online: When and which patients should receive remdesivir?

    Garcia-Vidal, Carolina / Sanguinetti, Maurizio

    Lancet (London, England)

    2022  Volume 399, Issue 10339, Page(s) 1918–1920

    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/therapeutic use ; Humans
    Chemical Substances Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00789-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevention and treatment of C. difficile in cancer patients.

    Puerta-Alcalde, Pedro / Garcia-Vidal, Carolina / Soriano, Alex

    Current opinion in infectious diseases

    2023  Volume 36, Issue 6, Page(s) 473–480

    Abstract: Purpose of review: We provide an update on the recent literature on Clostridioides difficile infection (CDI) in cancer patients.: Recent findings: Distinguishing between colonization and infection remains challenging in cancer patients. Many patients ...

    Abstract Purpose of review: We provide an update on the recent literature on Clostridioides difficile infection (CDI) in cancer patients.
    Recent findings: Distinguishing between colonization and infection remains challenging in cancer patients. Many patients with negative toxin analysis are still treated for CDI, and some meet criteria for severe cases. The incidence of CDI is high in cancer patients, especially those with haematological malignancies. Disruption of the gut microbiome due to antibiotic consumption, chemotherapy and radiotherapy is the primary factor contributing to CDI development. The severity of CDI in cancer patients is often unclear due to the absence of well-defined severity criteria. Certain microbiome species predominance and specific ribotypes have been associated with worse outcomes. Whole genome sequencing could be helpful for differentiating recurrence from reinfection and exploring potential nosocomial transmission. While certain new drugs such as fidaxomicin or bezlotoxumab show promise, the optimal treatment and prevention strategies for CDI in cancer patients remain uncertain. Faecal microbiota transplantation (FMT) holds potential for reducing CDI recurrence rates.
    Summary: Further studies are needed to provide robust recommendations for diagnosis, grading severity, and therapeutic management of CDI in cancer patients. Recurrences are particularly concerning due to subsequent exposition to CDI risk factors.
    MeSH term(s) Humans ; Clostridioides difficile ; Neoplasm Recurrence, Local/chemically induced ; Neoplasm Recurrence, Local/drug therapy ; Anti-Bacterial Agents ; Fidaxomicin ; Clostridium Infections/prevention & control
    Chemical Substances Anti-Bacterial Agents ; Fidaxomicin (Z5N076G8YQ)
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2462: Show issues Location:
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  3. Article: Correction: Promoting the use of social networks in pneumonia.

    Cillóniz, Catia / Greenslade, Leith / Dominedò, Cristina / Garcia-Vidal, Carolina

    Pneumonia (Nathan Qld.)

    2023  Volume 15, Issue 1, Page(s) 9

    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2803296-2
    ISSN 2200-6133
    ISSN 2200-6133
    DOI 10.1186/s41479-023-00111-x
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  4. Article ; Online: Relevancia de la anfotericina B liposomal en el tratamiento de las infecciones fúngicas invasoras en pacientes oncohematológicos.

    García-Vidal, Carolina / Vázquez, Lourdes / Jarque, Isidro

    Revista iberoamericana de micologia

    2021  Volume 38, Issue 2, Page(s) 61–67

    Abstract: Liposomal amphotericin B (L-AmB) has been a key cornerstone for the management of invasive fungal infections (IFI) caused by a wide array of molds and yeasts during the last three decades. Multiple studies performed over this period have generated a ... ...

    Title translation Relevance of liposomal amphotericin B in the treatment of invasive fungal infections in patients with hematologic malignancies.
    Abstract Liposomal amphotericin B (L-AmB) has been a key cornerstone for the management of invasive fungal infections (IFI) caused by a wide array of molds and yeasts during the last three decades. Multiple studies performed over this period have generated a large body of evidence on its efficacy and safety, becoming the main antifungal agent in the management of IFI in patients with hematologic malignancies in several not mutually exclusive clinical settings. First, L-AmB is the most commonly used antifungal agent in patients undergoing intensive chemotherapy for acute leukemia and high-risk myelodysplastic syndrome, as well as in hematopoietic stem cell transplant recipients. Additionally, due to the administration of newer targeted therapies (such as monoclonal antibodies or small molecule inhibitors), opportunistic mold infections are increasingly being reported in patients with hematologic malignancies usually considered low-risk for IFI. These agents usually have a high drug-drug interaction potential, being triazoles, commonly used for antifungal prophylaxis, included. Finally, patients developing breakthrough IFI because of either subtherapeutic concentrations of antifungal prophylactic drugs in blood or selection of resistant strains, require broad spectrum antifungal therapy, usually with an antifungal of a different class. In both situations, L-AmB remains as the best option for early antifungal therapy.
    MeSH term(s) Amphotericin B/therapeutic use ; Antifungal Agents/therapeutic use ; Hematologic Neoplasms/complications ; Humans ; Invasive Fungal Infections/drug therapy
    Chemical Substances Antifungal Agents ; liposomal amphotericin B ; Amphotericin B (7XU7A7DROE)
    Language Spanish
    Publishing date 2021-05-12
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-9188
    ISSN (online) 2173-9188
    DOI 10.1016/j.riam.2021.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fe de errores de “Opciones terapéuticas actuales en las micosis invasoras y papel terapéutico potencial del isavuconazol”.

    Garcia-Vidal, Carolina

    Revista iberoamericana de micologia

    2019  Volume 36, Issue 3, Page(s) 169

    Title translation Erratum to: "Current therapeutic options in invasive mycosis and potential therapeutic role of isavuconazole".
    Language Spanish
    Publishing date 2019-11-21
    Publishing country Spain
    Document type Published Erratum
    ISSN 2173-9188
    ISSN (online) 2173-9188
    DOI 10.1016/j.riam.2019.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Non-

    Puerta-Alcalde, Pedro / Garcia-Vidal, Carolina

    European respiratory review : an official journal of the European Respiratory Society

    2022  Volume 31, Issue 166

    Abstract: Non- ...

    Abstract Non-
    MeSH term(s) Humans ; Mucormycosis/diagnosis ; Mucormycosis/drug therapy ; Mucormycosis/epidemiology ; Antifungal Agents/adverse effects ; Fungi ; Biomarkers ; Lung
    Chemical Substances Antifungal Agents ; Biomarkers
    Language English
    Publishing date 2022-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0104-2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3265: Show issues Location:
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  7. Article ; Online: Profile of patients with COVID-19 treated in Spanish emergency departments during the 2020 pandemic.

    Puerta-Alcalde, Pedro / García-Vidal, Carolina

    Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias

    2020  Volume 32, Issue 4, Page(s) 225–226

    Title translation El perfil del paciente COVID-19 atendido en los servicios de urgencias españoles durante la pandemia de 2020.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Emergency Service, Hospital ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Spain
    Keywords covid19
    Language Spanish
    Publishing date 2020-07-21
    Publishing country Spain
    Document type Editorial ; Comment
    ZDB-ID 2127173-2
    ISSN 2386-5857 ; 2386-5857
    ISSN (online) 2386-5857
    ISSN 2386-5857
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  8. Article ; Online: Opciones terapéuticas actuales en las micosis invasoras y papel terapéutico potencial del isavuconazol.

    Garcia-Vidal, Carolina

    Revista iberoamericana de micologia

    2018  Volume 35, Issue 4, Page(s) 192–197

    Abstract: The treatment of invasive fungal infections has deeply evolved in recent years with the inclusion of new antifungals to the therapeutic treatment arsenal. A new azole, isavuconazole, has been recently approved. This review focuses on the role of ... ...

    Title translation Current therapeutic options in invasive mycosis and potential therapeutic role of isavuconazole.
    Abstract The treatment of invasive fungal infections has deeply evolved in recent years with the inclusion of new antifungals to the therapeutic treatment arsenal. A new azole, isavuconazole, has been recently approved. This review focuses on the role of isavuconazole for treating the most important invasive fungal infections: invasive candidiasis, aspergillosis, mucormicosis, infections caused by other filamentous fungi and those caused by dimorphic fungi.
    MeSH term(s) Antifungal Agents/therapeutic use ; Aspergillosis/drug therapy ; Candidiasis, Invasive/drug therapy ; Humans ; Invasive Fungal Infections/drug therapy ; Nitriles/therapeutic use ; Pyridines/therapeutic use ; Triazoles/therapeutic use
    Chemical Substances Antifungal Agents ; Nitriles ; Pyridines ; Triazoles ; isavuconazole (60UTO373KE)
    Language Spanish
    Publishing date 2018-11-16
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 2173-9188
    ISSN (online) 2173-9188
    DOI 10.1016/j.riam.2018.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Changing Epidemiology of Invasive Fungal Disease in Allogeneic Hematopoietic Stem Cell Transplantation.

    Puerta-Alcalde, Pedro / Garcia-Vidal, Carolina

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 10

    Abstract: Invasive fungal disease (IFD) is a common cause of morbidity and mortality in patients with hematologic malignancies, especially among those undergoing allogeneic hematopoietic stem cell transplantation (HSCT). The epidemiology of IFD in HSCT patients ... ...

    Abstract Invasive fungal disease (IFD) is a common cause of morbidity and mortality in patients with hematologic malignancies, especially among those undergoing allogeneic hematopoietic stem cell transplantation (HSCT). The epidemiology of IFD in HSCT patients has been evolving over the last decades, mainly in relation to changes in HSCT therapies such as antifungal prophylaxis. A progressive decrease in
    Language English
    Publishing date 2021-10-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7100848
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  10. Article ; Online: Clinical evaluation of antifungal de-escalation in Candida infections: A systematic review and meta-analysis.

    Albanell-Fernández, Marta / Salazar González, Fernando / Montero Pérez, Olalla / Aniyar, Victoria / Carrera Hueso, Francisco-Javier / Soriano, Alex / García-Vidal, Carolina / Puerta-Alcalde, Pedro / Martínez, José Antonio / Vázquez Ferreiro, Pedro

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 143, Page(s) 107020

    Abstract: Objectives: De-escalation (DES) from echinocandins to azoles is recommended by several medical societies in Candida infections. We summarise the evidence of DES on clinical and microbiological cure and 30-day survival and compare it with continuing the ... ...

    Abstract Objectives: De-escalation (DES) from echinocandins to azoles is recommended by several medical societies in Candida infections. We summarise the evidence of DES on clinical and microbiological cure and 30-day survival and compare it with continuing the treatment with echinocandins (non-DES).
    Methods: We searched MEDLINE, Embase, Web of Science and Scopus. Studies describing DES in inpatients and reporting any of the outcomes evaluated were included. Pooled estimates of the tree outcomes were calculated with a fixed or random-effects model. Heterogeneity was explored stratifying by subgroups and via meta-regression. This systematic review is registered with PROSPERO (CRD42023475486).
    Results: Of 1853 records identified, 9 studies were included, totalling 1575 patients. Five studies stepped-down to fluconazole; one to voriconazole and three to any of azoles. The mean day of DES was 5.2 (4.6-6.5) days. The clinical cure OR was 1.29 (95% CI: 0.88-1.88); the microbiological cure 1.62 (95% CI: 0.71-3.71); and 30-day survival 2.17 (95% CI: 1.09-4.32). The 30-day survival data into subgroups showed higher effect on critically ill patients and serious-risk bias studies. Meta-regression did not identify significant effect modifiers.
    Conclusions: DES is a safe strategy; it showed no higher 30-day mortality and a trend towards greater clinical and microbiological cure.
    Language English
    Publishing date 2024-03-26
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107020
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