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  1. Article ; Online: Complete genome sequence of

    Low, Adrian / Koh, Xiu Qi / Ding, Yichen / Seedorf, Henning

    Microbiology resource announcements

    2023  Volume 12, Issue 11, Page(s) e0079723

    Abstract: Here, the complete genome ... ...

    Abstract Here, the complete genome of
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00797-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: High-Throughput, High-Resolution Data Collection Workflow for Structure-Based Drug Discovery Using Cryo-Transmission Electron Microscopy.

    Adrian, Fujiet Koh / Cushing, Victoria / Greber, Basil / Kotecha, Abhay

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 29 Suppl 1, Page(s) 1037

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; E-Book: Imaging techniques

    Vaz, J. G. da Cunha / Koh, Adrian

    (ESASO course series ; 10)

    2018  

    Author's details volume editors José Cunha-Vaz, Adrian Koh
    Series title ESASO course series ; 10
    Collection
    Keywords Ophthalmology ; Internal Medicine ; Diabetes ; Netzhautkrankheit ; Bildgebendes Verfahren ; Optische Kohärenztomografie ; Angiographie
    Subject Optische Kohärenztomographie ; OCT ; Optical coherence tomography ; Bildgebendes Diagnoseverfahren ; Diagnostik ; Bilddiagnostik ; Bildgebende Methode ; Medical Imaging ; Medizinische Bildgebung ; Bildgebende Diagnostik ; Bildgebende Verfahren ; Imaging ; Netzhauterkrankung ; Angioradiographie ; Vasographie ; Gefäßdarstellung
    Subject code 617.7350754
    Language English
    Size 1 Online-Ressource (VIII, 126 Seiten), Illustrationen
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019838617
    ISBN 978-3-318-06356-1 ; 9783318063554 ; 3-318-06356-8 ; 331806355X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Complete genome sequences of butyrate producing

    Low, Adrian / Sheludchenko, Maxim / Cheng, Huay Ee / Koh, Xiu Qi / Lee, Jonathan Wei Jie

    Microbiology resource announcements

    2023  Volume 12, Issue 10, Page(s) e0070123

    Abstract: Anaerostipes ... ...

    Abstract Anaerostipes hadrus
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00701-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Needle Tract Seeding of Thyroid Follicular Carcinoma after Fine-Needle Aspiration.

    Guo, Yuxin / Koh, Adrian Jit Hin

    Case reports in otolaryngology

    2020  Volume 2020, Page(s) 7234864

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2020-02-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2648756-1
    ISSN 2090-6773 ; 2090-6765
    ISSN (online) 2090-6773
    ISSN 2090-6765
    DOI 10.1155/2020/7234864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cryo-EM structure of SRP68/72 reveals an extended dimerization domain with RNA-binding activity.

    Zhong, Yichen / Feng, Junjie / Koh, Adrian F / Kotecha, Abhay / Greber, Basil J / Ataide, Sandro F

    Nucleic acids research

    2024  

    Abstract: The signal recognition particle (SRP) is a critical component in protein sorting pathways in all domains of life. Human SRP contains six proteins bound to the 7S RNA and their structures and functions have been mostly elucidated. The SRP68/72 dimer is ... ...

    Abstract The signal recognition particle (SRP) is a critical component in protein sorting pathways in all domains of life. Human SRP contains six proteins bound to the 7S RNA and their structures and functions have been mostly elucidated. The SRP68/72 dimer is the largest SRP component and is essential for SRP function. Although the structures of the SRP68/72 RNA binding and dimerization domains have been previously reported, the structure and function of large portions of the SRP68/72 dimer remain unknown. Here, we analyse full-length SRP68/72 using cryo-EM and report that SRP68/72 depend on each other for stability and form an extended dimerization domain. This newly observed dimerization domain is both a protein- and RNA-binding domain. Comparative analysis with current structural models suggests that this dimerization domain undergoes dramatic translocation upon SRP docking onto SRP receptor and eventually comes close to the Alu domain. We propose that the SRP68/72 dimerization domain functions by binding and detaching the Alu domain and SRP9/14 from the ribosomal surface, thus releasing elongation arrest upon docking onto the ER membrane.
    Language English
    Publishing date 2024-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkae107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: High-Resolution Structure Determination at 100kV Enabled by New Falcon-C Direct Electron Detector.

    Koh, Adrian / Yang, Wen / Karia, Dimple / Yu, Lingbo / Lengyel, Jeff / Kotecha, Abhay

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 1053

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Perspective from Singapore and China on the COVID-19 Pandemic: The New World Order for Ophthalmic Practice.

    Koh, Adrian / Chen, Youxin

    Ophthalmology

    2020  Volume 127, Issue 8, Page(s) e49–e50

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Continuity of Patient Care ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Eye Diseases/diagnosis ; Eye Diseases/therapy ; Health Personnel ; Humans ; Ophthalmology/organization & administration ; Pandemics/prevention & control ; Patient Safety ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Practice Patterns, Physicians'/organization & administration ; SARS-CoV-2 ; Safety Management/organization & administration ; Singapore ; Telemedicine/organization & administration
    Keywords covid19
    Language English
    Publishing date 2020-05-23
    Publishing country United States
    Document type Editorial
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2020.05.039
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    Ul II Zs.83: Show issues Location:
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    Zs.MO 533: Show issues

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  9. Article ; Online: Clinical outcomes and performance indicators of patients with kidney failure and acute kidney injuries in ASEAN countries.

    Tan, Jackson / Liew, Adrian / Koh, David

    Nephrology (Carlton, Vic.)

    2022  Volume 27, Issue 9, Page(s) 739–752

    Abstract: Introduction: This review article reports clinical outcomes and performance indicators of patients with kidney failure (KF) and acute kidney injuries (AKI) in Association of South East Asian Nations (ASEAN) countries.: Methodology: Association of ... ...

    Abstract Introduction: This review article reports clinical outcomes and performance indicators of patients with kidney failure (KF) and acute kidney injuries (AKI) in Association of South East Asian Nations (ASEAN) countries.
    Methodology: Association of South East Asian Nations data, segregated by income status, from national registries and literature were collated, compared and benchmarked against international references.
    Results: The national incidence and prevalence of treated KF ranged from 172 to 479 per million population (pmp) and 36-2255 pmp, respectively. Brunei (79%), Malaysia (66%) and Singapore (66%) had world-leading proportions of diabetes-related KF. Hemodialysis (HD), Peritoneal Dialysis (PD) and transplant accounted for 68-100%, 0-27% and 0-18% of all KF replacement therapy, respectively. Transplant patient survival was superior with 90%-93% at 5 years and 71%-90% at 10 years, compared to PD (44%-54%) and HD (53-64%) at 5 years. Higher-income countries were able to achieve good anemia control, HD and PD adequacy targets, while usage of arteriovenous fistula in HD varied from 70% to 85%. Acute Kidney Injury rates ranged from 24.2% to 49.2% of high-dependency admissions. Lower incidences of PD peritonitis and HD catheter-related Bloodstream Infections; and PD-favouring quality-of-life were evident in higher-income countries.
    Conclusion: Association of South East Asian Nations has a challenging burden of kidney disease, with extremely high incidence, prevalence, DM-related KF and AKI rates. The magnitude of the prevailing problem calls for the creation of a regional society under the auspices of ASEAN with a shared perspective of universal, equitable and charitable access to quality renal care; consistent with the founding premises and healthcare initiatives of ASEAN.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/therapy ; Humans ; Kidney Failure, Chronic/therapy ; Peritoneal Dialysis/adverse effects ; Renal Dialysis/adverse effects ; Renal Replacement Therapy
    Language English
    Publishing date 2022-07-12
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4822: Show issues Location:
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  10. Article ; Online: Evaluating geographical disparities on clinical outcomes following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

    Siu, Adrian / Steffens, Daniel / Ansari, Nabila / Karunaratne, Sascha / Solanki, Henna / Ahmadi, Nima / Solomon, Michael / Moran, Brendan / Koh, Cherry

    Techniques in coloproctology

    2024  Volume 28, Issue 1, Page(s) 35

    Abstract: Background: Rural Australians typically encounter disparities in healthcare access leading to adverse health outcomes, delayed diagnosis and reduced quality of life (QoL) parameters. These disparities may be exacerbated in advanced malignancies, where ... ...

    Abstract Background: Rural Australians typically encounter disparities in healthcare access leading to adverse health outcomes, delayed diagnosis and reduced quality of life (QoL) parameters. These disparities may be exacerbated in advanced malignancies, where treatment is only available at highly specialised centres with appropriate multidisciplinary expertise. Thus, this study aims to determine the association between patient residence on oncological, surgical and QoL outcomes following cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC).
    Methods: A retrospective analysis was conducted on consecutive patients undergoing CRS and HIPEC at Royal Prince Alfred Hospital from January 2017 to March 2022. On the basis of their postcode of residence, patients were stratified into metropolitan and regional groups. Data encompassing demographics, oncological, surgical and QoL outcomes were compared. Statistical analysis included chi-square test, t-tests and Kaplan-Meier survival curves.
    Results: Among the 317 patients, 228 (72%) were categorised as metropolitan and 89 (28%) as regional. Metropolitan patients presented higher rates of recurrence (61.8% versus 40.0%, p = 0.014) and shorter overall mean survival [3.8 years (95% CI: 3.44-4.09) versus 4.2 years (95% CI: 3.76-4.63), p = 0.019] compared with regional patients. No other statistically significant differences were observed in oncological, surgical and QoL outcomes.
    Conclusions: Most oncological, surgical and QoL parameters did not differ by geographical location of patients undergoing CRS and HIPEC for peritoneal malignancies at a high-volume quaternary referral centre. Observed differences in recurrence and survival may be attributed to the selective nature of surgical referrals and variable follow-up patterns. Future research should focus on characterising referral pathways and its influence on post-operative outcomes.
    MeSH term(s) Humans ; Cytoreduction Surgical Procedures ; Hyperthermic Intraperitoneal Chemotherapy ; Quality of Life ; Retrospective Studies ; Australia ; Australasian People
    Language English
    Publishing date 2024-02-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-024-02911-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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