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Article ; Online: Iliac artery aneurysm in Behçet's syndrome: collaborative management is essential.

Bilgin, Emre / Sayinalp, Basak / Eldem, Gonca / Karadag, Omer

2021 Volume 60, Issue Suppl 3, Page(s) iii32–iii34

MeSH term(s)	Adult ; Behcet Syndrome/complications ; Humans ; Iliac Aneurysm/diagnostic imaging ; Iliac Aneurysm/etiology ; Iliac Aneurysm/therapy ; Male
Language	English
Publishing date	2021-06-17
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keab038
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

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Article ; Online: A Case of Acute Pancreatitis Following Computed-Tomography Scan

Erkan Parlak / Lale Özışık / Başak Sayınalp

Turkish Journal of Internal Medicine, Vol 4, Iss 1, Pp 45-

2022 Volume 48

Abstract: Introduction: Acute pancreatitis is a common cause of hospitalization among gastrointestinal disorders and its frequency has been rising in the past few years. The majority of cases are due to alcohol use, gallstones and hypertriglyceridemia. However, ... ...

Abstract	Introduction: Acute pancreatitis is a common cause of hospitalization among gastrointestinal disorders and its frequency has been rising in the past few years. The majority of cases are due to alcohol use, gallstones and hypertriglyceridemia. However, there still remain a significant number of cases in which no causative factor can be found and therefore called idiopathic. Contrast-induced pancreatitis is a rare cause pancreatitis and there are only a few cases reported so far. Here we present a case of mild acute pancreatitis following iodinated contrast exposure. Case Presentation: A 42-year-old female patient with a history of lymphoma was admitted to our clinic with severe abdominal pain and nausea. Her blood tests revealed elevated pancreatic enzyme levels and mildly elevated liver function tests. Upper abdomen magnetic resonance imaging revealed pancreatic inflammation without any sign of necrosis. Since her complaints began after a computed-tomography scan that she had earlier that day for the evaluation of lymphoma and no other cause could be found, iodinated contrast was thought to be the cause of acute pancreatitis in this patient. Conclusion: Contrast agents seem to be a rare cause of acute pancreatitis, however taking the increasing availability of procedures involving radiocontrast agents into consideration, it is important to keep in mind that clinicians may come across more cases of contrast-induced acute pancreatitis in the future.
Keywords	pancreatitis ; computed-tomography ; radiocontrast ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nizameddin KOCA
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Perspectives for immune plasma treatment of COVID-19

Sayinalp, Başak / Çinar, Olgu Erkin / Haznedaroğlu, İbrahİm Celalettin

Turkish journal of medical sciences

2021 Volume 51, Issue 1, Page(s) 1–9

MeSH term(s)	Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/immunology ; Antibodies, Viral/therapeutic use ; COVID-19/therapy ; Humans ; Immunization, Passive/methods ; SARS-CoV-2/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral
Keywords	covid19
Language	English
Publishing date	2021-02-26
Publishing country	Turkey
Document type	Journal Article ; Review
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-2005-410
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Zs.A 3242: Show issues

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Article ; Online: A case of Legionnaires’ disease with severe rhabdomyolysis misdiagnosed as COVID-19

Sayinalp-Arslan, Basak / Er, Ahmet Gorkem / Yildirim, Mehmet / Kilicaslan, Banu / Akinci, Seda Banu / Uzun, Omrum

Heliyon. 2022 Dec., v. 8, no. 12 p.e12341-

2022

Abstract: COVID-19 case numbers have begun to rise with the recently reported Omicron variant. In the last two years, COVID-19 is the first diagnosis that comes to mind when a patient is admitted with respiratory symptoms and pulmonary ground-glass opacities. ... ...

Abstract	COVID-19 case numbers have begun to rise with the recently reported Omicron variant. In the last two years, COVID-19 is the first diagnosis that comes to mind when a patient is admitted with respiratory symptoms and pulmonary ground-glass opacities. However, other causes should be kept in mind as well. Here we present a case of Legionnaires’ disease misdiagnosed as COVID-19. A 48-year-old male was admitted with complaints of dry cough and dyspnea. Chest computed-tomography revealed bilateral ground-glass opacities; therefore, a preliminary diagnosis of COVID-19 was made. However, two consecutive COVID PCR tests were negative and the patient deteriorated rapidly. As severe rhabdomyolysis and acute renal failure were present, Legionnaires’ disease was suspected. Urine antigen test for Legionella and Legionella pneumophila PCR turned out to be positive. The patient responded dramatically to intravenous levofloxacin and was discharged successfully. Legionnaires’ disease and COVID-19 may present with similar signs and symptoms. They also share common risk factors and radiological findings. Shared clinical and radiological features between COVID-19 and other causes of acute respiratory failure pose a challenge in diagnosis. Other causes such as Legionnaires’ disease must be kept in mind and appropriate diagnostic tests should be performed accordingly.
Keywords	COVID-19 infection ; Legionella pneumophila ; acute kidney injury ; antigens ; chest ; computed tomography ; cough ; dyspnea ; intravenous injection ; levofloxacin ; males ; patients ; rhabdomyolysis ; risk ; urine ; SARS-CoV-2 ; COVID-19 pandemic ; Legionella
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e12341
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A case of Legionnaires’ disease with severe rhabdomyolysis misdiagnosed as COVID-19

Basak Sayinalp-Arslan / Ahmet Gorkem Er / Mehmet Yildirim / Banu Kilicaslan / Seda Banu Akinci / Omrum Uzun

Heliyon, Vol 8, Iss 12, Pp e12341- (2022)

2022

Abstract: Background: COVID-19 case numbers have begun to rise with the recently reported Omicron variant. In the last two years, COVID-19 is the first diagnosis that comes to mind when a patient is admitted with respiratory symptoms and pulmonary ground-glass ... ...

Abstract	Background: COVID-19 case numbers have begun to rise with the recently reported Omicron variant. In the last two years, COVID-19 is the first diagnosis that comes to mind when a patient is admitted with respiratory symptoms and pulmonary ground-glass opacities. However, other causes should be kept in mind as well. Here we present a case of Legionnaires’ disease misdiagnosed as COVID-19. Case presentation: A 48-year-old male was admitted with complaints of dry cough and dyspnea. Chest computed-tomography revealed bilateral ground-glass opacities; therefore, a preliminary diagnosis of COVID-19 was made. However, two consecutive COVID PCR tests were negative and the patient deteriorated rapidly. As severe rhabdomyolysis and acute renal failure were present, Legionnaires’ disease was suspected. Urine antigen test for Legionella and Legionella pneumophila PCR turned out to be positive. The patient responded dramatically to intravenous levofloxacin and was discharged successfully. Discussion: Legionnaires’ disease and COVID-19 may present with similar signs and symptoms. They also share common risk factors and radiological findings. Conclusions: Shared clinical and radiological features between COVID-19 and other causes of acute respiratory failure pose a challenge in diagnosis. Other causes such as Legionnaires’ disease must be kept in mind and appropriate diagnostic tests should be performed accordingly.
Keywords	SARS-CoV-2 ; COVID-19 pandemic ; Legionella ; Rhabdomyolysis ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Perspectives for the immune plasma treatment of COVID-19

Sayinalp, BaSak / Çinar, Olgu ErkIn / HaznedaroGlu, IbrahIm CelalettIn

Abstract: INTRODUCTION AND AIM: SARS-CoV-2 infection was declared as a pandemic by World Health Organization (WHO) on March 11, 2020, and the death toll from COVID-19, which is the disease caused by SARS-CoV-2, has already passed those of many previous epidemics. ... ...

Abstract	INTRODUCTION AND AIM: SARS-CoV-2 infection was declared as a pandemic by World Health Organization (WHO) on March 11, 2020, and the death toll from COVID-19, which is the disease caused by SARS-CoV-2, has already passed those of many previous epidemics. A wide variety of treatment options are being considered for COVID-19, but there is still no definitive treatment or vaccine. This review aims to explain the background of the convalescent plasma treatment and its relations with COVID-19 immunity, to define the ideal treatment procedures and to reveal present and future perspectives in the light of rapidly growing data. Immunological basis of COVID-19 associated immune response and convalescent plasma as a treatment option: Since it has been shown that the impaired immune response of the host is one of the most important factors that increase the severity of the infection, treatment strategies to suppress aberrant immune activation are being dwelled on. Convalescent/immune plasma, which is derived from recently recovered patients and contains neutralizing antibodies and many other immune-modulatory substances, seems to be the most convenient strategy to restore normal immune function considering the fast-spreading nature of the ongoing pandemic. Conclusion and future perspectives: Even though mechanisms of action of plasma therapy are not fully delineated, it has been shown that it could lead to a reduction in mortality since other alternatives such as monoclonal antibodies or SARS-CoV-2 hyper immunoglobulin require much more time and effort to be developed.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #689057
Database	COVID19

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Article: Convalescent (immune) plasma treatment in a myelodysplastic COVID-19 patient with disseminated tuberculosis.

Çınar, Olgu Erkin / Sayınalp, Başak / Aladağ Karakulak, Elifcan / Avşar Karataş, Ayşe / Velet, Mustafa / İnkaya, Ahmet Çağkan / Ersoy Ortaç, Nazmiye Ebru / Öcal, Serpil / Aksu, Salih / Haznedaroğlu, İbrahim Celalettin / Sayınalp, Nilgün / Özcebe, Osman İlhami

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2020 Volume 59, Issue 5, Page(s) 102821

Abstract: During the ongoing COVID-19 pandemic due to the SARS-CoV-2 virus of which evidence-based medical paradigms cannot be easily applied; difficult clinical decisions shall be required particularly in the 'difficult-to-treat' cases of high risk group with ... ...

Abstract	During the ongoing COVID-19 pandemic due to the SARS-CoV-2 virus of which evidence-based medical paradigms cannot be easily applied; difficult clinical decisions shall be required particularly in the 'difficult-to-treat' cases of high risk group with associated comorbidities. Convalescent immune plasma therapy is a promising option as a sort of 'rescue' treatment in COVID-19 immune syndrome, where miraculous antiviral drugs are not available yet. In this report, we aim to convey our experience of multi-task treatment approach with convalescent immune plasma and anti-cytokine drug combination in a COVID-19 patient with extremely challenging comorbidities including active myeloid malignancy, disseminated tuberculosis and kidney failure.
MeSH term(s)	Body Temperature ; COVID-19/complications ; COVID-19/diagnostic imaging ; COVID-19/immunology ; COVID-19/therapy ; Humans ; Immunization, Passive ; Lymphocyte Count ; Male ; Middle Aged ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/diagnostic imaging ; Myelodysplastic Syndromes/virology ; SARS-CoV-2/physiology ; Tomography, X-Ray Computed ; Tuberculosis/complications ; Tuberculosis/diagnostic imaging ; Tuberculosis/virology
Keywords	covid19
Language	English
Publishing date	2020-05-29
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2020.102821
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Zs.A 1739: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Evaluation of early unplanned readmissions and predisposing factors in an oncology clinic.

Guven, Deniz Can / Ceylan, Furkan / Cakir, Ibrahim Yahya / Cesmeci, Engin / Sayinalp, Basak / Yesilyurt, Berkay / Guner, Gurkan / Yildirim, Hasan Cagri / Aktepe, Oktay Halit / Arik, Zafer / Turker, Alev / Dizdar, Omer

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2021 Volume 29, Issue 7, Page(s) 4159–4164

Abstract: Background: Unplanned readmission in the first 30 days after discharge is an important medical problem, although the data on cancer patients is limited. So we planned to evaluate the rates and causes of early readmissions and the predisposing factors.!## ...

Abstract	Background: Unplanned readmission in the first 30 days after discharge is an important medical problem, although the data on cancer patients is limited. So we planned to evaluate the rates and causes of early readmissions and the predisposing factors. Methods: Patients hospitalized in Hacettepe University Oncology services between August 2018 and July 2019 were included. The demographic features, tumor stages, regular drugs, last laboratory parameters before discharge, and readmissions in the first 30 days after discharge were recorded. The predisposing features were evaluated with univariate and multivariate analyses. Results: A total of 562 hospitalizations were included. The mean age of the patients was 58.5 ± 14.5 years. Almost 2/3 of the hospitalizations were due to symptom palliation and infections. Eighty-three percent of the patients had advanced disease, and over 60% had an ECOG score of 2 and above. In the first 30 days after discharge, 127 patients were readmitted (22.6%). Advanced stage disease, presence of polypharmacy (5 or more regular drugs), hospitalization setting (emergency department (ED) vs. outpatient clinic), and hypoalbuminemia (< 3 gr/dL) were associated with a statistically significant increase in the risk of readmission. Among these factors, advanced-stage disease (HR: 2.847, 95% CI: 1.375-5.895), hospitalization from ED (HR: 1.832, 95% CI: 1.208-2.777), and polypharmacy (HR: 1.782, 95% CI: 1.173-2.706) remained significant in multivariate analyses. Conclusions: In this study, 22% of cancer patients had early readmissions. The readmission risk increased in patients with advanced disease, hospitalization from ED, and polypharmacy. The optimal post-discharge plan may reduce readmissions in all oncology patients, with priority for these patient groups.
MeSH term(s)	Adult ; Aftercare ; Aged ; Aged, 80 and over ; Ambulatory Care Facilities ; Causality ; Emergency Service, Hospital/statistics & numerical data ; Hospitalization/statistics & numerical data ; Humans ; Hypoalbuminemia/blood ; Male ; Middle Aged ; Neoplasms/pathology ; Neoplasms/therapy ; Patient Discharge ; Patient Readmission/statistics & numerical data ; Polypharmacy ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2021-01-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-020-05927-7
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Zs.A 3697: Show issues

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Article ; Online: Convalescent (immune) plasma treatment in a myelodysplastic COVID-19 patient with disseminated tuberculosis

Transfusion and Apheresis Science

2020 , Page(s) 102821

Keywords	Hematology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2020.102821
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Zs.A 1739: Show issues

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Article: Convalescent (immune) plasma treatment in a myelodysplastic COVID-19 patient with disseminated tuberculosis

Çinar, Olgu Erkin / Sayinalp, Basak / Aladag Karakulak, Elifcan / Avsar Karatas, Ayse / Velet, Mustafa / Inkaya, Ahmet Çagkan / Ersoy Ortaç, Nazmiye Ebru / Öcal, Serpil / Aksu, Salih / Haznedaroglu, Ibrahim Celalettin / Sayinalp, Nilgün / Özcebe, Osman Ilhami

Transfus Apher Sci

Abstract	During the ongoing COVID-19 pandemic due to the SARS-CoV-2 virus of which evidence-based medical paradigms cannot be easily applied; difficult clinical decisions shall be required particularly in the 'difficult-to-treat' cases of high risk group with associated comorbidities. Convalescent immune plasma therapy is a promising option as a sort of 'rescue' treatment in COVID-19 immune syndrome, where miraculous antiviral drugs are not available yet. In this report, we aim to convey our experience of multi-task treatment approach with convalescent immune plasma and anti-cytokine drug combination in a COVID-19 patient with extremely challenging comorbidities including active myeloid malignancy, disseminated tuberculosis and kidney failure.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #437255
Database	COVID19

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