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  1. Article ; Online: Bao Yuan decoction alleviates fatigue by restraining inflammation and oxidative stress via the AMPK/CRY2/PER1 signaling pathway.

    Zheng, Yuan / Ren, Xueyang / Qi, Xiaodan / Song, Ruolan / Zhao, Chongjun / Ma, Jiamu / Li, Xianxian / Deng, Qingyue / He, Yingyu / Kong, Lingmei / Qian, Liyan / Zhang, Feng / Li, Mingxia / Sun, Mengyu / Liu, Wei / Liu, Haibin / She, Gaimei

    Journal of ethnopharmacology

    2024  Volume 328, Page(s) 118058

    Abstract: Ethnopharmacological relevance: Baoyuan Decoction (BYD) was initially recorded in the classic of "Bo Ai Xin Jian" in the Ming dynasty. It is traditionally used for treating weakness and cowardice, and deficiency of vital energy. In researches related to ...

    Abstract Ethnopharmacological relevance: Baoyuan Decoction (BYD) was initially recorded in the classic of "Bo Ai Xin Jian" in the Ming dynasty. It is traditionally used for treating weakness and cowardice, and deficiency of vital energy. In researches related to anti-fatigue effects, the reciprocal regulation of AMPK and circadian clocks likely plays an important role in anti-fatigue mechanism, while it has not yet been revealed. Therefore, we elucidated the anti-fatigue mechanism of BYD through AMPK/CRY2/PER1 pathway.
    Aim of the study: To investigate the effect and mechanism of BYD in reducing fatigue, using pharmacodynamics, network pharmacology and transcriptomics through the AMPK/CRY2/PER1 signaling pathway.
    Materials and methods: Firstly, the chemical constituents of BYD were qualitatively identified by UHPLC-Q-Exactive Orbitrap/MS, establishing a comprehensive strategy with an in-house library, Xcalibur software and Pubchem combined. Secondly, a Na
    Results: In total, 114 compounds from the water extract of BYD were identified as major compounds. Na₂SO₃-induced fatigue model and AAPH-induced oxidative stress model indicated that BYD has significant anti-fatigue and antioxidant effects. Meanwhile, BYD showed significant anti-inflammatory effects on CuSO
    Conclusion: Herein, we identified 114 chemical constituents of BYD, performed zebrafish activity validation, while demonstrated that BYD can relieve fatigue by AMPK/CRY2/PER1 signaling pathway through network pharmacology and transcriptome.
    MeSH term(s) Animals ; AMP-Activated Protein Kinases ; Zebrafish ; Oxidative Stress ; Fatigue/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Inflammation/drug therapy ; Antioxidants ; Signal Transduction ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Amidines
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; 2,2'-azobis(2-amidinopropane) (7381JDR72F) ; Drugs, Chinese Herbal ; Antioxidants ; Anti-Inflammatory Agents ; Amidines
    Language English
    Publishing date 2024-03-20
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118058
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  2. Article: [Cost-benefit analysis of Ying Yang Bao (YYB) intervention in 6 to 23 months rural infants].

    Huang, Conghui / Wei, Yanli / Huo, Junsheng / Liu, Kejun / Sun, Jing / Huang, Jian / Gong, Weiyi / Wang, Ou

    Wei sheng yan jiu = Journal of hygiene research

    2022  Volume 51, Issue 3, Page(s) 432–436

    Abstract: Objective: To study on the cost-benefit from anemia and stunting reduction of Ying Yang Bao(YYB ...

    Abstract Objective: To study on the cost-benefit from anemia and stunting reduction of Ying Yang Bao(YYB) intervention in 6 to 23 months rural infants in the six counties of Shanxi, Hubei and Yunnan provinces.
    Methods: YYB was distributed to 6-23 months infants in 6 counties by YYB nutrition intervention project. The numbers of childhood recovered from stunting and anemia was collected by a designed project monitoring plan. The cost-benefit was analyzed with PROFILING model as a nutritional microeconomic tool.
    Results: Total numbers of monitored infants was 10 672 while the total cost of YYB intervention was estimated 2.57 million RMB. From 2012 to 2020, the total benefit was 14.92 million RMB from recover of stunting and anemia by YYB project and the average cost-benefit ratio of 6 counties was 1∶5.8. Sensitivity analysis showed the result of this study was stable.
    Conclusion: The YYB nutrition intervention for infants aged 6-23 months in the six counties of Shanxi, Hubei and Yunnan provinces showed a high cost-benefit ratio.
    MeSH term(s) Anemia ; China ; Cost-Benefit Analysis ; Dietary Supplements ; Growth Disorders ; Humans ; Infant
    Language Chinese
    Publishing date 2022-06-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 1050909-4
    ISSN 1000-8020
    ISSN 1000-8020
    DOI 10.19813/j.cnki.weishengyanjiu.2022.03.015
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  3. Article ; Online: Assessment of Water Eutrophication at Bao’an Lake in the Middle Reaches of the Yangtze River Based on Multiple Methods

    Mingkai Leng / Lian Feng / Xiaodong Wu / Xuguang Ge / Xiaowen Lin / Shixing Song / Rui Xu / Zhenhua Sun

    International Journal of Environmental Research and Public Health, Vol 20, Iss 4615, p

    2023  Volume 4615

    Abstract: Based on the monthly monitoring of Bao’an Lake in Hubei Province from 2018 to 2020 ... the eutrophication level of Bao’an Lake in the middle reaches of the Yangtze River is investigated using ... The results demonstrate that the overall water quality of Bao’an Lake remained at levels III–V during 2018 ...

    Abstract Based on the monthly monitoring of Bao’an Lake in Hubei Province from 2018 to 2020, the eutrophication level of Bao’an Lake in the middle reaches of the Yangtze River is investigated using the comprehensive trophic level index (TLI), chromophoric dissolved organic matter (CDOM) absorption coefficient, and the phytoplankton water quality biological method. The influencing factors are then identified. The results demonstrate that the overall water quality of Bao’an Lake remained at levels III–V during 2018–2020. Due to different eutrophication assessment methods, the results are different, but all show that Bao’an Lake is in a eutrophication state as a whole. The eutrophication level of Bao’an Lake is observed to vary with time, exhibiting an increasing then decreasing trend between 2018–2020, while levels are high in summer and autumn, and low in winter and spring. Moreover, the eutrophication level of Bao’an Lake presents an obviously varying spatial distribution. Potamogeton crispus is the dominant species of the Bao’an Lake, the water quality is good in spring when Potamogeton crispus vigorously grows, but poor in summer and autumn. The permanganate index (COD Mn ) and total phosphorous (TP), total nitrogen (TN), and chlorophyll a (Chl-a) contents are identified as the main influencing factors of the eutrophication level of Bao’an Lake, with a significant relationship observed between Chl-a and TP ( p < 0.01). The above results provide a solid theoretical basis for the ecological restoration of Bao’an Lake.
    Keywords Bao’an Lake ; eutrophication assessment ; comprehensive trophic level ; CDOM absorption coefficient ; biological method ; Medicine ; R
    Subject code 333
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Multitech-Based Study on Medicinal Material Basis and Action Mechanism of Herbal Formula Xian-Ling-Gu-Bao Capsule in Treatment of Osteoarthritis.

    Wu, Xiaowen / Sun, Shuai / Wu, Xiaoyi / Sun, Zengxian

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 6986372

    Abstract: ... The epidemiology of this disorder is complex, and the treatment is challenging. Xian-Ling-Gu-Bao (XLGB) capsule ...

    Abstract Currently, osteoarthritis (OA) is thought to be the most prevalent chronic joint disease worldwide. The epidemiology of this disorder is complex, and the treatment is challenging. Xian-Ling-Gu-Bao (XLGB) capsule, a herbal compound preparation, is widely used for the treatment of bone disorders, including OA. Although its efficacy and safety have been demonstrated in clinical trials and practice, the underlying medicinal constituents and mechanism have not been clearly elucidated. Therefore, this study aimed to explore the medicinal constituents and mechanism of XLGB for OA treatment. The phytochemical constituents in XLGB capsule were detected by liquid chromatography-mass spectrometry (LC-MS), the medicinal constituents and therapeutic mechanism for OA treatment were deduced by network analysis, and the deduced mechanism was validated by
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/6986372
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  5. Article: Corrigendum: Beneficial Effects and Toxicity Studies of Xian-ling-gu-bao on Bone Metabolism in Ovariectomized Rats.

    Wu, Hao / Zhong, Qingxiang / Wang, Jing / Wang, Man / Fang, Fang / Xia, Zhi / Zhong, Rongling / Huang, Houcai / Ke, Zhongcheng / Wei, Yingjie / Feng, Liang / Shi, Ziqi / Sun, E / Song, Jie / Jia, Xiaobin

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 570876

    Abstract: This corrects the article DOI: 10.3389/fphar.2017.00273.]. ...

    Abstract [This corrects the article DOI: 10.3389/fphar.2017.00273.].
    Language English
    Publishing date 2020-11-09
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.570876
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  6. Article: [Research on cost-benefit analysis of improved nutrition status by infants Ying Yang Bao intervention in poor rural regions].

    Huo, Junsheng / Sun, Jing / Chang, Suying / Liu, Kejun

    Wei sheng yan jiu = Journal of hygiene research

    2018  Volume 47, Issue 5, Page(s) 733–740

    Abstract: ... regions by Ying Yang Bao( YYB) intervention.: Methods: YYB was donated and distributed to 6-24 months ...

    Abstract Objective: To study on the cost-benefit from anemia reduction of 6-24 months infants in poor rural regions by Ying Yang Bao( YYB) intervention.
    Methods: YYB was donated and distributed to 6-24 months infants in 8 counties in provinces of Sichuan, Gansu and Shaanxi. Total covered infants were 25 125 within them 1200 were sampled and measured hemoglobin levels and change of anemia prevalence in the baseline and after 1 year intervention. Total recovered infants number from anemia was calculated with decrease of anemia rate. The cost-benefit was analyzed with PROFILING and DALY models.
    Results: The total cost estimated was 6 134 871 RMB, average cost per person was 244 RMB among which costs of YYB, administration and manpower were 121 RMB, 104 RMB and 19 RMB respectively. After 1 year intervention, the anemia rate significantly declined from 52. 8 % to 26. 3 %. The recovered DALYs from present anemia and future cognition was 4863. 08 person·year. Benefit from 1 year YYB intervention in the counties was 69. 3065 million RMB from PROFILING model and60. 6874 million RMB from DALY model. The average cost of the intervention was 938. 46 RMB in saving 1 anemic and 1261. 52 RMB in saving 1 DALY loss in YYB intervention project. The cost-benefit ratio was 1 ∶ 10 at least. Sensitivity analysis showed stability of this cost-benefit analysis acceptable.
    Conclusion: The nutrition intervention using YYB for poor rural region showed high economic benefit.
    MeSH term(s) Anemia ; China ; Cost-Benefit Analysis ; Humans ; Infant ; Infant Health ; Nutritional Status ; Research ; Rural Population
    Language Chinese
    Publishing date 2018-12-28
    Publishing country China
    Document type Journal Article
    ZDB-ID 1050909-4
    ISSN 1000-8020
    ISSN 1000-8020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Xian-Ling-Gu-Bao induced inflammatory stress rat liver injury: Inflammatory and oxidative stress playing important roles.

    Wu, Wenxiao / Wang, Ting / Sun, Bo / Liu, Dong / Lin, Zhi / Miao, Yufa / Wang, Chao / Geng, Xingchao / Li, Bo

    Journal of ethnopharmacology

    2019  Volume 239, Page(s) 111910

    Abstract: Ethnopharmacological relevance: Xian-Ling-Gu-Bao (XLGB) Fufang is an herbal formula that has been ...

    Abstract Ethnopharmacological relevance: Xian-Ling-Gu-Bao (XLGB) Fufang is an herbal formula that has been used in clinical settings to treat osteoporosis, osteoarthritis, aseptic bone necrosis, and climacteric syndrome. Despite its uses, XLGB treatment has been linked to potential liver injury. To date, there is a lack of clear demonstration of such toxicity in animal models.
    Aim of the study: As animal models fail to reproduce the XLGB hepatotoxicity reported in humans, because human hepatocytes are clearly more sensitive to XLGB, this study was designed to investigate a more reliable animal model of such toxicity.
    Materials and methods: We randomized rats into five groups, as follows: CON (control), XLGB, lipopolysaccharide (LPS), L-XLGB/LPS (XLGB, 0.125 g/kg; LPS, 0.1 mg/kg), and XLGB/LPS (XLGB, 1.25 g/kg; LPS, 0.1 mg/kg). These groups were treated with 0.5% sodium carboxymethyl cellulose (CMC-Na), XLGB suspension, normal saline, or LPS. The first administration of XLGB [0.125 g/kg or 1.25 g/kg, by mouth (PO)] or its solvent (0.5% CMC-Na) was delivered, and then food was removed. Twelve hours after the first administration of XLGB, rats received LPS [0.1 mg/kg, intravenously (IV)] or saline control. After 30 min, a second administration of XLGB (0.125 g/kg or 1.25 g/kg, PO) or solvent was administered. The rats were anesthetized at 12 h or 24 h following the second administration of XLGB. Liver function was evaluated by measuring liver weight, liver microscopy, serum biochemistry and plasma microRNA-122 (miR-122). The plasma levels of 27 cytokines were measured to evaluate inflammation. Moreover, the expression of cytochrome P450 2E1 (CYP2E1), nicotinic adenine dinucleotide phosphate (NADPH) oxidase and inducible nitric oxide synthase (iNOS) at protein levels were observed; immunofluorescence and immunohistochemistry were used to confirmed the hepatotoxicity of XLGB.
    Results: Hepatotoxicity in male rats with moderate inflammation induced by XLGB was indicated by liver histopathology, serum biochemical analysis, serum miR-122 levels, and immunofluorescent assessments. We observed significant increases in liver weight and liver indexes in male rats with moderate inflammation in response to XLGB. Histopathological assessment further showed that extensive hepatocellular necrosis and inflammatory infiltration were evident in rats co-treated with XLGB/LPS. The levels of serum transaminases [alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT)], total bilirubin (TBIL) and triglyceride (TG), which are markers of liver function, were also significantly increased by XLGB/LPS treatment. Similarly, miR-122 was significantly elevated in XLGB/LPS treated rats relative to other groups. An immunofluorescent assessment showed extensive apoptosis in hepatocytes from these co-treated rats. What is more, XLGB can dose-dependently induce liver injury in male rats with moderate inflammation. Hepatic CYP2E1, neutrophil chemotactic factor (NCF-1), iNOS, and NOX-2 (an NADPH oxidase subunit) levels were increased in response to XLGB treatment, and staining for DMPO nitrone adducts further showed elevated oxidative stress level in XLGB/LPS-treated rats relative to the other experimental groups.
    Conclusion: LPS and XLGB co-treatment in rats led to marked hepatotoxicity. This toxicity was associated with disrupted lipid metabolism, extensive liver necrosis and inflammatory infiltration, apoptosis, and expression of oxidative stress-related proteins. These results demonstrate a valuable model for the study of iDILI in the context of XLGB treatment, and further provide insights into the potential mechanisms by which XLGB may induce hepatotoxicity in humans.
    MeSH term(s) Animals ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/pathology ; Cytokines/blood ; Drugs, Chinese Herbal/toxicity ; Lipopolysaccharides/pharmacology ; Liver/drug effects ; Liver/pathology ; Male ; MicroRNAs/blood ; Oxidative Stress/drug effects ; Rats, Sprague-Dawley
    Chemical Substances Cytokines ; Drugs, Chinese Herbal ; Lipopolysaccharides ; MIRN122 microRNA, rat ; MicroRNAs ; xian ling gu bao
    Language English
    Publishing date 2019-04-23
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2019.111910
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  8. Article: Beneficial Effects and Toxicity Studies of Xian-ling-gu-bao on Bone Metabolism in Ovariectomized Rats.

    Wu, Hao / Zhong, Qingxiang / Wang, Jing / Wang, Man / Fang, Fang / Xia, Zhi / Zhong, Rongling / Huang, Houcai / Ke, Zhongcheng / Wei, Yingjie / Feng, Liang / Shi, Ziqi / Sun, E / Song, Jie / Jia, Xiaobin

    Frontiers in pharmacology

    2017  Volume 8, Page(s) 273

    Abstract: Xian-ling-gu-bao (XLGB) is a well-known patented traditional Chinese prescription widely used ...

    Abstract Xian-ling-gu-bao (XLGB) is a well-known patented traditional Chinese prescription widely used to treat osteoporosis, osteoarthritis, aseptic bone necrosis, or climacteric syndrome. However, recent reports have suggested that XLGB may cause liver injury in humans. In the present study, we aimed to evaluate the efficacy of XLGB in the prevention of osteoporosis in the zebrafish and ovariectomized (OVX) rats, both of which have been used as osteoporosis models. The safety of XLGB after long-term administration to OVX rats was also assessed. OVX rats were administered by oral gavage 270 mg/kg (recommended daily dose), 1350 mg/kg, and 1800 mg/kg of XLGB for 26 weeks. Bone mineral density, relative bone surface to bone volume, relative bone volume to total volume, trabecular number, mean trabecular thickness, and mean trabecular spacing in OVX rats were examined at the end of the 26-week dosing period. Additionally, OPG and RANKL expression in the femur were determined by western blot and immunohistochemical staining. To evaluate the safety of XLGB, body weight, hematology, serum biochemistry markers related to toxicology, and organ histopathology were determined in each group of OVX rats. Conversely, the zebrafish was treated with prednisolone to induce osteoporosis in the embryo. Disodium etidronate was used as a treatment control. XLGB was shown to be effective in preventing osteoporosis in both the OVX rats and the prednisolone-treated zebrafish. Similarly, XLGB increased OPG protein and decreased RANKL protein in OVX rats. Interestingly, no obvious toxicity was observed in the heart, liver, kidney, small intestine, or stomach at dosages of up to 1800 mg/kg after treating the OVX rats for 26 weeks. XLGB was shown to be very effective in treating osteoporosis in OVX rats. No obvious toxicity or adverse effects developed in OVX rats at dosages up to 1800 mg/kg, which is equivalent to six times the daily-recommended dose. Therefore, XLGB should be considered a good option for the treatment of post-menopausal osteoporosis.
    Language English
    Publishing date 2017-05-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2017.00273
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  9. Article: SAFETY EVALUATION OF AN APITHERAPY FORMULATION, BAO-YUAN-LING: ACUTE AND SUBACUTE ORAL TOXICITY IN WISTAR RATS

    Sun, Yanru / Shen, Zhenhuang / Jia, Zhe / Miao, Xiaoqing

    Current topics in nutraceutical research

    2019  Volume 17, Issue 1, Page(s) 85

    Language English
    Document type Article
    ZDB-ID 2116319-4
    ISSN 1540-7535
    Database Current Contents Nutrition, Environment, Agriculture

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  10. Article ; Online: HPLC-DAD-MS(n) analysis and HPLC quantitation of chemical constituents in Xian-ling-gu-bao capsules.

    Guan, Xiang-Yu / Li, Hui-Fang / Yang, Wen-Zhi / Lin, Chang-Hu / Sun, Chao / Wang, Bao-Rong / Guo, De-An / Ye, Min

    Journal of pharmaceutical and biomedical analysis

    2011  Volume 55, Issue 5, Page(s) 923–933

    Abstract: ... bao capsules (XLGB), a popular six-herb Traditional Chinese Patent Medicine (TCPM) for the treatment ...

    Abstract In this study, a systematic method was established for the global quality control of Xian-ling-gu-bao capsules (XLGB), a popular six-herb Traditional Chinese Patent Medicine (TCPM) for the treatment of osteoporosis. Both qualitative and quantitative analyses were conducted. In qualitative analysis part, a fast and sensitive method based on high-performance liquid chromatography coupled with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-MS(n)) was established for rapid separation and sensitive identification. Samples were separated on a Waters Symmetry C(18) column (250mm×4.6mm, 5μm) by gradient elution using acetonitrile (A) and water-formic acid (B; 0.03%, v/v) as mobile phase at a flow rate of 1.0ml/min. Based on the mass spectra, UV spectra and retention time, 47 compounds were identified or tentatively characterized, including 27 flavonols (all from Epimedii Herba, the major component herb), 4 coumarins, 3 flavonones, 1 chalcone, 3 isoflavones, 1 coumestrol, 3 triterpenoid saponins, 1 iridoid, 3 steroidal saponins, and 1 phenolic acid. Among them, 18 compounds were confirmed by comparing with reference standards. In quantitative analysis part, 10 major compounds in 18 batches of XLGB were simultaneously determined by HPLC/UV detected at 270nm. The method was validated with respect to intra- and inter-day precision, repeatability and stability, with RSD less than 1.0%, 1.5%, 2.9% and 1.8%, respectively. All the 10 analytes showed good linearity in wide linear ranges (r(2)=0.9999), and their average recoveries varied between 97.8% and 104.9%.
    MeSH term(s) Calibration ; Capsules ; Chemistry Techniques, Analytical/methods ; Chemistry, Pharmaceutical/methods ; Chromatography/methods ; Chromatography, High Pressure Liquid/methods ; Flavones/analysis ; Mass Spectrometry/methods ; Medicine, Chinese Traditional ; Plant Preparations/analysis ; Quality Control ; Regression Analysis ; Reproducibility of Results ; Spectrometry, Mass, Electrospray Ionization/methods
    Chemical Substances Capsules ; Flavones ; Plant Preparations
    Language English
    Publishing date 2011-07-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2011.03.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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