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Article ; Online: Diagnosis, classification, and assessment in psoriatic arthritis.

Antony, Anna / Tillett, William

Best practice & research. Clinical rheumatology

2021 Volume 35, Issue 2, Page(s) 101669

Abstract: There have been considerable advances in the classification and assessment of psoriatic arthritis (PsA). In this report, we give an overview of historic and current classification criteria and discuss its role and limitations in research and clinical ... ...

Abstract	There have been considerable advances in the classification and assessment of psoriatic arthritis (PsA). In this report, we give an overview of historic and current classification criteria and discuss its role and limitations in research and clinical practice. We discuss the most commonly used assessment instruments for arthritis, psoriasis, onychodystrophy, enthesitis, dactylitis and axial PsA with a focus on clinical practice. We pay particular attention to the current evidence for the use of composite outcome measures, and their use in randomised controlled trials and routine care.
MeSH term(s)	Arthritis, Psoriatic/diagnosis ; Humans ; Outcome Assessment, Health Care ; Psoriasis
Language	English
Publishing date	2021-04-08
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2052323-3
ISSN	1532-1770 ; 1521-6942
ISSN (online)	1532-1770
ISSN	1521-6942
DOI	10.1016/j.berh.2021.101669
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Article ; Online: Mental health and quality of life among patients with chronic respiratory failure on domiciliary oxygen: a prospective cohort study from a tertiary care centre in India.

Antony, Thomas / Acharya, Vishak K / Ray, Rojina Anna / Holla, Ramesh

BMJ open

2023 Volume 13, Issue 7, Page(s) e067321

Abstract: Objectives: The study aims to assess the prevalence of anxiety, depression and the quality of life among patients with chronic respiratory failure and the changes in anxiety and depression scores after initiating domiciliary oxygen.: Design and ... ...

Abstract	Objectives: The study aims to assess the prevalence of anxiety, depression and the quality of life among patients with chronic respiratory failure and the changes in anxiety and depression scores after initiating domiciliary oxygen. Design and setting: Prospective, single-centre cohort study conducted in a tertiary care hospital in India. Participants: Patients of Indian origin with chronic respiratory failure who visited the hospital where domiciliary oxygen is indicated were included in the study. Patients with acute respiratory failure on a mechanical ventilator, haemodynamic instability and already-diagnosed psychiatric conditions were excluded from the study. Interventions: Patients who met the inclusion criteria were assessed at baseline, at 3 and 6 months, for anxiety and depression using the 7-item Generalised Anxiety Disorder questionnaire (GAD-7) and 9-item Patient Health Questionnaire (PHQ-9). Quality of life was evaluated using the WHO Quality of Life-BREF questionnaire. Primary and secondary outcome measures: The primary outcome is the proportion of patients with chronic respiratory failure having depression and anxiety and assessing the changes in anxiety and depression scores after initiating domiciliary oxygen. The secondary outcome is the change in health-related quality of life (HRQOL) of patients on domiciliary oxygen. Results: 121 patients who met the inclusion criteria were included in the study. Of 102 patients who completed the study, 36.2% (n=37) had anxiety and 44.1% (n=45) had depression at baseline. There is a worsening trend in the mean GAD-7 (p=0.003) and PHQ-9 score (p=0.015) in patients over 6 months while on domiciliary oxygen. HRQOL is poor in all the domains at baseline, and there is a progressive worsening during follow-up while on oxygen. Conclusions: The worsening trend in anxiety and depression in patients after initiating domiciliary oxygen may be related to social isolation, restricted mobility, economic issues, addictions and frequency of exacerbations. Screening for psychological problems in these patients at baseline and on follow-ups helps early detection, and prompt intervention could improve the quality of life and survival.
MeSH term(s)	Humans ; Mental Health ; Tertiary Care Centers ; Prospective Studies ; Quality of Life ; Cohort Studies ; Acidosis, Respiratory ; India/epidemiology ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-067321
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Article ; Online: The evolving demographics of participants in psoriatic arthritis phase III randomised controlled trials of b/tsDMARDs: A systematic review.

Zhu, Wendy / Ayoub, Sally / Morand, Eric / Tillett, William / Antony, Anna

Seminars in arthritis and rheumatism

2023 Volume 60, Page(s) 152175

Abstract: Objectives: To characterize the evolving demographics of participants recruited to phase III randomised controlled trials (RCTs) of biologic/targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) in peripheral psoriatic arthritis (PsA).!# ...

Abstract	Objectives: To characterize the evolving demographics of participants recruited to phase III randomised controlled trials (RCTs) of biologic/targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) in peripheral psoriatic arthritis (PsA). Methods: We conducted a systematic review of EMBASE, MEDLINE, and the Cochrane Database of Clinical Trials (CENTRAL) to identify all placebo-controlled phase III RCTs of b/tsDMARDs in peripheral PsA published up to 1 June 2022. Data extracted included inclusion criteria, date of initiation, countries in which studies were conducted, age, sex, race, disease duration, swollen joint count, tender joint count, Health Assessment Questionnaire - Disability Index, Psoriasis Area and Severity Index, and radiographic damage scores. Trends over time were evaluated using descriptive statistics. Results: 34 eligible RCTs from 33 reports were included. The proportion of female participants increased over time with females representing 29.0-43.7% of participants in studies initiated in 2000-2004 which increased to 46.0-58.8% in 2015-2019. While the number of countries included in RCTs increased significantly from 1-8 countries (2000-2004) to 2-46 (2015-2019), the proportion of white participants changed marginally from 90.0-98.0% (2000-2004) to 80.9-97.3% (2015-2019). The SJC and TJC decreased from 13.9 to 24.6 respectively (2000-2004), to 7.0-13.9 and 12.9-24.9 (2015-2019). Baseline CRP and HAQ-DI remained stable. Conclusion: Despite the expansion of countries from which PsA RCT participants were recruited from, non-white participants continue to be under-represented. Improving diversity in patient representation is imperative to further our understanding of PsA phenotypes, proteogenomics, socioeconomic determinants, and treatment effects, to advance the care of all patients with psoriatic disease.
MeSH term(s)	Female ; Humans ; Arthritis, Psoriatic/drug therapy ; Antirheumatic Agents/therapeutic use ; Psoriasis ; Demography ; Randomized Controlled Trials as Topic
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	120247-9
ISSN	1532-866X ; 0049-0172
ISSN (online)	1532-866X
ISSN	0049-0172
DOI	10.1016/j.semarthrit.2023.152175
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Article ; Online: Active and effective replay: systems consolidation reconsidered again.

Antony, James W / Schapiro, Anna C

Nature reviews. Neuroscience

2019 Volume 20, Issue 8, Page(s) 506–507

MeSH term(s)	Hippocampus ; Memory Consolidation ; Memory, Episodic
Language	English
Publishing date	2019-06-03
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2034150-7
ISSN	1471-0048 ; 1471-0048 ; 1471-003X
ISSN (online)	1471-0048
ISSN	1471-0048 ; 1471-003X
DOI	10.1038/s41583-019-0191-8
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Article: The Heliotropium marifolium complex in India and five new combinations in Euploca (Heliotropiaceae) from H. sect. Orthostachys (Boraginaceae s.l.)

Antony, Anna Ancy / Javad, P

Nordic journal of botany. 2020 Nov., v. 38, no. 11

2020

Abstract: This paper includes studies on Heliotropium marifolium complex from India. Five new combinations in Euploca from H. sect. Orthostachys are proposed here. H. marifolium, H. marifolium subsp. wallichii, H. rottleri, H. cornutum and H. madurense are ... ...

Abstract	This paper includes studies on Heliotropium marifolium complex from India. Five new combinations in Euploca from H. sect. Orthostachys are proposed here. H. marifolium, H. marifolium subsp. wallichii, H. rottleri, H. cornutum and H. madurense are transferred to the genus Euploca. The taxonomic status of the unresolved name H. rottleri is also discussed.
Keywords	Heliotropiaceae ; Heliotropium ; botany ; India
Language	English
Dates of publication	2020-11
Publishing place	Blackwell Publishing Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	2406507-9
ISSN	1756-1051 ; 0107-055X
ISSN (online)	1756-1051
ISSN	0107-055X
DOI	10.1111/njb.02913
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Mental health and quality of life among patients with chronic respiratory failure on domiciliary oxygen

Ramesh Holla / Thomas Antony / Vishak K Acharya / Rojina Anna Ray

BMJ Open, Vol 13, Iss

a prospective cohort study from a tertiary care centre in India

2023 Volume 7

Abstract: Objectives The study aims to assess the prevalence of anxiety, depression and the quality of life among patients with chronic respiratory failure and the changes in anxiety and depression scores after initiating domiciliary oxygen.Design and setting ... ...

Abstract	Objectives The study aims to assess the prevalence of anxiety, depression and the quality of life among patients with chronic respiratory failure and the changes in anxiety and depression scores after initiating domiciliary oxygen.Design and setting Prospective, single-centre cohort study conducted in a tertiary care hospital in India.Participants Patients of Indian origin with chronic respiratory failure who visited the hospital where domiciliary oxygen is indicated were included in the study. Patients with acute respiratory failure on a mechanical ventilator, haemodynamic instability and already-diagnosed psychiatric conditions were excluded from the study.Interventions Patients who met the inclusion criteria were assessed at baseline, at 3 and 6 months, for anxiety and depression using the 7-item Generalised Anxiety Disorder questionnaire (GAD-7) and 9-item Patient Health Questionnaire (PHQ-9). Quality of life was evaluated using the WHO Quality of Life-BREF questionnaire.Primary and secondary outcome measures The primary outcome is the proportion of patients with chronic respiratory failure having depression and anxiety and assessing the changes in anxiety and depression scores after initiating domiciliary oxygen. The secondary outcome is the change in health-related quality of life (HRQOL) of patients on domiciliary oxygen.Results 121 patients who met the inclusion criteria were included in the study. Of 102 patients who completed the study, 36.2% (n=37) had anxiety and 44.1% (n=45) had depression at baseline. There is a worsening trend in the mean GAD-7 (p=0.003) and PHQ-9 score (p=0.015) in patients over 6 months while on domiciliary oxygen. HRQOL is poor in all the domains at baseline, and there is a progressive worsening during follow-up while on oxygen.Conclusions The worsening trend in anxiety and depression in patients after initiating domiciliary oxygen may be related to social isolation, restricted mobility, economic issues, addictions and frequency of exacerbations. Screening for psychological ...
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The state of the art-psoriatic arthritis outcome assessment in clinical trials and daily practice.

Day, Julia / Antony, Anna / Tillett, William / Coates, Laura C

The Lancet. Rheumatology

2022 Volume 4, Issue 3, Page(s) e220–e228

Abstract: Psoriatic arthritis is a heterogeneous condition with substantial challenges in optimising outcome measures for both clinical trials and daily practice. As with other inflammatory arthritides, there is no gold standard instrument for measuring disease ... ...

Abstract	Psoriatic arthritis is a heterogeneous condition with substantial challenges in optimising outcome measures for both clinical trials and daily practice. As with other inflammatory arthritides, there is no gold standard instrument for measuring disease activity or impact, both of which are key to evaluate therapeutic approaches in trials and monitor disease in daily practice. A wide range of domains have been highlighted in the Outcome Measures in Rheumatology (OMERACT) core domain set for psoriatic arthritis; reflecting the disease involvement in multiple tissues (joints, tendons, skin, and spine) and the heterogenous impact of the disease on individuals. This Review summarises the current evidence around outcome measure selection, considering factors such as unidimensional versus multidimensional outcomes, continuous versus binary measures, and the feasibility of these approaches in trials compared with clinical practice.
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article ; Review
ISSN	2665-9913
ISSN (online)	2665-9913
DOI	10.1016/S2665-9913(21)00349-0
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Article: Protecting group free glycosylation: one-pot stereocontrolled access to 1,2-

Qiu, Xin / Garden, Anna L / Fairbanks, Antony J

Chemical science

2022 Volume 13, Issue 14, Page(s) 4122–4130

Abstract: Unprotected 2-acetamido sugars may be directly converted into their oxazolines using 2-chloro-1,3-dimethylimidazolinium chloride (DMC), and a suitable base, in aqueous solution. Freeze drying and acid catalysed reaction with an alcohol as solvent ... ...

Abstract	Unprotected 2-acetamido sugars may be directly converted into their oxazolines using 2-chloro-1,3-dimethylimidazolinium chloride (DMC), and a suitable base, in aqueous solution. Freeze drying and acid catalysed reaction with an alcohol as solvent produces the corresponding 1,2-
Language	English
Publishing date	2022-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d2sc00222a
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Article ; Online: Built Environmental Correlates of Cycling Accidents Involving Fatalities and Serious Injuries in London, UK

Anna Labetski / Antony Chum

Frontiers in Sustainable Cities, Vol

2020 Volume 2

Abstract: Introduction: Approximately 2,552 individuals were killed or seriously injured through cycling accidents in the Greater London Area between 2010 and 2015. The purpose of this study is to investigate a wide range of built environmental correlates of ... ...

Abstract	Introduction: Approximately 2,552 individuals were killed or seriously injured through cycling accidents in the Greater London Area between 2010 and 2015. The purpose of this study is to investigate a wide range of built environmental correlates of cycling accidents resulting in KSI so that we can identify potential areas for targeted interventions.Methods: We performed a cross-sectional analysis to examine the association between serious cycling injuries (2010-15), using road segment as the unit of analysis, and a wide range of built environmental characteristics. Multilevel models were used to account for potential spatial clustering.Results: Serious cycling injuries were independently associated with higher commercial and residential densities, higher distance to speed camera, higher bus, car, and 2-wheeled (motorcycle and moped) traffic, and higher density of alcohol outlets. Greenspace was associated with decreased odds of injuries up to the 3rd quartile, but roads adjacent to the highest levels of green space (4th quartile) had increased odds of injuries. Findings from our study point to the potential of urban planning interventions to reduce serious cycling injuries (e.g., speed cameras, improving safety near alcohol outlets and in parks, and recreational areas, etc.). Further research using quasi-experimental approaches is required to evaluate whether the implementation of interventions leads to injury reductions.
Keywords	injuries ; built environment ; urban planning ; transportation ; cycling ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	710 ; 380
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Marine Antimicrobial Peptides: An Emerging Nightmare to the Life-Threatening Pathogens.

Thomas, Anne Maria / Antony, Swapna P

Probiotics and antimicrobial proteins

2023 Volume 16, Issue 2, Page(s) 552–578

Abstract: The emergence of multidrug-resistant pathogens due to improper usage of conventional antibiotics has created a global health crisis. Alternatives to antibiotics being an urgent need, the scientific community is forced to search for new antimicrobials. ... ...

Abstract	The emergence of multidrug-resistant pathogens due to improper usage of conventional antibiotics has created a global health crisis. Alternatives to antibiotics being an urgent need, the scientific community is forced to search for new antimicrobials. This exploration has led to the discovery of antimicrobial peptides, a group of small peptides occurring in different phyla such as Porifera, Cnidaria, Annelida, Arthropoda, Mollusca, Echinodermata, and Chordata, as a component of their innate immune system. The marine environment, possessing immense diversity of organisms, is undoubtedly one of the richest sources of unique potential antimicrobial peptides. The distinctiveness of marine antimicrobial peptides lies in their broad-spectrum activity, mechanism of action, less cytotoxicity, and high stability, which form the benchmark for developing a potential therapeutic. This review aims to (1) synthesise the available information on the distinctive antimicrobial peptides discovered from marine organisms, particularly over the last decade, and (2) discuss the distinctiveness of marine antimicrobial peptides and their prospects.
MeSH term(s)	Animals ; Antimicrobial Peptides ; Dreams ; Echinodermata ; Cnidaria ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Antimicrobial Peptides ; Anti-Bacterial Agents
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2487792-X
ISSN	1867-1314 ; 1867-1306
ISSN (online)	1867-1314
ISSN	1867-1306
DOI	10.1007/s12602-023-10061-x
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