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Article ; Online: Perspectives on COVID-19.

Dunkley, Arthur

The International journal of risk & safety in medicine

2020 Volume 31, Issue 4, Page(s) 183–191

Abstract: A few ideas that deserve to see the light of day. I wrote this essay on 23/3/2020. I have started updating in the form of post scripts. Please relate the information to the date on which it was written. ...

Abstract	A few ideas that deserve to see the light of day. I wrote this essay on 23/3/2020. I have started updating in the form of post scripts. Please relate the information to the date on which it was written.
MeSH term(s)	COVID-19/economics ; COVID-19/epidemiology ; COVID-19/psychology ; Communicable Disease Control/economics ; Communicable Disease Control/methods ; Humans ; Pandemics ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1055458-0
ISSN	1878-6847 ; 0924-6479
ISSN (online)	1878-6847
ISSN	0924-6479
DOI	10.3233/JRS-201007
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Article: Perspectives on COVID-19

Dunkley, Arthur

Abstract	A few ideas that deserve to see the light of day. I wrote this essay on 23/3/2020. I have started updating in the form of post scripts. Please relate the information to the date on which it was written.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #843754
Database	COVID19

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Article: Platelet glycoprotein VI-related clinical defects.

Arthur, Jane F / Dunkley, Scott / Andrews, Robert K

British journal of haematology

2007 Volume 139, Issue 3, Page(s) 363–372

Abstract: Human patients with defects associated with the platelet collagen receptor, glycoprotein (GP)VI, are rare and usually described as having a mild bleeding disorder. However, here we review clinical profiles of patients with familial or acquired GPVI ... ...

Abstract	Human patients with defects associated with the platelet collagen receptor, glycoprotein (GP)VI, are rare and usually described as having a mild bleeding disorder. However, here we review clinical profiles of patients with familial or acquired GPVI defects, revealing the bleeding defect is often severe and associated with immune dysfunction. GPVI is a member of the immunoreceptor family, and co-expressed on platelets with Fc receptor gamma-chain (FcRgamma). Ligand binding to GPVI leads to activation of platelet integrins, in particular alpha(IIb)beta(3) that mediates platelet aggregation; and activation of endogenous platelet metalloproteinases resulting in ectodomain shedding and release of a soluble GPVI fragment. Increasing evidence supports the functional importance of GPVI/FcRgamma in thrombus formation at arterial shear rates, and expression levels of platelet GPVI may be a marker of thrombotic risk. Over the past 20 years, patients have been reported with GPVI-related defects involving: (i) an acquired deficiency, resulting from (a) anti-GPVI autoantibodies or (b) other causes; or (ii) a congenital deficiency, where (c) GPVI is not expressed or (d) is expressed in a dysfunctional form with defective signalling to alpha(IIb)beta(3). Clinical consequences of GPVI-related defects may be uniquely informative about the role of platelet GPVI in health and disease.
MeSH term(s)	Autoimmune Diseases/blood ; Autoimmune Diseases/genetics ; Blood Platelet Disorders/diagnosis ; Blood Platelet Disorders/genetics ; Humans ; Ligands ; Platelet Membrane Glycoproteins/deficiency ; Platelet Membrane Glycoproteins/genetics ; Platelet Membrane Glycoproteins/metabolism ; Polymorphism, Genetic
Chemical Substances	Ligands ; Platelet Membrane Glycoproteins ; platelet membrane glycoprotein VI
Language	English
Publishing date	2007-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/j.1365-2141.2007.06799.x
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Article: A familial platelet function disorder associated with abnormal signalling through the glycoprotein VI pathway.

Dunkley, Scott / Arthur, Jane F / Evans, Sue / Gardiner, Elizabeth E / Shen, Yang / Andrews, Robert K

British journal of haematology

2007 Volume 137, Issue 6, Page(s) 569–577

Abstract: The platelet collagen receptor, glycoprotein (GP)VI, of the immunoreceptor family forms a complex with the von Willebrand factor (VWF) receptor, GPIb-IX-V, critical for initiating thrombus formation. GPVI is co-associated with Fc receptor gamma-chain ( ... ...

Abstract	The platelet collagen receptor, glycoprotein (GP)VI, of the immunoreceptor family forms a complex with the von Willebrand factor (VWF) receptor, GPIb-IX-V, critical for initiating thrombus formation. GPVI is co-associated with Fc receptor gamma-chain (FcRgamma), which contains a cytoplasmic immunoreceptor tyrosine-based activation motif domain, involved in activation of Syk, and a signalling cascade leading to (i) activation of alpha(IIb)beta(3), which binds VWF and fibrinogen and mediates platelet aggregation, and (ii) metalloproteinase-mediated shedding of the GPVI ectodomain (blocked by Syk inhibitors), a key mechanism for regulating GPVI surface expression. In this study, we report a familial case of abnormal platelet aggregation with dysfunctional signalling through GPVI that uniquely demonstrates divergent alpha(IIb)beta(3)-activating and GPVI-shedding pathways. The patient is a 60-year-old female with a history of immune disorders, excessive bleeding from childhood and a life-threatening haemorrhage post-trauma. Platelet aggregation to ADP, thrombin receptor-agonist peptide or ristocetin/VWF was normal (indicating normal expression and function of alpha(IIb)beta(3)), but platelet aggregation to GPVI agonists, collagen, collagen-related peptide, or convulxin, was defective. Both GPVI/FcRgamma expression and ligand-induced GPVI ectodomain shedding were normal, confirming expression of functional GPVI/FcRgamma, but suggesting a signalling defect downstream of Syk. A genetic defect in GPVI/Fcgamma signalling compromising platelet function is hypothesised in this family.
MeSH term(s)	Blood Platelet Disorders/genetics ; Blood Platelet Disorders/metabolism ; Blood Platelets/chemistry ; Blood Platelets/metabolism ; Blotting, Western ; Female ; Flow Cytometry ; Humans ; Immunoblotting ; Ligands ; Middle Aged ; Platelet Aggregation ; Platelet Function Tests ; Platelet Membrane Glycoproteins/analysis ; Platelet Membrane Glycoproteins/genetics ; Platelet Membrane Glycoproteins/metabolism ; Receptors, IgG/genetics ; Receptors, IgG/metabolism ; Sequence Analysis, DNA ; Signal Transduction/physiology
Chemical Substances	Ligands ; Platelet Membrane Glycoproteins ; Receptors, IgG ; platelet membrane glycoprotein VI
Language	English
Publishing date	2007-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/j.1365-2141.2007.06603.x
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Article ; Online: Impact of early dose intensity on cytogenetic and molecular responses in chronic- phase CML patients receiving 600 mg/day of imatinib as initial therapy.

Hughes, Timothy P / Branford, Susan / White, Deborah L / Reynolds, John / Koelmeyer, Rachel / Seymour, John F / Taylor, Kerry / Arthur, Chris / Schwarer, Anthony / Morton, James / Cooney, Julian / Leahy, Michael F / Rowlings, Philip / Catalano, John / Hertzberg, Mark / Filshie, Robin / Mills, Anthony K / Fay, Keith / Durrant, Simon /

Januszewicz, Henry / Joske, David / Underhill, Craig / Dunkley, Scott / Lynch, Kevin / Grigg, Andrew

Blood

2008 Volume 112, Issue 10, Page(s) 3965–3973

Abstract: We conducted a trial in 103 patients with newly diagnosed chronic phase chronic myeloid leukemia (CP-CML) using imatinib 600 mg/day, with dose escalation to 800 mg/day for suboptimal response. The estimated cumulative incidences of complete cytogenetic ... ...

Abstract	We conducted a trial in 103 patients with newly diagnosed chronic phase chronic myeloid leukemia (CP-CML) using imatinib 600 mg/day, with dose escalation to 800 mg/day for suboptimal response. The estimated cumulative incidences of complete cytogenetic response (CCR) by 12 and 24 months were 88% and 90%, and major molecular responses (MMRs) were 47% and 73%. In patients who maintained a daily average of 600 mg of imatinib for the first 6 months (n = 60), MMR rates by 12 and 24 months were 55% and 77% compared with 32% and 53% in patients averaging less than 600 mg (P = .037 and .016, respectively). Dose escalation was indicated for 17 patients before 12 months for failure to achieve, or maintain, major cytogenetic response at 6 months or CCR at 9 months but was only possible in 8 patients (47%). Dose escalation was indicated for 73 patients after 12 months because their BCR-ABL level remained more than 0.01% (international scale) and was possible in 45 of 73 (62%). Superior responses achieved in patients able to tolerate imatinib at 600 mg suggests that early dose intensity may be critical to optimize response in CP-CML. The trial was registered at www.ANZCTR.org.au as #ACTRN12607000614493.
MeSH term(s)	Adolescent ; Adult ; Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Benzamides ; Dose-Response Relationship, Drug ; Female ; Fusion Proteins, bcr-abl/metabolism ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism ; Male ; Middle Aged ; Piperazines/administration & dosage ; Piperazines/adverse effects ; Pyrimidines/administration & dosage ; Pyrimidines/adverse effects ; Time Factors
Chemical Substances	Antineoplastic Agents ; Benzamides ; Piperazines ; Pyrimidines ; Imatinib Mesylate (8A1O1M485B) ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
Language	English
Publishing date	2008-09-03
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2008-06-161737
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Article ; Online: Evidence of lensing of the cosmic microwave background by dark matter halos.

Madhavacheril, Mathew / Sehgal, Neelima / Allison, Rupert / Battaglia, Nick / Bond, J Richard / Calabrese, Erminia / Caligiuri, Jerod / Coughlin, Kevin / Crichton, Devin / Datta, Rahul / Devlin, Mark J / Dunkley, Joanna / Dünner, Rolando / Fogarty, Kevin / Grace, Emily / Hajian, Amir / Hasselfield, Matthew / Hill, J Colin / Hilton, Matt /

Physical review letters

2015 Volume 114, Issue 15, Page(s) 151302

Abstract: We present evidence of the gravitational lensing of the cosmic microwave background by 10(13) solar mass dark matter halos. Lensing convergence maps from the Atacama Cosmology Telescope Polarimeter (ACTPol) are stacked at the positions of around 12 000 ... ...

Abstract	We present evidence of the gravitational lensing of the cosmic microwave background by 10(13) solar mass dark matter halos. Lensing convergence maps from the Atacama Cosmology Telescope Polarimeter (ACTPol) are stacked at the positions of around 12 000 optically selected CMASS galaxies from the SDSS-III/BOSS survey. The mean lensing signal is consistent with simulated dark matter halo profiles and is favored over a null signal at 3.2σ significance. This result demonstrates the potential of microwave background lensing to probe the dark matter distribution in galaxy group and galaxy cluster halos.
Language	English
Publishing date	2015-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.114.151302
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Article ; Online: Evidence for dark energy from the cosmic microwave background alone using the Atacama Cosmology Telescope lensing measurements.

Sherwin, Blake D / Dunkley, Joanna / Das, Sudeep / Appel, John W / Bond, J Richard / Carvalho, C Sofia / Devlin, Mark J / Dünner, Rolando / Essinger-Hileman, Thomas / Fowler, Joseph W / Hajian, Amir / Halpern, Mark / Hasselfield, Matthew / Hincks, Adam D / Hlozek, Renée / Hughes, John P / Irwin, Kent D / Klein, Jeff / Kosowsky, Arthur /

Marriage, Tobias A / Marsden, Danica / Moodley, Kavilan / Menanteau, Felipe / Niemack, Michael D / Nolta, Michael R / Page, Lyman A / Parker, Lucas / Reese, Erik D / Schmitt, Benjamin L / Sehgal, Neelima / Sievers, Jon / Spergel, David N / Staggs, Suzanne T / Swetz, Daniel S / Switzer, Eric R / Thornton, Robert / Visnjic, Katerina / Wollack, Ed

Physical review letters

2011 Volume 107, Issue 2, Page(s) 21302

Abstract: For the first time, measurements of the cosmic microwave background radiation (CMB) alone favor cosmologies with w = -1 dark energy over models without dark energy at a 3.2-sigma level. We demonstrate this by combining the CMB lensing deflection power ... ...

Abstract	For the first time, measurements of the cosmic microwave background radiation (CMB) alone favor cosmologies with w = -1 dark energy over models without dark energy at a 3.2-sigma level. We demonstrate this by combining the CMB lensing deflection power spectrum from the Atacama Cosmology Telescope with temperature and polarization power spectra from the Wilkinson Microwave Anisotropy Probe. The lensing data break the geometric degeneracy of different cosmological models with similar CMB temperature power spectra. Our CMB-only measurement of the dark energy density Ω(Λ) confirms other measurements from supernovae, galaxy clusters, and baryon acoustic oscillations, and demonstrates the power of CMB lensing as a new cosmological tool.
Language	English
Publishing date	2011-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.107.021302
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Article ; Online: Detection of the power spectrum of cosmic microwave background lensing by the Atacama Cosmology Telescope.

Das, Sudeep / Sherwin, Blake D / Aguirre, Paula / Appel, John W / Bond, J Richard / Carvalho, C Sofia / Devlin, Mark J / Dunkley, Joanna / Dünner, Rolando / Essinger-Hileman, Thomas / Fowler, Joseph W / Hajian, Amir / Halpern, Mark / Hasselfield, Matthew / Hincks, Adam D / Hlozek, Renée / Huffenberger, Kevin M / Hughes, John P / Irwin, Kent D /

Physical review letters

2011 Volume 107, Issue 2, Page(s) 21301

Abstract: We report the first detection of the gravitational lensing of the cosmic microwave background through a measurement of the four-point correlation function in the temperature maps made by the Atacama Cosmology Telescope. We verify our detection by ... ...

Abstract	We report the first detection of the gravitational lensing of the cosmic microwave background through a measurement of the four-point correlation function in the temperature maps made by the Atacama Cosmology Telescope. We verify our detection by calculating the levels of potential contaminants and performing a number of null tests. The resulting convergence power spectrum at 2° angular scales measures the amplitude of matter density fluctuations on comoving length scales of around 100 Mpc at redshifts around 0.5 to 3. The measured amplitude of the signal agrees with Lambda cold dark matter cosmology predictions. Since the amplitude of the convergence power spectrum scales as the square of the amplitude of the density fluctuations, the 4σ detection of the lensing signal measures the amplitude of density fluctuations to 12%.
Language	English
Publishing date	2011-07-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.107.021301
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Article ; Online: Evidence of galaxy cluster motions with the kinematic Sunyaev-Zel'dovich effect.

Hand, Nick / Addison, Graeme E / Aubourg, Eric / Battaglia, Nick / Battistelli, Elia S / Bizyaev, Dmitry / Bond, J Richard / Brewington, Howard / Brinkmann, Jon / Brown, Benjamin R / Das, Sudeep / Dawson, Kyle S / Devlin, Mark J / Dunkley, Joanna / Dunner, Rolando / Eisenstein, Daniel J / Fowler, Joseph W / Gralla, Megan B / Hajian, Amir /

Halpern, Mark / Hilton, Matt / Hincks, Adam D / Hlozek, Renée / Hughes, John P / Infante, Leopoldo / Irwin, Kent D / Kosowsky, Arthur / Lin, Yen-Ting / Malanushenko, Elena / Malanushenko, Viktor / Marriage, Tobias A / Marsden, Danica / Menanteau, Felipe / Moodley, Kavilan / Niemack, Michael D / Nolta, Michael R / Oravetz, Daniel / Page, Lyman A / Palanque-Delabrouille, Nathalie / Pan, Kaike / Reese, Erik D / Schlegel, David J / Schneider, Donald P / Sehgal, Neelima / Shelden, Alaina / Sievers, Jon / Sifón, Cristóbal / Simmons, Audrey / Snedden, Stephanie / Spergel, David N / Staggs, Suzanne T / Swetz, Daniel S / Switzer, Eric R / Trac, Hy / Weaver, Benjamin A / Wollack, Edward J / Yeche, Christophe / Zunckel, Caroline

Physical review letters

2012 Volume 109, Issue 4, Page(s) 41101

Abstract: Using high-resolution microwave sky maps made by the Atacama Cosmology Telescope, we for the first time present strong evidence for motions of galaxy clusters and groups via microwave background temperature distortions due to the kinematic Sunyaev-Zel' ... ...

Abstract	Using high-resolution microwave sky maps made by the Atacama Cosmology Telescope, we for the first time present strong evidence for motions of galaxy clusters and groups via microwave background temperature distortions due to the kinematic Sunyaev-Zel'dovich effect. Galaxy clusters are identified by their constituent luminous galaxies observed by the Baryon Oscillation Spectroscopic Survey, part of the Sloan Digital Sky Survey III. We measure the mean pairwise momentum of clusters, with a probability of the signal being due to random errors of 0.002, and the signal is consistent with the growth of cosmic structure in the standard model of cosmology.
Language	English
Publishing date	2012-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.109.041101
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