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Article: Counting on Numbers-Numerical Abilities in Grey Bamboo Sharks and Ocellate River Stingrays.

Kreuter, Nils / Christofzik, Nele / Niederbremer, Carolin / Bollé, Janik / Schluessel, Vera

Animals : an open access journal from MDPI

2021 Volume 11, Issue 9

Abstract: Over the last decade, studies examining the cognitive abilities of fish have increased, using a broad range of approaches. One of the foci has been to test the ability of fish to discriminate quantities of items and to determine whether fish can solve ... ...

Abstract	Over the last decade, studies examining the cognitive abilities of fish have increased, using a broad range of approaches. One of the foci has been to test the ability of fish to discriminate quantities of items and to determine whether fish can solve tasks solely on the basis of numerical information. This study is the first to investigate this ability in two elasmobranch species. All animals were trained in two-alternative forced-choice visual experiments and then examined in transfer tests, to determine if previously gained knowledge could be applied to new tasks. Results show that the grey bamboo shark (
Language	English
Publishing date	2021-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11092634
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Article: Non-Sterile Gloves as a Source of Radiation-Tolerant Microorganisms.

Cabeau, Celine / Bolle-Reddat, Romain / Hauschild, James / McDonnell, Gerald

Microorganisms

2023 Volume 11, Issue 12

Abstract: Radiation methods are widely used for disinfection and sterilization applications. Microorganisms demonstrate known, variable tolerance levels to inactivation with lower doses of ionizing and non-ionizing radiation based on multiple mechanisms of ... ...

Abstract	Radiation methods are widely used for disinfection and sterilization applications. Microorganisms demonstrate known, variable tolerance levels to inactivation with lower doses of ionizing and non-ionizing radiation based on multiple mechanisms of resistance in their structures and nucleic acid repair mechanisms. The radiation dose required to ensure microbial inactivation during sterilization is typically based on the understanding and routine monitoring of the natural population and resistance of microorganisms on products exposed to radiation sterilization processes. This report describes the isolation of
Language	English
Publishing date	2023-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11122859
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Article ; Online: NORSE seasonality may vary geographically in adults.

Bolle, Andrea Enerstad / Gaist, Thomas / Kuljis, Anna Maria Eleonora / Blaabjerg, Morten / Beier, Christoph Patrick

Epilepsia open

2024

Abstract: ... 152), NORSE patients were more likely to have symptoms of systemic inflammation (C-reactive ...

Abstract	The mechanisms causing new onset refractory status epilepticus (NORSE) are often unknown. Recently, a seasonal variation with NORSE peaking during the summer was described in a mixed cohort of adults and children why we here studied the seasonal variation in a Danish status epilepticus (SE) cohort. This retrospective cohort study comprised SE patients aged ≥18 diagnosed and treated 2008-2017 at the Odense University Hospital. Clinical characteristics and seasonality of patients fulfilling the diagnostic criteria for NORSE were compared with patients with refractory SE (RSE) due to other reasons and with the seasonal variation of autoantibodies associated with autoimmune encephalitis in the Danish autoimmune encephalitis register. In this cohort, 26 patients met NORSE criteria. As compared to RSE patients not fulfilling NORSE criteria (n = 152), NORSE patients were more likely to have symptoms of systemic inflammation (C-reactive protein concentrations ≥10 mg/L or fever ≥38°C) at admission; nine fulfilled the criteria for febrile infection related epilepsy syndrome (FIRES). In contrast to the even seasonal distribution of patients with RSE not fulfilling the NORSE criteria, admissions due to NORSE peaked during the winter (46.1%, p = 0.04 as compared to non-NORSE RSE); six out of nine FIRES episodes occurred in the winter season. The seasonal variation was not explained by a seasonal variation of the detection rates of autoantibodies associated with autoimmune encephalitis (incl. NMDAR, LGI1, CASPR2, GABAR, GFAP) in a Danish nationwide register (n = 259). In conclusion, we confirm the seasonality of NORSE in a Danish cohort, however, with a peak during winter suggesting a geographical variation not solely explained by autoimmune encephalitis associated with known autoantibodies. PLAIN LANGUAGE SUMMARY: The study investigated the seasonal patterns of new-onset refractory status epilepticus (NORSE), i.e. severe seizures that occur without an obvious cause and require very intensive treatment. In contrast to the previously observed peak frequency in summer, this Danish study found that NORSE cases peak in winter. Furthermore, the seasonal variation in NORSE cases was not found to be associated with autoimmune encephalitis caused by known autoantibodies. Together with the high rate of patients showing symptoms of systemic inflammation compared to other status epilepticus patients, the data suggest a link between misdirected immune system responses and NORSE. The study can therefore help in the further search for the currently unknown causes of NORSE.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ISSN	2470-9239
ISSN (online)	2470-9239
DOI	10.1002/epi4.12944
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Article ; Online: [Translated article] Role of radiotherapy in the management of spine metastases.

Díaz Silvera, C M / Azinovic, I / Bolle, S L E / Pérez Cobos, M / Matute, R

Revista espanola de cirugia ortopedica y traumatologia

2023 Volume 67, Issue 6, Page(s) S542–S551

Abstract: Spine metastases are a common cause of pain in the oncologic patient which can generate functional limitation, in addition to complications derived from spinal cord compression, radicular compression and fractures. A complex approach to these metastases ... ...

Abstract	Spine metastases are a common cause of pain in the oncologic patient which can generate functional limitation, in addition to complications derived from spinal cord compression, radicular compression and fractures. A complex approach to these metastases is required due to the risk of permanent sequelae. With the increase in survival rates due to new emerging treatments, the possibilities of presenting vertebral metastases are increasing, therefore, the management of these lesions should be aimed at pain relief and maintenance of ambulation. Radiotherapy has a fundamental role in the management of these lesions, and technological advances in recent years have made it possible to improve the quality and intentionality of the treatments, going from having a palliative intent to proposing treatments that improve local control. In this article, we describe how the stereotactic body radiotherapy (SBRT) technique, in selected patients, can improve local control and its value in oligometastatic patients and after surgery.
Language	Spanish
Publishing date	2023-08-03
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2417057-4
ISSN	1988-8856 ; 1888-4415
ISSN (online)	1988-8856
ISSN	1888-4415
DOI	10.1016/j.recot.2023.08.009
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Article ; Online: Role of radiotherapy in the management of spine metastases.

Díaz Silvera, C M / Azinovic, I / Bolle, S L E / Pérez Cobos, M / Matute, R

Revista espanola de cirugia ortopedica y traumatologia

2023 Volume 67, Issue 6, Page(s) 542–551

Title translation	Papel de la radioterapia en el manejo de las metástasis vertebrales: últimas novedades.
Abstract	Spine metastases are a common cause of pain in the oncologic patient which can generate functional limitation, in addition to complications derived from spinal cord compression, radicular compression and fractures. A complex approach to these metastases is required due to the risk of permanent sequelae. With the increase in survival rates due to new emerging treatments, the possibilities of presenting vertebral metastases are increasing, therefore, the management of these lesions should be aimed at pain relief and maintenance of ambulation. Radiotherapy has a fundamental role in the management of these lesions, and technological advances in recent years have made it possible to improve the quality and intentionality of the treatments, going from having a palliative intent to proposing treatments that improve local control. In this article we describe how the stereotactic body radiotherapy (SBRT) technique, in selected patients, can improve local control and its value in oligometastatic patients and after surgery.
Language	Spanish
Publishing date	2023-05-26
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2417057-4
ISSN	1988-8856 ; 1888-4415
ISSN (online)	1988-8856
ISSN	1888-4415
DOI	10.1016/j.recot.2023.05.010
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Article ; Online: On the dual behaviour of water in octanol-rich aqueous

Požar, Martina / Bolle, Jennifer / Dogan-Surmeier, Susanne / Schneider, Eric / Paulus, Michael / Sternemann, Christian / Perera, Aurélien

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 5, Page(s) 4099–4110

Abstract: ... ...

Abstract	Aqueous
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp04651f
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Article ; Online: Probe-based quantitative PCR and RPA-Cas12a molecular diagnostics for detection of the tomato pest Phthorimaea absoluta (Lepidoptera: Gelechiidae).

Lewald, Kyle M / Song, Wenqi / Eweis-LaBolle, Daniel / Truong, Cindy / Godfrey, Kristine E / Chiu, Joanna C

Journal of economic entomology

2023 Volume 116, Issue 3, Page(s) 993–1001

Abstract: The tomato pest Phthorimaea absoluta Meyrick is highly invasive but has not yet invaded North America. However, several morphologically similar species are already present, making detection of P. absoluta presence and invasion challenging. We designed a ... ...

Abstract	The tomato pest Phthorimaea absoluta Meyrick is highly invasive but has not yet invaded North America. However, several morphologically similar species are already present, making detection of P. absoluta presence and invasion challenging. We designed a quantitative PCR molecular diagnostic to differentiate P. absoluta, P. operculella (Zeller), or Keiferia lycopersicella (Walsingham) (Lepidoptera: Gelechiidae) DNA. Additionally, we developed an RPA-Cas12a molecular diagnostic that allows for the isothermal detection of P. absoluta DNA, eliminating the need for a thermocycler. The results of the RPA-Cas12a diagnostic can be visualized simply using a UV light source and cell phone camera. We expect these diagnostics to improve quarantine and prevention measures against this serious agricultural threat.
MeSH term(s)	Animals ; Lepidoptera ; Moths/genetics ; Solanum lycopersicum/genetics ; CRISPR-Cas Systems ; Pathology, Molecular ; Polymerase Chain Reaction
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3031-4
ISSN	1938-291X ; 0022-0493
ISSN (online)	1938-291X
ISSN	0022-0493
DOI	10.1093/jee/toad079
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Article: Induction of immune response in BALB/c mice with a DNA vaccine encoding bacterioferritin or P39 of Brucella spp.

Al-Mariri, A / Tibor, A / Mertens, P / De Bolle, X / Michel, P / Godfroid, J / Walravens, K / Letesson, J J

Infection and immunity

2001 Volume 69, Issue 10, Page(s) 6264–6270

Abstract: ... proteins of Brucella spp. to induce cellular and humoral immune responses and to protect BALB/c mice ... a moderate protection in BALB/c mice challenged with B. abortus 544 compared to that observed in positive ...

Abstract	In this study, we evaluated the ability of DNA vaccines encoding the bacterioferritin (BFR) or P39 proteins of Brucella spp. to induce cellular and humoral immune responses and to protect BALB/c mice against a challenge with B. abortus 544. We constructed eukaryotic expression vectors called pCIBFR and pCIP39, encoding BFR or P39 antigens, respectively, and we verified that these proteins were produced after transfection of COS-7 cells. PCIBFR or pCIP39 was injected intramuscularly three times, at 3-week intervals. pCIP39 induced higher antibody responses than did the DNA vector encoding BFR. Both vectors elicited a T-cell-proliferative response and also induced a strong gamma interferon production upon restimulation with either the specific antigens or Brucella extract. In this report, we also demonstrate that animals immunized with these plasmids elicited a strong and long-lived memory immune response which persisted at least 3 months after the third vaccination. Furthermore, pCIBFR and pCIP39 induced a typical T-helper 1-dominated immune response in mice, as determined by cytokine or immunoglobulin G isotype analysis. The pCIP39 delivered by intramuscular injection (but not the pCIBFR or control vectors) induced a moderate protection in BALB/c mice challenged with B. abortus 544 compared to that observed in positive control mice vaccinated with S19.
MeSH term(s)	Animals ; Antibodies, Bacterial/biosynthesis ; Bacterial Proteins ; Brucella Vaccine/immunology ; Brucella abortus/immunology ; Brucellosis/prevention & control ; COS Cells ; Carrier Proteins/genetics ; Carrier Proteins/immunology ; Cell Division ; Cercopithecus aethiops ; Cytochrome b Group/genetics ; Cytochrome b Group/immunology ; DNA, Bacterial/immunology ; Ferritins/genetics ; Ferritins/immunology ; Genetic Vectors ; Interferon-gamma/biosynthesis ; Interleukin-5/biosynthesis ; Membrane Proteins/genetics ; Membrane Proteins/immunology ; Mice ; Mice, Inbred BALB C ; Periplasmic Binding Proteins ; Spleen/cytology ; Spleen/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology ; Vaccines, DNA/immunology
Chemical Substances	Antibodies, Bacterial ; Bacterial Proteins ; Brucella Vaccine ; Carrier Proteins ; Cytochrome b Group ; DNA, Bacterial ; Interleukin-5 ; Membrane Proteins ; Periplasmic Binding Proteins ; Vaccines, DNA ; p39 protein, Brucella ; Interferon-gamma (82115-62-6) ; Ferritins (9007-73-2) ; bacterioferritin (9035-38-5)
Language	English
Publishing date	2001-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.69.10.6264-6270.2001
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Article ; Online: Two native types of phytochrome A, phyA' and phyA", differ by the state of phosphorylation at the N-terminus as revealed by fluorescence investigations of the Ser/Ala mutant of rice phyA expressed in transgenic Arabidopsis.

Sineshchekov, Vitaly A / Koppel, Larissa A / Bolle, Cordelia

Functional plant biology : FPB

2020 Volume 45, Issue 2, Page(s) 150–159

Abstract: Phytochrome A (phyA) mediates different photoresponses what may be connected with the existence of its two types, phyA' and phyA'', differing by spectroscopic, photochemical and functional properties. We investigated a role of phyA phosphorylation in ... ...

Abstract	Phytochrome A (phyA) mediates different photoresponses what may be connected with the existence of its two types, phyA' and phyA'', differing by spectroscopic, photochemical and functional properties. We investigated a role of phyA phosphorylation in their formation turning to transgenic Arabidopsis thaliana (L. Heynh.) phyA or phyAphyB mutants overexpressing rice wild-type phyA (phyA WT) or mutant phyA (phyA SA) with the first 10 serines substituted by alanines. This prevents phyA phosphorylation at these sites and modifies photoresponses. Etiolated seedlings were employed and phyA parameters were evaluated with the use of low temperature fluorescence spectroscopy and photochemistry. Germination of seeds was induced by white light (WL) pre-treatment for 15min or 3h. Emission spectra of rice phyA WT and phyA SA were similar and their total content was comparable. However, the phyA'/phyA'' proportion in phyA WT was high and varied with the duration of the WL pre-treatment, whereas in phyA SA it was substantially shifted towards phyA'' and did not depend on the pre-illumination. This suggests that phyA SA comprises primarily or exclusively the phyA'' pool and supports the notion that the two phyA types differ by the state of serine phosphorylation. phyA'' was also found to be much more effective in the germination induction than phyA'.
Language	English
Publishing date	2020-04-15
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2071582-1
ISSN	1445-4416 ; 1445-4408
ISSN (online)	1445-4416
ISSN	1445-4408
DOI	10.1071/FP16261
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Article ; Online: On the X-ray Scattering Pre-peak of Linear Mono-ols and the Related Microstructure from Computer Simulations.

Požar, Martina / Bolle, Jennifer / Sternemann, Christian / Perera, Aurélien

The journal of physical chemistry. B

2020 Volume 124, Issue 38, Page(s) 8358–8371

Abstract: The X-ray scattering intensities ( ...

Abstract	The X-ray scattering intensities (
Language	English
Publishing date	2020-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.0c05932
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