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  1. Article: Editorial: Cerebellar structure and function in psychotic disorders: from mechanisms to clinics.

    Cao, Hengyi / Shinn, Ann K / Guo, Wenbin

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1344882

    Language English
    Publishing date 2023-12-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1344882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Medication Adherence in a Transdiagnostic First-Episode Psychosis Sample.

    London, Stephanie M / Cawkwell, Philip B / Shinn, Ann K

    The Journal of clinical psychiatry

    2023  Volume 84, Issue 6

    Abstract: Objective:: Methods:: Results:: Conclusions: ...

    Abstract Objective:
    Methods:
    Results:
    Conclusions:
    MeSH term(s) Humans ; Psychotic Disorders/diagnosis ; Psychotic Disorders/drug therapy ; Hospitalization ; Hospitals, Psychiatric ; Medication Adherence ; Substance-Related Disorders
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.23m14947
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  3. Article ; Online: The Importance of Context in Identifying the Recovery Needs of Women With Psychosis.

    Shinn, Ann K / Carol, Emily E

    The Journal of clinical psychiatry

    2021  Volume 82, Issue 4

    MeSH term(s) Female ; Humans ; Psychotic Disorders/diagnosis ; Psychotic Disorders/therapy
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.21com13936
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  4. Article: Editorial: Psychiatric diagnoses: current state and methodological issues.

    Nordgaard, Julie / Madeira, Luis / Shinn, Ann K / Cermolacce, Michel

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1194755

    Language English
    Publishing date 2023-04-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1194755
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  5. Article: Identifying Psychosis Episodes in Psychiatric Admission Notes via Rule-based Methods, Machine Learning, and Pre-Trained Language Models.

    Hua, Yining / Blackley, Suzanne V / Shinn, Ann K / Skinner, Joseph P / Moran, Lauren V / Zhou, Li

    medRxiv : the preprint server for health sciences

    2024  

    Abstract: Early and accurate diagnosis is crucial for effective treatment and improved outcomes, yet identifying psychotic episodes presents significant challenges due to its complex nature and the varied presentation of symptoms among individuals. One of the ... ...

    Abstract Early and accurate diagnosis is crucial for effective treatment and improved outcomes, yet identifying psychotic episodes presents significant challenges due to its complex nature and the varied presentation of symptoms among individuals. One of the primary difficulties lies in the underreporting and underdiagnosis of psychosis, compounded by the stigma surrounding mental health and the individuals' often diminished insight into their condition. Existing efforts leveraging Electronic Health Records (EHRs) to retrospectively identify psychosis typically rely on structured data, such as medical codes and patient demographics, which frequently lack essential information. Addressing these challenges, our study leverages Natural Language Processing (NLP) algorithms to analyze psychiatric admission notes for the diagnosis of psychosis, providing a detailed evaluation of rule-based algorithms, machine learning models, and pre-trained language models. Additionally, the study investigates the effectiveness of employing keywords to streamline extensive note data before training and evaluating the models. Analyzing 4,617 initial psychiatric admission notes (1,196 cases of psychosis versus 3,433 controls) from 2005 to 2019, we discovered that the XGBoost classifier employing Term Frequency-Inverse Document Frequency (TF-IDF) features derived from notes pre-selected by expert-curated keywords, attained the highest performance with an F1 score of 0.8881 (AUROC [95% CI]: 0.9725 [0.9717, 0.9733]). BlueBERT demonstrated comparable efficacy an F1 score of 0.8841 (AUROC [95% CI]: 0.97 [0.9580, 0.9820]) on the same set of notes. Both models markedly outperformed traditional International Classification of Diseases (ICD) code-based detection methods from discharge summaries, which had an F1 score of 0.7608, thus improving the margin by 0.12. Furthermore, our findings indicate that keyword pre-selection markedly enhances the performance of both machine learning and pre-trained language models. This study illustrates the potential of NLP techniques to improve psychosis detection within admission notes and aims to serve as a foundational reference for future research on applying NLP for psychosis identification in EHR notes.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.18.24304475
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  6. Article ; Online: Perspectives on the COVID-19 Pandemic and Individuals With Serious Mental Illness.

    Shinn, Ann K / Viron, Mark

    The Journal of clinical psychiatry

    2020  Volume 81, Issue 3

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Delivery of Health Care ; Humans ; Mental Disorders/complications ; Mental Health Services ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; Prognosis ; Public Health ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.20com13412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Test-retest reliability of the Childhood Trauma Questionnaire in psychotic disorders.

    Cay, Mariesa / Chouinard, Virginie-Anne / Hall, Mei-Hua / Shinn, Ann K

    Journal of psychiatric research

    2022  Volume 156, Page(s) 78–83

    Abstract: Background: Childhood trauma is common and associated with worse psychiatric outcomes. Yet, clinicians may not inquire about childhood trauma due to a misconception that patients cannot provide reliable reports. The goal of this study was to examine the ...

    Abstract Background: Childhood trauma is common and associated with worse psychiatric outcomes. Yet, clinicians may not inquire about childhood trauma due to a misconception that patients cannot provide reliable reports. The goal of this study was to examine the reliability of self-reports of childhood trauma in psychotic disorders.
    Methods: We examined the test-retest reliability of the Childhood Trauma Questionnaire (CTQ) in schizophrenia (SZ, n = 19), psychotic bipolar disorder (BD, n = 17), and healthy control (HC, n = 28) participants who completed the CTQ on ≥2 occasions over variable time periods (mean 19.6 months). We calculated the intraclass correlation (ICC) for the total CTQ score, each of the five CTQ domains, and the minimization/denial subscale for the three groups. For any CTQ domains showing low test-retest reliability (ICC < 0.61), we also explored whether positive, negative, depressive, and manic symptom severity were associated with CTQ variability.
    Results: We found high ICC values for the total CTQ score in all three groups (SZ 0.82, BD 0.85, HC 0.88). The ICC values for CTQ subdomains were also high with the exceptions of scores for sexual abuse in BD (0.40), emotional neglect in SZ (0.60), and physical neglect in BD (0.51) and HC (0.43). In exploratory analyses, self-reports of sexual abuse in BD were associated with greater severity of depressive symptoms (β = 0.108, p = 0.004).
    Conclusions: Patients with SZ and BD can provide reliable self-reports of childhood trauma, especially related to physical and emotional abuse. The presence of psychosis should not deter clinicians from asking patients about childhood trauma.
    MeSH term(s) Humans ; Reproducibility of Results ; Adverse Childhood Experiences ; Psychotic Disorders/diagnosis
    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2022.09.053
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  9. Article ; Online: The Intersection Between Childhood Trauma, the COVID-19 Pandemic, and Trauma-related and Psychotic Symptoms in People With Psychotic Disorders.

    Stone, Lena M D / Millman, Zachary B / Öngür, Dost / Shinn, Ann K

    Schizophrenia bulletin open

    2021  Volume 2, Issue 1, Page(s) sgab050

    Abstract: Introduction: People with psychotic disorders may be disproportionately affected by the traumatic effects of the COVID-19 pandemic. Childhood trauma, which also increases vulnerability to subsequent stressors, is common in individuals with psychosis. In ...

    Abstract Introduction: People with psychotic disorders may be disproportionately affected by the traumatic effects of the COVID-19 pandemic. Childhood trauma, which also increases vulnerability to subsequent stressors, is common in individuals with psychosis. In this study, we investigated the intersection of the pandemic, childhood trauma, and psychotic and trauma-related symptoms in individuals with psychotic disorders.
    Methods: We administered a cross-sectional survey to 151 participants [47 schizophrenia (SZ), 53 psychotic bipolar disorder (BP)], 51 healthy control (HC)] during the COVID-19 pandemic. Participants were asked about exposure to the pandemic's impacts, childhood trauma, and post-traumatic stress, dissociative, and psychotic symptoms.
    Results: BP reported greater negative impacts to emotional health than SZ and HC and to non-COVID physical health than HC. SZ reported
    Discussion: Our results suggest that having a psychotic disorder does not, in and of itself, increase susceptibility to the pandemic's negative impacts. Instead, we provide evidence of a graded relationship between cumulative exposure to the pandemic's negative impacts and PTSD symptom severity, as well as a graded relationship between cumulative childhood traumatic experiences and the number pandemic adversities, across diagnoses.
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article
    ISSN 2632-7899
    ISSN (online) 2632-7899
    DOI 10.1093/schizbullopen/sgab050
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  10. Article: Cerebellar transcranial magnetic stimulation in psychotic disorders: intermittent, continuous, and sham theta-burst stimulation on time perception and symptom severity.

    Shinn, Ann K / Hurtado-Puerto, Aura M / Roh, Youkyung S / Ho, Victoria / Hwang, Melissa / Cohen, Bruce M / Öngür, Dost / Camprodon, Joan A

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1218321

    Abstract: Background: The cerebellum contributes to the precise timing of non-motor and motor functions, and cerebellum abnormalities have been implicated in psychosis pathophysiology. In this study, we explored the effects of cerebellar theta burst stimulation ( ... ...

    Abstract Background: The cerebellum contributes to the precise timing of non-motor and motor functions, and cerebellum abnormalities have been implicated in psychosis pathophysiology. In this study, we explored the effects of cerebellar theta burst stimulation (TBS), an efficient transcranial magnetic stimulation protocol, on temporal discrimination and self-reported mood and psychotic symptoms.
    Methods: We conducted a case-crossover study in which patients with psychosis (schizophrenias, schizoaffective disorders, or bipolar disorders with psychotic features) were assigned to three sessions of TBS to the cerebellar vermis: one session each of intermittent (iTBS), continuous (cTBS), and sham TBS. Of 28 enrolled patients, 26 underwent at least one TBS session, and 20 completed all three. Before and immediately following TBS, participants rated their mood and psychotic symptoms and performed a time interval discrimination task (IDT). We hypothesized that cerebellar iTBS and cTBS would modulate these measures in opposing directions, with iTBS being adaptive and cTBS maladaptive.
    Results: Reaction time (RT) in the IDT decreased significantly after iTBS vs. Sham (LS-mean difference = -73.3,
    Conclusion: We observed a frequency-dependent dissociation between the effects of iTBS vs. cTBS to the cerebellar midline on the reaction time of interval discrimination in patients with psychosis. iTBS showed improved (adaptive) while cTBS led to worsening (maladaptive) speed of response. These results demonstrate behavioral target engagement in a cognitive dimension of relevance to patients with psychosis and generate testable hypotheses about the potential therapeutic role of cerebellar iTBS in this clinical population.
    Clinical trial registration: clinicaltrials.gov, identifier NCT02642029.
    Language English
    Publishing date 2023-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1218321
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