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Article: A Bacteriophage Cocktail Targeting

Kilgore, Paul B / Sha, Jian / Hendrix, Emily K / Neil, Blake H / Lawrence, William S / Peel, Jennifer E / Hittle, Lauren / Woolston, Joelle / Sulakvelidze, Alexander / Schwartz, Jennifer A / Chopra, Ashok K

bioRxiv : the preprint server for biology

2024

Abstract: ... Yersinia ... ...

Abstract	Yersinia pestis
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.17.576055
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Control of SARS-CoV-2 infection in skilled nursing facilities in Detroit, Michigan: a model for emerging infectious diseases.

Joshi, Seema / Arshad, Samia / Lindsay, Abigail / Heinonen, Jessica / Misikir, Helina / Zervos, John / Prentiss, Tyler / Verkler, Jelena / Numi, Mariia / Czander, Bonnie / David, Randy E / Mossing, Michael / Kilgore, Paul E / Rehman, Najibah / Zervos, Marcus

Infection control and hospital epidemiology

2024 , Page(s) 1–3

Abstract: An infection prevention bundle that consisted of the development of a response team, public-academic partnership, daily assessment, regular testing, isolation, and environmental controls was implemented in 26 skilled nursing facilities in Detroit, ... ...

Abstract	An infection prevention bundle that consisted of the development of a response team, public-academic partnership, daily assessment, regular testing, isolation, and environmental controls was implemented in 26 skilled nursing facilities in Detroit, Michigan (March 2020-April 2021). This intervention was associated with sustained control of severe acute respiratory coronavirus virus 2 infection among residents and staff.
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2024.35
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Article: Corrigendum: Molecular Serotype-Specific Identification of Non-type b

Takano, Chika / Seki, Mitsuko / Kim, Dong Wook / Kilgore, Paul E / Fuwa, Kazumasa / Takahashi, Koji / Inazaki, Toshiaki / Hayakawa, Satoshi

Frontiers in microbiology

2022 Volume 13, Page(s) 870651

Abstract: This corrects the article DOI: 10.3389/fmicb.2017.01877.]. ...

Abstract	[This corrects the article DOI: 10.3389/fmicb.2017.01877.].
Language	English
Publishing date	2022-03-14
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.870651
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Article ; Online: A New Method to Detect Variants of SARS-CoV-2 Using Reverse Transcription Loop-Mediated Isothermal Amplification Combined with a Bioluminescent Assay in Real Time (RT-LAMP-BART).

Iijima, Takahiro / Sakai, Jun / Kanamori, Dai / Ando, Shinnosuke / Nomura, Tsutomu / Tisi, Laurence / Kilgore, Paul E / Percy, Neil / Kohase, Hikaru / Hayakawa, Satoshi / Maesaki, Shigefumi / Hoshino, Tomonori / Seki, Mitsuko

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), of which there are several variants. The three major variants (Alpha, Delta, and Omicron) carry the N501Y, L452R, and Q493R/Q498R mutations, ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), of which there are several variants. The three major variants (Alpha, Delta, and Omicron) carry the N501Y, L452R, and Q493R/Q498R mutations, respectively, in the
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; COVID-19/diagnosis ; COVID-19/genetics ; Reverse Transcription/genetics ; Sensitivity and Specificity ; Molecular Diagnostic Techniques/methods ; Nucleic Acid Amplification Techniques/methods ; RNA ; Luminescent Measurements ; RNA, Viral/genetics
Chemical Substances	spike protein, SARS-CoV-2 ; RNA (63231-63-0) ; RNA, Viral
Language	English
Publishing date	2023-06-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241310698
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Article: Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms.

Wang, Jiangwei / Su, Xiaolin / Jiang, Lingxiang / Boudreau, Matthew W / Chatkewitz, Lindsay E / Kilgore, Jessica A / Zahid, Kashif Rafiq / Williams, Noelle S / Chen, Yaomin / Liu, Shaohui / Hergenrother, Paul J / Huang, Xiumei

Cancers

2023 Volume 15, Issue 24

Abstract: Lung and breast cancers rank as two of the most common and lethal tumors, accounting for a substantial number of cancer-related deaths worldwide. While the past two decades have witnessed promising progress in tumor therapy, developing targeted tumor ... ...

Abstract	Lung and breast cancers rank as two of the most common and lethal tumors, accounting for a substantial number of cancer-related deaths worldwide. While the past two decades have witnessed promising progress in tumor therapy, developing targeted tumor therapies continues to pose a significant challenge. NAD(P)H quinone oxidoreductase 1 (NQO1), a two-electron reductase, has been reported as a promising therapeutic target across various solid tumors. β-Lapachone (β-Lap) and deoxynyboquinone (DNQ) are two NQO1 bioactivatable drugs that have demonstrated potent antitumor effects. However, their curative efficacy has been constrained by adverse effects and moderate lethality. To enhance the curative potential of NQO1 bioactivatable drugs, we developed a novel DNQ derivative termed isopentyl-deoxynyboquinone (IP-DNQ). Our study revealed that IP-DNQ treatment significantly increased reactive oxygen species generation, leading to double-strand break (DSB) formation, PARP1 hyperactivation, and catastrophic energy loss. Notably, we discovered that this novel drug induced both apoptosis and programmed necrosis events, which makes it entirely distinct from other NQO1 bioactivatable drugs. Furthermore, IP-DNQ monotherapy demonstrated significant antitumor efficacy and extended mice survival in A549 orthotopic xenograft models. Lastly, we identified that in mice IP-DNQ levels were significantly elevated in the plasma and tumor compared with IB-DNQ levels. This study provides novel preclinical evidence supporting IP-DNQ efficacy in
Language	English
Publishing date	2023-12-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15245844
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Article: Trends in Legionnaires' Disease-Associated Hospitalizations, United States, 2006-2010.

Mudali, Gayathri / Kilgore, Paul E / Salim, Abdulbaset / McElmurry, Shawn P / Zervos, Marcus

Open forum infectious diseases

2020 Volume 7, Issue 8, Page(s) ofaa296

Abstract: Background: Legionella pneumophila: Methods: In this study, we estimated the annual incidence of Legionnaires' disease-associated hospitalizations in United States and identified demographic, temporal, and regional characteristics of individuals ... ...

Abstract	Background: Legionella pneumophila Methods: In this study, we estimated the annual incidence of Legionnaires' disease-associated hospitalizations in United States and identified demographic, temporal, and regional characteristics of individuals hospitalized for Legionnaires' disease. A retrospective study was conducted using the National Hospital Discharge Survey (NHDS) data from 2006 to 2010. The NHDS is a nationally representative US survey, which includes estimates of inpatient stays in short-stay hospitals in the United States, excluding federal, military, and Veterans Administration hospitals. All discharges assigned with the Legionnaires' disease Results: We observed the annual incidence and number of Legionnaires' disease-associated hospitalizations (per 100 000 population) in the United States by year, age, sex, race, and region. Over a 5-year period, 14 574 individuals experienced Legionnaires' disease-associated hospitalizations in the United States The annual population-adjusted incidence (per 100 000 population) of Legionnaires' disease-associated hospitalizations was 5.37 (95% confidence interval [CI], 5.12-5.64) in 2006, 7.06 (95% CI, 6.80-7.40) in 2007, 8.77 (95% CI, 8.44-9.11) in 2008, 17.07 (95% CI, 16.62-17.54) in 2009, and 9.66 (95% CI, 9.32-10.01) in 2010. A summer peak of Legionnaires' disease-associated hospitalizations occurred from June through September in 2006, 2007, 2008, and 2010. Conclusions: Legionnaires' disease-associated hospitalizations significantly increased over the 5-year study period. The increasing disease burden of Legionnaires' disease suggests that large segments of the US population are at risk for exposure to this waterborne pathogen.
Language	English
Publishing date	2020-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofaa296
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Article ; Online: Vaccine administration by pharmacy technicians: Impact on vaccination volume, pharmacy workflow and job satisfaction.

Miran, Neil Kenneth / DeLor, Bonnie / Baker, Michelle / Fakhouri, Joy / Metz, Kyle / Huskey, Eleonora / Kilgore, Paul / Fava, Joseph P

Exploratory research in clinical and social pharmacy

2023 Volume 13, Page(s) 100397

Abstract: Background: Immunizing pharmacy technicians (IPTs) have become more prevalent in recent years, but their impact on community pharmacy practice has yet to be determined.: Objectives: Determine the impact of implementing IPTs on vaccination volume in a ...

Abstract	Background: Immunizing pharmacy technicians (IPTs) have become more prevalent in recent years, but their impact on community pharmacy practice has yet to be determined. Objectives: Determine the impact of implementing IPTs on vaccination volume in a community pharmacy chain and assess pharmacy staff's perspectives on the clinical abilities of IPTs and their impact on pharmacy workflow and job satisfaction. Methods: Retrospective data analysis comparing the number of vaccines administered in a supermarket pharmacy chain from September to March 2019-2020 and 2020-2021 in pharmacies with IPT(s) versus those without IPT(s). For the secondary objective, investigators developed and deployed two role-based mixed quantitative/qualitative surveys among pharmacy staff. Results: Pharmacies with IPT(s) observed a greater mean increase in vaccination volume from 2019-2020 to 2020-2021 versus those without IPTs (+159.35 vs. +104.57, Conclusion: Implementing IPTs can increase the volume of vaccines administered in a chain pharmacy and may positively affect job satisfaction and pharmacy workflow.
Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article
ISSN	2667-2766
ISSN (online)	2667-2766
DOI	10.1016/j.rcsop.2023.100397
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Article ; Online: Development of a novel loop-mediated isothermal amplification assay for ß-lactamase gene identification using clinical isolates of Gram-negative bacteria.

Kim, Eun Jin / Lee, Jiwon / Yoon, Youngbae / Lee, Donghyun / Baek, Yeongjun / Takano, Chika / Sakai, Jun / Iijima, Takahiro / Kanamori, Dai / Gardner, Humphrey / McLaughlin, Robert E / Kilgore, Paul E / Nakamura, Akihiro / Ogihara, Takashi / Hayakawa, Satoshi / Hoshino, Tomonori / Kim, Dong Wook / Seki, Mitsuko

Frontiers in cellular and infection microbiology

2023 Volume 12, Page(s) 1000445

Abstract: Rapid evaluation of antimicrobial susceptibility is important in the treatment of nosocomial infections by Gram-negative bacteria, which increasingly carry carbapenemases and metallo-β-lactamases. We developed loop-mediated isothermal amplification (LAMP) ...

Abstract	Rapid evaluation of antimicrobial susceptibility is important in the treatment of nosocomial infections by Gram-negative bacteria, which increasingly carry carbapenemases and metallo-β-lactamases. We developed loop-mediated isothermal amplification (LAMP)-based assays for four β-lactamase genes (
MeSH term(s)	beta-Lactamases/genetics ; Bacterial Proteins/genetics ; Nucleic Acid Amplification Techniques/methods ; Molecular Diagnostic Techniques ; Gram-Negative Bacteria/genetics ; Escherichia coli/genetics ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology
Chemical Substances	beta-Lactamases (EC 3.5.2.6) ; Bacterial Proteins ; Anti-Bacterial Agents
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.1000445
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Advocacy for pneumonia prevention in Korea: a multi-dimensional program organised around World Pneumonia Day.

Kim, Soon A / Kilgore, Paul E

Pneumonia (Nathan Qld.)

2013 Volume 2, Page(s) 26–32

Abstract: ... WPD internet website in the local language, d) organisation of a WPD venue in central Seoul, e ...

Abstract	There are limited examples of population-based approaches that engage a broad range of stakeholders for prevention of pneumonia. In 2010, a multi-dimensional public-private partnership was established around World Pneumonia Day (WPD) in Seoul, Korea and included the following components: a) formation of an expert advisory group, b) creation of educational materials tailored for lay persons, c) creation of a dedicated WPD internet website in the local language, d) organisation of a WPD venue in central Seoul, e) creation of video and social networking messages for wide distribution, and f) engagement of parents, health-care professionals, public health agencies and policymakers. This project directly engaged 7 expert health professionals, 5 national- and city-level health facilities, and parents from communities. The program reached out to 70,560 persons including 25,200 persons who were contacted in person at publicly-held WPD events. An educational video produced for WPD was aired in the Seoul subway and visible to several million persons riding subway lines that aired the pneumonia public service announcements over a two-month period (February to March, 2011). In addition, the Korean WPD website experienced 4,975 page views with 3,338 visitors and the micro blog associated with this site hosted 82 posts from site visitors. Based on participant numbers and contact volumes achieved in this project, the Korean WPD program was widely accepted and proved to be a highly effective in reaching a large audience to advocate for pneumonia prevention. One key to success of this program appears to be the unique public-private partnership around a major health issue. The methods and tools developed in this program have excellent potential for adaptation and application in other countries where pneumonia may be an under recognised problem among the general public.
Language	English
Publishing date	2013-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2803296-2
ISSN	2200-6133
ISSN	2200-6133
DOI	10.15172/pneu.2013.2/245
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Article ; Online: A New Method to Detect Variants of SARS-CoV-2 Using Reverse Transcription Loop-Mediated Isothermal Amplification Combined with a Bioluminescent Assay in Real Time (RT-LAMP-BART)

Takahiro Iijima / Jun Sakai / Dai Kanamori / Shinnosuke Ando / Tsutomu Nomura / Laurence Tisi / Paul E. Kilgore / Neil Percy / Hikaru Kohase / Satoshi Hayakawa / Shigefumi Maesaki / Tomonori Hoshino / Mitsuko Seki

International Journal of Molecular Sciences, Vol 24, Iss 10698, p

2023 Volume 10698

Abstract	Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), of which there are several variants. The three major variants (Alpha, Delta, and Omicron) carry the N501Y, L452R, and Q493R/Q498R mutations, respectively, in the S gene. Control of COVID-19 requires rapid and reliable detection of not only SARS-CoV-2 but also its variants. We previously developed a reverse transcription loop-mediated isothermal amplification assay combined with a bioluminescent assay in real time (RT-LAMP-BART) to detect the L452R mutation in the SARS-CoV-2 spike protein. In this study, we established LAMP primers and peptide nucleic acid probes to detect N501Y and Q493R/Q498R. The LAMP primer sets and PNA probes were designed for the N501Y and Q493R/Q498R mutations on the S gene of SARS-CoV-2. The specificities of RT-LAMP-BART assays were evaluated using five viral and four bacterial reference strains. The sensitivities of RT-LAMP-BART assays were evaluated using synthetic RNAs that included the target sequences, together with RNA-spiked clinical nasopharyngeal and salivary specimens. The results were compared with those of conventional real-time reverse transcription-polymerase chain reaction (RT-PCR) methods. The method correctly identified N501Y and Q493R/Q498R. Within 30 min, the RT-LAMP-BART assays detected up to 100–200 copies of the target genes; conventional real-time RT-PCR required 130 min and detected up to 500–3000 copies. Surprisingly, the real-time RT-PCR for N501Y did not detect the BA.1 and BA.2 variants (Omicron) that exhibited the N501Y mutation. The novel RT-LAMP-BART assay is highly specific and more sensitive than conventional real-time RT-PCR. The new assay is simple, inexpensive, and rapid; thus, it can be useful in efforts to identify SARS-CoV-2 variants of concern.
Keywords	SARS-CoV-2 ; variants of concern ; spike protein ; loop-mediated isothermal amplification ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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