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  1. Article: Synchronous Parathyroid Carcinoma and Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features.

    Alajaimi, Ahmed / Altooq, Noor / Chandran, Nisha / Alderazi, Yaser

    Cureus

    2022  Volume 14, Issue 4, Page(s) e24006

    Abstract: Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Compared to parathyroid adenoma, parathyroid cancer is more likely to be associated with marked levels of serum parathyroid hormone (PTH) and hypercalcemia with severe clinical ... ...

    Abstract Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Compared to parathyroid adenoma, parathyroid cancer is more likely to be associated with marked levels of serum parathyroid hormone (PTH) and hypercalcemia with severe clinical manifestations. Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a rare variant of papillary thyroid cancer. Here, we report the case of a middle-aged woman who presented with multiple fractures and neck swelling. Neck ultrasound and fine-needle aspiration cytology revealed a provisional diagnosis of thyroid carcinoma. Parathyroid and bone scan were performed because of primary hyperparathyroidism and hypercalcemia and established the diagnosis of hyperfunctioning right-sided parathyroid tumor. Right parathyroidectomy and total thyroidectomy were performed, and the histopathological report confirmed the diagnosis of parathyroid carcinoma and NIFTP. The synchronic coexistence between parathyroid cancer and thyroid neoplasms is an extremely rare condition that prompted us to report this case.
    Language English
    Publishing date 2022-04-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.24006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Disseminated Peritoneal Leiomyomatosis With Unusual Lung Mesenchymal Malignant Transformation.

    Buhusayyen, Huda E / Alkhan, Fatema A / Behzad, Nouf / Alderazi, Yaser / Salman, Ghassan

    Cureus

    2022  Volume 14, Issue 11, Page(s) e31307

    Abstract: Disseminated peritoneal leiomyomatosis (DPL) is a benign metastasis of leiomyoma mimicking metastasis of malignancy. It usually affects premenopausal women. Malignant transformation is a rare clinical scenario of DPL. However, its etiology is unknown ... ...

    Abstract Disseminated peritoneal leiomyomatosis (DPL) is a benign metastasis of leiomyoma mimicking metastasis of malignancy. It usually affects premenopausal women. Malignant transformation is a rare clinical scenario of DPL. However, its etiology is unknown with unusual growth patterns, either of which makes the diagnosis difficult. It was postulated that the pathophysiology of DPL is metaplasia of mesothelial cells under the effect of hormonal stimulation. Hence, we reported the case of a 62-year-old woman with a history of left breast cancer, who presented with DPL and metastasis to the lung with malignant transformation after two years of starting prophylactic tamoxifen therapy. The influence of tamoxifen use on the development of DPL is not fully understood; this is a rare case that highlights a possible association between tamoxifen and the malignancy transformation of DPL. Hence, it may help raise awareness among clinicians dealing with women using tamoxifen or other hormonal therapy, and the risk of DPL development with potential malignant transformation in such patients.
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.31307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metachronous prostate and colon adenocarcinomas.

    AlHarmi, Rawan A Rahman / Hezam, Abdulhakim Motea / Sayed Adnan, Jalila / Alderazi, Yaser

    BMJ case reports

    2021  Volume 14, Issue 5

    Abstract: Multiple primaries in patients with prostate cancer are uncommon. We report a case of prostate adenocarcinoma who did not receive any form of treatment, diagnosed 7 months later with colon adenocarcinoma. The patient underwent right extended ... ...

    Abstract Multiple primaries in patients with prostate cancer are uncommon. We report a case of prostate adenocarcinoma who did not receive any form of treatment, diagnosed 7 months later with colon adenocarcinoma. The patient underwent right extended hemicolectomy and recovered well. He is planned to receive adjuvant chemotherapy and hormonal therapy. Management of such cases can present a dilemma and multiple factors must be taken into consideration, particularly when the first primary tumour is still active.
    MeSH term(s) Adenocarcinoma/drug therapy ; Adenocarcinoma/surgery ; Colonic Neoplasms/drug therapy ; Humans ; Male ; Prostatic Neoplasms/drug therapy
    Language English
    Publishing date 2021-05-10
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-242273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Phaeochromocytoma: current concepts.

    Alderazi, Yaser / Yeh, Michael W / Robinson, Bruce G / Benn, Diana E / Sywak, Mark S / Learoyd, Diana L / Delbridge, Leigh W / Sidhu, Stan B

    The Medical journal of Australia

    2005  Volume 183, Issue 4, Page(s) 201–204

    Abstract: The discovery of novel mutations in genes encoding succinate dehydrogenase subunits has revealed that familial phaeochromocytomas are much more common than previously thought. Genetic screening should be offered to patients with apparently sporadic ... ...

    Abstract The discovery of novel mutations in genes encoding succinate dehydrogenase subunits has revealed that familial phaeochromocytomas are much more common than previously thought. Genetic screening should be offered to patients with apparently sporadic phaeochromocytomas and their first-degree relatives. An increasing proportion of phaeochromocytomas present preclinically on genetic testing or as "incidentalomas" on abdominal imaging, rather than with classic symptoms and signs. Clinical suspicion should prompt measurement of plasma levels of free metanephrine or 24-hour urinary catecholamine and metanephrine levels, followed, if positive, by tumour localisation studies. With appropriate perioperative care, surgical management of phaeochromocytomas is safe and effective. Most tumours can be removed laparoscopically.
    MeSH term(s) Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/genetics ; Adrenal Gland Neoplasms/metabolism ; Adrenal Gland Neoplasms/therapy ; Catecholamines/urine ; Genetic Predisposition to Disease ; Humans ; Medical Oncology/trends ; Metanephrine/blood ; Metanephrine/urine ; Mutation/genetics ; Pheochromocytoma/diagnosis ; Pheochromocytoma/genetics ; Pheochromocytoma/metabolism ; Pheochromocytoma/therapy ; Sensitivity and Specificity ; Treatment Outcome
    Chemical Substances Catecholamines ; Metanephrine (5001-33-2)
    Language English
    Publishing date 2005-08-15
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/j.1326-5377.2005.tb06997.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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