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Article ; Online: Fluorogenic enzyme-linked immunosorbent assay with a dual color variation.

Yun, Hanool / Jeong, Hee-Jin

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 310, Page(s) 123973

Abstract: ... multiple samples were conveniently assayed within 20 h using FELISA, demonstrating its applicability ...

Abstract	The development of accurate and high-throughput biomarker detection tools is crucial for the diagnosis, monitoring, and treatment of various diseases. In this study, a sensitive fluorogenic enzyme-linked immunosorbent assay (FELISA) using Amplex Red or QuantaBlu fluorescent substrate was developed for the detection of tumor necrosis factor alpha and programmed cell death-ligand 1. The limit of detection of FELISA was in the nanogram order and multiple samples were conveniently assayed within 20 h using FELISA, demonstrating its applicability as a powerful immunoassay tool. FELISA can be widely used for rapid and accurate TNFα and PDL1 detection and applied to various fluorogenic immunoassays against other antigens of interest.
MeSH term(s)	Enzyme-Linked Immunosorbent Assay ; Immunoassay ; Coloring Agents
Chemical Substances	Coloring Agents
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.123973
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Article ; Online: Degradation of dissolved sulfide in water using multi-hole dielectric barrier discharge.

Yang, Geon Woo / Lee, Heejae / Kim, Kangil / Chun, Se Min / Jeong, Sang Yun / Jung, Jinmu / Hong, Yong Cheol

Chemosphere

2024 Volume 354, Page(s) 141687

Abstract: Biogas obtained from livestock manure is used as fuel for solid oxide fuel cells. Although H ...

Abstract	Biogas obtained from livestock manure is used as fuel for solid oxide fuel cells. Although H
MeSH term(s)	Water ; Biofuels ; Water Pollutants, Chemical/analysis ; Oxygen/analysis ; Ozone/chemistry
Chemical Substances	Water (059QF0KO0R) ; Biofuels ; Water Pollutants, Chemical ; Oxygen (S88TT14065) ; Ozone (66H7ZZK23N)
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141687
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Article ; Online: Periostin is a novel histological biomarker for the diagnosis of chondroid tumor.

Kim, Dough / Jeong, Ji Yun / Han, Man-Hoon / Chae, Jongmin / Park, Ilhyung / Yoon, Jongphil / Kyung, Heesoo / Kim, Ha-Jeong / Jeong, Wonju

Translational cancer research

2022 Volume 10, Issue 1, Page(s) 434–444

Abstract: ... formalin-fixed paraffin-embedded and hematoxylin and eosin (H&E) and immunohistochemistry (IHC) stains were ...

Abstract	Background: The chondroid tumor is generally classified into three types, enchondroma, low-grade chondrosarcoma, and high-grade chondrosarcoma. A histological evaluation of a biopsy sample is the best predictor of the clinical course in most patients with carcinomas or sarcomas. Sometimes serological or molecular markers are used as prediction markers, but there has been no reliable marker for chondroid tumor diagnosis. Clinical and radiological, but not histological features, are still used in the diagnosis and staging of chondroid tumors. During a histopathological diagnosis, it has been difficult to distinguish between benign enchondroma and low-grade chondrosarcoma. To allow for more accurate treatments, new histological biomarkers for the differential diagnosis are needed. Methods: Twenty-eight cases of enchondromas and thirty-three cases of low-grade chondrosarcoma were selected. Thirteen cases of non-tumorous cartilage were used for the control group, who underwent artificial joint surgery for degenerative arthritis. Surgically removed tissue specimens were formalin-fixed paraffin-embedded and hematoxylin and eosin (H&E) and immunohistochemistry (IHC) stains were performed. Results: Periostin was expressed in chondroid tumors but not in the normal cartilage. Periostin was observed via immunostaining in the cytoplasm but not in the extracellular matrix of enchondroma tissue, and was observed in the cytoplasm and extracellular matrix of low-grade chondrosarcoma. The sensitivity and specificity of these stains were 93.9% and 96.4%, respectively. Conclusions: Based on these results, we suggest that periostin could be used as a novel prognostic marker to distinguish between enchondroma and low-grade chondrosarcoma.
Language	English
Publishing date	2022-01-15
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-20-2499
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Article ; Online: Differential Implications of Cerebral Hypoperfusion and Hyperperfusion in Parkinson's Disease.

Jeong, Seong Ho / Kim, Su Hong / Park, Chan Wook / Lee, Hye Sun / Lee, Phil Hyu / Kim, Yun Joong / Sohn, Young H / Jeong, Yong / Chung, Seok Jong

Movement disorders : official journal of the Movement Disorder Society

2023 Volume 38, Issue 10, Page(s) 1881–1890

Abstract: Background: Patients with Parkinson's disease (PD) exhibit widespread brain perfusion changes.: Objective: This study investigated whether cerebral regions with hypoperfusion and hyperperfusion have differential effects on motor and cognitive ... ...

Abstract	Background: Patients with Parkinson's disease (PD) exhibit widespread brain perfusion changes. Objective: This study investigated whether cerebral regions with hypoperfusion and hyperperfusion have differential effects on motor and cognitive symptoms in PD using early-phase Methods: We enrolled 394 patients with newly diagnosed PD who underwent dual-phase Results: There was a weak correlation between PD Conclusions: These findings suggest that PD
MeSH term(s)	Humans ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Gait Disorders, Neurologic/complications ; Tropanes ; Positron-Emission Tomography ; Dopamine Plasma Membrane Transport Proteins ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane (155797-99-2) ; Tropanes ; Dopamine Plasma Membrane Transport Proteins
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29565
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Zs.MO 238: Show issues

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Article ; Online: Patterns of regional cerebral hypoperfusion in early Parkinson's disease: Clinical implications.

Chung, Seok Jong / Kim, Su Hong / Park, Chan Wook / Lee, Hye Sun / Yun, Mijin / Kim, Yun Joong / Sohn, Young H / Jeong, Yong / Lee, Phil Hyu

Parkinsonism & related disorders

2024 Volume 121, Page(s) 106024

Abstract: Introduction: This study aimed to investigate whether regional cerebral perfusion patterns on early-phase : Methods: We enrolled 397 drug-naïve patients with early-stage PD who underwent dual-phase : Results: Cluster analysis classified patients ... ...

Abstract	Introduction: This study aimed to investigate whether regional cerebral perfusion patterns on early-phase Methods: We enrolled 397 drug-naïve patients with early-stage PD who underwent dual-phase Results: Cluster analysis classified patients into three subtypes: cluster 1 (relatively preserved cortical uptake; n = 175), cluster 2 (decreased uptake in the frontal, parietal, and temporal regions; n = 151), and cluster 3 (decreased uptake in more extensive regions, additionally involving the lateral occipital regions; n = 71). Cluster 1 was characterized by a younger age-of-onset, less severe motor deficits, less severely decreased Conclusion: The patterns of regional cerebral perfusion can provide information on long-term prognosis with regards to cognitive, but not motor aspects of patients with early-stage PD.
MeSH term(s)	Humans ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/metabolism ; Gait Disorders, Neurologic ; Positron-Emission Tomography/methods ; Tropanes ; Dementia ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane (155797-99-2) ; Tropanes ; Dopamine Plasma Membrane Transport Proteins
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1311489-x
ISSN	1873-5126 ; 1353-8020
ISSN (online)	1873-5126
ISSN	1353-8020
DOI	10.1016/j.parkreldis.2024.106024
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Zs.A 4553: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 420: Show issues

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Article ; Online: T cell-oriented strategies for controlling the COVID-19 pandemic.

Noh, Ji Yun / Jeong, Hye Won / Kim, Jerome H / Shin, Eui-Cheol

Nature reviews. Immunology

2021 Volume 21, Issue 11, Page(s) 687–688

MeSH term(s)	COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/therapy ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Humans ; Immunologic Memory ; Pandemics ; SARS-CoV-2/physiology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-09-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/s41577-021-00625-9
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Zs.MG 34: Show issues

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Article ; Online: Electro-assisted methane oxidation to formic acid via in-situ cathodically generated H

Kim, Jiwon / Kim, Jae Hyung / Oh, Cheoulwoo / Yun, Hyewon / Lee, Eunchong / Oh, Hyung-Suk / Park, Jong Hyeok / Hwang, Yun Jeong

Nature communications

2023 Volume 14, Issue 1, Page(s) 4704

Abstract: Direct partial oxidation of methane to liquid oxygenates has been regarded as a potential route to valorize methane. However, ... ...

Abstract	Direct partial oxidation of methane to liquid oxygenates has been regarded as a potential route to valorize methane. However, CH
Language	English
Publishing date	2023-08-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-40415-6
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Article ; Online: Choroid Plexus Volume, Amyloid Burden, and Cognition in the Alzheimer's Disease Continuum.

Jeong, Seong Ho / Park, Chae Jung / Cha, Jungho / Kim, Sang-Young / Lee, Seung-Koo / Kim, Yun Joong / Sohn, Young H / Chung, Seok Jong / Lee, Phil Hyu

Aging and disease

2024

Abstract: As a part of the glymphatic system, the choroid plexus (CP) is involved in the clearance of harmful metabolites from the brain. We investigated the association between CP volume (CPV), amyloid-β (Aβ) burden, and cognition in patients on the Alzheimer's ... ...

Abstract	As a part of the glymphatic system, the choroid plexus (CP) is involved in the clearance of harmful metabolites from the brain. We investigated the association between CP volume (CPV), amyloid-β (Aβ) burden, and cognition in patients on the Alzheimer's disease (AD) continuum. We retrospectively reviewed the records of 203 patients on the AD continuum and 82 healthy controls who underwent brain magnetic resonance imaging and
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2625789-0
ISSN	2152-5250 ; 2152-5250
ISSN (online)	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2024.0118
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Article ; Online: In Vivo Fluorescence Molecular Imaging Using Covalent Organic Nanosheets Without Labeling.

Kang, Seokmin / Ahn, Heesu / Park, Chanho / Yun, Won Hyeok / Jeong, Ju Gyeong / Lee, Yong Jin / Kim, Dong Wook

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 10, Issue 16, Page(s) e2300462

Abstract: ... h, without reduction in cell activity or cytosolic aggregation. To investigate the biological ... from normal tissues at 1, 3, 12, and 24 h after injection. Furthermore, these in vivo imaging results ...

Abstract	Organic nanomaterials, as nanocarrier platforms, have tremendous potential for biomedical applications. The authors successfully prepared novel two-dimensional covalent organic nanosheets (CONs) that can be used as efficient in vivo bioimaging probes by condensing 1,3,5-triformylglucinol (Tp) and 2,7-diaminopyrene (Py) to produce TpPy covalent organic frameworks (COFs). TpPy COFs are then subjected to a liquid exfoliation process to obtain TpPy CONs (< 200 nm in size and < 1.7 nm in thickness). TpPy CONs disperse well in water to provide a stable, homogeneous colloidal suspension, which shows favorable photoluminescence properties. Cell viability tests using MDA-MB-231 and RAW 264.7 cells reveal that TpPy CONs are low in cytotoxicity. Confocal microscopy reveals clear fluorescent cell images after incubation with TpPy CONs for 24 h, without reduction in cell activity or cytosolic aggregation. To investigate the biological behavior of the TpPy CONs, the authors perform an in vivo fluorescence imaging study using MDA-MB-231 tumor-bearing mice. After intravenous injection of TpPy CONs disperse in phosphate-buffered saline (PBS), persistent and strong fluorescence signals are observed in the tumor region, with low background signals from normal tissues at 1, 3, 12, and 24 h after injection. Furthermore, these in vivo imaging results concurred with ex vivo biodistribution and histological results.
MeSH term(s)	Animals ; Mice ; Tissue Distribution ; Nanostructures ; Neoplasms ; Molecular Imaging ; Optical Imaging
Language	English
Publishing date	2023-04-17
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202300462
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Article ; Online: Hippocampal Perfusion Affects Motor and Cognitive Functions in Parkinson Disease: An Early Phase

Chun, Min Young / Chung, Seok Jong / Kim, Su Hong / Park, Chan Wook / Jeong, Seong Ho / Lee, Hye Sun / Lee, Phil Hyu / Sohn, Young H / Jeong, Yong / Kim, Yun Joong

Annals of neurology

2023 Volume 95, Issue 2, Page(s) 388–399

Abstract: Objective: We investigated whether hippocampal perfusion changes are associated with cognitive decline, motor deficits, and the risk of dementia conversion in patients with Parkinson disease (PD).: Methods: We recruited patients with newly diagnosed ... ...

Abstract	Objective: We investigated whether hippocampal perfusion changes are associated with cognitive decline, motor deficits, and the risk of dementia conversion in patients with Parkinson disease (PD). Methods: We recruited patients with newly diagnosed and nonmedicated PD and healthy participants who underwent dual phase Results: We included 235 patients (PD-hippo-hypo, n = 21; PD-hippo-normal, n = 157; PD-hippo-hyper, n = 57) and 48 healthy participants. Patients in the PD-hippo-hypo group were older and had smaller hippocampal volumes than those in the other PD groups. The PD-hippo-hypo group showed less severely decreased DAT availability in the putamen than the other groups despite similar severities of motor deficit. The PD-hippo-hypo group had a higher risk of dementia conversion compared to the PD-hippo-normal (hazard ratio = 2.59, p = 0.013) and PD-hippo-hyper (hazard ratio = 3.73, p = 0.006) groups, despite similar cognitive performance at initial assessment between groups. Interpretation: Hippocampal hypoperfusion may indicate a reduced capacity to cope with neurodegenerative processes in terms of the development of motor deficits and cognitive decline in patients with PD. ANN NEUROL 2024;95:388-399.
MeSH term(s)	Humans ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Positron-Emission Tomography/methods ; Tropanes ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Cognition ; Hippocampus/diagnostic imaging ; Hippocampus/metabolism ; Dementia/complications ; Perfusion ; Tomography, Emission-Computed, Single-Photon/methods
Chemical Substances	2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane (155797-99-2) ; Tropanes ; Dopamine Plasma Membrane Transport Proteins
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.26827
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Zs.MO 478: Show issues

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