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  1. Article ; Online: Closing the gap between murine neutrophils and neutrophil-like cell lines.

    Allen, Lee-Ann H

    Journal of leukocyte biology

    2023  Volume 114, Issue 3, Page(s) 199–201

    MeSH term(s) Animals ; Mice ; Humans ; Neutrophils/metabolism ; HL-60 Cells ; NADPH Oxidases/metabolism
    Chemical Substances NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: PCNA at the crossroads of human neutrophil activation, metabolism, and survival.

    Allen, Lee-Ann H

    Journal of leukocyte biology

    2023  Volume 115, Issue 2, Page(s) 201–204

    MeSH term(s) Humans ; Neutrophils/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Neutrophil Activation ; Granulocyte Colony-Stimulating Factor/metabolism ; NADPH Oxidases/metabolism ; Glycolysis
    Chemical Substances Proliferating Cell Nuclear Antigen ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Metabolic Reprogramming Mediates Delayed Apoptosis of Human Neutrophils Infected With

    Krysa, Samantha J / Allen, Lee-Ann H

    Frontiers in immunology

    2022  Volume 13, Page(s) 836754

    Abstract: Neutrophils (polymorphonuclear leukocytes, PMNs) have a distinctively short lifespan, and tight regulation of cell survival and death is imperative for their normal function. We demonstrated previously ... ...

    Abstract Neutrophils (polymorphonuclear leukocytes, PMNs) have a distinctively short lifespan, and tight regulation of cell survival and death is imperative for their normal function. We demonstrated previously that
    MeSH term(s) Apoptosis/physiology ; Francisella tularensis ; Glucose/metabolism ; Glycogen/metabolism ; Humans ; Neutrophils ; Tularemia
    Chemical Substances Glycogen (9005-79-2) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.836754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neutrophil Survival Signaling During

    Kinkead, Lauren C / Krysa, Samantha J / Allen, Lee-Ann H

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 889290

    Abstract: Neutrophils are the most abundant and shortest-lived leukocytes in humans and tight regulation of neutrophil ... ...

    Abstract Neutrophils are the most abundant and shortest-lived leukocytes in humans and tight regulation of neutrophil turnover
    MeSH term(s) Apoptosis/physiology ; Francisella tularensis ; Humans ; NF-kappa B/metabolism ; Neutrophils/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Protein Isoforms/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Tularemia/microbiology
    Chemical Substances NF-kappa B ; Protein Isoforms ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-07-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.889290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Microtubules and Dynein Regulate Human Neutrophil Nuclear Volume and Hypersegmentation During

    Silva-Del Toro, Stephanie L / Allen, Lee-Ann H

    Frontiers in immunology

    2021  Volume 12, Page(s) 653100

    Abstract: Neutrophils (also called polymorphonuclear leukocytes, PMNs) are heterogeneous and can exhibit considerable phenotypic and functional plasticity. In keeping with this, we discovered previously ... ...

    Abstract Neutrophils (also called polymorphonuclear leukocytes, PMNs) are heterogeneous and can exhibit considerable phenotypic and functional plasticity. In keeping with this, we discovered previously that
    MeSH term(s) Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cells, Cultured ; Centrosome/drug effects ; Centrosome/metabolism ; Dyneins/metabolism ; Helicobacter Infections/immunology ; Helicobacter Infections/microbiology ; Helicobacter pylori/immunology ; Humans ; Intravital Microscopy ; Microtubules/metabolism ; Neutrophils/cytology ; Neutrophils/drug effects ; Neutrophils/immunology ; Neutrophils/metabolism ; Nocodazole/pharmacology ; Paclitaxel/pharmacology ; Primary Cell Culture ; Tubulin Modulators/pharmacology
    Chemical Substances Tubulin Modulators ; Dyneins (EC 3.6.4.2) ; Paclitaxel (P88XT4IS4D) ; Nocodazole (SH1WY3R615)
    Language English
    Publishing date 2021-03-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.653100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: NR4A proteins and neutrophil lifespan.

    Allen, Lee-Ann H

    Blood

    2017  Volume 130, Issue 8, Page(s) 958–959

    MeSH term(s) Neutrophils ; Nuclear Receptor Subfamily 4, Group A, Member 1 ; Nuclear Receptor Subfamily 4, Group A, Member 2
    Chemical Substances Nuclear Receptor Subfamily 4, Group A, Member 1 ; Nuclear Receptor Subfamily 4, Group A, Member 2
    Language English
    Publishing date 2017-08-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-07-793380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  7. Article ; Online: Helicobacter pylori

    Prichard, Allan / Khuu, Lisa / Whitmore, Laura C / Irimia, Daniel / Allen, Lee-Ann H

    Frontiers in immunology

    2022  Volume 13, Page(s) 1038349

    Abstract: Helicobacter ... ...

    Abstract Helicobacter pylori
    MeSH term(s) Humans ; Chemotaxis ; Neutrophils/metabolism ; Helicobacter pylori/metabolism ; Nonmuscle Myosin Type IIA/metabolism ; Leukocyte Disorders/metabolism ; Actins/metabolism ; Myosin Light Chains/metabolism
    Chemical Substances Nonmuscle Myosin Type IIA (EC 3.6.1.-) ; Actins ; Myosin Light Chains
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1038349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Phagocytosis and neutrophil extracellular traps.

    DeLeo, Frank R / Allen, Lee-Ann H

    Faculty reviews

    2020  Volume 9, Page(s) 25

    Abstract: Neutrophils are recruited rapidly to sites of infection in response to host- and/or microbe-derived proinflammatory molecules. At such sites, neutrophils phagocytose microbes and are activated to produce superoxide and other reactive oxygen species (ROS). ...

    Abstract Neutrophils are recruited rapidly to sites of infection in response to host- and/or microbe-derived proinflammatory molecules. At such sites, neutrophils phagocytose microbes and are activated to produce superoxide and other reactive oxygen species (ROS). In addition, neutrophils contain stores of antimicrobial peptides and enzymes that work in concert with ROS to kill ingested microbes. Neutrophils can also release chromosomal DNA bound with antimicrobial peptides and enzymes to form web-like structures known as extracellular traps. Neutrophil extracellular traps (NETs) have been reported to ensnare and kill microbes and are commonly considered to be an important component of innate host defense. Notably, the formation of NETs is most often reported as a cytolytic process. Whereas intraphagosomal killing of microbes sequesters cytotoxic antimicrobial molecules that would otherwise damage host tissues, the formation of NETs and associated extracellular release of these molecules can contribute to host tissue destruction and disease. Here we compare and contrast phagocytosis and NETs in host defense, with emphasis on recent studies of NETs that ultimately underscore the importance of phagocytosis as the primary means by which neutrophils eliminate microbes.
    Language English
    Publishing date 2020-12-21
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-432X
    ISSN (online) 2732-432X
    DOI 10.12703/r/9-25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cell intrinsic functions of neutrophils and their manipulation by pathogens.

    Allen, Lee-Ann H / Criss, Alison K

    Current opinion in immunology

    2019  Volume 60, Page(s) 124–129

    Abstract: Neutrophils are a crucial first line of defense against infection, migrating rapidly into tissues where they deploy granule components and toxic oxidants for efficient phagocytosis and microbe killing. Subsequent apoptosis and clearance of dying ... ...

    Abstract Neutrophils are a crucial first line of defense against infection, migrating rapidly into tissues where they deploy granule components and toxic oxidants for efficient phagocytosis and microbe killing. Subsequent apoptosis and clearance of dying neutrophils are essential for control of infection and resolution of the inflammatory response. A subset of microbial pathogens survive exposure to neutrophils by manipulating phagocytosis, phagosome-granule fusion, oxidant production, and lifespan. Elucidating how they accomplish this unusual feat provides new insights into normal neutrophil function. In this review, we highlight recent discoveries about the ways in which neutrophils use cell-intrinsic mechanisms to control infection, and how these defenses are subverted by pathogens.
    MeSH term(s) Animals ; Biomarkers ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Neutrophils/physiology ; Oxidation-Reduction ; Oxidative Stress ; Phagocytosis/immunology ; Phagosomes/metabolism ; Reactive Oxygen Species
    Chemical Substances Biomarkers ; Reactive Oxygen Species
    Language English
    Publishing date 2019-07-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2019.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2773: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 13: Show issues

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  10. Article ; Online: Immunofluorescence and confocal microscopy of neutrophils.

    Allen, Lee-Ann H

    Methods in molecular biology (Clifton, N.J.)

    2014  Volume 1124, Page(s) 251–268

    Abstract: Rapid recruitment of neutrophils to sites of infection and their ability to phagocytose and kill microbes is an important aspect of the innate immune response. Challenges associated with imaging of these cells include their short lifespan and small size ... ...

    Abstract Rapid recruitment of neutrophils to sites of infection and their ability to phagocytose and kill microbes is an important aspect of the innate immune response. Challenges associated with imaging of these cells include their short lifespan and small size and the fact that unstimulated cells are nonadherent. In addition, although cytoplasmic granules are plentiful, the abundance of many other organelles is diminished. Here we reprise methods for analysis of resting and activated cells using immunofluorescence and confocal microscopy, including kinetic analysis of phagosome maturation and degranulation, and detection of intraphagosomal superoxide accumulation. We describe approaches for rapid cell fixation and permeabilization that maximize antigen detection and discuss other variables that also affect data interpretation and image quality (such as cell spreading, degranulation, and phagocytosis). Finally, we show that these methods are also applicable to studies of neutrophil interactions with the extracellular matrix.
    MeSH term(s) Cell Culture Techniques ; Humans ; Microscopy, Confocal/methods ; Microscopy, Fluorescence/methods ; Neutrophils/cytology ; Neutrophils/immunology
    Language English
    Publishing date 2014-02-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-62703-845-4_16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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