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  1. Book ; Online ; E-Book: Albumin in medicine

    Otagiri, Masaki / Chuang, Victor Tuan Giam

    pathological and clinical applications

    2016  

    Author's details Masaki Otagiri, Victor Tuan Giam Chuang editors
    Keywords Serum albumin ; Ligand binding ; Genetic variants ; Disease treatment ; Pathological conditions ; Drug delivery systems
    Language English
    Size 1 Online-Ressource (x, 277 Seiten), Illustrationen
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019157292
    ISBN 978-981-10-2116-9 ; 9789811021152 ; 981-10-2116-3 ; 9811021155
    DOI 10.1007/978-981-10-2116-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Possible Involvement of Protein Binding Inhibition in Changes in Dexmedetomidine Concentration in Extracorporeal Circuits during Midazolam Use.

    Yamasaki, Keishi / Tokuno, Masahiro / Tsukigawa, Kenji / Nagatsuka, Yuka / Nishi, Koji / Otagiri, Masaki / Sato, Yuhki

    Biological & pharmaceutical bulletin

    2024  Volume 47, Issue 2, Page(s) 389–393

    Abstract: It was recently reported that the dexmedetomidine concentration within the extracorporeal circuit decreases with co-administration of midazolam. In this study, we investigated whether displacement of dexmedetomidine by midazolam from the binding site of ... ...

    Abstract It was recently reported that the dexmedetomidine concentration within the extracorporeal circuit decreases with co-administration of midazolam. In this study, we investigated whether displacement of dexmedetomidine by midazolam from the binding site of major plasma proteins, human serum albumin (HSA) and α
    MeSH term(s) Humans ; Protein Binding/physiology ; Midazolam ; Dexmedetomidine/pharmacology ; Blood Proteins/metabolism ; Orosomucoid/metabolism ; Serum Albumin, Human/metabolism
    Chemical Substances Midazolam (R60L0SM5BC) ; Dexmedetomidine (67VB76HONO) ; Blood Proteins ; Orosomucoid ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2024-02-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b23-00659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Carbon Monoxide Alleviates Post-ischemia-reperfusion Skeletal Muscle Injury and Systemic Inflammation.

    Taguchi, Kazuaki / Ogaki, Shigeru / Maeda, Hitoshi / Ishima, Yu / Watanabe, Hiroshi / Otagiri, Masaki / Maruyama, Toru

    Biological & pharmaceutical bulletin

    2024  Volume 47, Issue 4, Page(s) 868–871

    Abstract: Restoration of blood flow in skeletal muscle after a prolonged period of ischemia induces muscular ischemia-reperfusion injury, leading to local injury/dysfunction in muscles followed by systemic inflammatory responses. However, preventive/curative ... ...

    Abstract Restoration of blood flow in skeletal muscle after a prolonged period of ischemia induces muscular ischemia-reperfusion injury, leading to local injury/dysfunction in muscles followed by systemic inflammatory responses. However, preventive/curative agents for skeletal muscle ischemia injury are unavailable in clinics to date. Increasing evidence has validated that carbon monoxide (CO) prevents the progression of ischemia-reperfusion injury in various organs owing to its versatile bioactivity. Previously, we developed a bioinspired CO donor, CO-bound red blood cells (CO-RBC), which mimics the dynamics of RBC-associated CO in the body. In the present study, we have tested the therapeutic potential of CO-RBC in muscular injury/dysfunction and secondary systemic inflammation induced by skeletal muscle ischemia-reperfusion. The results indicate that CO-RBC rather than RBC alone suppressed elevation of plasma creatine phosphokinase, a marker of muscular injury, in rats subjected to both hind limbs ischemia-reperfusion. In addition, the results of the treadmill walking test revealed a significantly decreased muscular motor function in RBC-treated rats subjected to both hind limbs ischemia-reperfusion than that in healthy rats, however, CO-RBC treatment facilitated sustained muscular motor functions after hind limbs ischemia-reperfusion. Furthermore, CO-RBC rather than RBC suppressed the production of tumour necrosis factor (TNF)-α and interleukin (IL)-6, which were upregulated by muscular ischemia-reperfusion. Interestingly, CO-RBC treatment induced higher levels of IL-10 compared to saline or RBC treatments. Based on these findings, we suggest that CO-RBC exhibits a suppressive effect against skeletal muscle injury/dysfunction and systemic inflammatory responses after skeletal muscle ischemia-reperfusion.
    MeSH term(s) Animals ; Reperfusion Injury/drug therapy ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Carbon Monoxide ; Male ; Inflammation/drug therapy ; Rats, Sprague-Dawley ; Erythrocytes/drug effects ; Erythrocytes/metabolism ; Rats ; Creatine Kinase/blood ; Hindlimb/blood supply ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/blood ; Interleukin-6/metabolism ; Interleukin-6/blood
    Chemical Substances Carbon Monoxide (7U1EE4V452) ; Creatine Kinase (EC 2.7.3.2) ; Tumor Necrosis Factor-alpha ; Interleukin-6
    Language English
    Publishing date 2024-03-31
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b23-00917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: [Characterization of Supersulfide in Serum Albumin and Its Therapeutic Application].

    Ikeda, Mayumi / Fukuta, Tatsuya / Iwao, Yasunori / Otagiri, Masaki / Maruyama, Toru / Ishida, Tatsuhiro / Ishima, Yu

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2023  Volume 144, Issue 1, Page(s) 51–56

    Abstract: Recent studies have shown that proteins already possess supersulfides during the translation. However, the distribution and the role of supersulfides are not fully understood. In this review, we focus on supersulfides in biological fluids, especially in ... ...

    Abstract Recent studies have shown that proteins already possess supersulfides during the translation. However, the distribution and the role of supersulfides are not fully understood. In this review, we focus on supersulfides in biological fluids, especially in serum. Various methods for measuring supersulfides have been developed, and these methods have elucidated the presence of supersulfides in serum proteins including serum albumin. Since the levels of supersulfides in serum and serum albumin of patients with chronic kidney disease were lower than those in healthy subjects and recovered by hemodialysis, the levels of supersulfides in serum would be an indicator reflecting oxidative stress. In addition, it has long been known that serum albumin is responsible for sulfur transference. We have applied this phenomenon to the synthesis of sulfur-added albumin (S
    MeSH term(s) Humans ; Serum Albumin/metabolism ; Oxidative Stress ; Oxidation-Reduction ; Renal Insufficiency, Chronic ; Sulfur
    Chemical Substances Serum Albumin ; Sulfur (70FD1KFU70)
    Language Japanese
    Publishing date 2023-12-14
    Publishing country Japan
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.23-00162-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways.

    Ikeda-Imafuku, Mayumi / Fukuta, Tatsuya / Tuan Giam Chuang, Victor / Sawa, Tomohiro / Maruyama, Toru / Otagiri, Masaki / Ishida, Tatsuhiro / Ishima, Yu

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 1

    Abstract: Oxidative stress is responsible for the onset and progression of various kinds of diseases including rhabdomyolysis-induced acute kidney injury (AKI). Antioxidants are, therefore, thought to aid in the recovery of illnesses linked to oxidative stress. ... ...

    Abstract Oxidative stress is responsible for the onset and progression of various kinds of diseases including rhabdomyolysis-induced acute kidney injury (AKI). Antioxidants are, therefore, thought to aid in the recovery of illnesses linked to oxidative stress. Supersulfide species have been shown to have substantial antioxidative activity; however, due to their limited bioavailability, few supersulfide donors have had their actions evaluated in vivo. In this study, human serum albumin (HSA) and N-acetyl-L-cysteine polysulfides (NACSn), which have polysulfides in an oxidized form, were conjugated to create a supersulfide donor. HSA is chosen to be a carrier of NACSn because of its extended blood circulation and high level of biocompatibility. In contrast to a supersulfide donor containing reduced polysulfide in HSA, the NACSn-conjugated HSAs exhibited stronger antioxidant activity than HSA and free NACSn without being uptaken by the cells in vitro. The supersulfide donor reduced the levels of blood urea nitrogen and serum creatinine significantly in a mouse model of rhabdomyolysis-induced AKI. Supersulfide donors significantly reduced the expression of oxidative stress markers in the kidney. These results indicate that the developed supersulfide donor has the therapeutic effect on rhabdomyolysis-induced AKI.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Liposomal methemoglobin as a potent antidote for hydrogen sulfide poisoning.

    Suzuki, Yuto / Taguchi, Kazuaki / Kure, Tomoko / Enoki, Yuki / Otagiri, Masaki / Sakai, Hiromi / Matsumoto, Kazuaki

    Toxicology and applied pharmacology

    2022  Volume 450, Page(s) 116159

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    MeSH term(s) Antidotes/pharmacology ; Antidotes/therapeutic use ; Cyanides ; Humans ; Hydrogen Sulfide/metabolism ; Methemoglobin/metabolism ; Methemoglobin/pharmacology ; Poisoning/drug therapy
    Chemical Substances Antidotes ; Cyanides ; Methemoglobin (9008-37-1) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2022.116159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Serum Albumin, Lipid and Drug Binding.

    Nishi, Koji / Yamasaki, Keishi / Otagiri, Masaki

    Sub-cellular biochemistry

    2020  Volume 94, Page(s) 383–397

    Abstract: Albumin is widely conserved from vertebrates to invertebrates, and nature of mammalian albumins permit them to bind various endogenous ligands and drugs in the blood. It is known that at least two major ligand binding sites are present on the albumin ... ...

    Abstract Albumin is widely conserved from vertebrates to invertebrates, and nature of mammalian albumins permit them to bind various endogenous ligands and drugs in the blood. It is known that at least two major ligand binding sites are present on the albumin molecule, which are referred to as Site I and Site II. These binding sites are thought to be almost completely conserved among mammals, even though the degree of binding to these sites are different depending on the physical and chemical properties of drugs and differences in the microenvironment in the binding pockets. In addition, the binding sites for medium and long-chain fatty acids are also well conserved among mammals, and it is considered that there are at least seven binding sites, including Site I and Site II. These bindings properties of albumin in the blood are also widely known to be important for transporting drugs and fatty acids to various tissues. It can therefore be concluded that albumin is one of the most important serum proteins for various ligands, and information on human albumin can be very useful in predicting the ligand binding properties of the albumin of other vertebrates.
    MeSH term(s) Animals ; Binding Sites ; Fatty Acids/chemistry ; Fatty Acids/metabolism ; Humans ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Protein Binding ; Serum Albumin/chemistry ; Serum Albumin/metabolism
    Chemical Substances Fatty Acids ; Pharmaceutical Preparations ; Serum Albumin
    Language English
    Publishing date 2020-03-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-030-41769-7_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: [Strategy of Drug Development Based on the Bioactive Gas-carrying Capacity of Hemoglobin].

    Taguchi, Kazuaki / Matsumoto, Kazuaki / Maruyama, Toru / Otagiri, Masaki

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2020  Volume 140, Issue 2, Page(s) 141–146

    Abstract: Bioactive gas molecules, including oxygen, nitric oxide and carbon monoxide (CO), exhibit a variety of physiological activities, and are associated with the onset and progress of some disorders. These facts have led researchers to the development of ... ...

    Abstract Bioactive gas molecules, including oxygen, nitric oxide and carbon monoxide (CO), exhibit a variety of physiological activities, and are associated with the onset and progress of some disorders. These facts have led researchers to the development of bioactive gas donors for the treatment of intractable disorders. Hemoglobin is likely an ideal carrier of bioactive gases, since hemoglobin in red blood cells innately carries oxygen in the form of oxyhemoglobin, nitric oxide in the form of S-nitrosohemoglobin, and CO in the form of carbonylhemoglobin. In this study, we attempted to develop a biomimetic CO delivery system using a preparation of hemoglobin. Our strategy for the preparation of this hemoglobin-based CO carrier involves CO being exogenously bound to red blood cells or hemoglobin-encapsulated liposomes, called hemoglobin-vesicles (HbV), which mimic the structure and function of red blood cells. We accumulated evidence that the CO donors-CO-bound red blood cells and CO-bound HbV-showed therapeutic efficacy against intractable disorders in animal models. Here, we describe the potential of hemoglobin-based CO donors, especially CO-bound red blood cells and CO-bound HbV, for the treatment of certain disorders. Hemoglobin-based strategies for the delivery of other bioactive gases for novel drug development are also discussed.
    MeSH term(s) Carbon Monoxide/metabolism ; Drug Development ; Erythrocytes/metabolism ; Hemoglobins/metabolism ; Humans ; Nitric Oxide/metabolism ; Oxygen/metabolism
    Chemical Substances Hemoglobins ; Nitric Oxide (31C4KY9ESH) ; Carbon Monoxide (7U1EE4V452) ; Oxygen (S88TT14065)
    Language Japanese
    Publishing date 2020-01-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.19-00187-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Drug Delivery System for Refractory Cancer Therapy via an Endogenous Albumin Transport System.

    Ishima, Yu / Maruyama, Toru / Otagiri, Masaki / Ishida, Tatsuhiro

    Chemical & pharmaceutical bulletin

    2020  Volume 68, Issue 7, Page(s) 583–588

    Abstract: A unique phenomenon in solid tumors, the enhanced permeability and retention (EPR) effect is now well known in the development of macromolecular anticancer therapy. However, cancers with low vascular permeability have posed a challenge for these EPR ... ...

    Abstract A unique phenomenon in solid tumors, the enhanced permeability and retention (EPR) effect is now well known in the development of macromolecular anticancer therapy. However, cancers with low vascular permeability have posed a challenge for these EPR based therapeutic systems. An intrinsic vascular modulator, such as nitric oxide (NO), could augment the endogenous EPR effect. However, the most important aim has been to construct an effective NO delivery system for cancer. Since it is well known that human serum albumin is one of the most important endogenous NO transport proteins in human circulation, for more than a decade we have demonstrated that S-nitrosated human serum albumin dimer (SNO-HSA-Dimer) becomes an enhancer of the EPR effect. Here, we summarize the enhanced effect of SNO-HSA-Dimer on the anticancer effect of macromolecular anticancer drugs such as PEGylated liposomal doxorubicin (Doxil
    MeSH term(s) Animals ; Antibiotics, Antineoplastic/chemistry ; Antibiotics, Antineoplastic/therapeutic use ; Doxorubicin/chemistry ; Doxorubicin/therapeutic use ; Drug Delivery Systems ; Humans ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Nitric Oxide/chemistry ; Nitric Oxide/metabolism ; Serum Albumin/chemistry ; Serum Albumin/metabolism
    Chemical Substances Antibiotics, Antineoplastic ; Serum Albumin ; Nitric Oxide (31C4KY9ESH) ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2020-07-01
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c20-00026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hepatic Cytochrome P450 Profiles in Hemorrhagic Shock Model Rats After Transfusion With Stored Red Blood Cells.

    Tokuno, Masahiro / Taguchi, Kazuaki / Yamasaki, Keishi / Otagiri, Masaki

    Journal of pharmaceutical sciences

    2020  Volume 109, Issue 11, Page(s) 3490–3495

    Abstract: Red cell transfusions, which deteriorate in quality during storage, triggers several negative biological responses. However, little is known regarding the effects of stored red cell transfusion on cytochrome P450 (P450) profiles. To clarify this issue, ... ...

    Abstract Red cell transfusions, which deteriorate in quality during storage, triggers several negative biological responses. However, little is known regarding the effects of stored red cell transfusion on cytochrome P450 (P450) profiles. To clarify this issue, we investigated hepatic P450 profiles in hemorrhagic shock model rats after resuscitation with stored packed red cells (PRC). The pharmacokinetics data for P450-metabolizing substrates showed that the clearance of substrates for Cyp1A2 and Cyp3A2 in the stored PRC resuscitation group were decreased compared to sham group. The protein expression, metabolic activity and mRNA expression of the P450 isoforms in the stored PRC resuscitation group were lower than the corresponding values for the sham group. However, these changes would be expected to have weak effects on the in vivo pharmacokinetics of the concomitant drugs based on the criteria stated in the guideline on drug interactions. In contrast, the results of these P450 profiles in the stored PRC and fresh PRC resuscitation group exhibited a similar trend. These results suggest that the stored PRC transfusion has an influence on the hepatic P450 profiles, but is of little clinical significance, not by the deterioration of the quality of red cells but pathophysiological alterations following the hemorrhage and transfusion.
    MeSH term(s) Animals ; Cytochrome P-450 Enzyme System/genetics ; Erythrocytes ; Liver ; Pharmaceutical Preparations ; Rats ; Rats, Sprague-Dawley ; Shock, Hemorrhagic/therapy
    Chemical Substances Pharmaceutical Preparations ; Cytochrome P-450 Enzyme System (9035-51-2)
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2020.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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