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Article ; Online: [Pharmacokinetic Study of Antiviral Drugs in Patients with COVID-19].

Irie, Kei

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

2023 Volume 143, Issue 3, Page(s) 239–241

Abstract: The Faculty of Pharmaceutical Sciences, Kobe Gakuin University has collaborated in clinical research with Kobe City Medical Center General Hospital. In this university-medical institution collaboration, university faculty members discuss clinical ... ...

Abstract	The Faculty of Pharmaceutical Sciences, Kobe Gakuin University has collaborated in clinical research with Kobe City Medical Center General Hospital. In this university-medical institution collaboration, university faculty members discuss clinical problems with on-site pharmacists and doctors, and carry out clinical research to resolve these problems. During the coronavirus disease 2019 (COVID-19) pandemic, many patients with COVID-19 were treated at Kobe City Medical Center General Hospital. In February 2020, during the first increase in the number of patients with COVID-19 in Japan, treatment for COVID-19 was not established, and some existing anti-viral drugs, such as favipiravir, were experimentally used for COVID-19 treatment. However, since these drugs were not developed specifically for treating COVID-19, their pharmacokinetics have not been sufficiently studied. In particular, the pharmacokinetics of favipiravir in critically ill patients with COVID-19 was of concern, because critically ill patients have an urgent need for life-saving anti-viral drug treatment. Therefore, we conducted a collaborative clinical study to evaluate the pharmacokinetics of favipiravir in patients with COVID-19. The blood concentration of favipiravir in patients with COVID-19 at Kobe City Medical Center General Hospital was measured by lipid chromatography-tandem mass spectrometry at Kobe Gakuin University. Population pharmacokinetics analysis was then performed. In this symposium review, we introduce our pharmacokinetic study of antiviral drugs in patients with COVID-19, focusing on the university-medical institution collaboration. We believe collaborative clinical research will be useful for solving clinical issues and ensuring the effectiveness and safety of pharmacotherapies.
MeSH term(s)	Humans ; Antiviral Agents ; COVID-19 ; COVID-19 Drug Treatment ; Critical Illness
Chemical Substances	Antiviral Agents ; favipiravir (EW5GL2X7E0)
Language	Japanese
Publishing date	2023-03-01
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	200514-1
ISSN	1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
ISSN (online)	1347-5231
ISSN	0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
DOI	10.1248/yakushi.22-00169-1
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Zs.A 643: Show issues

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Article ; Online: Cerebrospinal fluid concentration of foscarnet in patients with HHV-6 encephalitis after haematopoietic stem cell transplantation.

Irie, Kei / Hiramoto, Nobuhiro / Yamaoka, Kenta / Fuckushima, Shoji

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 6, Page(s) 1549–1551

MeSH term(s)	Humans ; Foscarnet/therapeutic use ; Herpesvirus 6, Human ; Hematopoietic Stem Cell Transplantation/adverse effects ; Antiviral Agents/therapeutic use ; Encephalitis, Viral/drug therapy ; Roseolovirus Infections/drug therapy ; DNA, Viral
Chemical Substances	Foscarnet (364P9RVW4X) ; Antiviral Agents ; DNA, Viral
Language	English
Publishing date	2023-04-18
Publishing country	England
Document type	Letter
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad117
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article: Encephalopathy induced by high levels of ceftriaxone in the blood and cerebrospinal fluid.

Minamii, Takahiro / Shimizu, Hayato / Irie, Kei / Nishioka, Hiroaki

IDCases

2022 Volume 29, Page(s) e01581

Abstract: Ceftriaxone is commonly used to treat bacterial infections. Encephalopathy is a rare adverse effect of ceftriaxone therapy, and most cases have been diagnosed based on medical history. We report a case of a 73-year-old woman with ceftriaxone-associated ... ...

Abstract	Ceftriaxone is commonly used to treat bacterial infections. Encephalopathy is a rare adverse effect of ceftriaxone therapy, and most cases have been diagnosed based on medical history. We report a case of a 73-year-old woman with ceftriaxone-associated encephalopathy, which was confirmed by measuring the ceftriaxone levels in the blood and cerebrospinal fluid. She regularly underwent hemodialysis. She received intravenous ceftriaxone at a dose of 1 g/day for 4 days for enteritis, and mental status began to be disturbed during the therapy. Six days after ceftriaxone discontinuation, her consciousness level rapidly improved. Thus, ceftriaxone-associated encephalopathy was suspected. High ceftriaxone levels in the blood and cerebrospinal fluid were observed while the patient had disturbed consciousness. This case indicated that high ceftriaxone levels in the blood and cerebrospinal fluid were related to development of encephalopathy. The estimation of ceftriaxone levels may be useful for an accurate diagnosis.
Language	English
Publishing date	2022-07-26
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2022.e01581
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Article ; Online: Ceftriaxone-associated encephalopathy in a patient with high levels of ceftriaxone in blood and cerebrospinal fluid.

Nishioka, Hiroaki / Cho, Yojiro / Irie, Kei / Kanamori, Maki

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 116, Page(s) 223–225

Abstract: Neurotoxicity is a rare and intolerable adverse effect of ceftriaxone therapy. In most cases, it has been diagnosed on the basis of medical history rather than quantitative blood and cerebrospinal fluid testing. We report the case of a woman aged 78 ... ...

Abstract	Neurotoxicity is a rare and intolerable adverse effect of ceftriaxone therapy. In most cases, it has been diagnosed on the basis of medical history rather than quantitative blood and cerebrospinal fluid testing. We report the case of a woman aged 78 years with ceftriaxone-associated encephalopathy. She regularly underwent hemodialysis. The patient received intravenous ceftriaxone at a dose of 1 g/day for 10 days for a urinary tract infection, and her consciousness level began to deteriorate during the therapy. Five days after ceftriaxone discontinuation, her symptoms rapidly improved. Thus, ceftriaxone-associated encephalopathy was suspected. Ceftriaxone levels in the blood and cerebrospinal fluid were high while the patient had disturbed consciousness. This case showed that ceftriaxone levels were related to ceftriaxone-associated encephalopathy. Therefore, the estimation of ceftriaxone levels may facilitate an accurate diagnosis.
MeSH term(s)	Aged ; Anti-Bacterial Agents/adverse effects ; Brain Diseases ; Ceftriaxone/adverse effects ; Female ; Humans ; Renal Dialysis ; Urinary Tract Infections/drug therapy
Chemical Substances	Anti-Bacterial Agents ; Ceftriaxone (75J73V1629)
Language	English
Publishing date	2022-01-19
Publishing country	Canada
Document type	Case Reports
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2022.01.023
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Zs.A 4516: Show issues

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Article ; Online: Use of liquid chromatography-tandem mass spectrometry for foscarnet quantification in human serum and cerebrospinal fluid.

Irie, Kei / Hiramoto, Nobuhiro / Ishikawa, Takayuki / Fukushima, Shoji

Rapid communications in mass spectrometry : RCM

2022 Volume 36, Issue 7, Page(s) e9255

Abstract: Rationale: Foscarnet (FCV) is used to treat cytomegalovirus, human herpesvirus, and human immunodeficiency virus infections. It is a low-molecular-weight compound containing carboxylate and phosphate groups. There are no reports on the use of liquid ... ...

Abstract	Rationale: Foscarnet (FCV) is used to treat cytomegalovirus, human herpesvirus, and human immunodeficiency virus infections. It is a low-molecular-weight compound containing carboxylate and phosphate groups. There are no reports on the use of liquid chromatography-tandem mass spectrometry (LC/MS/MS) to analyze FCV via bioanalysis. In the present study, we developed the ion-pair LC/MS/MS method to analyze FCV in human serum and cerebrospinal fluid (CSF). Methods: FCV was extracted from human serum and CSF by weak anion exchange (WAX) solid-phase extraction. The LC/MS/MS systems were coated with 0.1% phosphoric acid in methanol to avoid nonspecific absorption. FCV was detected using ion-pair LC/MS/MS with dibutylammonium acetate. Selected reaction monitoring transition of FCV in the negative ion mode was selected at m/z 125.1 → 62.9. Results: FCV was selectively detected in human serum and CSF, and the liner range was 5-1000 μM (R Conclusions: A robust LC/MS/MS method to analyze FCV was successfully developed. FCV was selectively measured using LC/MS/MS in very low extract volumes (20 μL). The method will be useful in evaluating the FCV level in human serum and CSF.
MeSH term(s)	Chromatography, High Pressure Liquid ; Chromatography, Liquid/methods ; Foscarnet ; Humans ; Reproducibility of Results ; Solid Phase Extraction ; Tandem Mass Spectrometry/methods
Chemical Substances	Foscarnet (364P9RVW4X)
Language	English
Publishing date	2022-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	58731-x
ISSN	1097-0231 ; 0951-4198
ISSN (online)	1097-0231
ISSN	0951-4198
DOI	10.1002/rcm.9255
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Zs.A 3461: Show issues

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Article ; Online: Prototype and evaluation of automatic fingertip-blood-sampling system that uses fingertip blood-vessel images to determine puncture position.

Takenaka, Kei / Oyamada, Yuji / Kato, Masahiro / Nagasaka, Akio / Hokari, Junpei / Irie, Takashi / Tsukada, Nobuhiro / Yanagida, Atsushi

Medical engineering & physics

2024 Volume 125, Page(s) 104121

Abstract: We are developing an automatic fingertip-blood-sampling system to reduce the burden on trained medical personnel. For this system to withdraw a consistent volume of sampled blood for blood tests, we developed a mechanism for our system to select and ... ...

Abstract	We are developing an automatic fingertip-blood-sampling system to reduce the burden on trained medical personnel. For this system to withdraw a consistent volume of sampled blood for blood tests, we developed a mechanism for our system to select and puncture the vicinity of a large blood vessel from the blood-vessel image of an individual's fingertip. We call this mechanism the fingertip-vessel-puncture mechanism. From the results of an experiment in which the fingertips of 20 individuals (men and women in their 20 s to 60 s) were manually punctured at near and far locations from the blood vessel selected with our mechanism, the following conclusions were obtained. The fingertip-vessel-puncture mechanism tends to increase the volume of sampled blood, thus is effective in sampling more than 650 µL of blood for automatic blood analyzers. It was also found that it is more effective in increasing the volume of sampled blood in the men and those who were younger.
MeSH term(s)	Male ; Humans ; Female ; Blood Specimen Collection/methods ; Fingers
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1181080-4
ISSN	1873-4030 ; 1350-4533
ISSN (online)	1873-4030
ISSN	1350-4533
DOI	10.1016/j.medengphy.2024.104121
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Zs.B 2231: Show issues

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Article ; Online: High Estimated Glomerular Filtration Rate and Risk of Cancer Mortality in a Japanese Cohort Study: The Ibaraki Prefectural Health Study.

Nagai, Kei / Sairenchi, Toshimi / Yamagata, Kunihiro / Yamagishi, Kazumasa / Iso, Hiroyasu / Irie, Fujiko

JMA journal

2022 Volume 5, Issue 4, Page(s) 546–550

Language	English
Publishing date	2022-09-26
Publishing country	Japan
Document type	Journal Article
ZDB-ID	3053329-6
ISSN	2433-3298 ; 2433-328X
ISSN (online)	2433-3298
ISSN	2433-328X
DOI	10.31662/jmaj.2022-0120
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Article ; Online: Trabeculotomy Using the Kahook Dual Blade for Exfoliation Glaucoma and Primary Open Angle Glaucoma: Comparison of Outcomes According to Incision Range.

Irie, Anna / Nakashima, Kei-Ichi / Inoue, Toshihiro / Kojima, Sachi / Takihara, Yuji / Takahashi, Eri

Journal of glaucoma

2023 Volume 33, Issue 4, Page(s) 270–276

Abstract: Prcis: Large amount of trabeculotomy with Kahook Dual Blade (KDB) confers better intraocular pressure (IOP) lowering.: Purpose: We compared the postoperative outcomes of trabeculotomy using the KDB in patients with exfoliation glaucoma (EXG) and ... ...

Abstract	Prcis: Large amount of trabeculotomy with Kahook Dual Blade (KDB) confers better intraocular pressure (IOP) lowering. Purpose: We compared the postoperative outcomes of trabeculotomy using the KDB in patients with exfoliation glaucoma (EXG) and primary open angle glaucoma between the 120-degree incision and the 210- to 240-degree incision groups. Patients and methods: We retrospectively analyzed the postoperative outcomes of trabeculotomy performed using the KDB in 101 eyes with EXG and primary open angle glaucoma, who received 120- and 210- to 240-degree incisions at Kumamoto University Hospital between April 25, 2018, and August 11, 2021. Kaplan-Meyer survival curves were used to assess the outcomes. Surgical failure was defined as IOP ≥21 mm Hg (criterion A) and ≥19 mm Hg (criterion B), or an IOP ≤4 mm Hg in either criterion and the need for additional glaucoma surgery. Results: In total, 64 and 37 eyes were included in the 120 and 210- to 240-degree groups, respectively. The 210- to 240-degree group had a higher 1-year success rate compared with the 120-degree group, both when considering all eyes and when considering only those with EXG (P<0.05). Conclusions: In trabeculotomy with KDB, a 210- to 240-degree incision was more effective than a 120-degree incision in lowering IOP in EXG cases.
MeSH term(s)	Humans ; Trabeculectomy ; Exfoliation Syndrome/surgery ; Glaucoma, Open-Angle/diagnosis ; Glaucoma, Open-Angle/surgery ; Retrospective Studies ; Intraocular Pressure
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	913494-3
ISSN	1536-481X ; 1057-0829
ISSN (online)	1536-481X
ISSN	1057-0829
DOI	10.1097/IJG.0000000000002323
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Zs.A 3795: Show issues

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Article ; Online: Oxa-Michael-based divergent synthesis of artificial glutamate analogs.

Tsukamoto, Shuntaro / Hlokoane, Oriel / Miyako, Kei / Irie, Raku / Sakai, Ryuichi / Oikawa, Masato

RSC advances

2022 Volume 12, Issue 34, Page(s) 22175–22179

Abstract: Herein we report stereoselective generation of two skeletons, 1,3-dioxane and tetrahydropyranol, by oxa-Michael reaction as the key reaction from δ-hydroxyenone. The construction of the 1,3-dioxane skeleton, achieved through hemiacetal formation followed ...

Abstract	Herein we report stereoselective generation of two skeletons, 1,3-dioxane and tetrahydropyranol, by oxa-Michael reaction as the key reaction from δ-hydroxyenone. The construction of the 1,3-dioxane skeleton, achieved through hemiacetal formation followed by oxa-Michael reaction from δ-hydroxyenone, was exploited to access structurally diverse heterotricyclic artificial glutamate analogs. On the other hand, formation of a novel tetrahydro-2
Language	English
Publishing date	2022-08-10
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra03744k
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Article ; Online: Structure Revision of Protoaculeine B, a Post-translationally Modified N-Terminal Residue in the Peptide Toxin Aculeine B.

Irie, Raku / Miyako, Kei / Matsunaga, Satoko / Sakai, Ryuichi / Oikawa, Masato

Journal of natural products

2021 Volume 84, Issue 4, Page(s) 1203–1209

Abstract: The structure of protoaculeine B, the N-terminal residue of the marine peptide toxin aculeine B, is revised to ... ...

Abstract	The structure of protoaculeine B, the N-terminal residue of the marine peptide toxin aculeine B, is revised to the
MeSH term(s)	Carbolines/chemistry ; Indoles/chemistry ; Models, Molecular ; Molecular Structure ; Polyamines/chemistry ; Protein Processing, Post-Translational ; Toxins, Biological/chemistry ; Tryptophan
Chemical Substances	Carbolines ; Indoles ; Polyamines ; Toxins, Biological ; protoaculeine B ; tryptoline (65027TMI0H) ; Tryptophan (8DUH1N11BX)
Language	English
Publishing date	2021-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.0c01280
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Zs.A 1144: Show issues

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