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  1. Book: Doping für Deutschland

    Paoli, Letizia / Hoppeler, Hans / Mahler, Hellmut / Simon, Perikles / Sörgel, Fritz / Treutlein, Gerhard

    Die 'Evaluierungskommission Freiburger Sportmedizin': Geschichte, Ergebnisse und sportpolitische Forderungen

    (KörperKulturen)

    2022  

    Abstract: Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu ... ...

    Author's details Fritz Sörgel (Prof.) ist Pharmakologe und leitet das Institut für Biomedizinische und Pharmazeutische Forschung (IBMP) in Nürnberg. Seine Forschungsschwerpunkte beschäftigen sich mit dem Schicksal von Arzneimitteln und Drogen im menschlichen oder tierischen Körper. Diese Arbeiten basieren auf einer breiten Erfahrung in der Analytik, speziell der Massenspektroskopie. Darüberhinaus befasste er sich mit der Geschichte der Medizin und Pharmazie. Er war Gutachter in Dopingprozessen, Mitglied der Evaluierungskommission Freiburger Sportmediziner (2015-2016), zuvor Mitglied der Anti-Doping-Kommission des Bundes Deutscher Radfahrer (BDR) sowie Präsident der International Society for Anti-Infective Pharmacology (ISAP) (2004-2006). Im Jahr 2007 wurde ihm das Bundesverdienstkreuz verliehen
    Series title KörperKulturen
    Abstract Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »Evaluierungskommission Freiburger Sportmedizin« für eine breite Öffentlichkeit zusammenfassen. Zudem dokumentieren sie Plagiate und andere akademis...
    Keywords Albert-Ludwigs-Universität Freiburg ; Albert-ludiwgs-universität Freiburg ; Anti-Doping ; Anti-doping ; Cultural History ; Deutsche Geschichte ; Deutschland ; Doping ; Ethics ; Ethik ; Evaluation ; German History ; Germany ; Geschichtswissenschaft ; History ; History of Medicine ; History of Science ; Kulturgeschichte ; Medicine ; Medizin ; Medizingeschichte ; Science ; Sport ; Sport Medicine ; Sportmedizin ; Sportpolitik ; Sports Policy ; West Germany ; Westdeutschland ; Wissenschaft ; Wissenschaftsgeschichte
    Language German
    Size 260 p.
    Edition 1
    Publisher transcript Verlag
    Document type Book
    Note PDA Manuell_16
    Format 147 x 223 x 19
    ISBN 9783837660524 ; 3837660524
    Database PDA

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  2. Book ; Online ; E-Book: Doping für Deutschland

    Paoli, Letizia / Hoppeler, Hans / Mahler, Hellmut / Simon, Perikles / Sörgel, Fritz / Treutlein, Gerhard

    die »Evaluierungskommission Freiburger Sportmedizin«: Geschichte, Ergebnisse und sportpolitische Forderungen

    (KörperKulturen)

    2022  

    Author's details Letizia Paoli, Hans Hoppeler, Hellmut Mahler, Perikles Simon, Fritz Sörgel, Gerhard Treutlein
    Series title KörperKulturen
    Keywords Electronic books
    Language German
    Size 1 Online-Ressource (258 Seiten)
    Publisher transcript
    Publishing place Bielefeld
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030625957
    ISBN 978-3-8394-6052-8 ; 9783837660524 ; 3-8394-6052-2 ; 3837660524
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Application of advanced high resolution mass spectrometric techniques for the analysis of losartan potassium regarding known and unknown impurities.

    Backer, Laura / Buschmann, Helmut / Kinzig, Martina / Sörgel, Fritz / Scherf-Clavel, Oliver / Holzgrabe, Ulrike

    Journal of pharmaceutical and biomedical analysis

    2024  Volume 240, Page(s) 115955

    Abstract: Recalls of medicinal products can cause supply bottlenecks. This is often due to the findings of unexpected impurities that pose a health risk to patients. A recent example is losartan potassium which was contaminated with azido-impurities. The choice of ...

    Abstract Recalls of medicinal products can cause supply bottlenecks. This is often due to the findings of unexpected impurities that pose a health risk to patients. A recent example is losartan potassium which was contaminated with azido-impurities. The choice of the analytical method determines which substances can be detected and thus controlled. In this study a combination of an untargeted screening approach for impurities and a targeted evaluation of high-resolution mass spectrometry data was applied to search for impurities not described so far, leaving out a precise quantification. Six losartan potassium samples were studied regarding known and unknown impurities and hence highlight the applicability and capability of the approach. For separation a Zorbax RR StableBond C18 column (3.0 ×100 mm, particle size of 3.5 µm, pore size of 80 Å), a gradient elution and an electrospray ionization in positive and negative mode for mass spectrometric detection was used. An information-dependent acquisition method was applied for the measurement of losartan potassium samples. The untargeted data evaluation using general unknown comparative screening revealed the presence of N-methyl-2-pyrrolidone (NMP) and another impurity from synthesis. The identity of NMP was corroborated by a spiking experiment and the amount was estimated by means of standard addition. A targeted data evaluation by generating extracted ion chromatograms resulted in finding of four additional impurities. Combined approaches like this are needed to detect and respond to changes in the quality of drugs precociously.
    MeSH term(s) Humans ; Losartan ; Drug Contamination ; Mass Spectrometry ; Chromatography, High Pressure Liquid/methods
    Chemical Substances Losartan (JMS50MPO89)
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2023.115955
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  4. Article ; Online: Targeted and untargeted screening for impurities in losartan tablets marketed in Germany by means of liquid chromatography/high resolution mass spectrometry.

    Backer, Laura / Kinzig, Martina / Sörgel, Fritz / Scherf-Clavel, Oliver / Holzgrabe, Ulrike

    Journal of pharmaceutical and biomedical analysis

    2024  Volume 245, Page(s) 116160

    Abstract: Technical advances in the field of quality analysis allow an increasingly deeper look into the impurity profile of drugs. The ability to detect unexpected impurities in addition to known impurities ensures the supply of high-quality drugs and can prevent ...

    Abstract Technical advances in the field of quality analysis allow an increasingly deeper look into the impurity profile of drugs. The ability to detect unexpected impurities in addition to known impurities ensures the supply of high-quality drugs and can prevent recalls due to the detection of harmful unexpected impurities, as has happened recently with the N-nitrosamine and azido impurities in losartan (LOS) drug products. In the present study, the LC-MS/HRMS approach described by Backer et al. was applied to an even more complex system, being the investigation of 35 LOS drug products and combination preparations purchased in 2018 and 2022 in German pharmacies. The film-coated tablets were analysed by means of four LC-MS/HRMS method variants. For the separation a Zorbax RR StableBond C18 column (3.0 ×100 mm, particle size of 3.5 µm, pore size of 80 Å), a gradient elution and for mass spectrometric detection a qTOF mass spectrometer with electrospray ionization in positive and negative mode was used. An information-dependent acquisition method was applied for the acquisition of high-resolution mass spectrometry data. The combination of an untargeted and a targeted screening approach revealed the finding of eight impurities in total. Beside the five LOS related compounds, LOS impurity F, J, K, L, M, and related compound D from amlodipine besilate, LOS azide and an unknown derivative thereof were detected. Identification and structure elucidation, respectively, were successfully performed using in silico fragmentation. Differences in the impurity profiles of drug products from 2018 and 2022 could be observed. This study shows that broad screening approaches like this are applicable to the analysis of drug products and can be an important enhancement of the quality assurance of medicinal products.
    Language English
    Publishing date 2024-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2024.116160
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  5. Article ; Online: Understanding adefovir pharmacokinetics as a component of a transporter phenotyping cocktail.

    Dong, Qian / Chen, Chunli / Taubert, Max / Bilal, Muhammad / Kinzig, Martina / Sörgel, Fritz / Scherf-Clavel, Oliver / Fuhr, Uwe / Dokos, Charalambos

    European journal of clinical pharmacology

    2024  

    Abstract: Purpose: Adefovir (as dipivoxil) was selected as a probe drug in a previous transporter cocktail phenotyping study to assess renal organic anion transporter 1 (OAT1), with renal clearance (CL: Methods: Data from 24 healthy subjects were reanalyzed. ... ...

    Abstract Purpose: Adefovir (as dipivoxil) was selected as a probe drug in a previous transporter cocktail phenotyping study to assess renal organic anion transporter 1 (OAT1), with renal clearance (CL
    Methods: Data from 24 healthy subjects were reanalyzed. After establishing a base model, covariate effects, including the impact of co-administered drugs, were assessed using forward inclusion then backward elimination.
    Results: A one-compartment model with first-order absorption (including lag time) and a combination of nonlinear renal and linear nonrenal elimination best described the data. A significantly higher apparent bioavailability (73.6% vs. 59.0%) and a lower apparent absorption rate constant (2.29 h
    Conclusion: The popPK modeling approach indicated that the co-administration primarily affected the apparent absorption and/or prodrug conversion of adefovir dipivoxil, resulting in the minor drug-drug interaction observed for adefovir as a victim. However, renal elimination remained unaffected. The high K
    Language English
    Publishing date 2024-03-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 121960-1
    ISSN 1432-1041 ; 0031-6970
    ISSN (online) 1432-1041
    ISSN 0031-6970
    DOI 10.1007/s00228-024-03673-x
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  6. Article ; Online: Caffeine, Paraxanthine, Theophylline, and Theobromine Content in Human Milk.

    Purkiewicz, Aleksandra / Pietrzak-Fiećko, Renata / Sörgel, Fritz / Kinzig, Martina

    Nutrients

    2022  Volume 14, Issue 11

    Abstract: This study aimed to assess the content of caffeine and its metabolites-paraxanthine, theophylline, and theobromine-in breast milk according to selected factors. Samples of human milk were collected from 100 women living in the east-northeast region of ... ...

    Abstract This study aimed to assess the content of caffeine and its metabolites-paraxanthine, theophylline, and theobromine-in breast milk according to selected factors. Samples of human milk were collected from 100 women living in the east-northeast region of Poland. Information on the consumption of beverages and foods containing caffeine was collected using a 3 day food record. The determination of caffeine and its metabolite content was performed using liquid chromatography-mass spectrometry (LC-MS/MS). This study research showed that more caffeine was found in the milk of women living in cities, with secondary education, aged 34-43, and also in milk from the 3rd and 4th lactation periods (
    MeSH term(s) Caffeine/analysis ; Chromatography, Liquid ; Female ; Humans ; Milk, Human/chemistry ; Tandem Mass Spectrometry ; Theobromine ; Theophylline
    Chemical Substances Caffeine (3G6A5W338E) ; Theophylline (C137DTR5RG) ; Theobromine (OBD445WZ5P) ; 1,7-dimethylxanthine (Q3565Y41V7)
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14112196
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  7. Article ; Online: Identification of low-level impurities in drug prototypes of carbocisteine by means of liquid chromatography-high-resolution mass spectrometry and general unknown comparative screening.

    Walther, Rasmus / Kinzig, Martina / Zamponi, Annette / Sörgel, Fritz / Scherf-Clavel, Oliver / Holzgrabe, Ulrike

    Journal of chromatography. A

    2023  Volume 1706, Page(s) 464269

    Abstract: High-resolution tandem quadrupole time-of-flight mass analysers enable new automated workflows for untargeted data evaluation of complex samples like drug products. An example of such procedure is the so-called general unknown comparative screening (GUCS) ...

    Abstract High-resolution tandem quadrupole time-of-flight mass analysers enable new automated workflows for untargeted data evaluation of complex samples like drug products. An example of such procedure is the so-called general unknown comparative screening (GUCS), which is used for software-assisted, automated identification of components that are only present in a sample and not in a reference. The GUCS approach has been employed for the first time to detect both degradation products and reaction products in drug products. Two different carbocisteine containing syrup prototypes - one with sucrose and the other with artificial sweeteners - were selected as examples after nine months of storage at 40 °C and 75% relative humidity. The samples were analysed chromatographically using a Coresep SB mixed-mode column and high-resolution MS and MS/MS data were recorded in information dependant acquisition mode on a Sciex X500R quadrupole time-of-flight mass spectrometer. Data analysis was considerably facilitated using the corresponding placebo formulation as reference samples. With the GUCS approach two hitherto unknown degradation products of carbocisteine, i.e. the carbocisteine lactam of the sulfoxides and the disulfide between l-cysteine and thioglycolic acid, were detected at low concentrations in both of the syrup formulations. The presumed structures were confirmed by in silico analysis of the fragment spectra and high-resolution LC-MS experiments with reference substances. Two additional impurities were found in the sucrose-containing sample and identified as the N-glycosides of carbocisteine and its lactam, respectively, using binary mixtures with a
    MeSH term(s) Tandem Mass Spectrometry/methods ; Chromatography, Liquid/methods ; Drug Contamination ; Software ; Chromatography, High Pressure Liquid/methods
    Language English
    Publishing date 2023-08-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1171488-8
    ISSN 1873-3778 ; 0021-9673
    ISSN (online) 1873-3778
    ISSN 0021-9673
    DOI 10.1016/j.chroma.2023.464269
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  8. Article ; Online: Central nervous system infections and antimicrobial resistance: an evolving challenge.

    Nau, Roland / Sörgel, Fritz / Eiffert, Helmut

    Current opinion in neurology

    2021  Volume 34, Issue 3, Page(s) 456–467

    Abstract: Purpose of review: Antimicrobial resistance is an increasing threat to patients also in nosocomial central nervous system (CNS) infections. The present review focusses on optimizing intravenous treatment in order to achieve sufficient concentrations of ... ...

    Abstract Purpose of review: Antimicrobial resistance is an increasing threat to patients also in nosocomial central nervous system (CNS) infections. The present review focusses on optimizing intravenous treatment in order to achieve sufficient concentrations of antibiotics in the different compartments of the CNS when the causative pathogens have reduced sensitivity to antibiotics or/and the impairment of the blood-cerebrospinal fluid (CSF) and blood-brain barrier is mild.
    Recent findings: Experience has been gathered with treatment protocols for several established antibiotics using increased doses or continuous instead of intermittent intravenous therapy. Continuous infusion in general does not increase the average CSF concentrations (or the area under the concentration-time curve in CSF) compared to equal daily doses administered by short-term infusion. In some cases, it is postulated that it can reduce toxicity caused by high peak plasma concentrations. In case reports, new β-lactam/β-lactamase inhibitor combinations were shown to be effective treatments of CNS infections.
    Summary: Several antibiotics with a low to moderate toxicity (in particular, β-lactam antibiotics, fosfomycin, trimethoprim-sulfamethoxazole, rifampicin, vancomycin) can be administered at increased doses compared to traditional dosing with low or tolerable adverse effects. Intrathecal administration of antibiotics is only indicated, when multiresistant pathogens cannot be eliminated by systemic therapy. Intravenous should always accompany intrathecal treatment.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Blood-Brain Barrier ; Central Nervous System Infections/drug therapy ; Drug Resistance, Bacterial ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000931
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  9. Book ; Online ; Thesis: Analysis of Drug Impurities by Means of Chromatographic Methods: Targeted and Untargeted Approaches

    Wohlfart, Jonas Verfasser] / [Holzgrabe, Ulrike [Gutachter] / Sörgel, Fritz [Gutachter]

    2022  

    Author's details Jonas Wohlfart ; Gutachter: Ulrike Holzgrabe, Fritz Sörgel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Article ; Online: Intravenous cefiderocol for neurosurgical meningitis from an extensively drug-resistant New-Delhi metallo-β-lactamase-producing Pseudomonas aeruginosa strain.

    Stevenson, Daniel R / Cherian, Benny P / Kinzig, Martina / Sörgel, Fritz / Wareham, David W

    Journal of global antimicrobial resistance

    2022  Volume 32, Page(s) 29–30

    MeSH term(s) Pseudomonas aeruginosa ; Cephalosporins/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; beta-Lactamases/genetics ; Cefiderocol
    Chemical Substances Cephalosporins ; Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2022-12-25
    Publishing country Netherlands
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2022.11.019
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